Panangin Forte

Panangin Forte is a combined two-component drug to eliminate the lack of magnesium and potassium when their levels decrease below the physiological norm. The importance of these two macroelements for the normal functioning of the human body is difficult to overestimate. Without them, the operation of many enzymatic systems is impossible. They participate in the interaction of high-molecular compounds and interstitial structures, in the mechanism of contraction of muscle fibers. The balance of concentrations of potassium and magnesium ions inside and outside the cell determines the contractility of the heart muscle. The potassium and magnesium aspartates included in the drug act as a conductor of these ions. These salts have a high degree of affinity for cells and penetrate into them in an undissociated state in the form of complexes with potassium and magnesium ions. Potassium and magnesium ions improve metabolism in the heart muscle. Their lack creates conditions for the development of hypertension, increased deposition of cholesterol plaques on the walls of the coronary arteries, and metabolic disorders of the myocardium. When taken orally, both components of the drug undergo intense absorption in the small intestine and to a small extent in other parts of the gastrointestinal tract. Elimination from the body occurs through urine. Elimination from the body of both active components of the drug is carried out together with urine. Panangin Forte is used as an additional therapy for various manifestations of ischemia, including. for acute heart attacks, chronic decompensated myocardial failure, cardiac arrhythmias (including cardiac arrhythmias associated with an overdose of digoxin and other cardiac glycosides). Panangin Forte is sold from pharmacies without a doctor's prescription, however, medical consultation is recommended before taking it. The optimal time to take the drug is after meals, because... high gastric pH weakens the effect of the drug. The recommended (also maximum) daily dose of Panangin Forte is 1 tablet.

The frequency of administration is three times a day. Possible undesirable side reactions: painful sensation in the epigastric region, chest, oral cavity and pharynx, preceding vomiting (as well as vomiting itself), frequent (at least three times a day) bowel movements with watery stools, discomfort in the epigastric region (in patients with chronic inflammation of the gastric mucosa or inflammation of the gallbladder), atrioventricular block, an increase in the number of ventricular extrasystoles, hyperkalemia (manifestations - gagging, a feeling of crawling, diarrhea), hypermagnesemia (manifestations - flushing of the facial skin, the urge to drink, hypotension, difficulty breathing). Panangin Forte is not prescribed for individual intolerance to the components of the drug, insufficiency of renal function, increased levels of potassium and/or magnesium in the blood, chronic insufficiency of the adrenal cortex, atrioventricular block of 1-3 degrees, disorders of amino acid metabolism, severe asthenic bulbar palsy, dehydration. The drug is not used in pediatric practice due to the lack of clinical data on its effectiveness and safety in patients of this age group. Pregnancy is not a direct contraindication to the use of the drug; however, when prescribing the drug during this period, patients should be under constant medical supervision (which is especially important in the first trimester of pregnancy). Considering the ability of the active ingredients of the drug to pass into breast milk, you should refrain from using the drug during lactation. Persons suffering from diseases, one of the manifestations of which is an increased level of potassium in the blood, should be under strict medical supervision while taking the drug. Spironolactone and other potassium-sparing diuretics, as well as beta-adrenergic blockers, heparin, NSAIDs, angiotensin-converting enzyme inhibitors, when used in conjunction with Panangin Forte, increase the likelihood of developing hyperkalemia.

Cardiovascular drugs Gedeon Richter Panangin - reviews

Elena
https://med-otzyv.ru/lekarstva/158-p/28783-panangin#scomment-371511

My mother takes Panangin tablets and is very pleased. This medicine has a beneficial effect on the functioning of the heart. After starting to take Panangin, my mother stopped having extrasystoles during electrocardiography. And before that, even subjectively, my mother felt them, like interruptions in the functioning of the heart.

Alexei
https://med-otzyv.ru/lekarstva/158-p/28783-panangin#scomment-339806

In principle, I normally tolerate many blows of fate, but one day I experienced terrible stress and noticed that I began to feel every beat of my heart, I thought that it would jump out of me. I couldn’t relax, I had a constant feeling of anxiety, I started to get even more nervous and went to see a doctor. After examining me and hearing why this all started for me, the doctor prescribed me to take Panangin. When I bought the tablets, the pharmacist told me that this was the most popular drug. I started taking 1 tablet 3 times a day and now everything is fine.

YuliaAxent
https://irecommend.ru/content/khoroshii-uspokoil-takhikardiyu

Panic attacks caused by pain syndrome of intercostal neuralgia - diagnosed by a neurologist, an unpleasant thing that ends (for me) with tachycardia (120-130 beats per minute). They don’t die from this, of course, but it’s not very good for the heart. The pulse was consistently 82-84 beats at rest, shortness of breath at the slightest exertion (I don’t smoke, I don’t drink alcohol). Ultrasound and ECG showed no significant changes. The doctor prescribed Panangin 1t twice a day. After a week, results were already noticeable. After physical activity, the pulse returned to normal within 15-20 minutes. The norm for me was 72-75 beats per minute.

nikit_2017
https://irecommend.ru/content/panangin-zdorove-serdtsa-i-sosudov

I learned about this drug from the internet. I was looking for information on sports pharmacology, about means of recovery after physical activity. I do sports systematically, I go to the gym, where I often train with heavy weights.

Previously, when I was younger, I endured stress easily and did not go into much detail about sports pharmaceuticals. However, the years took their toll and by the age of forty I came to the realization that I could not do without drugs for restoring and maintaining organs and muscles in the appropriate tone. One of these means of recovery and became Panangin.

The content of potassium and magnesium in it helps my heart overcome and recover from stress. I take the drug in courses. One package (50 pcs) once every 3-4 months. I don’t know any problems with the heart and I avoid vascular diseases.

Preventive use of Panangin will also be useful for people who do not engage in sports. However, everything is individual. Decide for yourself whether you need it or not. I can’t do without this drug!

djessi1985
https://otzovik.com/review_2403533.html

Advantages:

Effective, inexpensive, convenient packaging

Flaws:

Greetings, my friends and site guests! In today’s review, I want to talk about a very effective drug that a cardiologist prescribed to me for heart rhythm disturbances, namely an increase in heart rate above 90 beats per minute. Price 149 rubles. The drug is sold in a plastic bottle, this is what it looks like: I took the drug one tablet three times a day. I felt the effect of the drug after about two weeks, my heart rate was restored, and unpleasant sensations such as shortness of breath and dizziness disappeared. In conclusion, I would like to say that the drug is very effective, but unfortunately, I now need to take it regularly; two months after stopping the drug, all the unpleasant symptoms return.

Masik280
https://otzovik.com/review_6433427.html

Advantages:

A good quality product.

Flaws:

I have known this drug for many years, even when I worked in a hospital, it was prescribed to everyone who drinks diuretics, since they not only relieve swelling, but also wash away potassium, calcium, and magnesium. This drug has several names: Asparkam and Panangin. In fact, this is the same drug, only it is produced in different countries, and accordingly their prices are different. Panangin has a smooth intestinal lining, the tablets are smooth and white. Asparkam without shell, white. I like Panangin better, so I only buy it. I like the size and quality of the tablet, it is slightly smaller than Asparkam, which means it is more purified. I started drinking Panangin first on my own, because from another drug that I am now taking, I began to have rapid heartbeats, my pulse was 125-145 beats. Then, a little later, my doctor prescribed it to me. I take 1 tablet 3 times a day. Panangin helped me literally within a few days, now my pulse has returned to normal. Price 200 rubles. The drug has been tested over the years and has proven itself to be excellent. It is a must for all people who take diuretics. I recommend it as excellent.

pedchenko
https://otzovik.com/review_1737913.html

Advantages:

Strengthens the heart muscle, normalizes the pulse. Calmness sets in. Potassium and magnesium are very necessary to nourish the heart.

Flaws:

Disadvantages: there are contraindications.

Neighbor Nina sometimes worries about her heart. The doctor advised her to take Panangin tablets to strengthen her heart muscle. But at the age of 67, my heart began to worry me too. I went to the doctor and she recommended these pills for me. I bought it. The price turned out to be not that high. And there are many benefits. Contains magnesium and potassium. I started drinking them now in spring and autumn. I feel like the pills are helping me. The pulse returns to normal. Somehow, imperceptibly, calm came. Take the medicine only on the recommendation of a doctor.

aiv
https://otzovik.com/review_2052519.html

Advantages:

effective

Flaws:

Expensive

Gedeon Richter Panangin tablets were prescribed to me by my endocrinologist to support my heart, since I had arrhythmia. Panangin tablets - they contain potassium and magnesium, which are necessary for normal heart function. The drug is very effective, there are fifty tablets in the box, you need to take one three times a day. In terms of price, the tablets are not cheap - more than a hundred hryvnia per pack, so I drank one pack of Panangin and switched to our drug Asparkam (which is much cheaper and no worse). I recommend Panangin, but you can also take cheaper analogues.

nadezhda601105
https://otzovik.com/review_3829124.html

Advantages:

Few side effects

Flaws:

A little expensive

I had cardiac arrhythmia and took Panangin as prescribed by a doctor for one year. Now there is no cardiac arrhythmia - it helped. In addition, it is recommended as a preventive measure, because it nourishes the cardiovascular system with magnesium.

Panangin 50 pcs. film-coated tablets

pharmachologic effect

Panangin is a drug that affects metabolic processes in the human body.
The drug is a source of magnesium and potassium ions. Potassium and magnesium are intracellular cations that play a major role in the proper functioning of most enzymes. These cations interact with macromolecules and intracellular structures, and also take part in the processes of muscle contraction in the body.

The contractile property of the myocardium depends on the intracellular and extracellular ratio of ions of such substances. Like calcium, magnesium, potassium and sodium. A low content of potassium and magnesium ions in the body can provoke a proarrhythmogenic effect, which will lead to the development of an increase in blood pressure in the vessels, atherosclerosis and the appearance of metabolic changes in the myocardium.

The most important physiological property of potassium is considered to maintain the stability of the membrane potential of neurons and other structures in myocardial tissue. If there is a violation of the relationship between the intracellular and extracellular presence of potassium, this can lead to a decrease in the ability of the myocardium to contract, to the occurrence of disturbances in the heartbeat rhythm, tachycardia, as well as to an increase in the level of toxicity in cardiac glycosides.

Magnesium is a substance necessary for the body to carry out more than three hundred enzymatic interactions of energy metabolism and synthesis in proteins and nucleic acids. Magnesium can reduce the tension that occurs as a result of contraction and heart rate. This leads to a decrease in myocardial oxygen demand. In addition, magnesium can be used to prevent ischemic effects on myocardial tissue.

The simultaneous combination of magnesium and potassium ions in the drug Panangin is based on the fact that potassium deficiency in the body is almost always accompanied by magnesium deficiency and vice versa. In such cases, simultaneous correction of the presence of these ions in the body is necessary. During correction of the levels of these electrolytes, an additive effect can be observed. In addition, magnesium and potassium reduce the toxicity of cardiac glycosides without affecting their effect on the force of heart contractions.

When the medicine is taken orally, it is characterized by high absorption. The drug is excreted in the urine.

Composition and release form Panangin 50 pcs. film-coated tablets

Tablets - 1 tablet.

Active ingredients: potassium aspartate hemihydrate - 166.3 mg, which corresponds to the content of potassium aspartate - 158 mg; magnesium aspartate tetrahydrate - 175 mg, which corresponds to the content of magnesium aspartate - 140 mg;
Excipients: colloidal silicon dioxide - 2 mg, povidone K30 - 3.3 mg, magnesium stearate - 4 mg, talc - 10 mg, corn starch - 86.1 mg, potato starch - 3.3 mg;
Shell composition: macrogol 6000 - 1.4 mg, titanium dioxide Color ind. 77891, E171 - 5.3 mg, butyl methacrylate, dimethylaminoethyl methacrylate and methacrylate copolymer [1:2:1] - 6 mg, talc - 7.3 mg.

Description of the dosage form

White or almost white film-coated tablets, round, biconvex, with a slightly shiny and uneven surface, almost odorless.

Directions for use and doses

Before use, the patient should consult a doctor.

Prescribe 1-2 tablets orally. 3 times/day. The maximum daily dose is 3 tablets. 3 times/day.

The drug should be used after meals, because the acidic environment of the stomach contents reduces its effectiveness.

The duration of taking the drug and the need for repeated courses is determined by the doctor.

Pharmacodynamics

The most important intracellular cations potassium and magnesium play a key role in the functioning of many enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Potassium and magnesium aspartate improves myocardial metabolism. A lack of potassium and/or magnesium ions predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries and the occurrence of metabolic changes in the myocardium.

Pharmacokinetics

When taken orally, absorption of the drug is high. Excreted by the kidneys.

Indications for use Panangin 50 pcs. film-coated tablets

As an additional remedy:

in the treatment of chronic heart diseases (heart failure, condition after myocardial infarction);
for heart rhythm disturbances (primarily ventricular arrhythmias);
during treatment with cardiac glycosides.

Replacement therapy for lack of magnesium/potassium in food.

Contraindications

hypersensitivity to the components of the drug;
acute and chronic renal failure;
hyperkalemia;
hypermagnesemia;
Addison's disease;
AV blockade I-III degree;
cardiogenic shock (BP
violation of amino acid metabolism;
myasthenia gravis;
hemolysis;
acute metabolic acidosis;
dehydration of the body.

With caution: pregnancy (especially in the first trimester) and during lactation.

Application Panangin 50 pcs. film-coated tablets during pregnancy and breastfeeding

The drug should be used with caution during pregnancy (especially in the first trimester) and during lactation (breastfeeding).

special instructions

Use for renal impairment

Acute and chronic renal failure, oliguria, anuria.

Particular attention is required for patients with diseases accompanied by hyperkalemia: regular monitoring of the potassium ionogram in the blood plasma is necessary.

Overdose

Symptoms: cardiac conduction disturbances (especially with previous pathology of the cardiac conduction system).

Treatment: intravenous administration of calcium chloride, if necessary, hemodialysis and peritoneal dialysis.

Side effects Panangin 50 pcs. film-coated tablets

From the cardiovascular system: AV blockade, paradoxical reaction (increased number of extrasystoles) are possible.

From the digestive system: possible nausea, vomiting, diarrhea, discomfort or burning sensation in the pancreas (in patients with anacid gastritis or cholecystitis).

From the side of water and electrolyte balance: possible hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (redness of the face, thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions).

Drug interactions

When used simultaneously with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs, the risk of developing hyperkalemia up to the appearance of arrhythmia and asystole increases.

The use of potassium supplements together with corticosteroids eliminates the hypokalemia they cause.

Under the influence of potassium, a decrease in the undesirable effects of cardiac glycosides is observed.

Strengthens the negative dromo- and bathmotropic effect of antiarrhythmic drugs.

Magnesium preparations reduce the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin.

Anesthetics enhance the inhibitory effect of magnesium on the central nervous system.

When used simultaneously with atracurium, dexamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced; with calcitriol - increasing the level of magnesium in the blood plasma.

Calcium supplements reduce the effect of magnesium supplements.

Pharmacokinetic interaction

Astringents and enveloping agents reduce the absorption of the drug in the gastrointestinal tract. It is necessary to observe a 3-hour interval between oral administration of the drug Panangin® with the listed means.