Tylenol - description of the drug, instructions for use, reviews

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Manufacturers: McNeil Consumer & Specialty Pharmaceuticals

Active ingredients

• Paracetamol

Disease class

• A sore throat
• Fever of unknown origin
• Headache
• Other constant pain
• Tooth pain

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Antipyretic
• Analgesic (non-narcotic)

Pharmacological group

• Anilides

Release form and composition of Tylenol

This medication is available in several forms, which allows the patient to choose the one that is more convenient for use; the name may be Tylenol tylenol extra strength, gold, etc. Currently it has the following release forms:

• capsules contain 500 mg of the main substance, sold in blisters in a package of two;
• suspensions are available in bottles with a measuring cup;
• infusion solution;
• suppositories are available in weights of 0.1, 0.2 and 0.35 g; one package contains ten rectal suppositories;
• powder.

The main active ingredient of this medicine is paracetamol; starch, stearic acid, and magnesium stearate will act as auxiliary ingredients. The composition will depend on the form of release of the medication.

Instructions for use in Russian

Tylenol instructions for use contain information on how to use the medicine correctly, contain information about to whom it is contraindicated and for what diseases it is recommended. Before ordering the product, you should read the instructions, which are publicly available on the Internet and contain all the necessary information.

Indications for use

Tylenol (Tylenol gold) is prescribed to people suffering from such diseases as:

1. arthrosis;
2. arthritis;
3. radiculitis;
4. for periodic or persistent headaches, including migraines;
5. myalgia.

It is also used to relieve toothaches and symptoms that occur during colds (chills, muscle pain, joint aches, etc.).

Directions for use and dosage

In accordance with the instructions, the medication should be taken before meals, as if taken after, the effects of paracetamol will be delayed, and you should also drink it with plenty of water.

• up to 12 years of age, Tylenol is prescribed in accordance with the instructions, taking into account the child’s weight, that is, a certain amount of grams is distributed per daily dose as needed;
• for persons whose age is over 12 years, a single dose should not exceed 1 g, no more than 4 g can be consumed per day. The period during which the medication can be taken daily is no more than seven days;
• As for taking the medicine rectally, for adults a single dose can be from 500 mg to 1 g, but during the day it should not exceed 4 g, for adolescents from 12 to 15 years old, up to 300 mg at a time up to four receptions per day.

Attention: for patients with Gilbert's syndrome and for elderly citizens with any diseases, the dose of the medicine should be reduced when used, and the intervals between doses should be increased.

Contraindications

Almost all medications have a number of contraindications, Tylenol is no exception; this drug is contraindicated:

1. if there is an allergic reaction or other intolerance to the components included in the medicine;
2. in the presence of insufficiency in the liver or kidneys;
3. with existing liver diseases, such as viral hepatitis;
4. chronic alcohol dependence;
5. diabetes of any type;
6. the drug is also contraindicated for children less than three months old;
7. During pregnancy and breastfeeding, the use of this product is not recommended.

Attention: the use of a medicinal substance is not permissible together with alcoholic beverages, as this combination reduces the effectiveness of the effect on the body and can lead to the development of acute pancreatitis.

Side effects

Almost every substance can have side effects caused by overdose or individual intolerance to the drug, Tylenol is no exception:

• manifestations on the skin can be in the form of rashes accompanied by itching, swelling of the mucous membranes, exudative erythema;
• the central nervous system may also be affected, manifested in the form of dizziness, the appearance of nervous excitement, possible disturbance of orientation;
• As for the digestive system, nausea followed by vomiting and pain in the abdominal area may appear;
• There may also be disturbances in the endocrine system, which will manifest themselves in the form of glycemia, which can lead to coma;
• side effects can affect the human circulatory system, resulting in diseases such as pain in the heart, shortness of breath, anemia, and with long-term use of the drug in excess of permissible doses in aplastic anemia, leukopenia, thrombocytopenia;
• In case of overdose, the genitourinary system may be damaged, renal colic, nephritis, papillary necrosis may appear;

Attention: in order to reduce the risks of overdose and side effects, you should carefully study the instructions for use and the composition of the drug; if in doubt, you should definitely consult a doctor.

Overdose

Symptoms of an acute overdose of the drug appear after 6-14 and are expressed in the form of diarrhea, nausea with possible vomiting, loss of appetite, as well as pain attacks in the abdominal area.

Chronic overdose appears after two to three days, accompanied by such symptoms as:

1. pain;
2. state of weakness;
3. increased sweating;
4. the appearance of seizures;
5. cerebral edema;
6. disturbances in liver function, etc. may also appear.

Treatment is prescribed depending on the situation, after a blood test is taken and the amount of paracetamol in the blood is determined. For first aid in case of acute overdose, gastric lavage is possible, followed by the introduction of SH donors, glutathione, and methionine into the body.

Instructions

MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION

Instructions for medical use of the drug Selank®

Read these instructions carefully before you start using this medicine because they contain information that is important to you. Save the instructions, you may need them again. If you have any questions, consult your doctor. The medicine you are using is for your own use and should not be given to others as it may harm them even if they have the same symptoms as you.

Registration number: LRS-003338/09 Trade name of the drug: Selank® Chemical name: threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline-diacetate. Dosage form: nasal drops Composition per 1 ml: Active ingredient: Selanka® in terms of 100% substance (threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate) – 1.5 mg. Excipients: methyl parahydroxybenzoate (nipagin) – 1 mg, purified water up to 1 ml. Description: colorless transparent liquid. Pharmacotherapeutic group: anxiolytic agent (tranquilizer). ATX code: N05BX

pharmachologic effect

Pharmacodynamics Selank® is a synthesized analogue of the endogenous tuftsin peptide, which has an original mechanism of neurospecific action on the central nervous system. Selank® has an anti-anxiety effect with an antidepressant effect; antiasthenic effect. Relieves symptoms of restlessness, anxiety, fear, apathy, depression and asthenia. It has a positive effect on cognitive functions, improves memory, speech, increases attention, activates learning processes, in particular, memorization, analysis and reproduction of information. Normalizes psychomotor reactions. In case of stress, Selank® eliminates emotional and negative tension and stimulates the development of adaptive behavior aimed at achieving a useful result.

Pharmacokinetics Selank® is administered intranasally (nasal drops). The absolute bioavailability of Selank® when administered to the nasal mucosa is 92.8%. The drug is quickly absorbed from the nasal mucosa and after 30 seconds is detected in the blood plasma, and then quickly distributed to various organs and tissues. Penetrates into brain tissue. Plasma concentrations decrease progressively over 5-5.5 minutes. Neither unchanged drug nor metabolites are detected in daily urine, which is due to the rapid degradation of Selank® under the influence of tissue peptidases.

Indications for use:

Alarm states:

• unmotivated anxiety, restlessness;
• panic attacks;
• neurasthenia;
• asthenia;
• mood instability;
• sleep disorders;
• decreased willpower, initiation of activities, indecisiveness, difficulties in making decisions, lack of self-confidence;
• lack of confidence in communication;
• adjustment disorders;

Prevention and treatment of stress disorders.

Contraindications

Individual intolerance to the drug. Pregnancy, breastfeeding (efficacy and safety studies have not been conducted). Children under 18 years of age (efficacy and safety studies have not been conducted).

Use during pregnancy and breastfeeding

Pregnancy Since controlled studies of the use of Selank® in pregnant women have not been conducted, it should not be used during pregnancy. Breastfeeding period If it is necessary to use the drug during lactation, you should refrain from breastfeeding.

Directions for use and doses

Selank® is administered intranasally, using a bottle sealed with a plastic screw cap or a dropper cap. If the bottle is sealed with a plastic screw cap, upon initial use, remove the plastic screw cap and replace it with the included capped dropper. Pipette the drug. Squeeze the required number of drops of the drug onto the clean mucous membrane of the nasal passage, then close the nostril with your finger for a short time. If the bottle is sealed with a dropper cap, carefully cut off the tip of the pipette and tightly cap the pipette. Before use, invert the bottle so that the liquid fills the entire pipette space. Remove the cap. Squeeze the required number of drops of the drug onto the clean mucous membrane of the nasal passage, then close the nostril with your finger for a short time. Instillation of the drug into the nasal passages is carried out in a sitting position with the head slightly thrown back or tilted to one side, after which each nostril is pinched for a short time with a finger. The effectiveness of absorption may be reduced in the presence of increased secretions from the nasal mucosa, therefore, before use (instillation), it is recommended to clear the nasal passage. Dose: 2 drops in each nasal passage 3 times a day. The duration of the course of use of the drug is 14 days. If necessary, the course of treatment can be repeated after 1–3 weeks, after consulting a doctor. Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Side effect

With increased sensitivity to the perception of smell and taste, unpleasant taste sensations may appear when the drug gets from the nasal cavity onto the mucous membrane of the pharynx. It is possible to develop allergic reactions due to individual intolerance. If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

No cases of overdose have been reported when using the drug Selank®.

Interaction with other drugs

Selank® does not affect the effects of drugs that depress and stimulate the central nervous system - haloperidol, pentobarbital, hexobarbital, analeptics. Selank® can be combined with any psycho- and neuroactive therapy. Selank® is safe when used in combination with ethanol-containing products. If you are taking other medications (including over-the-counter medications), consult your doctor before using Selank®.

special instructions

Selank® does not cause drug dependence or addiction.

Impact on the ability to drive vehicles and machinery

Does not affect the ability to drive vehicles or operate machinery.

Release form

Nasal drops of 3 ml in a glass bottle, sealed with a plastic pipette stopper, or in a glass bottle, sealed with a plastic screw cap with a pipette cap included. Each bottle with instructions for use is packaged in a cardboard box.

Storage conditions

Store in a place protected from light, at a temperature not exceeding 10oC. Do not freeze. Store the opened bottle at a temperature not exceeding 25oC for no more than 15 days. Keep out of the reach of children.

Best before date

2 years. Do not use after the expiration date.

Vacation conditions

Available without a prescription.

Manufacturer: Name and address of the manufacturer: CJSC Innovative Research and Production (CJSC INPC Peptogen). Russia, 123182, Moscow, pl. Academician Kurchatova, 2, building 1 Russia, 123458, Moscow, st. Tvardovskogo, 8 Tel./fax 8-499-686-05-50 E-mail

Quality claims are accepted by the manufacturer.

Use in childhood

Tylenol for children is used from three months and not earlier before giving it, you should consult your pediatrician. Children's Tylenol is given for colds to relieve pain during teething, and can be used when the temperature rises after vaccination. For children, Tylenol is available in the form:

• suspension (rainbow tylenol) is given to children from 3 months to one year in an amount of no more than 5 ml per day, from one year to six no more than 10 ml, for ages 6 to 12 the dose should not exceed 20 ml per day;
• Tylenol suppositories for babies from 3 to 6 months 80 g up to two times a day, for children up to one year also 80 g, but can be used up to three times a day, from one to two years, a single dose is also 80 g, up to 4 times , children from 2 to 4 150 g, up to 3 times, up to 6 years old can be given 150 g, up to 4 times a day;
• syrup for children is used in the same way as a suspension in accordance with the age and weight of the child;
• chewable tablets with flavoring additives are given to children from two years of age, from 2 to 4 years two tablets per day are allowed, from 4 to 5 to three, from 7 to 8 four, from 9-10 years up to five tablets per day.

Attention: it is not recommended to give medication to children for more than three days without consulting a doctor; the established intervals between doses should also be strictly observed; they should not be less than four hours. The use of medications must be strictly according to instructions.

Tylenol Caplets

Instructions for medical use of the drug

Description of pharmacological action

Inhibits cyclooxygenase, inhibits the synthesis of PGs in the central nervous system and their stimulating effect on the thermoregulation center of the hypothalamus; increases heat transfer.

Indications for use

Pain of mild to moderate intensity (including headache, toothache, sore throat and general malaise), fever.

Release form

caplets (caplets) 500 mg; blister 10, box (box) 1; caplets (caplets) 500 mg; strip 2, box (box) 50;

Use during pregnancy

Permissible, but only as prescribed by a doctor.

Contraindications for use

Hypersensitivity, severe dysfunction of the liver and kidneys, deficiency of glucose-6-phosphate dehydrogenase, children's age (up to 12 years).

Side effects

In rare cases - nausea, abdominal pain, allergic reactions (skin rash, itching, urticaria).

Directions for use and doses

Orally, 2 caplets 3-4 times a day, but not more than 8 caplets per day.

Overdose

Symptoms: in the first 24 hours - pallor, nausea, vomiting and pain in the abdominal area; after 12–48 hours - kidney and liver damage with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. Liver damage is possible when taking 10 g or more (in adults). Treatment: administration of methionine orally or intravenous administration of N-acetylcysteine.

Interactions with other drugs

Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage by hepatotoxic drugs. Metoclopramide increases and cholestyramine reduces the rate of absorption. Barbiturates reduce antipyretic activity.

Precautions for use

Use for more than 10 days for pain and 3 days as an antipyretic is not recommended. Should not be taken together with other drugs containing paracetamol.

Storage conditions

At a temperature of 15–30 °C.

Best before date

48 months

ATX classification:

N Nervous system

N02 Analgesics

N02B Analgesics and antipyretics

N02BE Anilides

N02BE01 Paracetamol

Interaction with other drugs

When using Tylenol, you should consider the interaction of the main substance with other medications used:

1. when Tylenol is used together with drugs that reduce the formation of stones in the urinary system and promote their elimination, their effect will be reduced;
2. if the prescribed doses for taking Tylenol are exceeded, the effect of anticoagulant drugs increases;
3. the use of substances such as ethanol, antidepressants, hepatotoxic drugs can contribute to the development of intoxication;
4. Barbiturates reduce the effectiveness of Tylenol.

Before you start taking Tylenol, you should study the instructions and in cases where you are taking any other medications, pay attention to what is said in the instructions about interactions with other substances. You should also consult a doctor.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; You should consult your doctor before starting to use Tylenol. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Tylenol is provided for informational purposes only and is not intended for prescribing treatment without the participation of a physician. Patients need to consult a specialist!

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Analogues of Tylenol in Russia

In Russia, there are a huge number of medications on sale that are similar in composition and action to Tylenol, analogues include:

• Efferalgan analogue price ranges from 100 to 300 rubles.
• Tsefekon D 45 rub.
• Panadol cost up to 120 rubles.
• Paracetamol up to 50 rub.
• Fervex, etc.
• Paracetamol Rivo.

There are many analogues, you can choose based on price and manufacturer, since, unlike Tylenol, most of the similar drugs are available in pharmacies across the country, and some analogues are produced in Russia. The cost will be influenced by the form of release of the medicine, that is, in suppositories, syrup, etc.

Price in pharmacies

A product called Tylenol can be found extremely rarely in Russian pharmacies; this medication can be purchased through foreign specialized websites and online pharmacies. The price if translated into rubles will range from 100 to 1000 rubles. The cost will be affected by the form in which the substance is released. If you are lucky and find it in Russian pharmacies, its cost will reach 2800 rubles. As you can see, in the country the cost of medicine doubles.