Compound
- 1 gram of Triderm ointment contains 10 mg of clotrimazole , 1 mg of gentamicin , 0.5 mg of betamethasone . Additional components: liquid paraffin, soft paraffin.
- 1 gram of Triderm cream also contains 10 mg of clotrimazole , 1 mg of gentamicin , 0.5 mg of betamethasone . Additional components: propylene glycol, petrolatum, liquid paraffin, cetostearyl alcohol, benzyl alcohol, macrogol cetostearate, phosphoric acid, sodium dihydrogen phosphate dihydrate, water, phosphoric acid.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Multicomponent product for external use. Combines the antipruritic, anti-inflammatory, antiallergic and antiexudative effect of betamethasone with the antifungal effect of clotrimazole and the antibacterial activity of gentamicin .
Clotrimazole has an antifungal effect due to its ability to inhibit the biosynthesis of ergosterol , which is an important structural unit of the fungal cell membrane. Effective on Epidermophyton floccosum, Trichophyton rubrum and mentagrophytes, Candida albicans, Microsporum canis, Malassezia furtur.
Gentamicin has a wide spectrum of effects. Exhibits a bactericidal effect and provides local treatment of bacterial skin lesions. Effective on:
- gram-negative bacteria – Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes;
- gram-positive bacteria – Staphylococcus aureus.
Pharmacokinetics
There is no data on the pharmacokinetics of this drug.
What effect does Triderm ointment have?
The instructions for Triderm ointment indicate that the drug belongs to the group of anti-inflammatory, antifungal and antibacterial agents.
The therapeutic effect of the drug is due to the properties of its constituent components:
- clotrimazole – has antifungal activity, promotes the destruction of cells of pathogenic dermatophytes, yeast and mold fungi;
- gentamicin is a broad-spectrum antibiotic that is harmful to gram-positive and gram-negative bacteria (staphylococci, Klebsiella, Escherichia coli, Proteus);
- betamethasone is a glucocorticosteroid that has antiallergic and anti-inflammatory effects, relieves itching and swelling at the site of injury.
Indications for use
What does Triderm ointment and Triderm cream treat and for what? Indications for use of Triderm ointment:
- infections associated with microorganisms sensitive to the drug and frolicking against the background of dermatoses , or suspicion of them, including atopic , allergic and simple dermatitis , diffuse and limited neurodermatitis , dermatomycosis ( candidiasis , dermatophytosis , pityriasis versicolor ), eczema ;
- lichen simplex of a chronic nature.
In what cases will Triderm help?
The drug has a wide range of applications. The ointment can be applied to dermatoses with existing signs of infection or to prevent bacterial complications in dermatological diseases.
The manufacturer indicates the following list of indications:
- dermatitis, simple or allergic in origin;
- eczema;
- atopic dermatitis syndrome, neurodermatitis;
- manifestations of simple chronic lichen;
- diseases of fungal origin, for example, candidiasis, lichen versicolor, located in the groin area and large skin folds.
Contraindications
- skin symptoms of syphilis ;
- chicken pox;
- lupus ;
- post-vaccination skin reactions;
- herpes simplex;
- hypersensitivity to the components of the drug;
- age less than 2 years.
It is recommended to use the drug with caution for long-term therapy, in children over 2 years of age, during pregnancy, on large areas of skin or in the presence of wounds, when applying occlusive dressings.
Contraindications for the use of ointment, possible side effects
Triderm ointment is not used in case of individual intolerance or hypersensitivity to any of the substances in the composition.
Also, the medication is not used:
- skin lesions due to tuberculosis;
- with syphilis;
- chickenpox;
- skin reactions to vaccine administration;
- herpetic rashes;
- chicken pox;
- open wounds;
- in the treatment of children under two years of age.
The ointment can be used with caution during pregnancy, in pediatrics, when using bandages, for long courses and on large areas of the skin.
Adverse reactions occur rarely. These are mainly local unpleasant sensations - burning, itching, severe redness, wetting of the skin at the site of application.
The manufacturer also points out the possibility of side effects that have been recorded when using glucocorticosteroids:
- stretch marks;
- prickly heat;
- feeling of dryness;
- increased hair growth;
- acne;
- secondary infection;
- swelling or atrophy of the skin.
Due to the action of clotrimazole, the following may occur: tingling, blisters, swelling at the site of application, peeling and itching, redness, and urticaria-type rashes.
Side effects
- Local phenomena: erythema , burning sensation, pigmentation disorder, exudation , itching.
- Side effects after using local glucocorticosteroids : itching, burning sensation, folliculitis , dry skin, hypertrichosis, hypopigmentation, acne, allergic contact dermatitis , skin maceration, perioral dermatitis , atrophy , secondary infection, prickly heat , stretch marks .
- Side effects after using clotrimazole : urticaria , tingling sensation, erythema , peeling, blistering, itching, local swelling, irritation.
- Side effects after using gentamicin : temporary erythema and itching, which does not require discontinuation of therapy.
Contraindications and adverse reactions
You should refrain from taking Triderm in the following cases:
- chickenpox;
- tuberculosis of the skin;
- common herpes;
- children under 2 years old;
- skin manifestations of syphilis;
- skin manifestations of the vaccine;
- increased susceptibility to constituent components.
Particular caution should be taken when taking the medicine during long-term treatment, in young children, pregnant women, on large skin areas, or in the presence of injuries.
The following adverse reactions may occur:
- local manifestations: burning, itching, impaired pigmentation;
- negative reactions after taking glucocorticosteroids: burning, itching, dry skin, allergies in the form of a rash;
- undesirable reactions after using clotrimazole: local swelling, skin irritation;
- negative manifestations after taking gentamicin: itching (no need to stop treatment).
Instructions for use of Triderm (Method and dosage)
Triderm ointment, instructions for use
The ointment is for external use only.
The use of Triderm ointment is carried out in the following way: a thin layer is applied to the affected and surrounding skin twice a day (morning and evening). To ensure a therapeutic effect, the product must be applied regularly. The duration of treatment depends on the size and location of the lesion, as well as the response to therapy.
If improvement is registered after 4 weeks of treatment, you should consult a doctor and clarify the diagnosis.
Triderm cream, instructions for use
The cream is for external use only. The method of application and dosage when using the cream are completely consistent with those when using the ointment.
How to take it correctly
Ointment
The medicine in the form of an ointment is used according to the following scheme: applied in a thin layer to the damaged area of the skin and around it 2 times a day. To achieve a therapeutic effect, it is important to observe regularity. The duration of the treatment course depends on the degree of infection, as well as the body’s reaction.
If the condition improves after a month, then it is worth informing a specialist so that he can make a diagnosis again.
Cream
The product in cream form is intended for topical use. The application regimen is identical to the ointment.
Overdose
Signs of overdose with local glucocorticosteroids : with long-term use in large doses, suppression of adrenal function with the appearance of adrenal insufficiency and hypercortisolism .
An overdose of clotrimazole when applied locally does not lead to the development of any symptoms.
In case of an overdose of gentamicin, no symptoms are detected either. Long-term treatment with gentamicin in large doses may cause the appearance of insensitive flora.
Overdose therapy: symptomatic. Acute hypercortisolism is usually reversible. If necessary, correct electrolyte imbalance. In case of chronic overdose of local glucocorticosteroids, slow withdrawal is recommended.
Interaction of the drug with other substances
If Triderm is used concomitantly with an anticholinergic drug (for example, atropine for pupil dilation), intraocular pressure may increase further.
Visible deposits in the conjunctival sac may occur when administered concomitantly with amphotericin B (an antifungal agent). The same applies to the simultaneous use of heparin (an anti-thrombosis drug). Sulfadiazine, cephalothin and cloxacillin can lead to the precipitation of proteins in the conjunctival vessel.
Amphotericin
The drug may impair vision and therefore the ability to drive and use machines. For eye treatments, contact lenses should be removed before application.
Advice! Sometimes medications cause allergic reactions. If you notice any signs of an allergic reaction, tell your doctor or pharmacist immediately.
special instructions
Triderm ointment and cream are not intended for use in ophthalmic practice.
Prolonged use of local antibiotics in some cases can lead to the emergence of resistant microflora. In such a case, as well as in case of sensitization , irritation or superinfection , Triderm therapy should be stopped and symptomatic treatment should be started. Cross allergic phenomena with aminoglycoside antibiotics cannot be excluded .
All side effects that occur when taking systemic glucocorticosteroids , including suppression of the adrenal cortex, can also develop when using local glucocorticosteroids , especially in children.
The absorption of active substances into the systemic circulation when applied topically is enhanced if treatment is carried out with the application of occlusive dressings or over large areas of the skin, especially during prolonged treatment or when the skin is wounded. It is strongly recommended to avoid contact of gentamicin with open wounds or broken skin, as this may cause adverse reactions characteristic of systemic use of gentamicin .
With long-term use of the drug, its withdrawal should be carried out slowly.
There was no effect of the drug on the ability to drive vehicles.
Additional recommendations
The ointment is not used for infectious diseases of the organs of vision. With long-term use of a local antibiotic, pathogenic microorganisms may develop resistance to it.
Do not apply the product to open wound surfaces or severely damaged skin. The use of dressings and application of the product to large areas of skin contribute to higher absorption of gentamicin and glucocorticosteroids, resulting in an increased risk of adverse reactions.
If use has been long-term, then it should be discontinued gradually.
Triderm's analogs
Level 4 ATX code matches:
Rederm
Losterine
Akriderm SK
Akriderm
Akriderm GK
Akriderm Genta
Elokom S
Diprosalik
Belosalik
Kanizon Plus
Betasalik
Triacutan
Momat-S
Analogues of Triderm cream and ointment: Akriderm (Russian substitute), Kanizon , Triakutan, Betazon Ultra, Lokoid, Diprosalik, Betasalik.
The price of analogues of Triderm ointment, which are listed above, is an order of magnitude lower than the price of the product itself.
Analogs
Proven analogues include:
Kanizon. Available in the form of cream, solution and tablets. The drug is effective for various diseases and joint problems.
Lokoid. It is produced in the form of ointment and cream. It has a local antipruritic and anti-inflammatory effect.
Betasalik. Available in the form of an ointment. It is a drug of combined action. has anti-inflammatory, antiseptic and antiallergic effects.
Triactutan. Sold in the form of ointment and cream. It has antifungal, antibacterial and anti-inflammatory effects.
Basically, the price of analogues will be lower than Triderma.
For children
The medicine is prescribed only to children over 2 years of age, according to strict indications and under the supervision of a doctor, since it is possible that systemic side effects associated with betamethasone appear in this category of patients more often than in adults. Such side effects include: Cushing's syndrome , inhibition of the pituitary-hypothalamic-adrenal system , growth retardation, increased intracranial pressure (as a consequence, headache, swelling of the optic nerve and bulging of the fontanelles), slower growth of body weight.
Reviews about Triderm
Reviews of the cream, as well as reviews of Triderm ointment, report rare cases of ineffectiveness and even more rarely undesirable effects (mainly itching). Otherwise, 90% of reports give an excellent rating to the drug. Due to the complex composition and the possibility of severe side effects, it is not recommended to use this medicine independently and unsupervised.
Is Triderm ointment hormonal or not?
The ointment and cream of the same name contain the hormonal component betamethasone , so they can be called hormonal.
Triderm and balanoposthitis
Despite the good results of treating balanoposthitis with this remedy, many doctors do not recommend its use for this pathology, due to the high probability of damage to the skin of the genitals under the influence of hormones.
Cream or ointment: which is better?
Reviews do not reveal any significant correlation between the effectiveness of these forms of release of the drug.
Is it possible to take Triderm during pregnancy?
During the period of bearing a child, the use of the drug is possible only as prescribed by a doctor and under constant supervision. In this case, the possible beneficial result must significantly outweigh the possible threat to the developing fetus and the expectant mother. It is better not to use the cream for a long time or on large areas of skin.
During breastfeeding, it is strictly forbidden to take the drug, since there is no data regarding the possibility of excretion of the constituent components together with breast milk.
Triderm price, where to buy
The price of Triderm ointment 15 g in Russia is 570-680 rubles, and cream 15 g costs 580-640 rubles. Buying a cream in Moscow (like ointment) will cost a large amount; here its cost reaches 820 rubles.
Ointment 15 g costs 230-300 hryvnia in Ukraine. The price of Triderm cream 15 g is on average 230-290 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Triderm cream 15gSchering-Plough Labo NV
RUR 711 order - Triderm ointment 15g Schering-Plough Labo NV
RUR 796 order
- Correction of photoaging Hyaluronic acid + ampoules MartiDerm/MatriDerm Platinum 2ml No. 10MARTIDERM, SL ES
RUR 4,226 order
- Correction of photoaging Hyaluronic acid + ampoules MartiDerm/MatriDerm Platinum 2ml No. 30MARTIDERM, SL ES
RUR 6,668 order
Pharmacy Dialogue
- Triderm cream tube 15gShering-Plough
RUR 751 order
- Triderm ointment (tube 15g)Shering-Plough
RUB 832 order
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PaniPharmacy
- Triderm cream Triderm cream 30g Belgium, Schering-Plough Labo
295 UAH.order - Triderm cream Triderm cream 15g Belgium, Schering-Plough Labo
187 UAH order
- Triderm ointment Triderm ointment 15g Belgium, Schering-Plough Labo
190 UAH order
- Triderm ointment Triderm ointment 30g Belgium, Schering-Plough Labo
345 UAH. order
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