Buy Amoxiclav powder for the preparation of oral suspension 250mg+62.5mg/5ml 100ml in pharmacies

00:22:44 — 04.12.2021

A fairly strong and almost universal antibacterial drug Amoxiclav contains a semi-synthetic drug ( amoxicillin

), as well as clavulanate (
clavulanic acid
), which is actively involved in the formation of beta-lactamases.
Due to its wide spectrum of activity, it is used for a variety of bacterial diseases. However, despite its effectiveness, the price of Amoxiclav
is somewhat high.
Therefore, we will try to understand the composition and purpose of the drug, and also determine the existing analogues of Amoxiclav
, what is their cost and effect on the body

Composition of Amoxiclav

• Amoxiclav 250 mg/125 mg tablets contain the active ingredients amoxicillin (trihydrate form) and clavulanic acid (potassium salt form). The tablets also contain auxiliary components: MCC sodium croscarmellose.
• Amoxiclav 2X 625 mg and 1000 mg tablets contain the active ingredients amoxicillin and clavulanic acid, as well as additional components: anhydrous colloidal silicon dioxide, flavorings, aspartame , yellow iron oxide, talc, hydrogenated castor oil, silicated MCC.
• Amoxiclav Quiktab 500 mg and 875 mg tablets contain the active ingredients amoxicillin and clavulanic acid, as well as additional components: anhydrous colloidal silicon dioxide, flavorings, aspartame, yellow iron oxide, talc, hydrogenated castor oil, silicated MCC.
• The powder from which the Amoxiclav suspension is prepared also contains amoxicillin and clavulanic acid, and also contains sodium citrate, MCC, sodium benzoate, mannitol, and sodium saccharin as inactive components.
• The powder for preparing Amoxiclav IV infusion contains amoxicillin and clavulanic acid.

Release form

The drug is produced in the form of tablets:

• Amoxiclav 250 mg/125 mg – film-coated tablets, package contains 15 pieces.
• Amoxiclav 2X (500 mg/125 mg; 875 mg/125 mg) - coated tablets; the package may contain 10 or 14 pieces.
• Amoxiclav Quiktab (500 mg/125 mg; 875 mg/125 mg) is available in the form of dispersed tablets, 10 such tablets per package.

The product is also produced in the form of a powder from which a suspension is made; the bottle contains powder for preparing 100 ml of the product.

A powder is also produced, from which a solution is made, which is administered intravenously. The bottle contains 600 mg of the product (amoxicillin 500 mg, clavulanic acid 100 mg), 1.2 g bottles are also available (amoxicillin 1000 mg, clavulanic acid 200 mg), the package contains 5 bottles.

pharmachologic effect

The abstract provides information that the antibiotic Amoxiclav (INN Amoksiklav) is a broad-spectrum agent. Group of antibiotics: broad-spectrum penicillins. The medicine contains amoxicillin (semi-synthetic penicillin) and clavulanic acid (β-lactamase inhibitor). The presence of clavulanic acid in the composition of the drug ensures the resistance of amoxicillin to the action of β-lactamases produced by microorganisms.

The structure of clavulanic acid is similar to beta-lactam antibiotics, this substance also has an antibacterial effect. Amoxiclav is active against strains that demonstrate sensitivity to Amoxicillin. These are a number of gram-positive bacteria, aerobic gram-negative bacteria, gram-positive and gram-negative anaerobes.

Pharmacokinetics and pharmacodynamics

As the Vidal drug reference book informs, after oral administration, both substances are actively absorbed from the gastrointestinal tract; the absorption of the components is not affected by food intake, so it does not matter how you take it - before or after meals. The highest concentration in the blood is observed one hour after the drug was taken. Both active ingredients of the drug are distributed in fluids and tissues. Amoxicillin also enters the liver, synovial fluid, prostate, tonsils, gall bladder, muscle tissue, saliva, and bronchial secretions.

If the membranes of the brain are not inflamed, both active substances do not penetrate through the BBB. At the same time, the active components penetrate the placental barrier and traces of them are detected in breast milk. They bind to blood proteins to a small extent.

In the body, amoxicillin undergoes partial metabolism , clavulanic acid is intensively metabolized. It is excreted from the body through the kidneys; small particles of active substances are excreted by the intestines and lungs. The half-life of amoxicillin and clavulanic acid is 1-1.5 hours.

Taking medications

Not everyone understands whether it is possible to take antibiotics for coronavirus and what symptoms should cause this. It is strictly forbidden to take medications on your own without a doctor’s prescription, since incorrectly selected antibiotics will not only weaken the body, but can also cause death.

Indications for taking antibiotics:

• for several days the body temperature exceeds 38 degrees;
• bacterial microflora develops in the respiratory tract; discharge of green and yellow sputum when coughing is often observed as confirmation of infection;
• with prolonged treatment with antiviral substances, general malaise persists;
• stool contains purulent mucus.

If the patient has all the symptoms, the doctor will not be able to prescribe antibiotics without bacteriological culture. To conduct research, a smear is taken from the trachea and nasopharynx, and the mucous part is removed from the stool. It is inoculated on a nutrient medium to identify the type of infection. After receiving the results, an additional type of antibiotic is determined that can destroy the virus.

If a patient is prescribed a course of antibiotics, this does not mean that antiviral medications do not need to be taken. A complex intake of drugs is prescribed to achieve the optimal effect in order to eliminate the bacterial environment from the gastrointestinal tract or respiratory tract. After completing therapy, all tests are taken from the patient; if coronavirus infection is not confirmed, the patient is discharged.

Indications for use of Amoxiclav

Amoxiclav is prescribed for infectious and inflammatory diseases that develop due to the influence of microorganisms sensitive to this medicine. The following indications for the use of this drug are determined:

• infections of the ENT organs, as well as infectious diseases of the upper respiratory tract ( otitis media , retropharyngeal abscess, sinusitis , pharyngitis , tonsillitis );
• urinary tract infections ( cystitis , prostatitis , etc.);
• infectious diseases of the lower respiratory tract (pneumonia, acute and chronic bronchitis
• gynecological diseases of an infectious nature;
• connective and bone tissue infections;
• infectious diseases of soft tissues, skin (including consequences of bites);
• biliary tract infections (cholangitis, cholecystitis );
• odontogenic infections.

What else Amoxiclav helps with, you should ask a specialist during an individual consultation.

Buy Amoxiclav powder for the preparation of oral suspension 250mg+62.5mg/5ml 100ml in pharmacies

Amoxiclav Buy Amoxiclav in pharmacies DOSAGE FORMS powder for the preparation of an oral suspension 250mg+62.5 mg/5ml powder for the preparation of an oral suspension 250mg+62.5mg/5ml 20dz

MANUFACTURERS Lek dd. (Slovenia)

GROUP Combined antimicrobial agents

COMPOSITION Active substance: amoxicillin + clavulanic acid.

INTERNATIONAL NON-PROPENTED NAME Amoxicillin + Clavulanic acid

SYNONYMS Amoxiclav Quiktab, Arlet, Augmentin, Augmentin EU, Augmentin SR, Clamosar, Medoclav, Panclave, Ranclave, Rapiclav, Sinulox, Sinulox RTU, Flemoclav Solutab, Ecoclave

PHARMACOLOGICAL ACTION Broad spectrum antibacterial. Blocks the synthesis of peptidoglycan of the membrane of microbial cells (amoxicillin), inhibits beta-lactamases (clavulanic acid). Clavulanic acid forms a stable inactivated complex with these enzymes and protects amoxicillin from the loss of antibacterial activity caused by the production of beta-lactamases by the main pathogens and opportunistic microorganisms. Active against gram-positive aerobes: Streptococcus pneumoniae, S.pyogenes, S.viridans, S.bovis, Staphylococcus aureus (except methicillin-resistant strains), S.epidermidis (except methicillin-resistant strains), Listeria spp., Enterococcus spp. Gram-negative aerobes: Bordetella pertussis, Brucella spp., Campylobacter jejuni, E.coli, Gardnerella vaginalis, H.influenzae, H.ducreyi, Klebsiella spp., Moraxella catarrhalis, N.gonorrhoeae, N.meningitidis, Pasteurella multocida, Proteus spp., Salmonella spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica. Anaerobes: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Bacteroides spp., Actinomyces israelii. Rapidly absorbed after oral administration (food intake does not affect absorption). The maximum concentration is reached 1 hour after administration. The maximum plasma concentration after a bolus injection of 1.2 g is 105.4 mg/l (for amoxicillin) and 28.5 mg/l (for clavulanic acid). It has a large volume of distribution - high concentrations are found in body fluids and tissues (lungs, pleural, peritoneal, synovial fluid, tonsils, bronchial secretions, prostate gland, peritoneal abscess, muscle tissue, adipose tissue, paranasal sinus secretions, middle ear, etc. .). Peak concentrations in body fluids are observed 1 hour after peak plasma concentrations are reached. Does not pass through the BBB when the meninges are not inflamed, passes through the placental barrier and penetrates into breast milk in trace concentrations. Weakly binds to plasma proteins. Amoxicillin is partially metabolized, clavulanic acid undergoes intensive metabolism. Amoxicillin is excreted by the kidneys almost unchanged by tubular secretion and glomerular filtration; clavulanic acid - by glomerular filtration, partly in the form of metabolites. Small amounts are excreted by the intestines and lungs. The half-life is 1-1.5 hours, with severe renal failure it increases to 7.5 (for amoxicillin) and 4.5 hours (for clavulanic acid). It is removed during hemodialysis, and slightly - during peritoneal dialysis.

INDICATIONS FOR USE Infectious diseases of the upper (acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsilopharyngitis) and lower respiratory tract (acute and chronic bronchitis, pneumonia, pleural empyema); urinary tract infections (including cystitis, urethritis, pyelonephritis), gynecological infections (including salpingitis, salpingoophoritis, endometritis, septic abortion, pelvioperitonitis); biliary tract (cholecystitis, cholangitis), bone and connective tissue (including chronic osteomyelitis), skin and soft tissue (phlegmon, wound infection), odontogenic infections (periodontitis); sexually transmitted infections (gonorrhea, chancroid).

CONTRAINDICATIONS Hypersensitivity; history of allergic reactions to antibiotics of the penicillin and cephalosporin group; cholestatic jaundice, hepatitis caused by taking penicillin antibiotics (in history); liver failure; infectious mononucleosis, lymphocytic leukemia. Use during pregnancy and breastfeeding: Possible if the expected effect of therapy exceeds the potential risk to the fetus. Breastfeeding should be stopped during treatment.

SIDE EFFECTS In most cases, side effects are weak and transient, most often affecting the gastrointestinal tract: loss of appetite, nausea, vomiting, diarrhea. Possible development of superinfection, stomatitis, vaginitis; in rare cases - pseudomembranous colitis with severe diarrhea. Allergic reactions may occur: itching, skin rashes; in sensitive patients, immediate hypersensitivity reactions may develop (angioedema, bronchospasm, rarely - anaphylactic shock). It is extremely rare that a transient increase in the level of transaminases in the blood plasma can be observed. There are isolated reports of cholestatic jaundice, hepatitis, and liver dysfunction.

INTERACTION When used simultaneously with methotrexate, the toxicity of methotrexate increases, with allopurinol - the incidence of exanthema, and with anticoagulants - the prothrombin time is prolonged. Reduces the effectiveness of oral contraceptives. Concomitant use with disulfiram should be avoided. The effectiveness of Amoxiclav is weakened by combination with bacteriostatic antibiotics (macrolides, tetracyclines); combination with rifampicin is antagonistic. Probenecid reduces the excretion of amoxicillin, increasing its serum concentration. Pharmaceutically incompatible with solutions containing blood, proteins, lipids, glucose, dextran, bicarbonate. Do not mix in a syringe or infusion bottle with other drugs. Incompatible with aminoglycosides.

OVERDOSE Symptoms: in most cases nausea, diarrhea, vomiting, possible agitation, insomnia, dizziness, and in some cases seizures. There are no reports of deaths or life-threatening side effects. Treatment: symptomatic, in case of recent use (less than 4 hours), remove the drug from the gastrointestinal tract (gastric lavage, taking activated charcoal to reduce absorption), hemodialysis is effective.

SPECIAL INSTRUCTIONS Prescribe with caution to patients prone to allergic reactions to cephalosporins and other beta-lactam antibiotics (risk of cross-sensitivity), with severe impairment of liver and kidney function (dosage regimen adjustment is necessary). High concentrations give a false positive reaction for glucose in urine when using Benedict's reagent or Felling's solution (it is recommended to use enzymatic reactions with glucose oxidase).

STORAGE CONDITIONS List B. At room temperature.

Contraindications

When determining why tablets and other forms of the drug help, you should also take into account existing contraindications:

• Infectious mononucleosis;
• previous liver disease or cholestatic jaundice when taking clavulanic acid or Amoxicillin;
• lymphocytic leukemia;
• high sensitivity to antibiotic drugs from the group of cephalosporins, penicillins, as well as other beta-lactam antibiotics;
• high sensitivity to the active components of the drug.

It is prescribed with caution to people suffering from liver failure and people with severe kidney disease.

Instructions for use AMOXIKLAV® (AMOKSIKLAV®)

Before prescribing the drug, a detailed history should be obtained regarding previous hypersensitivity reactions to penicillins, cephalosporins or other β-lactam antibiotics.

Serious (in some cases fatal) hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to penicillins. If an allergic reaction occurs, it is necessary to stop treatment with Amoxiclav and begin alternative therapy. For severe hypersensitivity reactions, the patient should be given epinephrine (adrenaline) immediately. Oxygen therapy, intravenous administration of corticosteroids, and airway management, including intubation, may also be required.

Amoxiclav® should not be prescribed if infectious mononucleosis is suspected, since amoxicillin can cause a skin rash in patients with this disease, which makes diagnosing the disease difficult.

It is not recommended to prescribe Amoxiclav® if there is a high risk that the suspected pathogens have reduced susceptibility or are resistant to beta-lactam antibiotics (for example, penicillin-resistant Streptococcus pneumoniae). Seizures may occur in patients with impaired renal function or in patients receiving high doses.

Special caution is required if it is necessary to use the drug Amoxiclav® in patients with severe allergic diseases, bronchial asthma, with diarrhea and/or vomiting.

Amoxiclav® should be prescribed with caution to patients with impaired liver function. Drug-induced liver failure has been reported predominantly in men and elderly patients and may be associated with long-term therapy. Liver dysfunction has been very rarely reported in children. In all groups of patients, symptoms usually begin during or shortly after treatment, but in some cases become apparent only several weeks after treatment has stopped. Symptoms are usually reversible. Liver failure can be severe and, in extremely rare cases, fatal. It is almost always observed in patients with a serious underlying disease or who are concomitantly taking medications that can have undesirable effects on the liver.

During long-term therapy with Amoxiclav, it is recommended to periodically evaluate renal, liver and hematopoietic function. In patients receiving amoxicillin, an increase in prothrombin time is occasionally observed, therefore, with the simultaneous use of Amoxiclav and anticoagulants, it is necessary to regularly monitor the relevant indicators. With this combination, dose adjustment of oral anticoagulants may be required to achieve the desired level of coagulation.

Long-term treatment with Amoxiclav sometimes leads to excessive growth of insensitive microflora.

The appearance of febrile generalized erythema associated with a pustule at the beginning of treatment may be a symptom of acute generalized exanthemal pustulosis. This reaction requires discontinuation of treatment with Amoxiclav and is a contraindication for any subsequent prescriptions of amoxicillin.

In general, amoxicillin is well tolerated and has the low toxicity characteristic of all penicillins.

Antibiotic-induced colitis occurs with almost all antibacterial drugs and can range in severity from mild to life-threatening. Therefore, it is important to recognize this diagnosis in patients with diarrhea during or after taking any antibiotic. In case of colitis caused by an antibiotic, Amoxiclav should be stopped immediately, a doctor should be consulted, and appropriate therapy should be started. Antiperistaltic drugs are contraindicated in this situation.

In patients with reduced diuresis, crystalluria very rarely occurs, mainly during parenteral therapy. During administration of high doses of amoxicillin, it is recommended to take sufficient fluids and maintain adequate diuresis to reduce the likelihood of amoxicillin crystal formation. In patients with a catheter installed in the bladder, it is necessary to regularly monitor its patency.

The presence of clavulanic acid in Amoxiclav may cause nonspecific binding of IgG and albumin to red blood cell membranes, which may lead to false-positive Coombs test results.

When taking Amoxiclav orally, amoxicillin is detected in the urine. High concentrations of amoxicillin give a false-positive reaction to urine glucose when using Benedict's reagent or Fehling's solution. It is recommended to use enzymatic reactions with glucose oxidase.

Cases of positive enzyme immunoassay (ELISA) results for Aspergillus have been observed in patients receiving the drug, who were subsequently determined to be free of Aspergillus infections. Cross-reactions with non-Aspergillus polysaccharides and polyfuranoses have been observed in the Aspergillus ELISA test. Positive test results in patients receiving Amoxiclav® should be interpreted with caution and confirmed by other diagnostic methods.

Impact on the ability to drive vehicles and operate machinery

Undesirable effects may develop (for example, allergic reactions, dizziness, convulsions), potentially affecting the performance of these functions.

Side effects

When taking this antibiotic, patients may experience the following side effects:

• Digestive system: loss of appetite, vomiting, nausea, diarrhea ; in rare cases, abdominal pain and liver dysfunction may occur; isolated manifestations - hepatitis, jaundice, pseudomembranous colitis.
• Hematopoietic system: in rare cases - reversible leukopenia , thrombocytopenia ; in very rare cases - eosinophilia , pancytopenia .
• Allergic manifestations: itching , erythematous rash, urticaria ; in rare cases - anaphylactic shock , exudative erythema, edema , allergic vasculitis; isolated manifestations - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
• Functions of the nervous system: dizziness , headache ; in rare cases - convulsions, anxiety, hyperactivity, insomnia .
• Urinary system: crystalluria , interstitial nephritis .
• In rare cases, superinfection may occur.

It is noted that such treatment, as a rule, does not provoke significant side effects.

About the safety of Amoxiclav and analogues

Amoxiclav analogs have common not only indications, but also limitations to treatment. Thus, drugs in tablet form are not intended for the treatment of children under 12 years of age. Pregnancy and breastfeeding are not included in the list of contraindications. But Amoxiclav and its analogues are prescribed to women in any trimester and during lactation after assessing the benefits for them and the risks for the fetus or child. Potential side effects of Amoxiclav and its analogues:

In combination with alcohol, Amoxiclav will lose most of its pharmacological effects. Ethyl alcohol will slow down the active substances so that they are excreted from the body unchanged. The likelihood of an antibacterial agent exhibiting significant side effects also increases significantly.

Instructions for use of Amoxiclav (Method and dosage of Amoxiclav for adults)

Medicine in tablets is not prescribed to children under 12 years of age. When prescribing the drug, it should be taken into account that the permissible dose per day of clavulanic acid is 600 mg (adults) and 10 mg per 1 kg of weight (child). The permissible daily dose of amoxicillin is 6 g for an adult and 45 mg per 1 kg of weight for a child.

The agent for parenteral administration is prepared by dissolving the contents of the vial in water for injection. To dissolve 600 mg of the product, you need 10 mol of water, to dissolve 1.2 g of the product - 20 ml of water. The solution should be administered slowly over 3-4 minutes. The intravenous infusion should continue for 30-40 minutes. The solution must not be frozen.

Before anesthesia, to prevent purulent complications, 1.2 g of drugs should be administered intravenously. If there is a risk of complications, the drug is administered intravenously or taken orally in the period after surgery. The duration of the appointment is determined by the doctor.

Amoxiclav tablets, instructions for use

As a rule, adults and children (who weigh more than 40 kg) receive 1 tablet every eight hours. (375 mg), provided the infection is mild or moderate. Another acceptable treatment regimen in this case is to take 1 tablet every 12 hours. (500 mg+125 mg). For severe infectious diseases, as well as for infectious diseases of the respiratory tract, taking 1 tablet every eight hours is recommended. (500 mg+125 mg) or taken every 12 hours 1 tablet. (875 mg+125 mg). Depending on the disease, you need to take an antibiotic from five to fourteen days, but the doctor must individually prescribe a treatment regimen.

Patients with odontogenic infections should take 1 tablet every 8 hours. (250 mg + 125 mg) or once 12 hours, 1 tablet. (500 mg + 125 mg) for five days.

People suffering from moderate renal failure are advised to take 1 tablet. (500 mg + 125 mg) every twelve hours. Severe renal failure is a reason to increase the interval between doses to 24 hours.

Amoxiclav suspension, instructions for use

The patient's childhood involves calculating the dose taking into account the child's weight. Before preparing the syrup, shake the bottle well. In two doses you need to add 86 ml of water to the bottle, each time you need to shake its contents well. Please note that the measuring spoon contains 5 ml of product. Prescribed in a dose depending on the age and weight of the child.

Instructions for use Amoxiclav for children

Children from birth to three months are prescribed the drug at the rate of 30 mg per 1 kg of weight (dose per day), this dose should be divided equally and administered at equal intervals. From the age of three months, Amoxiclav is prescribed at a dose of 25 mg per 1 kg of weight, which is similarly divided equally into two administrations. For infectious diseases of moderate severity, the dose is prescribed at the rate of 20 mg per 1 kg of weight, divided into three administrations. For severe infectious diseases, the dose is prescribed at the rate of 45 mg per 1 kg of weight, divided into two doses per day.

Instructions for use Amoxiclav Quiktab

Before taking, the tablet must be dissolved in 100 ml of water (the amount of water may be more). Before taking, you need to stir the contents well. You can also chew the tablet; it is better to take the drug before meals. Adults and children after reaching 12 years of age should take 1 tablet per day. 625 mg 2-3 times a day. For severe infectious diseases, 1 tablet is prescribed. 1000 mg 2 times a day. Treatment should not last more than 2 weeks.

Sometimes a doctor may prescribe analogues of the drug, for example, Flemoclav Solutab , etc.

Amoxiclav for sore throat

The drug Amoxiclav for angina for an adult is prescribed 1 tablet. 325 mg once every 8 hours. Another treatment regimen involves taking 1 tablet once every 12 hours. A doctor may prescribe a higher dose of an antibiotic if the disease in an adult is severe. Treatment of sore throat in children involves the use of a suspension. As a rule, 1 spoon is prescribed (a dosage spoon is 5 ml). The frequency of administration is determined by the doctor, whose recommendations are important to follow. How to take Amoxiclav for children with sore throat depends on the severity of the disease.

Dosage of Amoxiclav for sinusitis

Whether Amoxiclav helps with sinusitis depends on the causes and characteristics of the course of the disease. The dosage is determined by the otolaryngologist. It is recommended to take 500 mg tablets three times a day. How many days to take the medicine depends on the severity of the disease. But after the symptoms disappear, you need to take the drug for two more days.

Suprax from the group of cephalosporins

The Italian pharmaceutical company Menarini Manufacturing Logis produces Suprax in the form of dispersible tablets. This means that they can be used to prepare a solution for oral administration. Unlike traditional tablets, dispersible tablets release the active substance, cefixime, faster. Suprax is a representative of the third generation cephalosporins, which have the following advantages:

• active ingredients penetrate deep into tissues, destroying pathogenic bacteria;

• are broad-spectrum drugs, to the action of which almost all known infectious pathogens are sensitive;
• have a powerful bactericidal effect and quickly disrupt the integrity of bacterial cell membranes.

Which is better, Suprax or Amoxiclav for the treatment of a particular pathology, it is possible to answer after studying the results of laboratory diagnostics. Both drugs quickly cope with the infection. But Suprax is considered a safer remedy.

For adults, the daily dose is 400 mg once a day or 200 mg twice a day, the average duration of the therapeutic course is 7-10 days. Unlike Amoxiclav, negative consequences are less likely to occur after taking Suprax; its list of contraindications is somewhat narrower. But there are also fewer indications for use. For example, their list does not include flux, the treatment of which is often carried out with Amoxiclav tablets.

Fluoroquinolone Levofloxacin

The therapeutic line Levofloxacin consists of tablets and a solution for parenteral administration, as well as eye drops. The drug is included in the clinical and pharmacological group of fluoroquinolones, to the action of which most pathogens have not lost sensitivity. Most often, Levofloxacin is prescribed to patients suffering from infections of the following vital systems:

• genitourinary, including the urogenital tract;

• bronchopulmonary, including the upper and lower respiratory tract;
• skin.

Levofloxacin helps to quickly cope with the painful symptoms of cystitis, pyelonephritis, urethritis and other diseases. It is usually started at a dose of 250 mg, which is increased to 750 mg if necessary. The duration of therapy is individual and varies depending on the clinical situation.

Which is better, Levofloxacin or Amoxiclav, depends on the type of disease diagnosed. The latter has proven itself especially well in the treatment of respiratory bacterial lesions. And Levofloxacin is more often used in the treatment of infections of the bladder, kidneys, and urethra.

Flemoklav Solutab

Flemoklav is produced by the pharmaceutical company Astellas Pharma Europe, BV (Netherlands) in the form of biconvex tablets intended for dissolution in water.

The active substances - amoxicillin and clavulanic acid - are almost not destroyed in the stomach by aggressive hydrochloric acid, but penetrate intact into the small intestine, where they are absorbed into the blood. The closest analogue of Flemoklav is Amoxiclav Kviktab, which is a dispersible tablet. The duration of therapy depends on the severity of the infection, but longer than 14 days the drug is used in exceptional cases.

Adults are prescribed 500/125 mg three times a day or 875/125 mg twice a day. For the treatment of chronic, recurrent, severe infections, this dose is doubled. An analogue of Amoxiclav is the product of the same pharmaceutical company Flemoxin Solutab in the form of tablets for oral administration and preparation of a solution. But there is an important difference - it contains only amoxicillin as an active ingredient. The absence of clavulanic acid makes it less therapeutically effective.

Overdose

To avoid overdose, the prescribed dosage for children and the dosage of Amoxiclav for adults must be strictly observed. It is recommended to carefully study the instructions or watch a video on how to dilute the suspension.

Wikipedia indicates that an overdose of the drug may result in a number of unpleasant symptoms, but there is no data on life-threatening conditions for the patient. , abdominal pain , vomiting , diarrhea may occur . In severe cases, seizures may occur.

If the drug has been taken recently, gastric lavage is performed, activated charcoal . The patient must be monitored by a doctor. In this case, hemodialysis .

Interaction

When taking the drug simultaneously with some drugs, undesirable manifestations may occur, which is why tablets, syrup and intravenous administration of the drug should not be used in parallel with a number of drugs.

The simultaneous use of the drug with Glucosamine , antacids, aminoglycosides, and laxatives slows down the absorption of Amoxiclav; when taken simultaneously with Ascorbic acid , the absorption accelerates.

With simultaneous treatment with Phenylbutazone , diuretics, NSAIDs, Allopurinol and other drugs that block tubular secretion, the concentration of amoxicillin increases.

If anticoagulants and Amoxiclav are taken simultaneously, the prothrombin time increases. Therefore, drugs in such a combination must be prescribed with caution.

Amoxiclav increases the toxicity of Methotrexate when taken simultaneously.

When taking Amoxiclav and Allopurinol , the likelihood of exanthema increases.

You should not take Disulfiram and Amoxiclav at the same time.

Antagonists when taken together are amoxicillin and Rifampicin . The drugs mutually weaken the antibacterial effect.

You should not take Amoxiclav and bacteriostatic antibiotics (tetracyclines, macrolides), as well as sulfonamides at the same time, as these drugs can reduce the effectiveness of Amoxiclav.

Probenecid increases the concentration of amoxicillin and slows down its elimination.

When using Amoxiclav, the effectiveness of oral contraceptives may decrease.

special instructions

Since most people with lymphocytic leukemia and infectious mononucleosis who received Ampicillin subsequently noted the appearance of an erythematous rash, such people are not recommended to take ampicillin antibiotics.

It is prescribed with caution to people with a tendency to allergies .

If a course of treatment with the drug is prescribed for adults or children, it is important to monitor the functions of the kidneys, liver, and the process of hematopoiesis.

People who have impaired renal function need a dose adjustment of the drug or an increase in the interval between taking the drug.

It is optimal to take the product during meals to reduce the likelihood of side effects from the digestive system.

Patients undergoing treatment with Amoxiclav may experience a false positive reaction when determining glucose levels in urine when using Felling's solution or Benedict's reagent .

There is no data on the negative impact of Amoxiclav on the ability to drive vehicles and work with precision machinery.

Patients who are interested in whether Amoxiclav is an antibiotic or not should keep in mind that the product is an antibacterial drug.

It is recommended to drink plenty of water and other liquids during the course of treatment with the drug.

If Amoxiclav is prescribed, the patient's childhood age must be taken into account when prescribing the medication form and dosage.

How to choose an antibiotic

In case of an acute viral disease, an antibiotic is prescribed by a doctor, referring to the results of laboratory tests. To select the correct drug you need:

• determine the properties and type of infectious agent;
• choose a course of treatment and calculate the dose of the drug;
• select a set of medications for microorganisms that are difficult to treat;
• when the pathogen has not been identified, it is worth using a broad-spectrum antibiotic, and after bacteriological tests, use a drug with a narrow spectrum of influence.

To eliminate negative side effects, when prescribing drug treatment, the patient’s age, general condition, and severe symptoms are taken into account.

Analogues of Amoxiclav

Level 4 ATX code matches:
Arlet

Ecoclave

Panclave

Oxamp-Sodium

Oxamp

Amoxicillin + Clavulanic acid

Augmentin

Ampisid

Amoxil K 625

Flemoklav Solutab

Sultasin

There are a number of analogues of this drug. The price of analogues depends, first of all, on the manufacturer of the drug. There are analogues on sale that are cheaper than Amoxiclav. For patients interested in what can replace this antibiotic, experts offer a large list of medications. These are Moxiclav , Co-Amoxiclav , Augmentin , Clavocin , Flemoclav , Medoclav , Baktoklav , Ranclave , Amoviklav , etc. However, any substitute should only be prescribed by a doctor. You can choose a cheaper analogue in tablets, for example, Augmentin. You can also choose a Russian analogue, for example, Amoxicillin .

Flemoklav Solutab and Amoxiclav - the difference between the drugs

The active components of the drugs are similar. The difference between drugs is in the dosage of the active components in the release forms of these drugs. Both drugs fall into approximately the same price category.

Which is better: Amoxiclav or Augmentin?

What is the composition of Amoxiclav and Augmentin , what is the difference between these drugs? Both of these products contain similar active ingredients, that is, in fact they are the same thing. Accordingly, the pharmacological action of the drugs is almost identical, as are the side effects. Only the manufacturers of these drugs differ.

Which is better: Sumamed or Amoxiclav?

Sumamed contains azithromycin, which is a broad-spectrum antibiotic. Before prescribing any of the drugs, it is important to check the sensitivity of the microflora to their action.

Which is better: Flemoxin Solutab or Amoxiclav?

Flemoxin contains only amoxicillin. Accordingly, its spectrum of influence is smaller than that of the drug Amoxiclav, which also contains clavulonic acid .

Harm of Amoxiclav and adverse reactions

The main prohibitions in using the medicine are

:

• individual sensitivity to the excipients of the drug and clavulanic acid
• penicillin intolerance
• liver or kidney failure
• liver dysfunction
• pseudomembranous colitis

Short-term use of the product, not exceeding 7 days, cannot cause harm

Side effects are observed mainly with long-term therapy or courses of injections that can provoke

:

• diarrhea
• itchy skin
• lack of appetite
• anaphylactic shock
• nausea
• bad taste
• changes in blood composition

When faced with manifestations of such reactions, it is necessary to inform the doctor, who will decide what can replace the remedy.

Existing inexpensive analogues of Amoxiclav

When selecting analogues, you should remember that the drugs must meet the basic requirements

:

• fully comply with the structure of the drug being replaced
• provide a therapeutic effect corresponding to the main drug

Some Amoxiclav instructions contain a list of medications that can be used if necessary. However, they contain only penicillin drugs, although other groups of antibiotics may be more effective

Cheap analogues that can replace Amoxiclav

Among inexpensive analogues, the most worthy include

:

• Amoxicillin tablets
• Amosin tablets
• Augmentin tablets
• Suprax capsules
• Flemoxin solutax tablets
• Sumamed tablets
• Azithromycin capsules

Naturally, this list is far from complete, but it is compiled in accordance with the dosage of 500 mg

Criteria for choosing analogues of Amoxiclav

When determining which remedy will be more effective for children or for treating a similar disease in adults, doctors rely on their own practical experience

Pediatric otolaryngologists for sore throat prefer Sumamed

- this powerful drug is able to “block” a huge amount of pathogenic microflora. Moreover, it is enough to take it for 3 or 5 days no more than once a day

The severity of the disease also influences the choice of antibiotics.

For more complex lacunar angina, substances are chosen that are more powerful than for follicular or catarrhal. Despite the strong similarity of analogues in composition, those that are suitable for the patient’s age, have less toxicity and are easy to use are selected

• Amoxicillin

Among domestic drugs, it is worth noting Amoxicillin

, which is a cheap analogue
of Amoxiclav
, which has an effective bactericidal effect. It is resistant to gastric hydrochloric acid and is almost completely dissolved in the intestines. The drug is prescribed for manifestations of respiratory, nephro-urological, intestinal and other infections

The drug is used for:

• tonsillitis
• bronchitis
• leptospirosis
• urethritis
• pneumonia
• gonorrhea
• tick-borne borreliosis
• sepsis
• cystitis
• endocarditis
• salmonellosis
• meningitis
• pyelonephritis

When supplemented with the drug Metronidazole

", chronic gastritis is treated, as well as exacerbation of peptic ulcers of the intestines and stomach caused by
Helicobacteriosis
The most dangerous side effects include the development of superinfection, with re-infection of the body with another strain

• Augmentin

Looking through the instructions for these drugs, you can make sure that their composition is absolutely identical. Considering the cost of Amoxiclav

It is clear that
Augmentin
is its cheap analogue, which has similar limitations and adverse reactions.
Accordingly, the therapeutic effect is the same, since the main active substance in the products is Ampicillin
, which exhibits excellent antimicrobial properties.
The only difference is the price, which is
significantly lower Augmentin

• Amosin

This powerful broad-spectrum antibiotic is a relatively inexpensive analogue of Amoxiclav

.
The bactericidal activity of an antibiotic based on Ampicillin
is expressed in
the suppression of microorganisms of streptococci, staphylococci, salmonella, sepsis, E. coli, meningitis pathogens
and others.
This analogue of Amoxiclav successfully inhibits the synthesis of peptidoglycan
, which acts as the basis of the bacterial membrane. The maximum effectiveness of the drug occurs one hour after administration

• Flemoxin solutab

The drug differs from Amoxiclav in the absence of clavulanic acid

, as well as the ability to be destroyed by the action of penicillinase. Considering this, he has undeniable superiority. The list of indications includes almost all odontogenic infections. This remedy has a slight antibacterial effect on infectious and inflammatory pathologies of joints and bones, but does not help with full treatment

Parents are often interested in which medicine will be safer and more effective for children, Amoxiclav tablets or Flemoxin Solutab. They are more concerned about the side effects and adverse reactions of the baby’s body. The right to choose any of the medications must be left to the doctor.

, who will be able to professionally select Amoxiclav analogues suitable for the child’s age

• Sumamed

The drug belongs to macrolides and has stronger properties. With the average course of infectious processes, taking Sumamed

will be the optimal solution.
Its active ingredient is azithromycin dihydrate
.
In comparison with this analogue, Amoxiclav
has the advantage of being used for children from infancy.
But Sumamed
is easy to use

As you know, treatment of the most severe infectious processes begins with penicillin-containing drugs. Only if there is no result, they turn to macrolides - a stronger category of antibacterial drugs. The advantage of Sumamed is its speed

, allowing you to eliminate the symptoms of diseases with maximum speed. This significantly reduces the recovery period

• Suprax

Considering that the medicine is a third generation cephalosporin, its composition is radically different from Amoxiclav

.
Being a more powerful drug, Suprax
is used in cases of severe infectious processes that have a complicated form.
The drug suspension is recommended for children from 6 months of age
, Amoxiclav - from birth

• Azithromycin

Having identical composition, these products are completely interchangeable

.
However, given that Azithromycin is produced in India
, consumers prefer cheaper analogues, for example
Sumamed, produced in Croatia
, with full compliance with the necessary technologies and requirements

About generics

Global pharmaceutical companies produce both original drugs and generics. The cost of the former is significantly higher than those that have a generic name. For example, generic Amoxiclav costs exactly half as much. The original refers to the innovative developments of certain companies that synthesized and patented the created substance for 20 years

The original medicine is unique and has no analogues. However, after the expiration of patent protection, the situation changes dramatically, and generics produced by competitors appear in pharmacy chains. Production costs for clinical trials leave an imprint on the cost of original drugs. Incredible resources are involved in development: technical, human and financial. The production of one drug requires material costs in the range of $1 billion.

Quite often, the cost of one generic is very different from another, which is associated with therapeutic and pharmaceutical equivalence, which coincides with the originals. Cheap copies of drugs contain only bioequivalence

Bottom line

In conclusion, I would like to note that since Amoxiclav is an antibacterial drug, its substitutes should also be antibiotics

. First of all, you should pay attention to the composition, therapeutic effectiveness and contraindications, trying to choose a more structurally cheaper analogue. If shock therapy is necessary, substitutes containing powerful antibiotics such as cephalosporins and macrolides are chosen.

The company that manufactured the products and pricing policy are also important. It’s not difficult to choose cheap Russian analogues; the main thing is to decide which one is better suited for children or adult patients. This should be provided to the doctor. You should not stop treatment prescribed by a specialist or change medications.

. Even if the temperature returned to normal and there was a general improvement. It should be remembered that taking antibiotics has a certain specificity that actively affects infectious agents.

Reviews about Amoxiclav

In the process of discussing the drug Amoxiclav, reviews from doctors and patients are predominantly positive. It is noted that the antibiotic is effective in the treatment of respiratory tract diseases, and it is suitable for both adults and children. Reviews mention the effectiveness of the product for sinusitis, otitis media, and genital tract infections. As a rule, adult patients take 875 mg + 125 mg tablets; if the dosage is correct, relief occurs quickly. Reviews note that after a course of antibiotic treatment, it is advisable to take drugs that restore normal microflora .

Reviews of the Amoxiclav suspension are also positive. Parents write that it is convenient to give the product to children, as it has a pleasant taste and is normally perceived by children.

Amoxiclav price, where to buy

• The price of Amoxiclav tablets 250 mg + 125 mg is on average 250 rubles for 15 pieces. You can buy the antibiotic Amoxiclav 500 mg + 125 mg at a price of 350 – 400 rubles for 15 pcs. How much 875 mg + 125 mg tablets cost depends on the place of sale. On average, their cost is 400 - 500 rubles for 14 pieces.
• Price Amoxiclav Kviktab 625 mg – from 350 rubles for 14 pcs.
• The price of Amoxiclav suspension for children is 300 rubles (100 ml).
• The price of Amoxiclav 1000 mg in Ukraine (Kyiv, Kharkov, etc.) is from 300 hryvnia for 14 pieces.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Amoxiclav powder for suspension.
  for internal approx. 400mg+57mg/5ml 17.5gLek dd RUB 187 order
• Amoxiclav powder for suspension. for internal approx. 250mg+62.5mg/5ml 20 doses 25gLek dd

  RUB 242 order

• Amoxiclav Quiktab dispersible tablets 250mg+62.5mg 20 pcs. Lek dd

  RUB 246 order

• Amoxiclav powder for suspension. for internal approx. 400mg+57mg/5ml 35gLek dd

  280 rub. order

• Amoxiclav tablets p.p.o. 875mg+125mg 14 pcs.Lek dd

  RUB 396 order

Pharmacy Dialogue

• Amoxiclav powder for suspension 250mg+62.5mg/5ml 100mlLek

  RUB 274 order

• Amoxiclav powder for suspension 125mg+31.25mg/5ml 100mlLek

  119 RUR order

• Amoxiclav (tablet p/o 625 mg No. 15)Lek

  RUB 202 order

• Amoxiclav Quiktab (dispersible tablet 625 mg No. 14)Lek

  RUB 311 order

• Amoxiclav Quiktab (dispersible tablet 1000 mg No. 14)Lek

  RUR 442 order

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Pharmacy24

• Amoxiclav 125 mg/31.25 mg 5 ml 100 ml powder for oral suspension Lek pharmaceutical company d.d., Slovenia
  131 UAH. order
• Amoxiclav 500mg/100mg No. 5 powder for the preparation of solution for injection Sandoz GmbH, Austria

  379 UAH. order

• Amoxiclav Quiktab 875mg/125mg N14 tablets Lek pharmaceutical company d.d. Slovenia / Sandoz Ilac Sanay ve Tikaret A.S., Turecchina

  164 UAH order

• Amoxiclav 2x 875 mg / 125 mg No. 14 tablets Lek pharmaceutical company d.d., Slovenia

  189 UAH order

• Amoxiclav 2S 400 mg/57 mg 5 ml 17.5 70 ml powder for oral suspension Lek pharmaceutical company d.d., Slovenia

  115 UAH order

PaniPharmacy

• Amoxiclav 2 tablets Amoxiclav 2 film-coated tablets 875/125 mg No. 14 Slovenia, Lek

  217 UAH. order

• Amoxiclav Quiktab tablets Amoxiclav Quiktab dispersible tablets 500mg/125mg No. 10 Slovenia, Lek

  87 UAH order

• Amoxiclav bottle Amoxiclav lyophilized powder for injection 1.2g No. 5 Slovenia, Lek

  454 UAH. order

• Amoxiclav liquid Amoxiclav powder for suspension 250mg/62.5mg (312.5mg)/5ml 100ml Slovenia, Lek

  167 UAH order

• Amoxiclav liquid Amoxiclav powder for suspension 125mg/31.25mg (156.25mg)/5ml 100ml Slovenia, Lek

  131 UAH order

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