Alpha Normix tablets: instructions for use, price, reviews, analogues

Prohibited during pregnancy

Prohibited during breastfeeding

Alfa Normix is often called Normix, given that there is no other medicine with that name. The drug is a broad-spectrum antibiotic. The action of the drug is aimed at eliminating gastrointestinal infections, including salmonellosis, diarrhea, dysentery, etc. It does not penetrate into the blood and is concentrated exclusively within the intestines. It is used to prevent the occurrence of infectious complications in the gastrointestinal tract after surgery.

After using Normix the following effects are observed:

the formation of ammonia in the intestines is reduced, which prevents the development of encephalopathy;
if there is a predisposition to excessive growth of microorganisms in the intestines, the drug reduces the rate of bacterial reproduction;
reduces the number of bacteria in the diverticulum that cause diverticular diseases and complications;
eliminates the risk of progression of infections in the postoperative period of the intestine.

The medicine is an effective drug, but it is not the only one; there is a whole list of analogues of Alpha Normix. Medicines have practically the same properties, but also benefit in cost.

The drug is produced in several forms:

coated tablets, two hundred milligrams for oral use, 12 pieces in a package;
granules. They are intended to prepare a suspension, which should be taken orally in doses of one hundred milligrams.

Alpha Normix is a drug with a unique structure. There are no generics on the pharmaceutical market, but pharmacies have a number of substitutes that are identical in mechanism of action, but consisting of different components. The price of Alpha Normix tablets is a disadvantage of the drug, so many doctors, when prescribing it, recommend several analogues so that patients can complete the course of treatment rather than refuse it.

Compound

1 tablet contains 200 mg of the active ingredient rifaximin + additional substances (sodium carboxymethyl starch, microcrystalline cellulose, glycerol palmitostearate, colloidal silicon dioxide, talc, hypromellose, E172, titanium dioxide, disodium edetate, propylene glycol).
For 5 ml of a pre-prepared suspension of the drug there is 100 mg of rifaximin + additional ingredients (sodium carmellose, kaolin, sodium benzoate, wild cherry flavor, microcrystalline cellulose, pectin, sodium saccharinate, sucrose).

Alpha Normix or Enterofuril - which is better?

Manufacturer: Bosnalek, Bosnia and Herzegovina
Release form: capsules, suspension

Active ingredient: nifuroxazide

Synonyms: Nifuroxazide, Stopdiar, Nifural, Ersefuril

Enterofuril is an analogue that is used for acute diarrhea. Unlike the antibiotic Alpha Normix, Enterofuril does not disrupt the intestinal microflora. At the same time, the product blocks the development of pathogenic bacteria using a more gentle method.

The list of indications for the use of this substitute is much narrower, which allows its use only for acute uncomplicated diarrhea caused by sensitive bacteria. This analogue is approved for use from 1 month, which indicates its high safety.

Pharmacodynamics and pharmacokinetics

The drug contains the active substance in alpha form. It is an antibiotic belonging to the rifampicin . The active substance has the property of binding the beta subunits of the DNA-dependent enzyme of bacteria, thus, rifaximin inhibits the process of RNA and protein synthesis in bacterial cells. This process is irreversible, the bacterium dies.

The product is sensitive to a variety of gram-positive and gram-negative bacteria .

In the intestine, the antibiotic is not absorbed and does not enter the systemic bloodstream; therefore, the substance affects only the intestinal microflora and significantly reduces the level of pathogenic intestinal bacterial flora. However, the antibiotic rarely causes serious adverse reactions.

The drug reduces:

the amount of ammonia and other waste products of bacteria;
the number of bacteria present in colonic diverticula , thereby reducing inflammation around the diverticular sac , eliminating symptoms and reducing the risk of complications from diverticular disease ;
proliferation of microorganisms (if it is increased due to bacterial overgrowth syndrome in the intestines);
a specific antigenic stimulus that can initiate and maintain chronic inflammation in the intestine;
the risk of infectious complications arising after or during colorectal surgery. operations.

Less than one percent of the antibiotic is absorbed through the gastric mucosa. It is not detected in the blood after administration (sometimes present in small quantities). At a maximum daily dose of 0.8 g, it reaches its peak concentration in the intestines within three hours. It is then found in urine, but in an amount of less than one percent.

Cheap analogues of Alpha Normix

Alpha Normix can be replaced with the following drugs:

Nifuroxazide;
Phthalazole;
Enterofuril;
Stopdiar;
Sulgin;
Sangviritrin.

Nifuroxazidum (Nifuroxazide) is the main analogue of the drug Alpha Normix, an antimicrobial drug that effectively affects intestinal infections. Belongs to the group of nitrofurans. The main active ingredient is nitroxazide, auxiliary ingredients: cellulose, lactose, calcium stearate, povidone, yellow iron oxide, indigo carmite. The medicine has a blocking effect on microorganisms. Due to this, cellular respiration is reduced, and tricarboxylic acids change the cycle. This further leads to a reduction in the release of toxins produced by pathogenic microorganisms. When taking daily doses, a bactericidal effect occurs. It is excreted from the body along with feces.

Phthalazolum (Phthalazol) is an effective antimicrobial drug with a broad spectrum of action. It affects pathogens of intestinal infections in the intestinal lumen and destroys them. It is characterized by a pronounced bacteriostatic effect, stopping the growth and reproduction of microorganisms. Blocks the cellular process of synthesis of factors for enlargement and proliferation of bacterial cells.

Prescribed to patients after surgery, for gastroenteritis, colitis, dysentery and other diseases.

Enterofuryl (Enterofuril) is another analogue of Alpha Normix tablets. It contains the active substance: nifuroxazide. The medicine is an antimicrobial drug with a wide spectrum of influence, but it is not one of those drugs that have a systemic effect. Used in the treatment of diarrhea of infectious etiology. The medicine Enterofuril is not prescribed for diarrhea, if the presence of helminthic infestation is detected.

The medicine can be used in the treatment of acute and chronic diarrhea of unknown etiology. The drug does not enter the systemic bloodstream or into mother's milk during lactation, therefore it is prescribed, if necessary, to nursing mothers, as well as pregnant women.

Stopdiar (Stopdiar) is used in the treatment of intestinal infections, having antidiarrheal, anti-inflammatory, antimicrobial properties. It is used to treat not only adults, but also children over six years of age. After taking the tablets, nifuroxazide does not leave the digestive tract. Thus, a high concentration of the active component is created in the intestines, after which the therapeutic effect quickly occurs.

Sulgin (Sulgin). It has a bacteriostatic effect on microorganisms that cause intestinal infections. Seven percent of the drug, which is a small fraction, penetrates the circulatory system and is subsequently excreted through the urine.

Sulgin is prescribed to patients with an established diagnosis of diseases:

acute diarrhea due to shigellosis;
chronic diarrhea during exacerbation;
gastroenterocolitis, chronic or acute;
after surgery of any kind to prevent infectious diseases;
Typhoid fever bacilli detected (after three examinations).

Sulgin differs from previous drugs in its mechanism of action.

Sanguiritrin (Sangviritrin) is a medicine with an antiseptic and disinfectant effect. A distinctive feature of this drug is its plant origin. The preparation is based on components of two types of malea grass: heart-shaped and small-fruited.

As a prophylactic agent, Sangviritrin is prescribed to newborns to prevent purulent-inflammatory skin diseases and to surgical patients to prevent wound infections.

Sangviritrin has a wide range of uses:

prescribed to newborns with purulent-inflammatory skin diseases;
for people who have undergone surgery - as a prophylactic anti-infective agent;
for skin diseases, the presence of a fungal infection;
for stomatitis, periodontitis, etc. - in dentistry;
sore throat, middle ear disease is the reason for prescribing this medicine;
vaginitis, cervical erosion - in gynecology;
various diseases - in dermatology.

All these and other analogues are cheaper than Alpha Normix, but their therapeutic effect is not inferior to Normix, so specialists can, at their discretion, prescribe drugs for the treatment of identical diseases.

Indications for use

An antibiotic is prescribed to treat infections that are sensitive to its effects, namely:

intestinal bacterial overgrowth syndrome;
diverticular disease of the colon;
traveler's diarrhea;
acute infections in the gastrointestinal tract ;
hepatic encephalopathy ;
inflammation of the intestines (chronicle);
prevention of complications after surgical operations in the colorectal region .

Alpha Normix or Ciprofloxacin - which is better?

Manufacturer: Ozone, Russia
Release form: tablets

Active ingredient: ciprofloxacin

Synonyms: Quintor, Procipro, Tsiprinol, Tsiprodox, Tsiprolet, Tsifran OD

Ciprofloxacin is a bactericidal analogue of Alpha Normix, a fluoroquinolone antibiotic. The medicine is safe and has low toxicity. Widely used for gastrointestinal infections, including intravenously for complicated forms of diseases.

It is prescribed orally for children from 3 years of age, intravenously - from 15 years of age. Use in high doses can lead to disturbances in the formation of the musculoskeletal system. Among the side effects, as with the analogue of Alpha Normix, dyspepsia, allergies to the components of the drug and arthropathy are common.

Side effects

Side effects are rare. Of those observed during the drug study, most were symptoms of concomitant diseases: increased blood pressure , dizziness , palpitations, headache , distortion or loss of taste, shortness of breath rash , cold sweat, fever , diarrhea , heartburn , angioedema .

The most likely reactions to occur are from the gastrointestinal tract: nausea , pain in the epigastric region , vomiting . Most often, reactions of this kind go away on their own some time after the start of use.

Alpha Normix or Alfaxim - which is better?

Manufacturer: Obolenskoye FP, Russia
Release form: tablets

Active ingredient: rifaximin

Synonyms: Alpha Normix

Alfaxim is a complete analogue, which differs only in the manufacturer. The cost of the drug in tablets is lower than its European substitute Alpha Normix. According to doctors, the product is effective for various gastrointestinal infections if they are caused by sensitive bacteria. Also, this analogue of Alpha Normix is often prescribed for IBS and SIBO.

The medicine does not cause serious side effects and is very well tolerated. Alfaxim does not lead to severe disturbances of the intestinal microflora, unlike stronger antibiotics of other groups.

Alpha Normix, instructions for use (Method and dosage)

Alpha Normix tablets

The tablets are taken orally, without splitting or chewing. The dosage and duration of administration are determined by the attending physician.

Persons over 12 years of age are prescribed one tablet every 8 hours or 2 tablets every 12 hours. Treatment should not last longer than 7 days.

The course can be repeated no earlier than in a month.

Instructions for use of Alpha Normix granules

To prepare the suspension, add water to the bottle (up to the first mark), shake well and add water to the next mark. The required amount of the finished suspension is measured using a measuring cup.

The already prepared solution can be used within a week (if stored at room temperature). The suspension must be shaken before use.

For children over 12 years of age and adults, the dose per day is 600-1200 mg of antibiotic, which corresponds to taking 10-20 ml 2-3 times a day.

At the age of 6 to 12 years, the daily dose is 400-800 mg. Take 10-20 ml of suspension 2 times a day.

For children 2-6 years old, the daily dosage is 200-600 mg. Prescribe 5-10 ml 2-3 times a day.

The course does not exceed 7 days. Before taking, you should consult your doctor.

Alpha Normix or Rifaximin - which is better?

Release form: tablets

Active ingredient: rifaximin

Synonyms: Alpha Normix, Alfaxim

Rifaximin is a direct analogue of Alpha Normix. The medication has identical composition, dosage and pharmacological effects. Widely used for infectious and inflammatory diseases of the gastrointestinal tract. Since the drug is not available in Russian pharmacies under this trade name, doctors prescribe its full analogues Alfa Normix or Alfaxim.

Rifaximin is indicated for use in children from 12 years of age. It is undesirable to prescribe this analogue to pregnant and lactating women. There is a high probability of musculoskeletal system disorders in the fetus and newborn.

Reviews about Alpha Normix

The drug is good. Reviews of Alpha Normix are mostly positive. The medicine helps to cope not only with chronic intestinal diseases, but is also effective as an emergency remedy. Many people forget that after taking such strong antibiotics, it is worth taking a course of probiotics to restore normal microflora in the intestines .

You should not self-medicate; the medicine should be taken under supervision and after consultation with a doctor.

Alpha Normix or Metronidazole - which is better?

Manufacturer: Ozone, Russia
Release form: tablets

Active ingredient: metronidazole

Synonyms: Trichopolum, Flagyl, Trichobrol, Klion

Metronidazole has similar effects. This product cannot be considered a full-fledged replacement, since it does not provide the full range of actions compared to Alpha Normix. Metronidazole is often prescribed as part of complex therapy for peptic ulcers and Helicobacter pylori infections.

Both medications are effective in preventing complications during intestinal surgery. Metronidazole is prescribed with caution for a number of liver diseases. The medicine is used in children from 6 years of age. It has a more extensive list of side effects.

Alpha Normix price, where to buy

You can buy tablets for 600 rubles for 12 pieces.

The price of Alpha Normix for 36 tablets is 1,400 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Alpha Normix tablets p.p.o.
200 mg 28 pcs. Alfasigma S.p.A. RUB 1,519 order
Alpha Normix tablets p.p.o. 200 mg 36 pcs. Alfasigma S.p.A.
1800 rub. order
Alpha Normix tablets p.p.o. 200 mg 12 pcs. Alfasigma S.p.A.
RUB 845 order

Pharmacy Dialogue

Alpha normix (tab.p.pl/vol. 200 mg No. 12)Alfa Wassermann
RUB 823 order
Alpha normix tablets 200 mg No. 28Alfa Wassermann
RUB 1,585 order
Alpha normix (gran.d/susp.0.1/5ml 60ml)Alfa Wassermann
RUR 708 order
Alpha Normix (tab.p.pl/vol. 200 mg No. 36)Alfa Wassermann
RUB 1,743 order

Pharmacy24

Alpha Normix 200 mg No. 12 tablets Alpha Wasserman, Italy
386 UAH. order

PaniPharmacy

Alpha Normix tablets Alpha Normix tablets. 200 mg No. 12 Italy, Alfa Wassermann
373 UAH. order

Alpha Normix or McMirror - which is better?

Manufacturer: Doppel Pharmaceuticals, Italy
Release form: tablets

Active ingredient: nifuratel

Synonyms: Nifuratel SZ

Macmiror is an analogue based on the antimicrobial substance nifuratel. A drug with a smaller list of indications compared to Alpha Normix. As a rule, it is used for chronic pathologies of the stomach and intestines, mainly caused by Helicobacter pylori infection.

The product is also effective against infection with protozoa - Giardia, amoebae. In terms of activity against intestinal diseases, Macmiror is a weaker drug, but also safer. Used in children from 10 years of age.