Ketoprofen gel for external use 2.5% 30g
Compound
Active substance: ketoprofen 2.5 g.
Excipients: carbomer - 1.5 g, ethanol 95% - 32 g, trolamine - 2.9 g, lavender oil - 0.1 g, water - up to 100 g.
Pharmacokinetics
Ketoprofen is absorbed very slowly and practically does not accumulate in the body. Bioavailability is 5%. Ketoprofen penetrates into the subcutaneous tissue, ligaments and muscles, synovial fluid and reaches therapeutic concentrations there. The concentration of the drug in the blood plasma is extremely low. Ketoprofen is metabolized in the liver to form conjugates, which are mainly excreted in the urine. Ketoprofen is characterized by slow excretion in urine.
Indications for use
- Acute and chronic inflammatory diseases of the musculoskeletal system (articular syndrome with exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory damage to ligaments and tendons, bursitis, sciatica, lumbago);
- muscle pain of rheumatic and non-rheumatic origin;
- post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and rupture of ligaments, bruises).
The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease.
Contraindications
- Individual hypersensitivity to ketoprofen or other components of the drug, acetylsalicylic acid or other NSAIDs (history of bronchospasm, urticaria or rhinitis caused by taking acetylsalicylic acid), tiaprofenic acid and fenofibrate;
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including a history);
- a history of increased skin sensitivity to solar radiation (photosensitivity);
- history of skin allergies to sunscreens or perfumes;
- exposure to the sun on the treated areas, including solariums, during the course of using the drug and 2 weeks after;
- weeping dermatoses, eczema, infected abrasions, wounds (at the site of application of the gel);
- children under 12 years of age (efficacy and safety have not been studied);
- pregnancy (III trimester) and breastfeeding period.
With caution:
Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe dysfunction of the liver and kidneys, chronic heart failure, bronchial asthma, old age, pregnancy (I and II trimester).
Directions for use and doses
For external use.
A strip of gel 5-10 cm long is applied in a thin layer to the affected area or skin over the source of inflammation 2 times a day and rubbed in lightly.
The amount of gel applied depends on the size of the area being treated.
It is possible to use ketoprofen in combination with physiotherapy (phonophoresis and iontophoresis).
The dosage in children over 12 years of age corresponds to that in adults and depends on the area of application and the doctor’s recommendations.
Storage conditions
In a dark place at a temperature not exceeding 25° C. Keep out of the reach of children.
Best before date
3 years. Do not use after the expiration date.
special instructions
Do not apply to damaged (including open wounds) and inflamed skin!
Avoid contact with eyes (risk of conjunctival irritation).
It is recommended to wash your hands thoroughly after using the drug.
Do not use as hermetic dressings. Do not use in combination with sealed clothing.
Long-term use of topical agents may result in sensitization or local irritation.
To avoid any manifestations of hypersensitivity or photosensitivity, exposure to direct sunlight (including visiting a solarium) should be avoided during the treatment period and for two weeks after using the drug, and it is recommended to cover the treated areas with clothing. Patients with severe renal, cardiac or hepatic impairment should be careful when using ketoprofen.
You should stop using the drug if any skin reaction occurs, including reactions when simultaneously applying sunscreen or other cosmetics containing the organic sunscreen filter octocrylene to the skin.
When using the drug in large quantities, it is possible, in very rare cases, to develop systemic side effects (hypersensitivity, bronchial asthma, gastrointestinal disorders, aggravation of renal failure).
The risk of systemic side effects increases depending on the amount of gel applied, the area of the skin being treated, the condition of the skin, and the duration of treatment.
Avoid exposure of treated areas to sunlight or UV rays, including tanning beds, during treatment and for two weeks after treatment.
Description
Non-steroidal anti-inflammatory drug (NSAID).
Use in children
Contraindicated in children under 12 years of age (efficacy and safety have not been studied).
Pharmacodynamics
NSAIDs. It has analgesic, anti-inflammatory and anti-edema effects. Inhibits the activity of COX, which leads to inhibition of prostaglandin synthesis. In addition, ketoprofen inhibits lipoxygenase, bradykinin synthesis, stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process.
Ketoprofen does not have a negative effect on the condition of articular cartilage.
Side effects
Possible side effects are listed in descending frequency of occurrence: very common (> 10%), common (> 1%, < 10%), uncommon (> 0.1%, < 1%), rare (> 0.01%, < 0.1%), very rare (<0.01%).
From the skin: infrequently - erythema, itching, eczema; rarely - photosensitivity, bullous dermatitis, urticaria; very rarely - contact dermatitis, angioedema.
From the gastrointestinal tract: very rarely - peptic ulcer, bleeding, diarrhea.
From the immune system: very rarely - anaphylactic reactions, hypersensitivity reactions.
From the urinary system: very rarely - aggravation of renal failure.
Use during pregnancy and breastfeeding
The use of the drug during breastfeeding is not recommended.
Interaction
When ketoprofen is used externally in the form of a gel, it is possible to enhance the effect of drugs that cause photosensitivity. Other interactions have not been established, however, patients taking coumarin anticoagulants are recommended to regularly monitor the international normalized ratio (INR).
Overdose
The extremely low systemic absorption of the active components of the drug when used externally makes overdose almost impossible.
If large quantities of the drug (more than 20 g) are accidentally ingested, systemic adverse reactions characteristic of NSAIDs may occur. It is necessary to lavage the stomach and take activated charcoal. Treatment is symptomatic.
Impact on the ability to drive vehicles and operate machinery
The drug does not affect the ability to drive a car or use other mechanical means.
Ketoprofen, 5 pcs., 2 ml, 50 mg/ml, solution for intravenous and intramuscular administration
Definition of categories of frequency of undesirable effects (according to WHO): very often (≥1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥ 1/10,000, <1/1000) and very rarely (<1/10,000); frequency unknown (the incidence of adverse events cannot be determined based on available data).
From the hematopoietic and lymphatic systems: rarely - hemorrhagic anemia, hemolytic anemia, leukopenia; frequency unknown - agranulocytosis, thrombocytopenia, impaired bone marrow hematopoiesis.
From the immune system: frequency unknown - anaphylactic reactions (including anaphylactic shock).
From the nervous system: often - insomnia, depression, asthenia; infrequently - headache, dizziness, drowsiness; rarely - paresthesia, confusion or loss of consciousness, peripheral polyneuropathy; frequency unknown - convulsions, taste disturbances, emotional lability.
From the senses: rarely - blurred vision, tinnitus, conjunctivitis, dry mucous membrane of the eye, pain in the eyes, hearing loss; frequency unknown - optic neuritis.
From the cardiovascular system: infrequently - tachycardia; frequency unknown - heart failure, arterial hypertension, vasodilation.
From the respiratory system: rarely - exacerbation of bronchial asthma, nosebleeds, laryngeal edema; frequency unknown - bronchospasm (especially in patients with hypersensitivity to NSAIDs), rhinitis.
From the digestive system: often - nausea, vomiting, dyspepsia, abdominal pain NSAID gastropathy; uncommon - constipation, diarrhea, bloating, gastritis; rarely - peptic ulcer, stomatitis; very rarely - exacerbation of UC Crohn's disease, gingival, gastrointestinal, hemorrhoidal bleeding, melena, perforation of the gastrointestinal tract; frequency unknown - gastrointestinal discomfort, stomach pain.
From the liver and biliary tract: rarely - hepatitis, increased activity of liver enzymes and bilirubin concentration.
From the skin: infrequently - skin rash, itching; frequency unknown - photosensitivity, alopecia, urticaria, exacerbation of chronic urticaria, angioedema, erythema, bullous rash, including Stevens-Johnson syndrome, toxic epidermal necrolysis, purpura.
From the urinary system: rarely - cystitis, urethritis, hematuria; very rarely - acute renal failure, interstitial nephritis, nephrotic syndrome, abnormal values of renal function indicators; frequency unknown - fluid retention in the body and, as a result, weight gain, hyperkalemia.
Other: infrequently - peripheral edema, fatigue; rarely - hemoptysis, menometrorrhagia, shortness of breath, thirst, muscle twitching.
KETOPROFEN VRAMED GEL TO RELIEF JOINT PAIN
Anti-inflammatory drugs are drugs that suppress the inflammatory process by preventing the mobilization or transformation of arachidonic acid. Anti-inflammatory drugs do not include drugs that can influence the inflammatory process through other mechanisms, in particular cytostatics, “basic” antirheumatic drugs (gold salts, D-penicillamine, sulfasalazine), anti-gout drugs (colchicine), quinoline derivatives (chloroquine). The indications for the use of glucocorticosteroids as anti-inflammatory drugs are predominantly pathoimmune inflammation. They are widely used in the acute phase of systemic connective tissue diseases, arthritis, sarcoidosis, alveolitis, and non-infectious inflammatory skin diseases. Nonsteroidal anti-inflammatory drugs (NSAIDs) are substances of various chemical structures that, in addition to anti-inflammatory, also usually have analgesic and antipyretic activity. The NSAID group consists of derivatives of salicylic acid (acetylsalicylic acid, mesalazine), indole (indomethacin, sulindac), pyrazolone (phenylbutazone, clofezone), phenylacetic acid (diclofenac), propionic acid (ibuprofen, naproxen, flurbiprofen, ketoprofen), oxicam (meloxicam, piroxicam , tenoxicam) and other chemical groups (benzydamine, nabumetone, niflumic acid, etc.).
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) from the group of propionic acid derivatives, which has an analgesic, anti-inflammatory and antipyretic effect. The main goal of treating most soft tissue injuries (bruised wounds, sprains and ruptures of the ligamentous apparatus of joints, dislocations) is to prevent and reduce swelling. In most cases, there is a need for effective pain relief, for which NSAIDs are most often used. In a randomized, double-blind, placebo-controlled study, oral ketoprofen in 120 patients with tendinitis, bursitis or periarthritis quickly and effectively relieved pain and reduced functional limitations in the joints. The analgesic effect occurred within 30 minutes after taking the drug with tolerability comparable to placebo. More details - ketoprofen for acute soft tissue injury, ketoprofen in postoperative pain relief, the effect of ketoprofen on postoperative complications and reparative processes in bone tissue.
Medicines containing ketoprofen:
Ketoprofen Vramed gel, Actron instructions, Artrozilen instructions, Ketolist retard instructions, Ketonal instructions, Ketonal Duo instructions, Ketoprofen-Verte instructions, Knavon instructions, OKI instructions , Oruvel (Oruveil) instructions, Ostofen (Ostofen) instructions, Prontoket (Prontoket) spray instructions, Profenid (Profenid) instructions, Fastum (Fastum) instructions, Fastum gel instructions, Febrofid (Febrofid) instructions, Flamax (Flamax) instructions, Flexen ( Flexen) instructions, Bystrumgel instructions, Bystrumcaps instructions, synonyms of the drug Ketoprofen: Alreumant instructions, Asozal, Dexal, Kefenid, Ketoprosil, Meprofen, Niflam, Reumoquin, Rofenid, Synpofen, etc. For all drugs, the main active ingredient is ketoprofen.
