Compound
Valocordin contains several active components:
- ethyl ether or ethyl bromoisovalerate. This substance has a sedative effect, a mild hypnotic effect, and relieves spasms;
- Phenobarbital – suppresses the activity of the central nervous system, which makes it possible to relieve emotional stress.
Among the auxiliary components are hop and mint oil, ethanol, purified water.
Valocordin drops are a clear liquid with a distinct odor.
Important! The product contains psychotropic substances in limited quantities. Considering this, the medicine should be used strictly as prescribed by the doctor.
"Valocordin": composition, description
"Valocordin" is a drug containing 2 active ingredients;
- phenobarbital;
- ethyl bromoisovalerate.
Additional ingredients include water, ethyl alcohol, mint and hop oil. They give the product a characteristic smell.
Available in the form of drops that are taken orally. The bottle is glass, dark, the volume can be 20 or 50 ml. Has a sedative effect, reduces blood pressure. May have a slight hypnotic effect. The product is not produced in tablets.
The container can be stored at a standard temperature of no more than 25 and no less than 15 degrees Celsius. The place should be dark. Access for children is prohibited. The shelf life of the drug is 5 years.
The active components of Valocordin lead to a decrease in the intensity of excitation processes in the nervous system. Due to this, the person calms down, and sleep can come faster due to natural physiological reasons. In addition, the drug acts as an antispasmodic, counteracting sudden compression of blood vessels. Due to this, it slightly reduces blood pressure.
Effect of the drug
The use of Valocordin allows you to achieve several goals at once, thanks to the combined composition of the drug. Phenobarbital is used to dilate blood vessels and eliminate nervous tension. Provided the correct dosage is used, the drops have a mild hypnotic effect and promote rapid falling asleep and restful sleep.
Ethylbromoisovalerate regulates the state of the central nervous system, helps a person overcome attacks of panic, anxiety, fear, and helps relieve excessive emotional excitability.
Peppermint oil enhances the therapeutic effect of the above-described components and has a mild antispasmodic and analgesic effect.
Indications for use
The drug is used to relieve symptoms of various pathologies of the cardiovascular and nervous systems, including:
- cardialgia;
- sinus type tachycardia;
- regular problems falling asleep;
- excited states with a strong vegetative reaction;
- anxiety, increased anxiety;
- constant state of fear;
- neurosis;
- irritability.
Who is the medicine prescribed to?
Indications for the use of Valocordin are quite extensive. These include:
- neuroses of various etiologies;
- vegetative lability;
- attacks of angina pectoris against the background of coronary heart disease and other cardiovascular pathologies;
- spasms in the intestines not caused by intestinal obstruction;
- comprehensive treatment of excessive gas formation;
- the initial stage of hypertension. Valocordin reduces blood pressure during frequent increases;
- panic attacks due to heart disease, stress;
- the patient has a headache that occurs periodically or is constant (migraine);
- pain in the sternum caused by spasm of the coronary vessels;
- decreased quality of sleep, insomnia;
- severe emotional stress provoked by stressful situations.
The main indication for use is high blood pressure
For high blood pressure, Valocordin is prescribed as an auxiliary therapy. Its use as an independent remedy for stage 2 and 3 hypertension is inappropriate.
Overdose: main symptoms
In case of overdose, increased drowsiness, dizziness, and decreased performance are observed. In case of severe overdose, more severe consequences may occur:
- pressure drop;
- coma;
- respiratory system disorder;
- vascular dysfunction;
- decreased manifestation of peripheral reflexes.
In this case, you should immediately seek medical help. Before the ambulance arrives, the patient must be laid down, ensuring complete rest. If possible, give several tablets of activated carbon and drink them with plenty of water.
Directions for use and doses
To achieve an optimal therapeutic effect, it is important to know how to take Valocordin. The standard treatment regimen is from 15 to 30 drops of the product three times a day before meals. For a single dose, a dosage of 40 drops is allowed.
How many drops are given to a child? For children, the drug is prescribed strictly under the supervision of a specialist. The dosage for them is usually no more than 15 drops.
Important! The exact dosage and duration of treatment should be determined by the doctor individually.
How does the drug affect blood pressure?
Patients often ask: “Does Valocordin increase or decrease blood pressure?” As already mentioned, the drug has a vasodilating effect. Increasing the lumen in the veins and capillaries leads to a decrease in blood pressure. This is what allows Valocordin to be used in the initial stages of hypertension.
It follows that the drug should not be used by patients with low blood pressure. Even a small dose of medication can cause undesirable consequences and greatly reduce the mercury level.
Should I use Valocordin if I have high blood pressure?
The antispasmodic and sedative effect of the drug on the human body can lead to a decrease in blood pressure, provided that hypertension:
- caused by emotional experiences;
- accompanied by minor changes in hemodynamic parameters;
- triggered by a change in weather;
- appeared as a result of physical overload.
If arterial hypertension is chronic, systolic and diastolic pressure are increased by more than 20 mm. Hg Art. from the normative values for a given person, the use of Valocordin will not lead to normalization of hemodynamic parameters.
Main contraindications
Contraindications for the drug are as follows:
- acute and chronic pathologies of the kidneys and liver;
- Valocordin should not be used during pregnancy and breastfeeding;
- patient age under 18 years;
- personal intolerance to the main or auxiliary substances of the drug;
- Quincke's edema;
- vascular collapse.
The medicine is strictly contraindicated for people with vegetative-vascular dystonia and hypotension. It is not prescribed for other conditions characterized by low blood pressure.
Valocordin is prohibited in childhood
Contraindications and side effects
In some cases, the use of Valocordin is contraindicated:
- individual intolerance to individual components;
- kidney disorders;
- liver disorders;
- all stages of pregnancy;
- feeding period;
- children up to 17 years old inclusive.
The drug can be used with caution in cases of diagnosed alcoholism, traumatic brain injury and other pathologies associated with the brain.
Side effects are rare, mainly due to long-term use. Main features:
- increased drowsiness;
- mild dizziness;
- decreased performance.
Due to constant violation of the dosage, symptoms of bromine poisoning may occur:
- depression, mood disorders;
- rhinitis;
- diathesis of hemorrhagic type;
- conjunctivitis;
- problems with coordination of movements;
- skin rashes and other allergic reactions.
If such symptoms occur, you should immediately stop taking it and consult a doctor. In case of bromine poisoning or allergic reactions, symptomatic treatment is indicated.
What is the danger of Valocordin
Many patients take Valocordin to lower blood pressure or normalize sleep without a doctor's prescription. Is it really that safe? The drug can bring not only benefits to the body, but also harm. More often, the side effects of Valocordin are caused by improper use of the drug or the individual characteristics of the patient.
Once in the body, phenobarbital promotes the synthesis of microsomal enzymes in the liver. Against this background, other medications taken that are metabolized in the liver do not have the desired therapeutic effect.
Phenobarbital, which is part of the medication, is a narcotic substance and is prohibited in some countries. If the dosage is strictly observed, this component does not cause negative consequences. If you violate the doctor’s recommendations or take the drug for too long, there is a risk of addiction, disruption of the functioning of the central nervous system or the development of withdrawal syndrome.
In addition, the drug can affect concentration and memory. After taking it, driving vehicles and operating potentially dangerous machinery is prohibited.
A combination such as Valocordin and alcohol poses a serious threat to human life and health. Ethyl alcohol enhances the narcotic effect of phenobarbital, so when taking alcoholic beverages, the use of Valocordin becomes extremely dangerous.
Is the drug compatible with alcohol?
The metabolism of alcohol and Valocordin occurs in the liver. To neutralize these substances, the same biochemical reactions are used, which occur only in the presence of special proteins (enzymes). Hepatocytes inactivate foreign compounds, preventing their toxic effect on the body.
However, if the liver has to process two substances at the same time, its truss systems are unable to inactivate the entire volume at once. Therefore, the process is delayed, allowing the full spectrum of toxic effects of the drug and ethanol to manifest itself. This mechanism explains the impossibility of compatibility of hangover and phenobarbital in one organism at the same time.
Taking Valocordin against the background of alcoholism leads to side effects of this medication and increased hangover symptoms:
- signs of dysfunction of the gastrointestinal tract (constipation, diarrhea, malabsorption syndrome);
- allergic reactions;
- impaired concentration and reaction speed.
Side effects
The instructions for use of the drug indicate the possibility of developing the following side effects of the drug:
- nasal congestion, allergic rhinitis;
- the appearance of irritability, drowsiness, nervousness;
- development of the inflammatory process of the mucous membrane of the eyes;
- deterioration of orientation in space;
- allergic manifestations on the skin, urticaria, itching.
In the absence of a response to these signs or with a single dose of the drug in an amount significantly exceeding the dose, an overdose of Valocordin occurs. Doctors distinguish between mild, moderate and severe stages of the severity of this condition. With a mild overdose, the patient notes drowsiness, apathy, and decreased blood pressure. The average degree is accompanied by a deterioration of the condition; it happens that it is difficult to wake a person, breathing and heart rate are impaired. The severe stage carries the threat of lethargic sleep, precoma and coma.
Important! If symptoms of overdose are detected, immediate action must be taken. The patient needs to rinse his stomach, and if his condition worsens, take him to the hospital.
Headache and malaise are considered side effects of the drug
special instructions
If there is a need to use the drug during lactation, breastfeeding should be abandoned.
Valocordin is not prescribed to patients with alcohol dependence, as it contains ethanol.
The product has a relaxing sedative effect. It is dangerous for people whose work requires special care to take the medicine. This applies to drivers, pilots, workers operating complex mechanisms.
Taking the drug for too long can cause addiction, accumulation of bromine in body tissues, and toxic poisoning.
Valocordin 20 ml drops for oral administration
Instructions for medical use of the drug VALOCORDIN® Trade name Valocordin® International nonproprietary name No Dosage form Drops for oral use, 20 ml and 50 ml Composition 100 g of solution contains active substances: phenobarbital - 2,000 g, ethyl bromoisovalerate - 2,000 g excipients: mint oil pepper, hop oil, ethanol 96% or 96.5%, purified water. 100 g contains 51 g of ethanol 96%. There are 20 drops in 1 ml. Description Transparent, colorless solution, with the odor of ethyl bromizovalerate and a pungent, bitter aromatic taste. Pharmacotherapeutic group: Hypnotics and sedatives. Sleeping pills and sedatives are different. ATC code N05CM Pharmacological properties Pharmacokinetics Barbiturate is resorbed already in the stomach. Approximately 35% of phenobarbital is bound to plasma albumin. The part not associated with albumin is filtered in the kidneys and, at low pH levels, is reabsorbed. Reverse diffusion does not occur due to the alkalinization of urine. The plasma half-life of phenobarbital is three days. 30% of phenobarbital is excreted unchanged in the urine, while a certain amount (a small amount) is oxidized in the liver. With prolonged use, phenobarbital accumulates in the plasma, as well as enzyme induction in the liver. This induction accelerates the breakdown of the barbiturate. Bromine bound in ethyl bromoisovalerate is excreted from the body very slowly. With prolonged use of the drug, it accumulates in the central nervous system, which leads to the development of bromism. Pharmacodynamics Valocordin® is a combination drug, the therapeutic effect of which is determined by the pharmacological properties of the components included in its composition. Phenobarbital has a sedative and vasodilating effect, and also has a mild hypnotic effect. Helps reduce excitation of the central nervous system and facilitates the onset of natural sleep. Ethyl bromizovalerate has sedative, hypnotic and antispasmodic effects. Peppermint oil has reflex vasodilator and antispasmodic activity. Indications for use - functional disorders of the cardiovascular system (including cardialgia, sinus tachycardia) - neuroses accompanied by irritability, anxiety, fear - insomnia (difficulty falling asleep) - states of excitation accompanied by pronounced vegetative reactions. Method of administration and dosage Valocordin® is taken orally, during meals, with a small amount of water. The dosage and duration of use of the drug is determined individually. Adults are usually prescribed 15-20 drops 3 times a day. If you have difficulty falling asleep, the dose can be increased to 30 drops. There is no experience of use for the treatment of children. Side effects Very rare (<1/10,000) - hypersensitivity reactions (shortness of breath, facial swelling, rash) - Stevens-Johnson syndrome (SJS) - toxic epidermal necrolysis (TEN) Uncommon (> 1/1,000 to <1 /100) - drowsiness, slight dizziness - pain in the stomach and intestines - allergic reactions Not known - reduction in bone mineral density, osteopenia, osteoporosis and fractures in patients who have taken phenobarbital for a long time - development of chronic bromine poisoning (with long-term use of large doses of the drug ), manifestations of which include: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements. Contraindications: hypersensitivity to any of the components of the drug; severe renal and/or liver dysfunction; pregnancy, lactation; children and adolescents under 18 years of age. Drug interactions When Valocordin® is used simultaneously with sedatives, the sedative effect increases. Simultaneous use with neuroleptics and tranquilizers enhances, and with stimulants of the central nervous system, weakens the effect of each of the components of the drug. Alcohol enhances the effects of Valocordin® and may increase its toxicity. The presence of phenobarbital in Valocordin® can induce liver enzymes, and this makes its simultaneous use with drugs that are metabolized in the liver undesirable, since their concentration and, accordingly, effectiveness will decrease as a result of more accelerated metabolism (indirect anticoagulants, antibiotics, sulfonamides, etc. ) Pharmaceutical preparations containing valproic acid enhance the effect of barbiturates. In combination with coumarin derivatives, griseofulvin, glucocorticoids or oral contraceptives, due to the phenobarbital content in Valocordin®, an accelerated weakening of the effect of the above drugs may be observed as an undesirable interaction. Increases the toxicity of pharmaceutical preparations containing methotrexate. Special instructions With long-term use of the drug, the formation of drug dependence is possible; Possible accumulation of bromine in the body and the development of poisoning. Features of the effect of the drug on the ability to drive a vehicle or drive potentially dangerous mechanisms Valocordin®, even when used correctly, may weaken the ability to react quickly. This effect is enhanced by alcohol. In this regard, it is not recommended to drive a vehicle or work with potentially dangerous mechanisms during treatment. Overdose Symptoms: overdose is expressed by intoxication of varying severity. Symptoms of intoxication Acute (mild to moderate) barbiturate intoxication Dizziness, fatigue, even deep sleep from which the patient cannot be awakened. Acute severe intoxication Deep coma, accompanied by tissue hypoxia, shallow breathing, rapid at the beginning, later slowing down. Rapid heartbeat, cardiac arrhythmia, low blood pressure, vascular insufficiency, weak or absent reflexes. If intoxication is not treated, death may occur from circulatory failure, respiratory paralysis, or pulmonary edema. Long-term use of formulations containing bromine can lead to bromine poisoning, which is characterized by the following symptoms: confusion, ataxia, apathy, depressed mood, conjunctivitis, colds, acne or purpura Treatment of intoxication Cases of acute intoxication with Valocordin® should be treated with the same method as and intoxication with hypnotics and barbiturates, depending on the severity of intoxication symptoms. It is necessary to rinse the stomach and take activated charcoal. It is necessary to normalize breathing and blood circulation. Respiratory failure is overcome by artificial respiration, shock by infusion of plasma or substances added to increase plasma volume. If not much time has passed since taking the barbiturate, gastric lavage is prescribed (pour in a solution of two full tablespoons of activated carbon and sodium sulfate). In order to accelerate the removal of barbiturate from the body, forced alkalizing diuresis and hemodialysis and/or hemoperfusion are prescribed. Treatment of bromine poisoning: Large amounts of table salt with simultaneous intake of saluretics accelerate the removal of bromine ions from the body. Release form and packaging 20 ml and 50 ml of the drug are poured into brown glass bottles (hydrolytic class 3), with a vertical polyethylene dropper and a polypropylene screw cap. A self-adhesive label is placed on each bottle. 1 bottle, along with instructions for medical use in the state and Russian languages, is placed in a cardboard pack. Storage conditions Store at temperatures between 15 °C and 22 °C. Keep out of the reach of children! Shelf life: 5 years Do not use after expiration date! Conditions for dispensing from pharmacies Without a prescription Manufacturer Krevel Meuselbach GmbH Krevelstrasse 2 D-53783 Eitorf Germany Owner of the registration certificate Krevel Meuselbach GmbH, Germany Address of the organization accepting claims on the territory of the Republic of Kazakhstan from consumers regarding the quality of products (products) KFK Medservice Plus LLP, Republic Kazakhstan, 050004, Almaty, Mametova street, 54 Telephone/fax Email address
Analogs
There are a large number of drugs similar in their composition and therapeutic effect to the drug in question. Analogs of Valocordin can be as follows:
- homeopathic Nott's drops - used for insomnia and excessive excitability of the central nervous system. The product has a relaxing effect and normalizes heart rate;
- Cavinton tablets are used as a vasodilator, help improve oxygen supply to the brain, and help utilize excess glucose. The drug is prescribed to patients with neuralgic and mental disorders caused by cerebral circulatory disorders;
- Sibazon tablets - eliminate spasms, have a relaxing effect, help get rid of seizures, and restore heart rhythm. Sibazon belongs to a number of psychotropic drugs;
- Corvalcaps capsules are prescribed to overcome excessive nervous excitability, normalize sleep, and lower blood pressure. Indications for use include insomnia, neuroses, conditions accompanied by spasm of the coronary vessels, and intestinal spasms.
Valoserdin is a popular analogue of Valocordin
Special attention should be paid to such an analogue as Valoserdin. Patients often compare these two drugs, asking which is better and what is the difference between these drugs? Valoserdin is a Russian medicine, Valocordin is a German drug. In terms of their therapeutic effect, both drugs are identical. Their difference is in composition and cost. Valoserdin contains oregano oil, Valocordin does not. Valoserdin costs almost half as much as the German drug.
Patient reviews
Further in the article you can read reviews about Valocordin. Patient responses are predominantly positive and are of the following nature.
Anastasia, Irkutsk “I myself am a nervous and irritable person, I try with all my might to fight these qualities, but sometimes my nerves give in. Six months ago, I encountered a symptom such as panic attacks. People who have encountered this will understand me, the condition is simply terrible. Valocordin helped me cope with this. The drug acts quickly, literally after 3 - 5 minutes it becomes easier. I have only positive impressions about the product.”
Veronica, Moscow “Valocordin is always on our pharmacy shelf. My mother and grandmother take this product. One day I had to take it, because I was very worried before the upcoming interview, I was shaking, it was even difficult to speak. After 5 minutes of taking the drops, she calmed down and her heart stopped beating wildly. The only negative is that I didn’t dare get behind the wheel, because I read that the medicine reduces concentration.”
Ekaterina, Ufa “I always took Valocordin during times of severe anxiety or insomnia. This continued until I learned about the possible negative consequences and addiction to the product. Now I take it much less often and with caution. Pros: fast action, affordable price. Disadvantages: strong, repulsive smell, unpleasant taste.”
conclusions
Valocordin brings calm and has the ability to relieve vasospasm. The main active ingredients (phenobarbital and ethyl ester of bromoisovaleric acid) are toxic. However, when following the instructions, the risk of overdose is minimized.
There are such analogues of the drug Valocordin: Valordin, Valoserdin, Valoferin, Corvalol, Lavocordin, Pangluferal. In some of them, phenobarbital is replaced by diazepam.
Valocordin and its substitutes are poorly compatible with a good reaction, so they should not be taken by people in professions that require constant concentration (drivers).
