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Manufacturers: Moscow Pharmaceutical Factory (Russia)
Active ingredients
- Beclomethasone
Disease class
- Vasomotor and allergic rhinitis
- Nasal polyp
- Polyposis sinus degeneration
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Anti-inflammatory
- Antiallergic
Pharmacological group
- Glucocorticoids
Pharmacodynamics and pharmacokinetics
The active ingredient is beclomethasone . The aerosol is effectively used in the treatment of bronchial asthma (basic therapy).
Aldecine has antiallergic and moderate anti-inflammatory effects. Beclomethasone enhances the production of the A2 phospholipase inhibitor - annexin (lipocortin), inhibits the production of inflammatory mediators, reduces the release of arachidonic acid , and has an inhibitory effect on the synthesis of arachidonic acid metabolic products - prostaglandins and endoperoxides.
The anti-inflammatory effect is due to inhibition of the formation of chemotaxis , the formation of a slow allergic reaction slows down.
Belomethasone improves mucociliary transport , reduces the number of mast cells in the bronchial mucosa, reduces bronchial hyperreactivity, and reduces the secretion of mucus produced by the bronchial glands.
Aldecine has a positive effect on functional indicators of external respiration. The drug allows you to restore the patient's response to the effects of bronchodilators, which significantly reduces the frequency of their use.
The drug increases the number of active beta-adrenergic receptors and does not have a resorptive effect when used in inhalation.
The use of the drug Aldecin in therapeutic doses does not lead to the development of systemic side effects that occur when using glucocorticosteroids. The therapeutic effect develops gradually; the drug does not relieve bronchospasm .
Pharmacological action of Aldecin
Aldecin has antiallergic and anti-inflammatory effects, has an immunosuppressive effect (suppresses the immune system). The active substance beclomethasone inhibits the release of inflammatory mediators from mast cells, thereby reducing swelling of the mucous membrane and reducing the production of secretions (mucus). The drug also has a beneficial effect on mucociliary clearance (improves the functioning of the ciliated epithelium, which promotes the removal of mucus).
Aldecin spray has a bronchodilator effect (relaxes the smooth muscles of the bronchi) and reduces their hyperreactivity. Aldecine has virtually no systemic effect on the adrenal cortex, which is typical for oral administration of glucocorticosteroids. The drug restores the patient's response to drugs that dilate the bronchial muscles. For hormone-dependent bronchial asthma, Aldecin allows you to reduce the dose of glucocorticoids taken orally.
Contraindications
Aldecine is contraindicated in non-asthmatic bronchitis, acute bronchospasm, beclomethasone intolerance, and status asthmaticus.
Contraindications also include: tuberculosis, nosebleeds, age under 6 years.
For glaucoma , liver cirrhosis, breastfeeding , osteoporosis , hypothyroidism , pregnancy , systemic diseases (viral, parasitic, fungal, bacterial infections) prescribe with caution.
Indications for use of Aldecin
According to the instructions for Aldecin, this drug is intended for inhalation use in cases of bronchial asthma, including:
- Hormone-dependent form of the disease;
- Severe form of the disease in childhood;
- The need for maintenance therapy over a long period of time;
- Presence of contraindications for the use of bronchodilators;
- Ineffective use of bronchodilators;
- Ineffectiveness of combination therapy with cromoglycic acid and bronchodilators.
According to the instructions for Aldecin, this drug is also effective for the treatment of chronic obstructive bronchitis in cases of a pronounced inflammatory component.
Aldecine nasal is used in the treatment of seasonal or year-round allergic rhinitis, as well as in cases of vasomotor rhinitis. In addition, the drug is often used for nasal polyposis as part of complex therapy.
Side effects
Irritation in the throat, hoarseness, sneezing , cough, paradoxical bronchospasm , oral candidiasis, allergies, eosinophilic pneumonia .
With long-term use of the drug in increased quantities, systemic side effects develop, adrenal insufficiency , leukocytosis, increased intraocular pressure, dizziness, headaches, eosinopenia, cataracts , lymphopenia.
With a single dose of high doses of Aldecin, a decrease in the function of the hypothalamic-pituitary and adrenal systems is recorded.
The systems are restored on their own after 2 days.
Guidelines for patients on inhalation with Aldecin spray
Before using a new bottle of the drug, you should calibrate it, that is, press the dosing device 6-7 times. After this, the stereotypical supply of the drug will be established. If the cylinder has not been used for more than 14 days, it must be recalibrated before use.
Before using Aldecin nasally, it is necessary that the nasal passages are clear. The nasal applicator is inserted in a vertical position towards the inner corner of the eye. The second nostril should be pressed with a finger, and the head should be tilted forward.
Pressing the Aldecin spray should occur while inhaling and exhaling through the mouth. Spraying the spray directly onto the nasal septum is unacceptable!
Instructions for use of Aldecin (Method and dosage)
Aerosol
Used by inhalation.
For adults:
- Mild bronchial asthma: 100 mcg 3 times a day.
- For severe bronchial asthma, 200 mcg is prescribed 3 times a day. The maximum daily dose is 1 mg.
Children from 6 to 12 years old can use a maximum of 0.5 mg per day.
Upon completion of inhalation, it is recommended to rinse the mouth with running water.
Aldecin spray, instructions for use
From the age of six, you can use one or two injections in each nostril twice a day.
Composition, release form and analogues
1 dose of Aldecin contains 50 mcg of beclomethasone dipropionate as an active ingredient and the following auxiliary components:
- Dispersed cellulose;
- Propylene glycol;
- Sodium citrate dihydrate;
- Glycerol;
- Polysorbate 80;
- Citric acid monohydrate;
- Purified water.
Aldecin spray is available in the form of aerosol cans with a metering valve, a nasal applicator and a special mouthpiece. One bottle contains 8.5 g of the drug, which is equivalent to 200 doses. One cardboard package contains 1 aerosol can.
Among Adeltsin's analogues, the following drugs can be distinguished:
- Beclazon;
- Beclazon Eco;
- Beclazon Easy Breathing;
- Beclazon Eco Easy Breathing;
- Beclomethasone;
- Beclomethasone dipropionate;
- Beclomethasone Orion Pharma;
- Beklomet Easyhaler;
- Beclospira;
- Becotide;
- Rinoclenil;
- Klenil;
- Klenil UDV;
- Plibekot;
- Nasobek.
Interaction
Aldecine allows you to restore the patient's response to the use of beta-agonists , which significantly reduces the frequency of their use.
There are no significant drug interactions between inhaled glucocorticosteroids and other medications.
Inducers of microsomal oxidation ( rifampicin , phenobarbital, phenytoin) reduce the effectiveness of beclomethasone.
Estrogens, methandrostenolone , theophylline, beta2-adrenergic stimulants enhance the effect of the drug Aldecin.
Similar drugs:
- Dexamethasone Solution for intravenous and intramuscular administration
- Calcium gluconate Chewable tablets
- Pulmicort Suspension for inhalation
- Cetrine Oral tablets
- Sodium cromoglicate Substance-powder
- Diprospan Solution for injection
- Mometasone furoate Substance-powder
- L-cet Oral tablets
- Dexamethasone Solution for injection
- Adrenaline (Adrenaline) Solution for injection
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Aldecin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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special instructions
Aldecine is not used to relieve acute attacks of bronchial asthma. Patients must be explained that the drug has a preventive effect, and that to achieve maximum effect, the drug must be used regularly, including in the absence of signs of asthma.
Regular use of the inhaler can improve respiratory function after just a week of treatment. The reason for the lack of effect may be the increased content of mucus and sputum in the respiratory system, as well as as a result of severe bronchospasm, which prevents beclomethasone from penetrating into the area of action.
Before prescribing Aldecin, the doctor must instruct the patient about the aspects of proper use of the inhaler, which will subsequently provide a better therapeutic effect due to the complete penetration of the main substance into the lungs.
When transferring a patient from an oral glucocorticosteroid to Aldecin, regular peak flow measurements .
Washing after using the drug helps prevent damage to the nose and eyelid skin.
Aldecin
Before prescribing inhaled drugs, it is necessary to instruct the patient about the rules for using the drug to ensure the most complete delivery of the drug to the desired areas of the lungs.
The drug is not intended for the relief of acute asthmatic attacks. Patients should be aware of the preventive nature of the drug and that to achieve optimal effect, the inhaler should be used regularly, even in the absence of asthma symptoms.
With regular inhalation of beclomethasone, improvement in breathing usually occurs after 1 week of treatment. Lack of effect is possible in patients with increased levels of sputum and mucus in the respiratory tract and severe bronchospasm, which prevents the drug from reaching the zone of action. In such cases, inhalation of adrenergic stimulants is prescribed 15-30 minutes before inhalation of beclomethasone or treatment is started with the systemic use of GCS.
The transfer of patients regularly taking oral corticosteroids to inhaled beclomethasone, as well as subsequent treatment, should be carried out with extreme caution, under daily monitoring of peak flowmetry (pneumotachometry), since suppression of the adrenal cortex caused by long-term use of corticosteroids is restored slowly.
Before prescribing inhaled forms of beclomethasone, patients should be in a relatively stable condition, and their prescription itself should complement the usual maintenance dose of systemic corticosteroids. After about 1 week, the daily dose of steroids begins to be gradually reduced - 1 mg/week (in terms of prednisolone). Deterioration of the condition against the background of a maintenance dose of 400 mcg/day means the need to transfer patients to oral prednisolone. Regular use allows in most cases to cancel oral corticosteroids (patients who need to take no more than 15 mg of prednisolone can be completely transferred to inhalation therapy), while in the first months after the transition the patient’s condition should be carefully monitored until his pituitary-adrenal system recover sufficiently to respond to stressful situations (such as injury, surgery, or infection).
Patients transferred to inhalation treatment and having impaired function of the adrenal cortex should have a supply of GCS and with them a warning card, which should indicate that in stressful situations they need additional systemic administration of GCS (after eliminating the stressful situation, the dose of steroids can be repeated reduce). Sometimes a transfer from taking systemic corticosteroids to inhalation administration can lead to the manifestation of previously suppressed forms of allergies, such as allergic rhinitis or eczema.
It is necessary to protect the eyes from contact with the drug.
It is advisable to rinse the mouth and throat after inhalation (prevention of candidiasis), and when initial signs of fungal infection of the oral mucosa appear, use nystatin, fluconazole, amphotericin. By washing after inhalation you can prevent damage to the skin of the eyelids and nose.
The maximum daily dose of the drug in adults should not exceed 1 mg. At a dose of up to 1.5 mg/day in most patients, it does not significantly suppress adrenal function. If this dose is exceeded, some patients may experience some suppression of adrenal function. Treatment in doses of more than 1 mg/day is carried out under the supervision of a physician.
During pregnancy and breastfeeding, beclomethasone should be used with caution and only when the benefits of its use outweigh the potential risks. There is insufficient data on the safety of beclomethasone dipropionate in pregnant women and on its excretion in women's breast milk.
Beclomethasone preparations, containing 50-100 mcg in 1 dose, play an important role in the treatment of severe forms of bronchial asthma in children, since they provide good control over the course of the disease and do not cause growth retardation in the child. Beclomethasone 250 mcg is not intended for use in pediatrics. It is recommended to regularly monitor the growth dynamics of children receiving inhaled corticosteroids over a long period of time.
Infectious and inflammatory diseases of the respiratory system are not a specific contraindication for treatment with beclomethasone.
The drug should not be frozen or exposed to direct sunlight. The bottle of the drug must not be pierced, disassembled or thrown into fire, even if it is empty. When the canister cools, it is recommended to remove it from the plastic case and warm it with your hands (at low temperatures, the effectiveness of the drug is reduced).
Aldecin's analogs
Level 4 ATX code matches:
Alvesco
Budenit Steri-Neb
Asmanex
Beclazon
Budesonide
Flixotide
Pulmicort
Analogs include the following drugs: Beclazon , Beclat , Glenbekar , Klenil .
