Dragee "Evening (VHM)" - valerian + hops + mint: instructions for use, reviews

Dragee Evening VHM - for sound sleep even with menopausal nervous system disorders

Increased irritability and nervousness can be caused by various reasons. The occurrence of psychoemotional disorders is not always provoked by external factors. Very often, the culprit is the body itself, or rather, malfunctions in its systems due to age-related hormonal changes. This happens, for example, in women during menopause. Dragee Evening VHM , containing powders of well-known herbs with a sedative and hormone-like effect, will gently and safely relieve sleep disturbances even with menopausal disorders of the nervous system.

Price, where to buy

The price of Evening dragees is 70-80 rubles per pack of 100 pieces.

• Online pharmacies in RussiaRussia
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Evening dragee 60 pcs Biocor
  51 RUR order
• Evening dragee 120pcs Biocor

  119 RUR order

• Evening dragee valerian + hops + mint biocore 30 pcsBiocore

  59 RUR order

• Evening + motherwort tablets 60 pcs Biocor
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  103 rub. order

• Tea drink evening calmness biocore 20 bagsBiocor

  120 rub. order

Pharmacy Dialogue

• Evening + Motherwort Biokor No. 120 Valerian + Motherwort Biokor Firm

  148 RUR order

• Evening Biokor (other 180 mg No. 60) Biokor Firma

  50 rub. order

• Evening Biokor No. 120 Valerian + Hops + MintBiokor Firm

  92 rub. order

• Evening Plus dragee (other 200 mg No. 50 (valerian + motherwort)) Parapharm LLC

  77 RUR order

• Evening dragee (other 200 mg No. 120 (valerian + hops + mint)) Parafarm LLC

  85 rub. order

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Advantages of the herbal remedy Evening VCM over other herbal sedatives

Dragee Evening VHM is a complex of plant components with a sedative effect - valerian root and rhizomes, hop fruits, peppermint leaves. What is its fundamental difference from drugs with a similar composition?

• Whole parts of plants with all their rich composition are used, and not extracts from them. Any extract is only a tiny fraction of the entire variety of biologically active substances that nature has endowed the plant with. Extracts always contain residues of the chemicals used during extraction.
• Processing of plant raw materials is carried out using ultra-low temperatures (-175°C). This allows you to preserve all, even the most capricious, substances, for example, valepotriates. This is impossible when using extraction and heat treatment.
• The company producing Vecherny VKhM itself grows plants for its preparations in ecologically clean areas of the Penza region, located at a considerable distance from industrial centers. This allows you to control the quality of the product at all stages of its production.
• High content of active substances. Most medications based on valerian rhizomes contain a standard dosage of the plant – 20 mg. The Evening VHM dragee contains 35 mg of valerian. This means that its sedative effect is more than 1.5 times stronger than its analogues.

The therapeutic effects and scope of application of Evening VCM are varied and are due to the complex composition of plant compounds included in the drug. Let's name the main ones.

Instructions for use

Despite the natural composition of the Evening Biokor tablet, it must be taken following the recommendations specified in the description. The product is intended for the treatment of adult patients (over 14 years of age). The dosage is selected individually, based on the severity of the symptoms of the pathological condition. It is recommended to take 1-2 tablets 3 times a day with meals. Thus, the load on the gastrointestinal tract (and in particular on the liver) will be minimal. Usually the course of treatment is 4 weeks.

Iron nerves and good sleep

All herbs included in the Evening VCM .

In medicinal valerian, experts counted more than 120 compounds that provide the sedative effect of the plant [1]. Valepotriates, alkaloids valerin and hatinin, sesquiterpenes valerenic acid and valeranone, isovaleric acid, borneol, flavonoids, the amino acid glutamine, and gamma-aminobutyric acid have a particularly strong effect on the human nervous system. The compounds activate the work of gamma-aminobutyric acid (GABA), a substance that “cools” an overexcited nervous system, improves its signal transmission, replenishes the inhibitory neurotransmitter and prevents its destruction.

Doctor of Medicine, Master of Science in Public Health from Ireland Kathi J. Kemper, in her scientific work on valerian (“Valerian (Valeriana officinalis)”, 1999 [2]), states that the sedative power of valerian officinalis is similar to that of synthetic drugs from the group of barbiturates and benzodiazepines. The latter have a powerful sedative and hypnotic effect. However, their use causes addiction and aftereffects - lethargy, weakness, irritability, nausea, drowsiness. Valerian is absolutely safe.

Soviet doctors used the sedative properties of the plant long before the discoveries of their Western European colleagues. The chief therapist of the army during the Great Patriotic War, B.E. Votchal, wrote: “Valerian, at first glance, is not a very effective sedative. It was found that it has an effect in some ways similar to Aminosin . It relieves anxiety. It does not give any side effects and, when used correctly, is a very valuable drug” [3]. The drug that the scientist mentions is a synthetic drug for the treatment of severe mental disorders and has a huge list of serious side effects that threaten the patient’s life. But what did the founder of Russian clinical pharmacology mean when he spoke about the correct use of the plant?

Could it be that “the whole valerian root should be considered as an active substance”, as recommended already in 2007 by the Committee on Herbal Products of the European Medicines Agency [4]? If this is so, then the Evening VHM is what you need. Cryoprocessing technology allows you to preserve ALL natural pharmacologically active compounds of the whole plant root, in contrast to extracts. The therapeutic effectiveness of tablets of finely ground raw materials of rhizomes with valerian roots is 2.5 times higher than that of valerian extract tablets (O. M. Khishova, 1997-1999 [5]).

It is also worth noting that the hypnotic effect of valerian is cumulative in nature and makes itself felt after 0.5-1 month of daily use . According to the observations of specialists from the University of Surrey (England) DA Diaper and I. Hindmarch, this effect is more pronounced in patients with objective sleep disorders than in healthy people [6].

Common hop fruits also contain a large amount of biologically active substances that affect the functional state of the nervous system. The main ones are the following.

• Bitter α- and β-acids . The former are represented by humulone, cohumulone, adhumulon, prehumulon, posthumulon, the latter - lupulone, colupulone, adlupulone, prelupulone and postlupulone. They have a pronounced sedative and antidepressant effect (K. Lee et al., 1993 [7]; H. Schiller, A. Forster et al., 2006 [8]; P. Zanoli, M. Zavatti et al. , 2005 [9], 2007 [10]) and are comparable to that of valerian.
• Chalcones (xanthohumol, isoxanthohumol, desmethylxanthohumol) and proanthocyanidins protect nervous tissue from the destructive effects of free radical oxidation (MN Diaz, B. Frei and others, 1997 [11]; JF Stevens, CL Miranda and others, 2002 [12]) , and the antioxidant activity of xanthohumol exceeds that of vitamin E and genistein (CL Miranda et al., 2000 [13]). According to I. A. Zavalishin, M. N. Zakharova (1996 [14]) and Yu. A. Aleksandrovsky (1991 [15]), the active activity of free radicals is a key link in the death of neurons .
• Flavonols and dihydroflavonols. According to a study by M.A. Alekseeva, candidate of pharmaceutical sciences (2005), hop fruits contain up to 0.6% dihydroquercetin, a powerful natural antioxidant [16]. Quercetin, kaempferol and myricetin were also found. These substances not only neutralize the effects of free radicals. Myricetin protects nerve cells from the action of toxins and prevents the development of Alzheimer's disease. Together with quercetin, this substance protects nerve cells in the brain during cerebral circulation disorders leading to oxygen and glucose deficiency (KS Panickar, RA Anderson, 2011 [17]). Kaempferol protects the neurons of the brain regions responsible for maintaining and contracting muscle tissue (subcortical nuclei) from the influence of neurotoxins, thereby preventing the development of Parkinson's disease. This compound also restores the concentration of the nerve signal transmitter dopamine to normal levels.
• Essential oil. Contains the volatile alcohol 2-methyl-3-buten-2-ol, which has a sedative effect (R. Hänsel et al., 1980 [18]; R. Wohlfart et al., 1983 [19]; ​​H. Schiller et al., 2006 [20]).
• Lupulin. This is a mixture of various substances - resins, fat, essential oil, ash, covering hop fruits and having a calming effect on the central nervous system. It has long been noticed that when collecting plant cones without gloves, a feeling of fatigue and drowsiness appears.

The diverse influence of common hop fruits on the functional state of the nervous system was studied by specialists from the Institute of General and Experimental Biology of the Siberian Branch of the Russian Academy of Sciences (Ulan-Ude) Ya. G. Razuvaeva, N. V. Kabachuk and colleagues [21]. During experiments on animals, they found that the plant is capable of:

• reduce the level of emotionality;
• reduce anxiety and fear;
• stimulate cognitive functions of the brain - memory, attention, thinking, imagination and others, have an anti-amnestic effect;
• reduce the severity of stress changes in internal organs;
• reduces by 25% the number of low-active (hyperchromic) neurons in the hippocampus and cerebral cortex, increases the number of functionally active (hypochromic) nerve cells (D. D. Orlovskaya, 1986 [22]);
• drowse;
• exhibit antidepressant properties;
• provide an anti-aggressive effect;
• protect nervous tissue from the action of free radicals, activate the body’s antioxidant system;
• normalize blood clotting under conditions of prolonged stress and thereby prevent the formation of blood clots (it has been proven that under prolonged stress, blood clotting increases);
• exhibit an antihypoxic effect (L.V. Pastushenkov, E.E. Lesiovskaya, 1991 [23]), helping to increase the reserve life time by 19-28% depending on the type of hypoxia (blood, tissue, normobaric);
• stimulate GABAergic neurotransmission.

Evening VHM tablet – peppermint leaves – also has a moderate sedative effect . According to the authoritative reference book of medicinal products, VIDAL, in medical practice the plant is used to treat increased excitability of the nervous system, neuroses, and mild sleep disorders.

The therapeutic effects of mint are largely due to the components of the essential oil - menthol, menthone, pinene and limonene . The most studied (60%) of them is menthol. When taken orally, the substance irritates the cold receptors of the oral mucosa. This leads to increased production and release of endorphins - substances that improve mood, overall well-being, give vigor, and protect against the negative effects of stress.

In addition, peppermint contains isovaleric acid esters , which act on the hypothalamus in a similar way to the antipsychotic drug chlorpromazine: they change the transition of nerve impulses from the cerebral cortex to the subcortex and thereby reduce emotional reactions.

By the way, both menthol and isovaleric acid are part of the famous sedative drug “Validol”.

In 2021, V.V. Dementieva, a specialist at Samara National Research University named after S.P. Korolev, studied the effect of peppermint on the behavior of laboratory animals [18][24]. It was found that the plant has an anti-stress effect, reduces anxiety levels, and changes the activity of the serotonergic and dopaminergic systems of the brain .

In the same year, specialists from the State Nikitsky Botanical Garden A. M. Yarosh, V. V. Tonkovtseva I. A. Batura and colleagues studied the effect of mint on elderly people - women 50-90 years old [25]. It turned out that the plant has a positive effect on the psycho-emotional state of the subjects, significantly and significantly reducing the manifestations of anxiety and depression, improving the general condition, well-being, mood, reducing psychological stress, increasing efficiency, vigor, and attention .

Release form of the drug and its price

“Evening” tablets are produced in the form of dragees, covered with a bright green coating.

Several pharmaceutical companies produce this product. Tablets manufactured by different companies have similar properties.

The price of the sedative “Evening” depends on the manufacturer and varies from 56 to 120 rubles per pack.

Evening ICM is a source of phytoestrogens. Indicated for women during menopause

All three components of the Evening VXM contain phytoestrogens.

These substances are not hormones in the full sense of the word. They are only similar in structure and molecular weight to female sex hormones. However, this gives them wide opportunities to influence the body of the weaker half of humanity. Phytoestrogens, like a master key to a keyhole, bind to the same receptors as estrogens: α-receptors located in the female reproductive organs, and β-receptors scattered throughout all organs and tissues . Moreover, they have a more pronounced affinity for the latter.

This explains the ability of plant compounds not only to reduce the severity and number of manifestations of menopausal syndrome (hot flashes, sweating, headaches, irritability, insomnia), but also to have a therapeutic effect in atherosclerosis, osteoporosis, diseases of the cardiovascular system and malignant tumors. Phytoestrogens:

• reduce the number of atherosclerotic plaques;
• thin the blood;
• reduce the level of “bad” cholesterol, increase cholesterol;
• neutralize the destructive effects of free radicals, increase the resistance of the vascular endothelium to it, strengthen the vascular walls;
• suppress the absorption of glucose in the intestine;
• activate collagen synthesis in the skin;
• prevent malignant degeneration of healthy tissue cells, suppress the division of cancer cells, significantly reduce metastases in women with positive estrogen-dependent breast cancer;
• promote the absorption of calcium and phosphorus;
• gently normalize blood pressure;
• strengthen the immune system.

Acting as an easy substitute for female sex hormones, phytoestrogens improve a woman’s appearance, slow down the aging process, and block the negative effects of estrone (an intermediate hormone from the estrogen group, which is converted to estradiol in young women), for example, estrogen-dependent proliferation of endometrial tissue.

Valerian officinalis began to be used relatively recently for menopause. In 2013, Iranian specialists from two large educational institutions of the country - Islamic Azad University and the University of Medical Sciences. Sh. Beheshti - P. Mirabi and F. Mojab published the results of a study on the effect of valerian on the condition of menopausal women [26].

68 women aged 45 to 55 years were divided into two groups: experimental and control. Subjects from the first group received capsules filled with crushed valerian root (255 mg) daily for 2 months, and those from the second group received the same capsules filled with starch. After a month, the scientists noted that the frequency of hot flashes in the experimental group had decreased significantly and their severity had decreased .

Earlier, in 2006, similar results were obtained by another Iranian researcher from Shahre-Kord University of Medical Sciences A. Kazemian [27].

It has been suggested (AF Berman, 1999 [28]; KP Jones, 2000 [29]) that the estrogenic activity of valerian is provided by volatile oily substances, including monoterpenes, sesquiterpenes and valepotriates.

Phytotherapist A. N. Alefirov calls the flavone apigenin as a phytoestrogen in valerian [30]. True, the scientist equates the estrogenic activity of this substance to zero, believing that it is not apigenin itself that works in a woman’s body, but its metabolites (transformation products).

According to Iranian scientists, the estrogenic activity of various plants ranges from 1/50 to 1/2000 of steroid hormones [31]. Moreover, phytoestrogens, unlike synthetic estrogens, do not cause any serious side effects.

Valerian can also affect the quality of sleep in postmenopausal women. It is known that almost half of women suffer from insomnia during this period. In 2010, this was proven by specialists from the Tehran University of Medical Sciences (Iran) MS Simin, BS Neda and colleagues, who conducted a clinical study involving 100 women 50-60 years old suffering from insomnia [32]. 30% of women taking valerian experienced improved sleep.

the Evening VHM dragee – common hop – also has a powerful estrogen-like effect on a woman’s hormonal background . Its estrogenic activity is 1,250,000 g of estrone per 1000 g of plant weight [33]. For comparison, the famous female herb, red clover, has 10 g of estrone per 1000 g of plant weight [33].

8-prenylnaringenin (8-PN) was found in the fruits of the plant This substance in an experiment (J. Pitkin, 2012 [34]) demonstrated 40 (!) times greater affinity for α-receptors than for β-receptors . In 2006, F. Roelens, N. Heldring and colleagues proved that 8-prenylnaringenin reduces the level of pituitary hormones responsible for the production of estrogens and testosterone (follicle-stimulating and luteinizing hormones) [35].

Also found in hop fruits is the substance isoxanthohumol , which, under the influence of intestinal microflora, can be converted into 8-prenylnaringenin (D. Szkutnik-Fiedler, M. Jedrzejczyk et al., 2010 [36]). By the way, the latter is useful not only for the female body, but also for the male one. In women, it accumulates in the mammary glands and stimulates breast growth (S. Bolca, J. Li, D. Nikolic et al., 2010 [37]); in representatives of the stronger half of humanity, it increases the volume of ejaculate, the number of sperm and, as a result, , probability of conception (E. Ricci, S. Noli, S. Ferrari et al., 2021) [38].

In 2005, specialists from the Catholic University of Leuven (Belgium) V. Jerkovic, D. Callemien and C. Collin discovered another group of substances with estrogenic activity in hops [39]. These are stilbenes - resveratrol and its glycoside piceid. In addition to hormone-like effects, they demonstrate powerful antioxidant, antiplatelet, anti-inflammatory, cardioprotective, antitumor, antiviral and neuroprotective properties.

Many women know that excess estrogen can cause pathological growth of the inner layer of the endometrium and are afraid to take phytoestrogens. In the case of hops, these fears are completely unfounded. The fact is that the plant contains substances that can activate progesterone receptors and thereby neutralize the negative effects of 8-prenylnaringenin (SE Geller, L. Studee, 2005 [40]).

At the moment, there is a large number of studies proving the ability of hop fruits to reduce such symptoms of menopause as hot flashes, decreased libido, vaginal dryness and osteoporosis (F. Roelens, N. Heldring et al., 2006 [35]; J. Pitkin, 2012 [34]). The plant affects bone density by increasing the amount and activity of the enzyme (alkaline phosphatase), which ensures phosphorus-calcium metabolism.

The fact that peppermint contains compounds with estrogen-like activity was known half a century ago. In 1975, Candidate of Biological Sciences M.F. Shakhova identified β-sitosterol . 206 mg of this substance was found in 100 g of dry plant material [41].

β-sitosterol is the most studied phytosterol today. It has high potential for treating various diseases. Numerous studies organized in clinics in the USA, Japan, Finland, and Russia suggest that the main pharmacological property of phytoestrogen is hypocholesterolemic. The substance causes a decrease in the level of cholesterol in the blood plasma, suppressing the absorption by the intestinal walls of both cholesterol synthesized in the liver and cholesterol supplied with food (AM Lees, HYI Mok, RS Lees and others, 1977 [42]). It is advisable to use it for the prevention of atherosclerosis and in the treatment of vascular disease. β-sitosterol is used to treat and alleviate the symptoms of prostate adenoma (TI Wilt, 1999 [43]; E. G. Privalova, V. G. Nikityuk, 1999 [44]). The substance also reduces the risk of cancer of the colon, breast, stomach, lungs, affects the state of the immune system and pathological inflammatory reactions.

Regular long-term use of mint can reduce high levels of androgens in women and reduce the resulting hair growth in places unusual for the female body, for example, on the face. In 2004, researchers from Turkey M. Akdogan, A. Kocak, E. Cicek and colleagues, in experiments on male rats, found that peppermint reduces the level of testosterone circulating in the blood plasma by 23% [45].

Dragee Evening VHM can be recommended for everyone to fall asleep easier, and especially for menopausal women, since the herbs included in the composition help to gently eliminate the symptoms of hormonal decline.

Composition and features of action

In the manufacture of the product the following is used:

1. Peppermint oil.

2. Valerian root extract.
3. Hop inflorescences.
4. Additional ingredients (molasses, granulated sugar, calcium, lactose, beeswax, talc).
5. Aromatic additives.

Valerian has a sedative effect, helps normalize sleep and the process of bile outflow, reduces spasms, and lowers blood pressure. In addition, this plant dilates blood vessels and eliminates problems associated with blood circulation.

Valerian is not used as a method of treating complex pathologies. However, it may be prescribed as an additional remedy for complex treatment.

Hop inflorescences also help normalize sleep, have a calming effect, reduce pain, inflammation and spasms, and eliminate problems associated with disruption of the genitourinary system.

Mint is known for its general strengthening properties. In addition, the plant reduces the process of inflammation, normalizes the outflow of bile, blood circulation, and gastrointestinal tract activity. Peppermint is also used to reduce cramps.

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