Pirenoxin eye drops are a modern anti-cataract drug for topical use. Using the drug to treat a disease often allows one to avoid complex surgical intervention. Pyrenoxine actively influences metabolic processes in the conjunctiva, cornea, and lens. Drops help slow down the process of clouding of the lens and preserve vision.
Form, composition, packaging
Pirenoxine is produced in the form of a tablet, which is used to prepare a solution. One tablet contains sodium pyrenoxine (25 mg), boric and sulfamic acid. Isotonic (buffer) water acts as a solvent.
The product is located in a branded cardboard pack. One package contains a 15 ml plastic bottle with solvent, a yellow tablet (0.75 mg) in a contour cell. The bottle is equipped with a special dispenser. The kit also includes an insert with characteristics of the medicine and a detailed description of the technology for preparing the ophthalmic solution.
Catalin 0.75 mg 15 ml dry eye drops + solvent
pharmachologic effect
Cataract treatment.
Composition and release form Katalin 0.75 mg 15 ml eye drops dry solution + solvent
Tablets - 1 tablet:
- Active component of the tablet: sodium pyrenoxine monohydrate (in terms of pyrenoxine 0.75 mg) - 0.85 mg;
- Auxiliary components of the tablet: aminoethyl sulfonic acid (taurine) - 62 mg, boric acid - 12.15 mg;
- Solvent components: boric acid - 180 mg, sodium borate - 1.2 mg, potassium chloride - 24 mg, methyl parahydroxybenzoate - 3 mg, propyl parahydroxybenzoate - 1.5 mg, purified water - up to 15 ml.
1 tablet in a blister made of aluminum foil and PVC film and 15 ml of transparent solvent in an amber-yellow polypropylene bottle are placed together with instructions for use in a cardboard pack.
Description of the dosage form
Orange-red to yellow tablets complete with a clear, colorless solvent. Once dissolved, the solution is clear, orange-red to yellow.
Directions for use and doses
Use only by instillation. Immediately before use, dissolve one tablet in 15 ml of solvent and instill 1-2 drops of solution into the conjunctival sac 3-5 times a day.
The duration of the course of treatment is determined by the doctor.
- Remove the large white cap from the solvent bottle. If a film has formed on the opening of the bottle neck, lightly press the bottle until it disappears. (Please note that if the broken part of the blister comes into contact with the film, the tablet will become wet, making it difficult to place the tablet inside the bottle).
- Without touching the fold line near the arrow, break the blister with the tablet, as shown in the figure.
- Place the tablet into the bottle directly from the blister without touching the tablet.
- Screw on the white cap tightly and shake the bottle vigorously to dissolve the tablet.
- Before instillation, remove the small brown lid, leaving the large white lid closed, otherwise the prepared solution may spill out.
Pharmacodynamics
Catalin has an inhibitory effect on the action of quinone compounds, the process of fat oxidation and the action of aldose reductase and prevents the progression of cataracts. The data are presented on the basis of the quinoid theory, the results were obtained in guinea pigs.
Pharmacokinetics
The action of quinone substances produced as a result of abnormal metabolism of aromatic amino acids stimulates the conversion of water-soluble protein in the lens into insoluble protein, as a result of which the lens substance becomes cloudy. By inhibiting the action of quinone substances, pyrenoxine prevents the development of cataracts. Based on data from a study of radioactively labeled hydrogen, when the drug Catalin was instilled into the eyes of rabbits, the concentration of pyrenoxine in the tear fluid 2 hours after instillation was 0.0189 mcg eq/ml, the maximum concentration 4 hours after instillation was 0.003 mcg eq/ml .
Indications for use Catalin 0.75 mg 15 ml dry eye drops + solvent
Initial stages of senile cataract.
Contraindications
Individual intolerance. Children's age, due to insufficient safety data.
Use of Catalin 0.75 mg 15 ml dry eye drops + solvent during pregnancy and breastfeeding
Due to the lack of sufficient research to date, the drug is not recommended for use during pregnancy and breastfeeding.
special instructions
When instilling, do not touch the tip of the bottle to your eye.
If you instill the solution immediately after removing the bottle from a cool place, especially in cases where a small amount of solution remains in the bottle, the solution may not pour out as a drip, but as a stream. This effect occurs due to the expansion of cool air in the bottle under the influence of the heat of the hand on the bottle. To avoid this effect, you need to warm the bottle by holding it in your hand for some time before instillation.
Impact on the ability to drive vehicles and operate machinery
To date, the possibility of the drug influencing the ability to drive vehicles has not been established.
Overdose
To date, no cases of overdose have been registered.
Side effects Catalin 0.75 mg 15 ml dry eye drops + solvent
Diffuse superficial keratitis, blepharitis, conjunctival hyperemia, itching, burning pain in the eye, contact dermatitis, conjunctivitis, irritation, lacrimation, discharge from the eyes, a feeling of discomfort and a foreign body in the eye, blurred vision. Allergic reactions may occur due to the presence of parabens in the drug. If adverse reactions occur, use of the drug should be discontinued.
Drug interactions
Drug interactions have not been studied. When used with other local ophthalmic drugs, the interval between their use should be at least 5 minutes. It is not recommended to use simultaneously with eye drops containing metal ions (silver solutions, Collargol, zinc sulfate), since Catalin changes color in their presence.
Therapeutic effect
Pirenoxin drops are an anti-cataract agent whose therapeutic effect is based on the properties of the active component. Sodium pyrenoxine affects metabolic processes in the lens, namely:
- improves the trophic properties of the cell membranes of eye tissues and activates metabolism in them;
- inhibits the formation of solid structures in the lens and normalizes glucose metabolism in the tissues of the organ of vision;
- prevents the deposition of salts and the formation of sorbitol, which provoke clouding of the lens.
As a result, Pyrenoxin prevents the appearance of opacities in the lens and helps stop the progression of the pathological process.
The maximum concentration of components in the structures of the lens is recorded 3-4 hours after instillation. The components of the drops penetrate into the systemic bloodstream in small quantities. The active substance remains virtually unchanged in the body and is excreted unchanged by the kidneys along with urine.
Indications and contraindications for use
Direct indications for the use of Pirenoxin drops:
- senile cataract - clouding of the lens substance that occurs upon reaching old age and is manifested by a decrease in visual acuity (cataract drops - list of the best);
- Diabetic cataract is a complication of the visual organs that accompanies diabetes mellitus.
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In both cases, the disease is accompanied by a deterioration in visual function, up to complete loss of vision. In addition, the drug is used to prevent the development of degenerative changes in the structure of the lens.
Individual hypersensitivity to at least one component of the medication is the only contraindication for use. It is not recommended to use drops for the treatment of children, pregnant and lactating women, since no research has been conducted in this direction.
Eye drops after cataract surgery
After surgery, eye drops are also prescribed. However, their mechanism of action is completely different. These compositions have anti-inflammatory and antibacterial effects. Among the most frequently prescribed by doctors: Tobradex, Korneregel, Indocolir.
There is no need to take prophylactic drops after surgery, since the lens is removed.
The operation lasts only 15 minutes. and allows you to restore vision almost immediately. Within an hour the patient will be able to see. Microsurgical intervention is performed under local anesthesia, is almost bloodless, does not require stitches, does not leave scars and does not require long rehabilitation. Therefore, if you suffer from cataracts, you need to have surgery. Conservative treatment with drops is indicated only in cases where degenerative changes do not yet cause significant inconvenience. The Clean View clinic provides a full range of procedures for successful cataract removal. More details by phone +7 (499) 141-13-75.
Instructions (method, mode)
Ophthalmic drops are used only topically; taking them orally is strictly prohibited. Before the first instillation, the medicinal composition must first be prepared, following the following steps:
- wash hands thoroughly with soap;
- open the package with the tablet;
- place it in a bottle with a solvent;
- The bottle is shaken vigorously until the tablet is completely dissolved.
The result should be a uniform orange liquid. The dosage regimen is selected by an ophthalmologist. But usually, for the treatment of cataracts of any kind, 1-2 drops are instilled into each conjunctivitis sac up to 5 times a day. The frequency of use is determined by the attending physician, taking into account the severity of the pathology. Treatment lasts no more than 30 days. Repeated use of drops is possible after a short break (10-14 days).
Catalin tablet d/drops 75 mg No. 1 + solution 15 ml
Compound
Active substance: pyrenoxine sodium monohydrate 0.85 mg, which corresponds to the content of pyrenoxine 0.75 mg.
Excipients: aminoethylsulfonic acid (taurine) - 62 mg, boric acid - 12.15 mg. Solvent: boric acid - 180 mg, sodium borate - 1.2 mg, potassium chloride - 24 mg, methyl parahydroxybenzoate - 3 mg, propyl parahydroxybenzoate - 1.5 mg, purified water - up to 15 ml.
Pharmacokinetics
The action of quinone substances produced as a result of abnormal metabolism of aromatic amino acids stimulates the conversion of water-soluble protein in the lens into insoluble protein, as a result of which the lens substance becomes cloudy. By inhibiting the action of quinone substances, pyrenoxine prevents the development of cataracts. Based on data from a study of radioactively labeled hydrogen, when the drug Catalin was instilled into the eyes of rabbits, the concentration of pyrenoxine in the tear fluid 2 hours after instillation was 0.0189 mcg eq/ml, the maximum concentration 4 hours after instillation was 0.003 mcg eq/ml .
Indications for use
Senile and diabetic cataracts.
Contraindications
Hypersensitivity to pyrenoxine. Children's age, due to insufficient safety data.
Directions for use and doses
Use only by instillation. Immediately before use, dissolve one tablet in 15 ml of solvent and instill 1-2 drops of solution into the conjunctival sac 3-5 times a day.
The duration of the course of treatment is determined by the doctor.
Cooking method:
1. Remove the large white cap from the solvent bottle. If a film has formed on the opening of the bottle neck, lightly press the bottle until it disappears.
(Please note that if the broken part of the blister comes into contact with the film, the tablet will become wet, making it difficult to place the tablet inside the bottle).
2. Without touching the fold line near the arrow, break the blister with the tablet, as shown in the figure.
3. Place the tablet into the bottle directly from the blister without touching the tablet.
4. Screw on the white cap tightly and shake the bottle vigorously to dissolve the tablet.
5. Before instillation, remove the small brown cap, leaving the large white cap closed, otherwise the prepared solution may spill out.
Storage conditions
Store at a temperature not exceeding 25 °C. Do not freeze.
After dissolution, store in a place protected from light, at a temperature not exceeding 15 °C. Keep out of the reach of children.
Best before date
5 years. After dissolution, use within 20 days.
special instructions
When instilling, do not touch the tip of the bottle to your eye.
If you instill the solution immediately after removing the bottle from a cool place, especially in cases where a small amount of solution remains in the bottle, the solution may not pour out as a drip, but as a stream. This effect occurs due to the expansion of cool air in the bottle under the influence of the heat of the hand on the bottle. To avoid this effect, you need to warm the bottle by holding it in your hand for some time before instillation.
Description
Cataract treatment.
Pharmacodynamics
Catalin has an inhibitory effect on the action of quinone compounds, the process of fat oxidation and the action of aldose reductase and prevents the progression of cataracts. The data are presented on the basis of the quinoid theory, the results were obtained in guinea pigs.
Side effects
Diffuse superficial keratitis, blepharitis, conjunctival hyperemia, itching, burning pain in the eye, contact dermatitis, conjunctivitis, irritation, lacrimation, discharge from the eyes, a feeling of discomfort and a foreign body in the eye, blurred vision. Allergic reactions may occur due to the presence of parabens in the drug. If adverse reactions occur, use of the drug should be discontinued.
Use during pregnancy and breastfeeding
Due to the lack of sufficient research to date, the drug is not recommended for use during pregnancy and breastfeeding.
Interaction
Drug interactions have not been studied. When used with other local ophthalmic drugs, the interval between their use should be at least 5 minutes. It is not recommended to use simultaneously with eye drops containing metal ions (silver solutions, Collargol, zinc sulfate), since Catalin changes color in their presence.
Overdose
To date, no cases of overdose have been registered.
Impact on the ability to drive vehicles and operate machinery
To date, the possibility of the drug influencing the ability to drive vehicles has not been established.
Adverse reactions, overdose
Undesirable consequences are extremely rarely recorded; they appear only when the dosage regimen is violated. First of all, side effects develop from the organ of vision:
- pain, itching, burning, pain in the eyes;
- redness and swelling of the eyelids;
- inflammation of the cornea of the eyes (superficial keratitis);
- inflammation of the edges of the eyelids (blepharitis).
Sometimes allergic manifestations are observed. The most common symptoms are rash and itching of the skin, runny nose, cough, as well as redness and swelling of the eye tissue. The longer the tissues of the organ of vision are in contact with the allergen, the more pronounced the signs of a pathological reaction.
There are no data on overdose. In any case, the occurrence of adverse reactions must be reported to your doctor.
special instructions
Pirenoxin drops should not be used simultaneously with other ophthalmic agents. If several drugs are prescribed, it is necessary to maintain an interval of 15-20 minutes between instillations.
The medicinal solution should be used carefully, without touching the mucous membrane and other surfaces. Otherwise, there is a possibility of infection of the bottle dispenser with subsequent contamination of the solution. Before instillation, the ophthalmic device must be removed. You can put on contact lenses no earlier than 30 minutes after the procedure.
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If blurred vision is observed after instillation, you should wait until your vision is restored and only then begin work that requires precision and driving.
additional information
The finished solution is suitable for use for 20 days; at the end of this period it is considered unsuitable and must be disposed of. Store the drops in the original, tightly closed bottle. The optimal storage temperature is no higher than 15°C. Access to the drug is limited to children and pets. The shelf life of an unopened bottle and sealed tablet is 5 years from the date of manufacture.
You can buy the drug at any pharmacy chain. It is dispensed without a prescription, but on the basis of a prescription from an ophthalmologist. The cost of Pirenoxin (one tablet for preparing a solution complete with a solvent) in Moscow is 650 rubles.
Analogs
Catalin is a direct analogue drug. It actively influences metabolic processes in the conjunctiva, cornea, and lens. You can also replace Pyrenoxine with the following drops:
- Vita-Iodural. Drops improve nutrition of the lens, blood supply and metabolism in the eyeball. Most often, the drug is used for preventive purposes and as an addition to primary therapy.
- Quinax. The drug has a wide range of actions. Intended for the treatment of inflammation of the ocular mucosa, cataracts, glaucoma and other pathologies.
- Emoxipin. Used for therapy and strengthening of eye vessels for hemorrhages, retinopathy, diseases of the circulatory system, glaucoma, cataracts, retinal pathologies and other disorders. It is an angioprotector, antihypoxant and antioxidant, reduces blood viscosity and platelet aggregation.
- Taufon. The medication saturates the organ of vision with vitamins. It is often prescribed for cataracts. The medicine is also prescribed in other cases, as it helps restore vision by nourishing the eyes.
- Oftan-Katachrome. This combination drug improves the energy metabolism of the lens. Usually prescribed in the early stages of cataract development.
- Cataxol. Drops are used as part of complex therapy for senile, congenital, traumatic and secondary opacification of the lens of the organ of vision. The active components of the drug accelerate the recovery processes in the tissues of the eye.
Substitutes have other active ingredients, other side effects, and contraindications. Therefore, only an ophthalmologist should select an analogue.
Read more Instructions for using Okumed eye drops
List of most commonly prescribed drugs
Among the most effective drugs are:
- Emoxipine, which is not only a synthetic antioxidant, but also reduces vascular permeability, thereby normalizing the circulation of intraocular fluid.
- Quinax. A Japanese drug that acts on the protein of the lens, preventing further clouding.
- Catalin is another actively used and well-reviewed drug. The composition prevents degenerative changes in the lens and also helps restore the penetrating ability of its membrane.
When purchasing analogues of original drugs, the price of which is much lower, you need to be prepared for the absence of a dispenser and possible side effects. Inexpensive drugs are not always less effective, but often less safe.
If examinations reveal that lens clouding is a consequence of a deficiency of certain components, replacement therapy is prescribed. Most often, various dietary supplements are used to improve eye nutrition.
