Derinat: instructions for use, price, reviews from doctors during pregnancy

pharmachologic effect

Derinat is an immunomodulatory drug that accelerates the processes of tissue regeneration and repair, relieves inflammation, stimulates anti-cancer immunity, has an anti-allergic effect, stimulates the natural detoxification of the body with immobilization and reduction of toxin .

In addition, the drug exhibits lymphotropic, cardioprotective and anti-ischemic properties, antioxidant and membrane stabilizer properties, and has a weak anticoagulant effect.

Pharmacodynamics and pharmacokinetics

The action of Derinat is aimed at stimulating cellular and humoral immunity, which in turn optimizes inflammatory reactions and acquired immunity (specific immune response) to foreign substances of bacterial, fungal and viral origin.

The immunomodulatory effect of the drug is determined by its ability to stimulate the activity of T- and B-lymphocytes and activate cells of the monocyte-macrophage series .

Derinat induces intracellular energy metabolism , and DNA synthesis . Due to the activation of the cellular immune response, the ability of natural killer cells (NK cells) to act on cells affected by viruses and bacteria increases.

While using the medication:

reparative and regenerative processes are activated in the body;
the condition of tissues and organs is normalized during dystrophic processes caused by vascular disorders;
the susceptibility of cells to the damaging effects of chemotherapy and radiation therapy ;
the body's resistance to various types of infections increases;
the detoxification function of the lymphatic system is stimulated;
indicators of myocardial contractile function improve;
the death of cardiac muscle cells, cardiomyocytes ;
physical performance increases.

Derinat helps remove free radicals from the body, accelerates the healing of wounds (including purulent and infected wounds), deep burns (while improving the dynamics of regeneration, epithelization and scarring of tissue), trophic ulcers.

Under the influence of the drug, scarless restoration of the mucous membranes occurs during the restoration of ulcerative defects.

Derinat does not cause any disturbances in intrauterine development or morphological abnormalities in the fetus. It also does not have a carcinogenic effect.

When used as a local remedy, it is quickly absorbed. The main route of transport of the active substance in organs and tissues is endolymphatic. At the stage of intensive entry of sodium deoxyribonucleate into the bloodstream, in parallel with metabolism and excretion, redistribution occurs between erythrocytes , leukocytes , platelets and plasma .

Metabolization occurs in the body. Metabolites are excreted partly with the intestinal contents, and mainly according to a biexponential dependence in the urine.

Derinat 1.5% 5ml 5 pcs. solution for intramuscular injection ampoule

pharmachologic effect

Immunomodulatory, wound healing, reparative, regenerating, stimulating hematopoiesis.

Composition and release form Derinat 1.5% 5ml 5 pcs. solution for intramuscular injection ampoule

Solution for intramuscular administration - 100 ml:

active substance: sodium deoxyribonucleate - 1.5 g;
excipients: sodium chloride - 0.9 g; water for injection - up to 100 ml.

Solution for intramuscular administration, 15 mg/ml. In bottles made of imported glass with injection infusion stoppers of 2 or 5 ml. In blister trays of 5 (5 ml) or 10 (2 ml) bottles. There is 1 blister tray in a cardboard pack.

Description of the dosage form

Transparent colorless liquid.

Directions for use and doses

V/m.

Adults. 5 ml of a 15 mg/ml solution (75 mg) is administered over 1–2 minutes, with an interval of 24–72 hours.

For acute inflammatory diseases - 3-5 injections with an interval of 24-72 hours.

For chronic inflammatory diseases - 5 injections with an interval of 24 hours, then - 5 injections with an interval of 72 hours.

In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, salpingoophoritis, fibroids, endometriosis) - 10 injections with an interval of 24–48 hours.

In urology and andrology (prostatitis, benign prostatic hyperplasia) - 10 injections with an interval of 24–48 hours.

For coronary artery disease - 10 injections with an interval of 48–72 hours.

For gastric and duodenal ulcers - 5 injections with an interval of 48 hours.

For oncological diseases - 3-10 injections with an interval of 24-72 hours.

For pulmonary tuberculosis - 10-15 injections with an interval of 24-48 hours.

For children, the drug is prescribed intramuscularly according to the same regimen as for adults. For children under 2 years of age, the drug is prescribed in a single dose of 7.5 mg (0.5 ml). In children aged 2 to 10 years, a single dose is determined at the rate of 0.5 ml of the drug per year of life. From the age of 10, a single dose is 5 ml of a 15 mg/ml solution, a course dose is up to 5 injections of the drug.

Pharmacodynamics

The drug has a modulating effect on the cellular and humoral components of the immune system and nonspecific resistance of the body, which leads to optimization of the inflammatory reaction and specific immune response to bacterial, viral and fungal antigens. The immunomodulatory effect of Derinat® is due to its ability to stimulate B-lymphocytes, activate T-helper cells and cells of the monocyte-macrophage system. The drug accelerates energy metabolism inside the cell, RNA and DNA synthesis. Activation of cellular immunity by Derinat® increases the ability of natural killer cells to act on cells affected by viruses, chlamydia, Staphylococcus aureus, Escherichia coli, Helicobacter, etc. Derinat® stimulates reparative and regenerative processes. The drug has anti-inflammatory, antitumor, antiallergic and detoxifying effects, as well as antioxidant and membrane-stabilizing properties. Derinat® normalizes the condition of the body in case of dystrophies of vascular origin and has a weak anticoagulant effect.

Derinat® helps remove free radicals from the body and reduces the sensitivity of cells to the damaging effects of chemotherapy drugs.

In the body, the drug accumulates mainly in the organs of the immune system and hematopoiesis - bone marrow, spleen, lymph nodes, as well as in the intestinal epithelium.

Increases the body's resistance to infections. Stimulates hematopoiesis (normalizing the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets).

Possessing pronounced lymphotropism, Derinat® stimulates the drainage and detoxification function of the lymphatic system. Derinat® significantly reduces the sensitivity of cells to the damaging effects of chemotherapy drugs and radiation therapy.

It has cardioprotective, anti-ischemic and cytoprotective effects. When Derinat® is included in the complex therapy of patients with coronary artery disease, the contractile function of the myocardium improves, the death of cardiomyocytes is prevented, and exercise tolerance increases.

In case of gastric and duodenal ulcers, the drug has a reparative effect, restoration of the mucous membrane and a pronounced immunomodulatory effect aimed at eliminating the infectious factor Helicobacter pylori.

The drug does not have embryotoxic, teratogenic or carcinogenic effects.

Pharmacokinetics

Suction and distribution

The drug is quickly absorbed and distributed in organs and tissues via the endolymphatic transport pathway. It has a high affinity for the organs of the hematopoietic system, takes an active part in cellular metabolism, integrating into cellular structures. During the phase of intensive entry of the drug into the blood, redistribution occurs between plasma and blood cells, in parallel with metabolism and excretion. After a single injection, all pharmacokinetic curves describing changes in the concentration of the drug in the studied organs and tissues are characterized by a rapid phase of increasing and a rapid phase of decreasing concentration in the time interval of 5–24 hours. T1/2 with intramuscular administration is 72.3 hours. Derinat ® is quickly distributed throughout the body, during daily course use it accumulates in organs and tissues: maximum - in the bone marrow, lymph nodes, spleen, thymus; to a lesser extent - in the liver, brain, stomach, small and large intestines. Cmax in the bone marrow is determined 5 hours after drug administration. The drug crosses the BBB. Cmax of the drug in the brain is reached after 30 minutes.

Metabolism and excretion

Derinat® is metabolized in the body. It is excreted from the body (in the form of metabolites) partially with feces and to a greater extent with urine, according to a biexponential dependence.

Indications for use Derinat 1.5% 5ml 5 pcs. solution for intramuscular injection ampoule

as part of complex therapy for chronic recurrent inflammatory diseases of various etiologies that are not amenable to standard therapy;
severe influenza, ARVI and their complications (pneumonia, bronchitis, bronchial asthma);
chronic obstructive pulmonary diseases;
as part of complex therapy of bacterial and viral infections;
allergic diseases (allergic rhinitis, bronchial asthma, atopic dermatitis, hay fever);
to activate regenerative processes;
peptic ulcer of the stomach and duodenum, erosive gastroduodenitis;
urogenital infections (chlamydia, ureaplasmosis, mycoplasmosis, including combined virus-associated infections);
endometritis, salpingoophoritis, endometriosis, fibroids;
prostatitis, benign prostatic hyperplasia;
preoperative and postoperative periods (in surgical practice);
cardiac ischemia;
trophic ulcers, long-term non-healing wounds;
obliterating diseases of the vessels of the lower extremities, chronic ischemic disease of the lower extremities of stages II and III;
burn disease;
rheumatoid arthritis, incl. complicated acute respiratory infection or acute respiratory viral infection;
stomatitis induced by cytostatic therapy;
odontogenic sepsis, purulent-septic complications;
myelosuppression and resistance to cytostatics in cancer patients, which developed against the background of cytostatic and/or radiation therapy (stabilization of hematopoiesis, reduction of cardio- and myelotoxicity of chemotherapy drugs);
hematopoiesis disorders;
treatment of radiation injuries;
pulmonary tuberculosis, inflammatory diseases of the respiratory tract;
secondary immunodeficiency states of various etiologies.

Contraindications

Individual intolerance.

Application Derinat 1.5% 5ml 5 pcs. solution for intramuscular administration of an ampoule during pregnancy and breastfeeding

A doctor's consultation is required. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed. During lactation, use strictly as prescribed by a doctor.

special instructions

The drug can be administered subcutaneously.

IV administration of the drug is not allowed.

Overdose

No negative effects from overdose were identified.

Side effects Derinat 1.5% 5ml 5 pcs. solution for intramuscular injection ampoule

In patients with diabetes mellitus, a hypoglycemic effect is observed, which should be taken into account when monitoring blood sugar levels.

Drug interactions

The use of Derinat® in complex therapy makes it possible to increase the effectiveness and shorten the duration of treatment, with a significant reduction in doses of antibiotics and antivirals with an increase in periods of remission.

Derinat® increases the effectiveness of antitumor anthracycline antibiotics and cytostatics.

The drug potentiates the therapeutic effect of basic therapy for gastric and duodenal ulcers. Derinat® reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis, achieving 50 and 70% improvement in a number of complex indicators of disease activity.

In case of surgical sepsis, the introduction of the drug Derinat® as part of complex therapy causes a decrease in the level of intoxication, activation of the immune system, normalization of hematopoiesis, and improves the functioning of organs responsible for the processes of detoxification of the internal environment of the body (including lymph nodes, spleen).

Indications for use

The solution is indicated as an independent remedy:

with acute respiratory infections ;
for the prevention and treatment of ARVI ;
for the treatment of inflammatory, purulent-inflammatory and dystrophic ophthalmological diseases;
for the treatment of inflammatory diseases of the mucous membranes of the oral cavity.

In combination with other drugs, Derinat is prescribed for the treatment of:

chronic inflammatory diseases, as well as bacterial, fungal and other infections in gynecology;
diseases of the upper respiratory tract occurring in acute and chronic forms (for example, rhinitis or sinusitis );
OZNK;
difficult-to-heal and infected wounds, trophic ulcers (including non-healing purulent wounds in diabetes mellitus );
gangrene;
frostbite and burns;
hemorrhoids;
necrosis of the skin and mucous membranes provoked by radiation therapy.

Derinat is administered intramuscularly:

to stimulate the function of hematopoiesis ( hematopoiesis );
in the treatment of radiation injuries ;
in the case of the development of myelodepression (inhibition of the function of bone marrow hematopoiesis) and resistance to cytostatic drugs, which manifests itself in patients with cancer during cytostatic and/or radiation antitumor therapy;
for the treatment of stomatitis provoked by cytostatic antitumor therapy;
with ischemic heart disease ;
for stomach ulcers ;
with duodenal ulcer ;
with acute neurological disease stages I and II;
for the treatment of difficult-to-heal wounds and trophic skin lesions (burns, ulcers, bedsores, etc.);
for the treatment of odontogenic sepsis complicated by purulent-resorptive fever ;
for rheumatoid arthritis ;
for the treatment of diseases of the urogenital tract caused by the activity of chlamydia, mycoplasmas , ureaplasmas ;
for burn disease;
for prostatitis ;
with endometritis ;
for COPD and pulmonary tuberculosis .

As an independent remedy, Derinat injections are also used in surgical practice, prescribed to patients both in the pre- and postoperative period.

Derinat solution d/in 1.5% 5 ml box x5

Trade name: Derinat

International name: Sodium deoxyribonucleate

Release form: solution for intramuscular administration 1.5% (ampoules, dark glass ampoules) 2 ml, 5 ml

Ingredients: sodium deoxyribonucleinate 15 mg - 1 ml

Pharmacological group: immunomodulatory agent

Pharmacological group according to ATK: L03AX (Other immunostimulants)

Pharmacological action: immunostimulating, leukopoietic, antitumor, radioprotective, thrombocytopoietic, stimulating tissue repair,

Description: Transparent colorless liquid - biologically active substance - extract from sturgeon milt. Sodium deoxyribonucleate - molecular weight 270,000-500,000 daltons, hypochromic effect - not less than 37%.

Ingredients: Sterile solution of sodium deoxyribonucleate 0.25% in 0.1% NaCl.

Indications: Myelosuppression and resistance to cytostatics in cancer patients, which developed during cytostatic or radiation therapy

· Stomatitis

Peptic ulcer of the stomach and duodenum

Gastroduodenitis

· Cardiac ischemia

Chronic ischemic disease of the lower extremities I and II stages

· Trophic ulcers, long-term non-healing wounds

· Purulent-septic processes

· Burns

Frostbite

· In surgical practice in the preoperative and postoperative periods

· In preparation for autotransplantation and during the period of graft engraftment

· Prostatitis

· Vaginitis

· Endometritis

· Infertility

· Impotence

· Chronic obstructive bronchitis.

Dosage regimen: For adults, the drug is prescribed intramuscularly in 5 ml (75 mg dry matter) at intervals of 24-72 hours.

For coronary heart disease - 10 injections with an interval of 48-72 hours

For peptic ulcer of the stomach and duodenum - 5 injections with an interval of 48 hours.

For oncological diseases, 3-10 injections with an interval of 24-72 hours.

In gynecology and andrology - 10 injections with an interval of 24-48 hours.

The drug is prescribed to children at the same frequency as adults.

For children under 2 years of age, the drug is prescribed in a single dose of 0.5 ml (7.5 mg on a dry matter basis). And from 2 to 10 years of age, a single dose is determined at the rate of 0.5 ml of the drug per year of life.

Interaction with other drugs:

When used in combination with other drugs, the therapeutic effect of Derinat may increase. Derinat's moderate potentiation of the action of anticoagulants should be taken into account.

Contraindications: Individual intolerance

Side effects: Administration of Derinat does not cause complications and is well combined with other treatment methods. In some cases, after intramuscular injections 3-24 hours later, there is a short-term (3-4 hours) increase in body temperature to an average of 38 C, which is easily copied by prescribing symptomatic drugs (analgin, diphenhydramine). In patients with diabetes mellitus, there is a hypoglycemic effect, which should be taken into account when monitoring blood sugar levels. In healthy people, no hypoglycemic effect is observed.

With rapid injection of the drug into the muscle, moderate pain is observed at the injection site, which does not require drug treatment.

Pharmacodynamics: The drug has an immunomodulatory effect at the cellular and humoral levels. Activates antiviral, antifungal and antimicrobial immunity. Stimulates reparative and regenerative processes, regulates hematopoiesis (causes normalization of the number of leukocytes, granulocytes, phagocytes, lymphocytes, platelets), has anti-inflammatory and antitumor effects, normalizes the condition of tissues and organs in dystrophies of vascular origin, has a weak anticoagulant effect. Stimulation of leukopoiesis during drug or radiation cytopenias is usually observed after a single injection.

The use of the drug for chronic ischemic disease of the lower extremities caused by atherosclerosis and arteritis, including in persons with concomitant diabetes mellitus, increases tolerance to stress when walking, relieves pain in the calf muscles, and prevents coldness and chilliness of the feet. Derinat helps increase blood pressure in the legs. Healing of gangrenous trophic ulcers and the appearance of a pulse in the peripheral arteries that was absent before treatment. The fate of patients is spontaneous rejection of necrotic masses in the lesion (for example, on the phalanges of the fingers), which makes it possible to avoid surgical intervention.

When Derinat is added to complex drug therapy for IHD, the contractile capabilities of the myocardium are improved, the death of myocytes is prevented, microcirculation in the heart muscle is improved, tolerance to physical activity is increased, and recovery time is reduced.

In case of peptic ulcer of the stomach and duodenum, there is a high separative effect on the ulcer with restoration of the mucous membrane and a powerful immunomodulatory effect aimed at eliminating the infectious factor Helicobacter pylori.

Derinat increases the engraftment of autografts during skin and eardrum transplantation.

Special instructions: To reduce pain, Derinat is administered intramuscularly slowly. Within 1-2 minutes. Immediately before administration, it is recommended to warm the ampoule in your hand to body temperature.

Intravenous administration of the drug is not allowed.

Storage conditions: The drug in sterile packaging is stored in a place protected from light at a temperature of +2°C to +10°C.

Shelf life: 5 years

Drug registration number: P No. 002916/01

Date of registration (re-registration) of the drug: 09/22/2003

Side effects

The use of Derinat in gangrenous processes provokes spontaneous rejection of necrotic tissue in areas of rejection, which is accompanied by restoration of the skin.

In patients with open wounds and burns, the use of the drug can slightly reduce the intensity of pain.

Rapid injection of the solution into the muscle provokes moderate pain at the injection site (such a reaction does not require special treatment).

In some cases, a few hours after the injection, the temperature may briefly rise to 38 ° C. To reduce it, symptomatic drugs are prescribed, for example: Analgin , Diphenhydramine , etc.

Patients with diabetes mellitus may experience a hypoglycemic effect of the drug. Therefore, they need to constantly monitor their blood sugar levels.

Derinat, instructions for use (Method and dosage)

The solution, used as a local and external remedy, is used in the form of eye drops, nasal drops, rinses, microenemas, applications and irrigations.

The drug is intended for the treatment of children (and it can be prescribed to children from the first day of life) and adult patients.

Treatment with Derinat can be combined with taking other medications in the form of tablets, ointments, and injection solutions.

Instructions for use of Derinat in the form of rinses, applications, irrigations and microenemas

Diseases of the oral mucosa are treated by rinsing with Derinat (one bottle of solution is enough for one or two rinses). The frequency of procedures is from 4 to 6 times a day. They must be done within 5-10 days.

For the treatment of chronic forms of inflammatory and infectious diseases in gynecology, intravaginal administration of the drug with irrigation of the cervix or intravaginal administration of tampons with the drug soaked in a solution are prescribed.

One procedure requires 5 ml of Derinat. The frequency of procedures is 1-2 per day, the course of treatment is from 10 to 14 days.

For hemorrhoids , microenemas into the rectum are indicated. For one procedure, take from 15 to 40 ml of solution. The duration of treatment is from 4 to 10 days.

For ophthalmological diseases accompanied by inflammatory and degenerative processes, Derinat is prescribed to be instilled into the eyes for 14-15 days, 2 or 3 times a day, one or two drops.

In case of necrosis of the skin and mucous membranes caused by irradiation, with difficult-to-heal wounds, trophic ulcers of various origins, frostbite, burns and gangrene , a sterile application bandage should be applied to the affected areas (using gauze folded in two layers) with a solution applied to it.

Applications are made 3-4 times during the day. It is also possible to treat lesions using Derinat in the form of a spray. The drug is sprayed 4 or 5 times a day. A single dose varies from 10 to 40 ml. The duration of treatment is from 1 to 3 months.

Derinat nasal drops, instructions for use

To prevent respiratory viral infections, Derinat nasal drops are instilled into each nasal passage, two at a time, with a frequency of use of 2 to 4 times a day. Duration of treatment is from one to two weeks.

When cold symptoms appear on the first day, it is recommended to instill two or three drops into each nasal passage every hour and a half. Then the treatment is continued by instilling two or three drops into each nasal passage for a month. The frequency of instillations is 3-4 times a day.

Treatment of inflammatory diseases of the paranasal sinuses and nasal cavity involves administering three to five drops into each nasal passage for one to two weeks, 4-6 times a day.

For acute nasal insufficiency, it is recommended to instill one or two drops into each nasal passage 6 times a day for six months.

Derinat injections, instructions for use

The average single dose of Derinat for an adult patient is 5 ml of a 1.5% solution (equivalent to 75 mg). To reduce pain, it is recommended to inject the drug into the muscle over one to two minutes, maintaining intervals of 24-72 hours between injections.

The frequency of injections and the interval between injections depend on the patient’s diagnosis. So, for ischemic disease , 10 injections are prescribed once every 2 or 3 days (every 48-72 hours). For patients with gastric ulcers or duodenal ulcers, 5 injections are recommended with an interval of 48 hours.

For cancer patients - from 3 to 10 injections with an interval of 1-3 days. In andrology (for example, for prostatitis ) and in gynecology (for fibroids , salpingitis , etc.) - 10 injections with an interval of 1-3 days. Patients with tuberculosis - 10-15 injections with an interval of 1-2 days.

For acute inflammatory diseases, it is recommended to give 3 to 5 injections with an interval of 1-3 days. For chronic inflammatory diseases, 5 injections are given every 24 hours, then another 5 injections every 72 hours.

The instructions for use of Derinat for children indicate that the frequency of intramuscular injections of the solution for a child is the same as for an adult patient.

For children under two years of age, the average single dose of a 1.5% solution is 0.5 ml (corresponding to 7.5 mg). For children from 2 to 10 years old, a single dose is determined at the rate of 0.5 ml of solution for each year of life.

Inhalations with Derinat

In the form of inhalations, the drug is prescribed for the treatment of diseases of the respiratory system: tonsillitis , bronchial asthma , hay fever , adenoids , allergies . For inhalation, the solution in ampoules is mixed with saline in a ratio of 1:4 (or 1 ml of Derinat per 4 ml of saline).

The full course of therapy is 10 procedures lasting 5 minutes each. Treatment should be carried out 2 times a day.

Derinat solution for internal and external use 0.25% fl 10ml

Derinat drops 0.25% fl 10ml N 1

Release form

Solution for external use

Package

Bottle 10 ml.

pharmachologic effect

Derinat is an immunomodulator.

It has a modulating effect on the cellular, humoral components of the immune system and nonspecific resistance of the body, which leads to optimization of the inflammatory reaction and specific immune response to bacterial, viral and fungal antigens.

Possessing pronounced lymphotropism, Derinat stimulates the drainage and detoxification function of the lymphatic system, primarily at the site of the inflammatory reaction.

The drug activates antiviral, antifungal and antimicrobial immunity, stimulates reparative and regenerative processes, has an anti-inflammatory effect, normalizes the condition of tissues and organs in dystrophies of vascular origin.

Derinat promotes the healing of trophic ulcers. In case of gangrenous processes under the influence of the drug, spontaneous rejection of necrotic masses in the affected areas (for example, on the phalanges of the fingers) is observed. Derinat promotes rapid healing of infected wounds and deep burns.

Indications

As monotherapy:

prevention and treatment of ARVI;
acute respiratory infections;
inflammatory and dystrophic eye diseases;
inflammatory diseases of the oral mucosa.

As part of complex therapy:

chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology;
acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis /including frontal sinusitis, sinusitis/);
obliterating diseases of the lower extremities;
trophic ulcers;
gangrene;
infected and long-term non-healing wounds (including diabetes mellitus);
burns;
frostbite;
post-radiation necrosis of the skin and mucous membranes;
haemorrhoids.

Contraindications

Hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The patient should be warned that before using the drug during pregnancy and lactation, consultation with a doctor is necessary. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed.

special instructions

IV administration of the drug Derinat is not allowed! To reduce pain during intramuscular injection, it is recommended to administer the drug slowly over 1-2 minutes. Immediately before administering the drug, the bottle with the solution should be warmed in your hand to body temperature.

Compound

1 ml of solution contains:

Active substance: sodium deoxyribonucleate 2.5 g;

Excipients: sodium chloride - 1 g; water for injection - up to 1000 ml.

Directions for use and doses

Externally, locally.

The drug is prescribed to children from the first day of life and to adults.

For the prevention of ARVI - 2 drops in each nasal passage 2-4 times a day for 1 month. When symptoms of colds appear - every 1-1.5 hours during the day, then - 2-3 drops in each nasal passage 3-4 times a day for 7-10 days (until recovery). For inflammatory diseases of the nasal cavity and paranasal sinuses - 3-5 drops in each nasal passage 3-6 times a day or insert cotton swabs with the drug into each nasal passage 1-2 times a day for 5-10 minutes, course duration - 1 –2 weeks

For chronic inflammatory diseases; fungal, bacterial and other infections and violations of the integrity of the mucous membrane in gynecological practice - intravaginal administration followed by irrigation of the cervix or intravaginal administration of tampons with the drug, 5 ml per procedure 1-2 times a day for 10-14 days.

Inflammatory eye diseases of a viral and bacterial nature (conjunctivitis, keratitis, adenoviral keratoconjunctivitis, uveitis, maculitis, blepharitis) - 2 drops 4-6 times a day, course - from 10 days to 1-3 months.

Injuries to the organ of vision, to speed up the healing process during surgical interventions - 2 drops 5 times a day, course - 1-3 months.

Eye irritation (including “computer vision syndrome”), progressive myopia and accommodation spasm - 2 drops 3 times a day for a month.

For diseases of the oral mucosa (stomatitis, gingivitis, aphthous ulcers), rinse with the drug 4-6 times a day (1 bottle - 1-2 rinses). The duration of treatment is 5–10 days.

In proctology, it is used in the form of microenemas in the rectum, 15–40 ml each, the course is 7–14 days.

For post-radiation necrosis of the skin and mucous membranes, for long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene - apply application bandages (gauze in two layers) to the affected areas and apply the drug to it 3-4 times during the day, with simultaneous instillation of 1-2 drops into the nose 6 times a day (course of treatment - 1-3 months).

Side effects

Local reactions: moderate pain at the injection site.

Possible: hypoglycemia (in patients with diabetes mellitus); in some cases - 1.5-3 hours after injection, short-term hyperthermia, which can be relieved by the use of symptomatic drugs.

Drug interactions

Combined use with other drugs may increase the therapeutic effect of Derinat. When used together, Derinat may enhance the effect of anticoagulants.

Interaction

When applied topically, the drug is not compatible with hydrogen peroxide and fat-based ointments.

The use of the drug in combination with the main therapy increases the therapeutic effect and reduces the duration of treatment. This also makes it possible to reduce the doses of antibiotics and antiviral drugs.

Against the background of using Derinat:

the effectiveness of therapy with antitumor anthracycline antibiotics and cytostatic drugs increases;
the effect of basic therapy prescribed to patients with peptic ulcer ;
The iatrogenicity of drugs prescribed for the treatment of rheumatoid arthritis (up to 50-70%, which is also accompanied by an improvement in a number of complex indicators of disease activity).

In cases where a surgical infection provokes the development of sepsis , the introduction of Derinat into combination therapy allows:

reduce the level of intoxication in the body;
increase the activity of the immune system;
normalize hematopoietic function;
improve the performance of organs involved in removing toxins from the body.

Derinat solution for IM injection 15 mg/ml fl 5 ml in pack No. 5x1

Name

Derinat solution for IM injection 15 mg/ml fl 5 ml in pack No. 5x1

Description

transparent colorless liquid.

Main active ingredient

Sodium deoxyribonucleate

Release form

Solution

Dosage

15mg/ml fl 5m

special instructions

The drug can be administered subcutaneously.

pharmachologic effect

The drug activates the processes of cellular and humoral immunity. The immunomodulatory effect is due to stimulation of B-lymphocytes and activation of T-helper cells. Derinat activates the body's nonspecific resistance, optimizing inflammatory reactions and the immune response to bacterial, viral and fungal antigens. Stimulates reparative and regenerative processes. Increases the body's resistance to infections. Possessing a pronounced lymphotropic effect, Derinat stimulates the drainage and detoxification function of the lymphatic system. Derinat significantly reduces the sensitivity of cells to the damaging effects of chemotherapy drugs and radiation therapy. The drug does not have embryotoxic, teratogenic or carcinogenic effects.

Pharmacokinetics

Absorption and Distribution The drug is quickly absorbed and distributed in organs and tissues via the endolymphatic transport route. It has a high affinity for the organs of the hematopoietic system, takes an active part in cellular metabolism, integrating into cellular structures. During the phase of intensive entry of the drug into the blood, redistribution occurs between plasma and blood cells, in parallel with metabolism and excretion. After a single injection, all pharmacokinetic curves describing changes in drug concentration in the studied organs and tissues are characterized by a rapid phase of increase and a rapid phase of decrease in concentration in a time interval of 5-24 hours. The half-life (T'/z) for intramuscular administration is 72.3 hours. Derinat is quickly distributed throughout the body, during daily course use it accumulates in organs and tissues: maximum: - in the bone marrow, lymph nodes, spleen, thymus: to a lesser extent - in the liver, brain, stomach, small and large intestines. The maximum concentration in the bone marrow is determined 5 hours after administration of the drug. The drug overcomes the blood-cephalic barrier. The maximum concentration of the drug in the brain is achieved after 30 minutes. Metabolism and excretion. Derinat is metabolized in the body. Excreted from the body (in the form of metabolites) partially with feces, etc. to a greater extent, with urine according to a biexponential dependence.

Indications for use

radiation injuries;
hematopoiesis disorder;
myelosuppression and resistance to cytostatics in cancer patients, which developed against the background of cytostatic and/or radiation therapy (stabilization of hematopoiesis, reduction of cardio- and myelotoxicity of chemotherapy drugs);
stomatitis induced by cytostatic therapy;
peptic ulcer of the stomach and duodenum, erosive gastroduodenitis;
cardiac ischemia;
trophic ulcers, long-term non-healing wounds;
odontogenic sepsis, purulent-septic complications;
rheumatoid arthritis;
burn disease;
preoperative and postoperative periods (in surgical practice);
endometritis, salpino-oophoritis. endometriosis. fibroids;
chlamydia. ureaplasmosis, myconplasmosis;
prostatitis, benign iperilasia of the prostate gland;
chronic obstructive pulmonary diseases;
pulmonary tuberculosis, inflammatory diseases of respiratory bullets.

Directions for use and doses

Adults: intramuscularly over 1-2 minutes, 5 ml of a 15 mg/ml solution, with an interval of 24-72 hours. For coronary heart disease - 10 injections with an interval of 48-72 hours. For gastric and duodenal ulcers - 5 injections with an interval of 48 hours. For cancer - 3-10 injections with an interval of 24-72 hours. In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, oophoritis, fibroids, endometriosis) - 10 injections with an interval of 24-48 hours. In andrology (prostatitis, benign prostatic hyperplasia) - 10 injections with an interval of 24-48 hours. For pulmonary tuberculosis - 10-15 injections with an interval of 24-48 hours. For acute inflammatory diseases - 3-5 injections with an interval of 24-72 hours. For chronic inflammatory diseases - 5 injections with an interval of 24 hours, then - 5 injections with an interval of 72 hours. When using a 15 mg/ml solution, 2 ml intramuscular injections should be carried out daily, recalculating, until the course dose of 375-750 mg is reached. For children, the drug is prescribed intramuscularly according to the same regimen as for adults. For children under 2 years of age, the drug is prescribed in a single dose of 7.5 mg (0.5 ml). In children aged 2 to 10 years, a single dose is determined at the rate of 0.5 ml of the drug per year of life. From the age of 10, a single dose is 5 ml of a 15 mg/ml solution. course dose - up to 5 injections of the drug.

Use during pregnancy and lactation

Interaction with other drugs

The use of Derinat in complex therapy makes it possible to increase the effectiveness and shorten the duration of treatment, with a significant reduction in doses of antibiotics and antiviral agents with an increase in periods of remission. Derinat increases the effectiveness of antitumor anthracycline antibiotics and cytostatics. The drug potentiates the therapeutic effect of basic therapy for gastric and duodenal ulcers. Derinat reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis, achieving 50% and 70% improvement in a number of complex indicators of disease activity. In case of surgical sepsis, the introduction of Derinat into complex therapy causes a decrease in the level of intoxication, activation of the immune system, normalization of hematopoiesis, and improves the functioning of the organs responsible for the processes of detoxification of the internal environment of the body (lymph nodes, spleen, etc.).

Contraindications

Individual intolerance.

Compound

Active substance: sodium deoxyribonucleate 75 mg Excipients: sodium chloride 45 mg, water for injection - up to 5 ml

Overdose

No negative effects from overdose were identified.

Side effect

In patients with diabetes mellitus, a hypoglycemic effect is observed, which should be taken into account when monitoring blood sugar levels

Storage conditions

Store in a place protected from light, out of reach of children, at a temperature of + 4°C to + 20°C.

Derinat's analogs

Level 4 ATC code matches:
Epobiocrine

Recormon

Epocrine

Erythropoietin

Structural analogues of Derinat are drugs:

Panagen
Deoxynate
Sodium deoxyribonucleate

There are a huge number of drugs on the market that have an effect similar to Derinat:

Grippferon
Anaferon
Viferon
Orvirem
Oscillococcinum

Derinat or Grippferon - which is better?

This question often arises for many mothers who are trying to protect their children from influenza and ARVI . The drugs are incomplete analogues, but at the same time they are very similar in therapeutic effect and indications.

The composition and origin of the drugs vary greatly, however, biologically active proteins in both Grippferon and Derinat have immunomodulatory, antiviral and anti-inflammatory effects.

Some are inclined to consider Derinat a slightly more effective medicine than Grippferon , it is a stronger immunomodulator and has a wider spectrum of action. This explains the presence of Derinat in a dosage form for intramuscular injection ( Grippferon is available only in the form of drops and nasal spray).

It should be remembered that in cases where health is involved, self-medication is unacceptable, and the final decision on prescribing a particular drug is made by the attending physician, because the same drug can act differently on different patients.

Derinat for children

The action of the drug is aimed at increasing the activity of immune cells. For this reason, it is often prescribed to children prone to frequent colds .

Research and reviews of Derinat drops for children and Derinat injection solution indicate that both of these dosage forms are well tolerated by children, have virtually no contraindications and rarely cause unwanted side reactions.

This allows the drug to be used to treat children of different ages, including newborns from the first days of life.

To treat upper respiratory tract infections, children are prescribed inhalations with Derinat. Nasal drops for children are indicated as a therapeutic and prophylactic remedy for runny nose, sinusitis , ARVI , influenza , etc.

As a rule, for preventive purposes, 1-3 drops are instilled into each nasal passage. If the drug is used to treat a child, the dose is increased to 3-5 drops. The frequency of administration can be every hour or hour and a half.

If there are problems with the adenoids , a runny nose or sinusitis , the most effective method of treatment with Derinat is to swab the nasal passages with a cotton swab soaked in the solution with a frequency of procedures 6 times a day.

If a child is susceptible to conjunctivitis and other purulent-inflammatory ophthalmological diseases, the instructions recommend instilling the solution into the conjunctival sac of the affected eye, 1-2 drops three times a day.

Inflammation of the oral mucosa or gums can be relieved by rinsing with Derinat. If the child is too small and does not know how to rinse his mouth, the mucous membrane is treated several times a day with gauze soaked in a solution.

In complex therapy, the solution is often prescribed for the treatment of helminthiasis, wounds, burns and frostbite, vulvovaginitis in girls, accompanied by perianal itching and intestinal disorders.

Buy Derinat external solution 0.25% 10ml in pharmacies

Instructions for use Derinat

Buy Derinat solution 0.25% 10 ml Dosage forms solution for external use 0.25% Manufacturers Technomedservice (Russia) Group Means that stimulate regeneration Composition Active substance: sodium deoxyribonucleate - 2.5 g. International nonproprietary name Sodium deoxyribonucleate Pharmacological action The drug activates cellular and humoral immunity. Optimizes specific responses against fungal, viral and bacterial infections. The drug stimulates reparative and regenerative processes, normalizes the condition of tissues and organs in dystrophies of vascular origin. Derinat promotes the healing of trophic ulcers of various etiologies. Derinat promotes rapid healing of deep burns, significantly accelerating the dynamics of epithelization. When ulcerative formations on the mucous membrane are restored under the influence of Derinat, scarless restoration occurs. The drug does not have teratogenic or carcinogenic effects. Pharmacokinetics. Derinat, when applied topically, is quickly absorbed and distributed in organs and tissues via the endolymphatic transport route. During the phase of intensive entry of the drug into the blood, redistribution occurs between plasma and blood cells, in parallel with metabolism and excretion. Derinat is metabolized in the body. It is excreted from the body (in the form of metabolites) partially with feces, and, to a greater extent, with urine according to a biexponential dependence. Indications for use Monotherapy: acute respiratory diseases (ARI); prevention and treatment of acute respiratory viral infections (ARVI); ophthalmology: inflammatory and dystrophic processes; inflammatory diseases of the mucous membranes of the oral cavity. Complex therapy: chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology; acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis, sinusitis, sinusitis); obliterating diseases of the lower extremities; trophic ulcers, long-term non-healing and infected wounds (including diabetes mellitus); gangrene; burns, frostbite; haemorrhoids; post-radiation necrosis of the skin and mucous membranes. Contraindications Individual intolerance. Side effect In case of gangrenous processes under the influence of the drug, spontaneous rejection of necrotic masses in the areas of rejection with restoration of the skin is noted. For open wounds and burns, an analgesic effect is observed. Interaction When applied topically, it is not compatible with fat-based ointments and hydrogen peroxide. Method of administration and dosage The drug is prescribed to children from the first day of life and to adults. To prevent ARVI, instill 2 drops into each nasal passage 2-4 times a day for 1-2 weeks. When symptoms of “colds” appear, the drug is instilled into the nose, 2-3 drops into each nasal passage every 1-1.5 hours, during the first 24 hours; further - 2-3 drops in each nasal passage 3-4 times a day, course duration - 1 month. For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times a day. Course duration is 7-15 days. For diseases of the oral mucosa, rinse with the drug 4-6 times a day (1 bottle 1-2 rinses). The duration of treatment is 5-10 days. For chronic inflammatory diseases, fungal, bacterial and other infections in gynecology - intravaginal administration with irrigation of the cervix or intravaginal administration of tampons with the drug, 5 ml per procedure, 1-2 times a day, for 10-14 days. For hemorrhoids, the drug is prescribed as microenemas of 15-40 ml into the rectum. The duration of treatment is 4-10 days. For severe inflammatory and dystrophic processes in ophthalmology, Derinat is instilled into the eyes 2-3 times a day, 1-2 drops, for 14-45 days. For obliterating diseases of the lower extremities, the drug is instilled into the nose, 1-2 drops in each nasal passage 6 times a day, course duration is up to 6 months. For post-radiation necrosis of the skin and mucous membranes, for long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene, application bandages (gauze in two layers) are applied to the affected areas with the drug applied to it 3-4 times during the day or treatment is carried out the affected surface with the drug from a nebulizer 4-5 times a day, 10 - 40 ml (course of treatment - 1-3 months). Overdose No information available. Special instructions Use the contents of the opened bottle within two weeks. Storage conditions Store in a place protected from light, out of reach of children at a temperature of + 4 C to + 20 C.

Reviews about Derinat

Reviews about the drug (and reviews about Derinat for children) are quite contradictory: some praise it, noting its high efficiency and ease of use, while others call it a rather expensive “dummy”.

Immune boosters are a complex topic. On the one hand, the pharmaceutical market offers a fairly large number of immunomodulators, differing both in strength and in the way they affect the body.

On the other hand, when trying to evaluate the real effectiveness of these drugs, a number of difficulties arise, since it is impossible to know how the body would react to a particular disease without stimulating its own immunity.

The main advantages of the drug are its naturalness, safety and ease of use, which is why it is prescribed even for infants. However, some doctors in reviews of the drug warn that its safety remains not fully studied today.

Reviews of Derinat injections and reviews of Derinat drops left by patients are more optimistic: the vast majority of patients say that the use of both drops and injections allows one to quite quickly relieve the symptoms of the disease and reduce the likelihood of its relapse.

In gynecology, injections are often included in the treatment regimen for inflammatory diseases and tumor processes. Both doctors and patients confirm that in some cases, as a result of therapy, tumors begin to shrink after one or two injections.

Studies show the effectiveness of the drug for the treatment of inflammation and pseudo-erosions of the cervix. In addition, Derinat exhibits the properties of a universal immunocorrector for hormonal-dependent endometrial hyperplasia .

Treatment with them allows one to obtain a fairly high percentage of recoveries from inflammatory processes in the organs of the reproductive system, mammary fibroids , fibroids , chlamydia and endometriosis .

Young mothers say that the drug helps children better resist so-called “kindergarten infections”, accelerates the maturation of the immune system and activates the body’s defenses.

They note the effectiveness of Derinat for adenoids , rhinitis , sinusitis , tonsillitis , bronchial asthma and a number of other diseases to which young children are so susceptible. In cases where nasal drops are used to treat viral infections, their use significantly reduces the severity of symptoms of fever and intoxication of the body, as well as the likelihood of developing disease complications.

At the same time, some parents state that the use of Derinat gives the most pronounced effect only in the early stages of the disease or when using the drug to prevent influenza and ARVI .

Negative reviews are due to the fact that the effect of the treatment was short-lived, as well as the pain of drug injections. Dr. Komarovsky believes that a child’s natural immunity to infection is formed five days after the child “caught” the virus, and a common cold goes away without specific treatment within the same period.

Therefore, in his opinion, to alleviate the course of the disease, the child simply needs to create favorable conditions: humidify the air in the room, provide plenty of fluids and access to fresh air.

Derinat price

Cost of the drug in Russia

The price of nasal drops for children and adults in Russian pharmacies is about 350 rubles, the price of Derinat in ampoules is about 2,000 rubles. The product for external use costs an average of 350 rubles.

The drug is available only in the form of solutions for injection and external use, so it is pointless to look for Derinat tablets in pharmacies.

Cost of the drug in Ukraine

The price of Derinat drops in Ukrainian pharmacies varies within 200 UAH per bottle of 0.25% solution with a volume of 10 ml. The cost of the solution for external use is within 250 UAH. You can buy Derinat injections in Kyiv and other large cities of Ukraine for an average of 1,500 UAH per pack of 5 ampoules of 5 ml.

Online pharmacies in RussiaRussia
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Derinat solution for in.
1.5% 5ml 5 pcs. Tekhnomedservis ZAO FP / Immunnolex LLC FZ 1667 rub. order
Derinat spray solution external. approx. 0.25% 10ml Tekhnomedservice ZAO FP/ Immunnolex LLC FZ
RUB 390 order
Derinat solution of places. and outside approx. 0.25% dropper bottle 10 mlTehnomedservice ZAO FP/ Immunnolex LLC FZ
300 rub. order

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Derinat capili 0.25% 10mlFZ Immunolex LLC
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Derinat solution 0.25% 10mlFZ Immunolex LLC
RUB 265 order
Derinat spray 0.25% 10mlFZ Immunnolex LLC
428 RUR order
Derinat solution for IM administration 1.5% 5ml bottle No. 5FZ Immunnolex LLC
RUB 2011 order