Throughout life, every person is attacked by viral infections to varying degrees. They often become a threat to human life, causing complications: bronchitis, pneumonia. It is generally accepted that antibiotics suppress viruses.
In fact, responsible doctors prescribe only when a bacterial disease develops against the background of a common cold. Despite the contradictory views among doctors, antiviral drugs are an indispensable salvation from influenza and respiratory outbreaks. The principle of influence on the body is grouped into two categories:
- direct action - kills the virus directly;
- indirect action or immunomodulators - drugs activate immune cells, so that the body copes with the disease faster.
Among antiviral drugs, there are drugs that combine different directions. The main task is error-free selection. Drugs with the main active ingredient umifenovir have proven themselves well on the pharmaceutical market.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Arpeflu is an antiviral drug for systemic use. Contains the active substance umifenovir , which suppresses influenza A and B . The specific effect is associated with the inhibition of the fusion of the viral shell with the cell membranes - thus preventing their penetration into the cells of the body. Also, umifenovir increases interferon . Refers to low-toxic drugs. When using it, there is a reduction in the duration of the disease, a decrease in the severity of influenza , ARVI and the frequency of complications.
Pharmacokinetics
When taken orally, it is quickly and completely absorbed and maximum concentrations in the blood are created after 1.5 hours. Metabolism of the active substance occurs in the liver. It is excreted unchanged by the intestines and a small part by the kidneys. The half-life is 17-20 hours; about 90% of the dose is eliminated within 24 hours.
Compound
The main active ingredient of the drug is umifenovir. It suppresses influenza viruses, due to the influence of which severe acute respiratory syndromes develop. The substance works as an immunomodulator, i.e. it increases the body’s resistance to the action of viruses. This happens due to:
- inducing the synthesis of interferons;
- increasing the ability of macrophages to recognize and destroy viruses and the results of their vital activity;
- activation of cellular and humoral (proceeding through fluids) reactions of the body.
Under the influence of Arpeflu, the lipid membranes of viral cells lose the ability to come into contact with the cells of the human body. In the absence of such contact, the virus cannot penetrate the cell, and infection does not occur.
The therapeutic effect consists of reducing the intensity of catarrhal influenza manifestations, accelerating the cleansing of the body from intoxication caused by the action of the virus, alleviating the course of febrile manifestations - reducing periods of elevated temperature, inflammation of the mucous membranes, and the total duration of the painful period. By taking the medicine Arpeflu, which can always be ordered on the pharmacy website https://apteka911.ua/shop/arpeflyu-tabl-po-100mg-10-p9667, the patient increases the body's resistance, as a result of which the risk of developing post-flu complications is minimal. At the same time, the drug itself does not harm the human body.
Arpeflu, instructions for use (Method and dosage)
Arpeflu tablets are taken before meals with plenty of liquid. Treatment regimens depend on the severity of the disease and are determined by the doctor. The duration of treatment is also adjusted by the doctor depending on the dynamics of the disease and concomitant pathology.
- A single dose for adults and children over 12 years of age is 200 mg.
- For influenza and ARVI - 200 mg 4 times a day. Duration of treatment is up to 5 days.
- For influenza complicated by pneumonia - 200 mg 4 times a day for 5 days, and then once a week, month.
- For recurrent herpetic infection - 200 mg 4 times a day for 7 days, with a transition to taking 200 mg twice a week for a month.
- Preventive administration after contact with patients - 200 mg 1 time per day for 10-14 days.
- During an epidemic - 200 mg 2 times a week for 3 weeks.
Arpeflu for children from 3 to 6 years old is recommended at a dose of 50 mg and 100 mg from 6 to 12 years old. For rotavirus intestinal infection - a single dose in accordance with age is taken 4 times a day for 5 days.
Indications
Arpeflu tablets are prescribed in therapy and pediatrics in appropriate dosages for the treatment of influenza conditions that are provoked by viruses of types A and B. They are also used as a prophylactic agent during epidemics caused by these viruses, to prevent frequent relapses of respiratory diseases.
In addition, Arpeflu is prescribed:
- with ARVI, which may be accompanied by pneumonia or bronchitis;
- in secondary immunodeficiency conditions;
- together with other medications during the treatment of chronic bronchitis, pneumonia, frequently recurring herpetic infections;
- to increase the level of the body's defenses, for example, after surgical interventions (for this purpose it is most often prescribed to adults).
Arpeflu's analogs
Level 4 ATC code matches:
Vekluri
Remdeform
Areplivir
Coronavirus
Avifavir
Triazavirin
Yodantipyrine
Flavoside
Amizon
Altabor
Lavomax
Hyporamine
Anaferon for children
Anaferon
Amiksin
Arbidol
Ferrovir
Tiloron
Kagocel
Isoprinosine
Arbidol , Arbidol Maximum , Afludol , Arbivir , Mednat , Immusstat , ORVItol NP , Arbimax .
Contraindications
Arpeflu is not usually prescribed to patients under 3 years of age. It should be used with caution in cases of complete galactose intolerance, insufficiency of lactase secretion, and glucose-galactose malabsorption. The drug should not be used if you have an allergic reaction to any of its components.
For patients with insufficient lactase secretion, it is advisable to discuss with their doctor the possibility of using Arpeflu simultaneously with drugs containing lactase, for example, Mamalak.
Reviews about Arpeflu
ARVI and influenza are a common group of infectious diseases. They often have a severe course and unfavorable outcomes. One of the reasons for this is reduced immunity . of endogenous interferon and immunomodulators , is relevant . One of these drugs is Arpeflu. It is especially relevant for children, since they have an increased susceptibility to viral infections and an insufficient immune response, which causes a protracted course of the disease. If we compare this drug with amantadine and Remantadine , then their spectrum of action is narrow - they act only on the influenza A virus and side effects are possible when taking them.
This drug has a direct effect on influenza A and B . The use of Arpeflu is also effective for herpes and rotavirus infections . The presence of interferon-inducing, immunomodulatory and antioxidant activity ensures high efficiency in the treatment and prevention of viral diseases, prevents complications and exacerbations of concomitant chronic pathology. The drug is well tolerated and is compatible with antibiotics if there is a need to take them. All these points are reflected in the reviews.
- “... I think it helps. My husband got sick, his temperature was 39. He only took the antiviral drugs Arpeflu and Nimesil. In three days I got myself back on my feet and went to work.”
- “... I was prescribed it for an exacerbation of chronic purulent bronchitis along with antibiotics, I tolerated it well. I recovered faster than usual.”
It is most advisable to use the drug for preventive measures before the rise in the incidence of influenza and ARVI in the fall. Its high effectiveness lasts for 2-3 months. According to observations, after the preventive course, the number of children who fell ill with ARVI was 1.4 times less. A sign of effectiveness is also a reduction in the incidence of acute respiratory viral infections in adults with chronic respiratory diseases.
Bottom line
It is known that many people use antibiotics to treat influenza, but they only act on harmful microorganisms and are absolutely useless for fighting viruses. Pharmacist-developed dual-action medications are most effective against seasonal outbreaks. On pharmacy shelves you can find a huge variety of antiviral drugs. The products differ in composition and mechanism of action, but they are all aimed at fighting infections. To relieve symptoms, it is difficult to determine which drug is best among the abundance. Only a doctor can make the right choice for a patient.
Arpeflu price, where to buy
You can buy Arpeflu in many pharmacies. The cost of 30 tablets of the drug 50 mg is 150 - 200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy Dialogue
- Arpeflu tablets 100 mg No. 20 Lekfarm LLC
269 rub. order - Arpeflu tablets 100 mg No. 30 Lekfarm LLC
RUR 454 order
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PaniPharmacy
- Arpeflu table.
p/o 100 mg No. 10 + Arpeflu tablet. p/o 50 mg No. 10 PROMOTION 104 UAH. order - Arpeflu capsule Arpeflu film-coated tablets 100 mg No. 10 Belarus, Lekpharm
114 UAH order
- Arpeflu capsule Arpeflu film-coated tablets 50 mg No. 10 Belarus, Lekpharm
55 UAH order
- Arpeflu table. 50 mg No. 10 Promotion 1+1 Ukraine, Lekpharm
55 UAH order
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Brands, price
Tablets with the active ingredient umifenovir are produced by different companies, but the additional substances in each of them may differ. Consultation with a specialist is required when using a non-original drug. You can buy Arpeflu in Moscow for an average of 400 rubles, dosage 100 mg, 30 tablets. 50 mg costs less, from 260 rubles. Other names:
- Arpetol;
- Arbedol;
- Umifenovir;
Doctors speak positively about the drug Arpeflu and its analogues. The medicine helps to quickly cope with illness, strengthens the immune system, and prevents the development of various complications. Doctors advise caution when using an over-the-counter drug, and uncontrolled use of any drug leads to unpredictable consequences.
Frequently asked questions about Arpeflu
How to take Arpeflu for prevention?
For the purpose of prevention, this immunomodulatory drug can be used only as prescribed by a doctor. Children are allowed to take 50–100 mg at a time (depending on age), teenagers and adults – 200 mg. As a rule, when taken for preventive purposes, a single dose is equal to the daily dose. The regimen for taking Arpeflu depends on the goal you plan to achieve. For example, in preparation for surgery and to prevent the development of ARVI during an epidemic, different dosage regimens are used.
Is it possible to drink Arpeflu without a doctor's prescription?
It is not advisable to take the drug without a doctor’s prescription, since the doctor calculates the dosage and treatment regimen that is optimal for the patient’s current state of health. The conclusion about the advisability of taking the medicine is made based on the medical history and test results. Since the drug is used in pediatric practice, special attention should be paid to the uncontrolled use of immunomodulatory drugs for the treatment of children. When prescribing Arpeflu to children, the doctor takes into account the drugs that were previously prescribed to the child that affect the production of their own interferons.
What to do in case of overdose?
In case of an overdose of the drug, you should rinse your stomach, take an adsorbent and call your doctor. If an allergic reaction begins, you should take an antihistamine.
Can the drug be stored in the refrigerator?
Arpeflu can be stored in the refrigerator or simply in a cool, dry place, preferably in packaging.
Note!
The description of the drug Arpeflu on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
