Amoxiclav Quiktab (dispersible tablet 625 mg No. 14)
A country
Slovenia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Amoxicillin + Clavulanic acid
Compound
1 tablet contains: amoxicillin trihydrate 574 mg, potassium clavulanate 148.87 mg. Excipients: tropical mixture flavor, sweet orange flavor, aspartame, colloidal anhydrous silicon dioxide, iron (III) oxide yellow (E172), talc, hydrogenated castor oil, microcrystalline cellulose silicon-containing. Dispersible tablets are light yellow in color with brown inclusions, oblong, octagonal, with a fruity odor.
pharmachologic effect
Broad-spectrum antibiotic; contains semisynthetic penicillin amoxicillin and irreversible β-lactamase inhibitor clavulanic acid. Clavulanic acid forms a stable inactivated complex with these enzymes and ensures the resistance of amoxicillin to the effects of β-lactamases produced by microorganisms. Clavulanic acid, similar in structure to beta-lactam antibiotics, has weak intrinsic antibacterial activity. Amoxiclav® is active against strains sensitive to amoxicillin, including strains producing β-lactamases, incl. aerobic gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Enterococcus spp., Staphylococcus aureus (except methicillin-resistant strains), Staphylococcus epidermidis (except methicillin-resistant strains), Staphylococcus saprophyticus, Listeria spp.; aerobic gram-negative bacteria: Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae, Helicobacter pylori, Klebsiella spp., Moraxella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Proteus spp. , Salmonella spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica, Eikenella corrodens; gram-positive anaerobes: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., gram-negative anaerobes: Bacteroides spp.
Indications for use
Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis); - infections of the lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia); - urinary tract infections; - gynecological infections; - skin and soft tissue infections, including human and animal bites; - bone and connective tissue infections; - biliary tract infections (cholecystitis, cholangitis); - odontogenic infections.
Mode of application
Inside. The tablets must be dissolved in half a glass of water (at least 30 ml) and mixed thoroughly and drunk. It is possible to hold the tablets in your mouth until completely dissolved, then swallow. In order to reduce the risk of developing side effects from the gastrointestinal tract, the drug should be taken at the beginning of a meal. Adults and children over 12 years of age (with body weight >40 kg) with mild or moderate infection are prescribed 1 tablet. (625 mg) every 12 hours, in case of severe infection and respiratory tract infections - 1 tablet. (625 mg) every 8 hours or 1 tablet. (1000 mg) every 12 hours. Duration of treatment is up to 14 days. If treatment is started with parenteral administration of the drug, therapy may be continued by taking Amoxiclav® Quiktab tablets orally. In accordance with the severity of renal functional disorders, the dose of the drug should be reduced and/or the interval of use should be increased . For moderate renal failure (creatinine clearance 10-30 ml/min), 1 tablet is prescribed. (625 mg) every 12 hours. In case of severe renal failure (CC Interaction, when using the drug Amoxiclav® Quiktab simultaneously with antacids, glucosamine, laxatives, aminoglycosides, absorption slows down, with ascorbic acid it increases. Diuretics, allopurinol, phenylbutazone, NSAIDs and other drugs agents that block tubular secretion increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration). When used simultaneously, Amoxiclav® Quiktab increases the toxicity of methotrexate. When using Amoxiclav® Quiktab with allopurinol, the incidence of exanthema increases. Simultaneous use of Amoxiclav should be avoided. ® Kviktab with disulfiram. In some cases, taking the drug may prolong the prothrombin time, therefore caution should be exercised when prescribing anticoagulants and the drug Amoxiclav® Kviktab simultaneously. The combination of amoxicillin with rifampicin is antagonistic (mutual weakening of the antibacterial effect is noted). Amoxiclav® Kviktab should be used several hours before taking bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides. Probenecid reduces the excretion of amoxicillin, increasing its serum concentration. Amoxiclav® Quiktab reduces the effectiveness of oral contraceptives.
Side effect
Side effects in most cases are weak and transient. From the digestive system: - loss of appetite, nausea, vomiting, diarrhea; - rarely - increased activity of liver enzymes (ALT, AST), increased alkaline phosphatase levels, liver dysfunction; - in isolated cases - cholestatic jaundice, hepatitis, pseudomembranous colitis. From the central nervous system: - dizziness, headache; - very rarely - convulsions (may occur in patients with impaired renal function when taking the drug in high doses). From the hematopoietic system: - rarely - reversible leukopenia (including neutropenia), thrombocytopenia; - very rarely - hemolytic anemia, reversible increase in prothrombin time (when used together with anticoagulants). From the urinary system: - very rarely - interstitial nephritis, crystalluria. Allergic reactions: - erythematous rash , itching, urticaria; - very rarely - exudative erythema multiforme, angioedema, anaphylactic shock, allergic vasculitis; - in isolated cases - exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis. Others: - rarely - development superinfections (incl. candidiasis).
Contraindications
- a history of indications of cholestatic jaundice and/or other liver dysfunction caused by taking amoxicillin/clavulanic acid; - children under 12 years of age or weighing less than 40 kg; - hypersensitivity to the components of the drug; - history of hypersensitivity to any antibiotic from the group of penicillins, cephalosporins and other beta-lactam antibiotics. The drug should be used with caution in patients with a history of pseudomembranous colitis, liver failure, severe renal impairment, and during lactation. Due to the fact that a large number of In patients suffering from infectious mononucleosis and lymphocytic leukemia who received ampicillin, the appearance of an erythematous rash was observed; the use of antibiotics from the ampicillin group is not recommended for such patients.
Overdose
There are no reports of death or life-threatening side effects due to an overdose of the drug. Symptoms: gastrointestinal disorders - abdominal pain, diarrhea, vomiting, possibly also anxiety, insomnia, dizziness; in some cases - convulsive seizures. Treatment: symptomatic, in case of recent use of the drug (less than 4 hours), it is necessary to perform gastric lavage and prescribe activated charcoal to reduce the absorption of the drug. The patient must be under medical supervision. Amoxicillin/potassium clavulanate is removed by hemodialysis.
special instructions
During a course of treatment, the functions of the hematopoietic organs, liver and kidneys should be monitored. In patients with severely impaired renal function, adequate adjustment of the dosage regimen or an increase in the intervals between doses of the drug is required. In order to reduce the risk of developing adverse reactions from the gastrointestinal tract, the drug should be taken at the beginning of meals. When using Amoxiclav Kviktab, a false positive reaction is possible when determining the level of glucose in urine using Benedict's reagent or Felling's solution (it is recommended to use enzymatic reactions with glucosidase). Impact on the ability to drive vehicles and operate machinery Data on the negative effect of the drug Amoxiclav® Kviktab in recommended doses on the ability no to driving vehicles and operating machinery.
Dispensing conditions in pharmacies
On prescription
Amoxiclav recipe in Latin step by step
So, we’ve figured out the release forms and dosages, now let’s move on to the rules for writing a prescription.
- The Latin recipe for amoxiclav begins, like any other recipe, with the Latin word Rp. - Recipe - “take.”
- Next, after the colon, it is necessary to indicate the dosage form of amoxiclav that we need (tablets or powder), with a capital letter, in the genitive case, singular and in Latin.
- Then we indicate “Amoxiclav”, put it in quotes as we are writing out the commercial name.
- Then in the same line you need to write the dosage and how much to dispense (after N - Numero).
- And, on a new line, we write DS - Da Signa - issue and designate - fill out the signature.
Prescription for amoxiclav in tablet form
For example, let’s write out a prescription for amoxiclav in Latin in the form of tablets with a dosage of 250/125 mg. Read more here - recipe for tablets in Latin.
Rp.: Tab. "Amoxiclav" 250/125 mg N 15 DS Orally, 1 tablet 4 times a day.
You can write the dosage as a sum, for example, not 250/125, but 375 mg. The pharmacist will understand too.
Amoxiclav recipe in Latin in powder form
For example, let’s write out a prescription for amoxiclav in powder form with a dosage of 500/100 mg. We will prescribe it intramuscularly. Read more - the recipe for the powder is in Latin and, since the powders are given in bottles, the recipe for the bottles is in Latin.
Rp.: Pulv. "Amoxiclav" 500/100 mg N 6 DS Dilute in saline solution. Intramuscularly 2 times a day.
Let's write out a recipe for amoxiclav in Latin in the form of a powder for preparing a suspension with a dosage of 125 mg + 31.25 mg/5 ml. Let's appoint inside.
Rp.: Pulv. "Amoxiclav" 125+31.25 mg /5 ml DS Add water to the mark. Inside, 1 spoon 4 times a day.
Dosages and release forms of amoxiclav
Amoxiclav can be prescribed in tablet form, as well as in powder form for the preparation of a suspension or injection solution.
- Amoxiclav tablets are available in 250/125 mg, 500/125 mg and 875/125 mg - in these dosages, the first digit is the content of amoxicillin, and the second is clavulonic acid;
- Powders for the preparation of amoxiclav suspension (taken orally) are available in 125 mg + 31.25 mg/5 ml, 250 mg + 62.5 mg/5 ml and 400 mg + 57 mg/5 ml;
- Powders for the preparation of amoxiclav injections are available in 500/100 mg, 1000/200 mg.
You can also write out a prescription for augmentin and flemoklav in Latin, these are analogues of amoxiclav.
