Libexin 100 mg 20 pcs. tablets chinoin pharmaceutical and chemical work

Indications for use

What are Libexin tablets for? This drug is used for:

• surgical intervention on the pleura;
• pulmonary infarction;
• pleuropneumonia;
• exudative and dry pleurisy ;
• emphysema;
• flu;
• bronchial asthma;
• chronic and acute bronchitis ;
• any non-productive cough;
• cough at night in patients with heart failure.

The principle of action of the drug Libexin

After oral administration, the drug is absorbed into the blood. 30 minutes after administration, the maximum possible concentration of the substance is reached. The therapeutic effect lasts for 8 hours. The half-life is slightly greater than 2.5 hours. More than half of the substance absorbed into the blood is excreted by the liver, where it undergoes metabolic processes. Less than a third of the ingested volume leaves the body unchanged. After taking a dose, after 72 hours, about 70% of the substance is excreted in the feces. The remaining volume leaves the body along with urine.

Due to the fact that the drug has an anesthetic effect, it is not recommended to chew it. The tablets are intended to be taken orally with water.

Once in the body, Libexin significantly reduces the activity of cough receptors. First of all, this is due to the “freezing” effect that the anesthetic effect can achieve. In addition, when absorbed into the blood, the active substance forces the receptors to stretch, the contraction of which leads to a cough impulse. Without depressing breathing, Libexin also acts on the respiratory center, reducing its activity. When compared with other antitussives, Libexin can be placed on a par with codeine in terms of effectiveness.

Libexin price, where to buy

The price of Libexin in Russia is on average 600 rubles. In Ukraine, the drug can be purchased for an average of 70 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Libexin tablets 100 mg 20 pcs. Chinoin
  586 RUR order

Pharmacy Dialogue

• Libexin (100 mg tablet No. 20)Chinoin

  RUR 631 order

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PaniPharmacy

• Libexin tablets Libexin tablets.
  100 mg No. 20 Hungary, Chinoin 68 UAH. order

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Composition of Libexin

Prenoxdiazine is the main active ingredient, the presence of which determines the effectiveness of the drug. The additional components are: magnesium stearate, talc, corn starch and lactose monohydrate. These components are found in many medications available in tablet form.

Prenoxdiazine has the ability to reduce the severity of inflammatory processes in the bronchi. In addition, the substance is a local anesthetic. But its main action is aimed at the peripheral nervous system, which makes it possible to achieve a pronounced antitussive effect. Taking the drug does not cause respiratory depression, and also does not carry the risk of addiction to the active substance.

Libexin 100 mg No. 20 tablet.

APPROVED by the Order of the Chairman of the Committee for Control of Medical and Pharmaceutical Activities of the Ministry of Health of the Republic of Kazakhstan dated "____"____________20, No. ____________ Instructions for the medical use of the drug LIBEXIN Trade name Libexin International nonproprietary name Prenoxdiazine Dosage form Tablets 100 mg Composition One tablet contains: active substance - prenoxdiazine hydrochloride 100.0 mg excipients: glycerin, magnesium stearate, talc, polyvidone, corn starch, lactose monohydrate. Description Tablets are almost white, flat-cylindrical in shape, with beveled edges, with a cross-shaped score on one side and “LIBEXIN” engraving on the other. Pharmacotherapeutic group Drugs to eliminate the symptoms of colds and coughs. Other antitussives. Prenoxdiazine ATX code R05DB18 Pharmacological properties Pharmacokinetics The active substance Libexin is quickly and intensively absorbed from the intestine. The peak concentration of the drug in the blood serum is achieved within 30 minutes after administration; The therapeutic level of drug concentration can be observed within 6-8 hours. The drug binds to plasma proteins to an average extent, 55%-59% during the first hour. Its half-life is 2.6 hours. Most of the dose taken is metabolized in the liver, approximately 1/3 of the dose taken is excreted unchanged from the body, the rest - in the form of metabolites. In the process of drug metabolism, bile secretion plays the most important role in the first 12 hours. Within 24 hours after administration, 93% of the drug is eliminated from the body. Within 72 hours after administration, 50% to 74% and 26% to 50% of the dose taken are excreted in feces and urine, respectively. Pharmacodynamics The antitussive effect of Libexin is carried out by several mechanisms: - by reducing the excitability of peripheral afferent receptors of the mucous membrane of the respiratory tract, the drug has a local anesthetic effect - by direct bronchodilator action (relaxation of contracted bronchi), stretching of the receptors in the wall of the bronchi, which play an important role in inducing the cough reflex, is prevented - the drug also has a central effect to a small extent by reducing the activity of the cough center without causing respiratory depression. Libexin makes breathing easier and also slightly reduces the amount of mucus produced. The antitussive effect of the drug lasts 3-4 hours. Libexin does not cause addiction or drug dependence. Indications for use: acute and chronic, primarily non-productive cough of any origin (tracheobronchial, pulmonary, pleural and cardiac) Libexin effectively softens the cough that accompanies diseases with impaired breathing and oxygenation, while not affecting the activity of the respiratory center. - for bronchoscopic and bronchographic studies in premedication. Method of administration and dosage Adults Standard dose: 1 tablet 3-4 times a day (3-4 tablets of 100 mg each). In especially severe cases, the dose can be increased to 2 tablets 3-4 times a day or 3 tablets 3 times a day (3-4 times 200 mg or 3 times 300 mg, respectively). Children's age Children aged 1 to 6 years or weighing from 10 to 20 kg: 1/4-½ tablet 3 times a day (3 times 50 mg). Children aged 6 to 12 years or weighing more than 20 kg: ½ tablet 3-4 times a day (3-4 times 50 mg). Premedication before bronchoscopic examination: 0.9-3.8 mg of prenoxdiazine hydrochloride per kilogram of body weight in combination with 0.5-1 mg of atropine, one hour before the intervention. The maximum single dose is ½ tablet for children and 3 tablets for adults. The maximum daily dose is 200 mg (2 tablets) for children and 900 mg (9 tablets) for adults. Side effects Rarely (from ³ 1/10,000 to <1/1,000) - temporary numbness and decreased sensitivity of the oral mucosa - dry mouth and throat - allergic reactions, skin rash, angioedema Frequency unknown - gastrointestinal disorders (stomach pain, tendency to constipation) - weakness, fatigue Contraindications - hypersensitivity to the active substance or to any of the excipients - conditions accompanied by abundant bronchial secretion; — postoperative conditions (after inhalation anesthesia). Drug interactions No data available. Special instructions Patients with viscous discharge and difficulty coughing also need to take an expectorant or mucolytic agent under the supervision of a physician. The tablets should be swallowed whole, as when chewed or crushed into powder, they may cause short-term insensitivity and numbness of the oral mucosa. The drug contains 38.0 mg of lactose monohydrate. Patients with rare hereditary galactose intolerance, congenital Lapp lactase deficiency or glucose malabsorption syndrome should not take this drug. Pregnancy The limited amount of available data indicates the absence of malformational or feto/neonatal toxicity of prenoxdiazine hydrochloride. To date, no other relevant epidemiological data exist. The drug should be prescribed to pregnant women with generally accepted precautions: if the potential benefit to the mother outweighs the possible risk to the fetus. Lactation period There are no clinical data on the penetration of the drug into breast milk, therefore, it can be used during breastfeeding according to doctor's indications only after a careful assessment of the benefit-risk ratio. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms. In high doses, the drug can reduce vigilance and reaction speed; therefore, driving a car and working with machinery requires an individual assessment when using the drug in high doses. Overdose When using doses higher than therapeutic ones, sedation and fatigue may be observed, which disappear within a few hours after administration. No specific treatment is required. Release form and packaging 20 tablets are placed in blister packs made of polyvinyl chloride film and aluminum foil. 1 contour package along with instructions for medical use in the state and Russian languages ​​is placed in a cardboard pack. Storage conditions Store at temperatures below 25C. Keep out of the reach of children. Shelf life: 5 years Do not use after expiration date. Conditions for dispensing from pharmacies Without a prescription Manufacturer HINOIN Pharmaceutical and Chemical Products Plant CJSC, Hungary Registration certificate holder Sanofi-Aventis CJSC, Hungary Address of the organization that accepts claims from consumers on the quality of products (products) in the territory of the Republic of Kazakhstan Sanofi-aventis Kazakhstan LLP 050016 Almaty, st. Kunaeva 21B phone fax e-mail

Libexin tablets: instructions for use

For laryngitis and croup, 1 tablet is prescribed three times a day. This will provide a significant reduction in the sensation of irritation in the throat and soothe inflamed areas. For acute bronchitis, a single dose can be increased to 2 tablets if 100 mg of the drug does not have the expected effect.

The appointment of Libexin may be justified before bronchoscopy. The drug will reduce the sensitivity of the upper respiratory tract and prevent difficulties during the procedure, which may be caused by a narrowing of certain areas of the bronchial tree due to infection.

Libexin is not contraindicated for children, but it is worth keeping in mind that self-administration of antitussives is extremely dangerous for children under 5 years of age. In case of breathing problems of any etiology, the child should be immediately taken to the pediatrician.

A single dose for a child over 5 years old should not exceed 0.5 tablets. A child can take up to 2 tablets per day, each of which will be divided into two/four doses.

For an irritating cough of unknown origin, you can take 1 tablet half an hour before bedtime. This will ensure a good night.

Possible adverse reactions

As a rule, if the recommended daily dosage is exceeded, a slight sedative effect may be observed, accompanied by general weakness. To eliminate it, it is enough to stop taking the drug and wait for it to be eliminated from the body.

Numbness of the root of the tongue or the entire oral cavity is not a side effect, since this effect is due to the anesthetic effect of the drug.

In rare cases, an allergic reaction in the form of a skin rash or swelling of the mucous membranes of the respiratory tract may occur. If a negative reaction begins to appear 10-15 minutes after taking the drug, it is necessary to perform a gastric lavage procedure to minimize the amount of absorption of the active substance.

From the gastrointestinal tract, dry mouth may be observed. As a rule, it occurs when an overdose of a drug is taken or when the drug is taken incorrectly - by chewing. In rare cases, constipation, stomach pain, or nausea may develop.

special instructions

It is important to remember that the combination of any antitussive drugs, including Libexin, with mucolytics, expectorants and drugs that dilute sputum is unacceptable.

Taking expectorants is justified in cases where respiratory tract disease is accompanied by complicated sputum discharge, as well as in cases where sputum is not produced in the required amount. As a rule, these are bronchitis of various etiologies. To alleviate the course of bronchitis, you can use mucolytics and other drugs with similar effects. But taking such drugs becomes a contraindication to the use of Libexin, since it blocks the cough reflex.

Sputum, the production of which is provoked by mucolytics and expectorants, must actively exit the respiratory tract, and remove waste products of pathogenic microorganisms along with it. Using Libexin will stop the production of sputum. It will accumulate in the lower respiratory tract, significantly increasing the risk of complications. Microbes in the damp environment of accumulated mucus will be able to multiply more intensively, which will certainly lead to pneumonia.

The use of an antitussive for bronchitis is permissible only at night, in order to ensure restful sleep, provided that the expectorant was taken no later than 3-4 hours before the expected bedtime.