ADHD
stands for
attention deficit hyperactivity disorder
, in other words, the child suffers from absent-minded attention and is in constant motion.
The prevalence of this diagnosis among school-age children is 3-7% (in some countries it reaches up to 14%), the syndrome is included in the group of neuropsychiatric disorders. Boys suffer from this disorder 9 times more often than girls.
For teachers, these are very “inconvenient” children, since the teacher is constantly distracted by such a child in order to make a remark. As a result, everyone suffers, since frequent interruptions interfere with the presentation and assimilation of the material.
But the child diagnosed with ADHD suffers the most. Indeed, due to his inattention, he does not fully listen, does not accurately understand the task, performs it in his own way, often incorrectly, which leads to a low grade.
Such children most often have intelligence corresponding to their age, but they suffer from dysgraphia (make frequent mistakes), dysorphorgraphia, lexical and grammatical disorders, and dyscalculia (have problems with arithmetic).
Parents of such children turn to a neurologist with various complaints. Some come with a detailed description from a teacher and psychologist, which describes his deviant behavior, as well as problems in his studies. Others say that the child is very vulnerable, whiny and irritable, and after examining and testing such a child, a diagnosis of ADHD is made.
Release form and composition
The drug is produced in the form of a homeopathic syrup, which is a transparent thick liquid from light yellow to light brown in color with a specific characteristic odor (100 ml in polymer bottles, one bottle in a cardboard box and instructions for use of Passambra Edas-306).
Composition per 100 g of syrup:
- active ingredients: Ambra grisea C6 – 2 g, Valerianae tinctura (Valerian alcohol tincture) – 4 g, Passiflora incarnata C1 – 2 g, Pulsatilla pratensis C9 – 2 g;
- auxiliary components: purified water, sucrose.
Contraindications and side effects
According to the instructions, Edas 306 soothing syrup for children is contraindicated in case of hypersensitivity to its composition. In this case, it can cause an allergy, which requires discontinuation of the homeopathic remedy and adjustment of the further treatment regimen.
Children with diabetes can be given the drug after consultation with a doctor.
Soothing syrup for children Passambra Edas 306 does not cause addiction when used for a long time, physical and mental dependence. After completion of therapy, there is no “withdrawal syndrome” - a deterioration in the child’s well-being after stopping taking a homeopathic remedy.
The drug does not cause an overdose.
If, while taking the medication Passambra Edas 306, a child experiences side effects that are not described in the instructions, you should consult a doctor.
Contraindications
Absolute:
- isomaltase/sucrase deficiency, glucose-galactose malabsorption syndrome, fructose intolerance (since the syrup contains sucrose);
- pregnancy period;
- breast-feeding;
- children under 1 year of age;
- hypersensitivity to the main or auxiliary ingredients of the drug.
Relative (Passambra Edas-306 syrup is used with caution, since the syrup contains ethanol):
- liver diseases;
- diabetes;
- epilepsy;
- brain diseases;
- traumatic brain injuries;
- alcoholism;
- children's age from 1 year.
Indications for use
It is recommended to give the homeopathic remedy Passambra Edas 306 to children if they have the following health problems:
- difficulty falling asleep, waking up at night, daytime sleepiness;
- irritability, aggressiveness;
- emotional excitability, with frequent mood swings;
- psychoneuroses, which are manifested by headache, dizziness, chest pain, decreased or increased blood pressure, increased heart rate, attacks of suffocation, a feeling of lack of air, fatigue, lack of appetite, diarrhea or stool retention, bloating, urinary incontinence;
- nervous excitability, which is observed during teething or after an infection.
Passambra Edas-306, instructions for use: method and dosage
The syrup is taken orally, between meals. The bottle must be shaken before each use.
Recommended doses of Passambra Edas-306 for children and adults (unless otherwise prescribed by a doctor):
- children aged 1 to 3 years: 0.5 teaspoon three times a day;
- children and adolescents aged 3 to 15 years: 1 teaspoon three times a day;
- adolescents over 15 years of age and adults: 1 dessert spoon three times a day.
The duration of the course is from 2 to 4 weeks.
results
The average age of patients at the time of the onset of tics in the general group of patients was 6.8±2.5 years. The average age at the onset of transient tics was 7.3±2.4 years, the average age at the onset of chronic tics was 5.2±1.9 years. Thus, the average age of children at the time of onset of chronic tics was significantly lower ( p
<0.05) than the corresponding age at the period of appearance of transient tics.
The most common tic hyperkinesis in the observed group were blinking and raising eyebrows. In many cases, the patient experienced several tics at once. Oculomotor tics (10 cases) were observed only in patients with the chronic form of the disease. Vocal tics (grunting, whistling, shouting sounds) of a transient nature were noted in 6 (7.3%) cases, of a chronic nature - in 18 (22.5%), i.e. vocal tics were significantly more frequent ( p
<0.01) were observed in chronic versus transient tics. There were no tics in the form of coprolalic vocalizations in the observed group.
The average frequency of tics on the TSGS scale in the group of children with transient tics was 3.1±0.3 points, with chronic tics - 4.4±0.5 points ( p
<0,05).
ADHD in children with transient tics was identified in 22 (26.9%) cases, in children with chronic tics - in 50 (62.5%, p
<0.05).
All indicators of the SNAP-IV scale (especially impulsivity) with chronic tics turned out to be significantly higher than with transient tics (Table 1)
.
In the control group, the average level of anxiety was 10.3±2.1 points (norm - 4-16 points). The level of anxiety in children with transient tics averaged 25.6±6.2 points, with chronic tics - 18.2±3.2 points ( p
<0.05). Thus, children with transient tics are the most anxious.
The results of a psychophysiological study (TOVA) showed that children with chronic tics, compared with children with transient tics, are characterized by significantly more pronounced deviations in the indicators of errors made, false alarms and reaction time (Table 2)
.
On the EEG, the majority of patients with tics noted the presence of a large number of slow waves, predominantly in the θ-range, weak expression or absence of a regular α-rhythm, and a change in the shape of α-oscillations (deformity, pointed or bifurcated apices). When quantitatively assessing the EEG, it was found that the bioelectrical activity of the brain in children with tics is characterized by an increase in slow-wave activity, as well as a decrease in β-activity in the frontal leads. The ratio of θ-rhythm and β1-rhythm in the frontal leads (in lead Fz) in the control group was 2.40±0.47 and 1.91±0.20 in children aged 10-12 and 13-15 years, respectively. In the group of 10-12 year olds these indicators were: for transient tics 4.81±0.60, for chronic ones - 5.80±0.54; in the group of patients 13-15 years old - 4.28±0.38 and 4.92±0.42. The differences were significant compared to the control group ( p
<0.01), and between groups of patients (
p
<0.05).
Thus, the electroencephalogram in children with chronic tics of both age groups is distinguished by higher values of the ratio of the θ-rhythm and β1-rhythm compared to healthy children and children with transient tics. As for the spectral power of the EEG, children with tics showed lower values of α-rhythm power in the occipital leads compared to healthy children. In turn, the electroencephalogram of children with chronic tics is characterized by lower values of α-rhythm power in the occipital leads compared to children suffering from transient tics (Table 3)
.
Treatment results for chronic tics
After a course of treatment with adaptol, there was a significant ( p
<0.05) reduction in chronic tics - this was observed in 26 of 40 (65%) patients suffering from this disorder. At the same time, positive changes were noted not only with motor, but also with vocal tics.
The average frequency of tics on the TSGS scale after treatment with adaptol was 2.2±0.8 points (with a maximum frequency of 5 points), which indicates a significant improvement ( p
<0.01) patient conditions.
Parents reported that their children not only had fewer tics, but their children also became more diligent in school and homework. The results of psychological studies showed a significant decrease ( p
<0.05) in anxiety indicators in children after treatment with adaptol: 22.18 ± 3.17 and 17.95 ± 2.86 points, respectively (in the comparison group - 20.74 ± 3.92 points).
Assessment of the patients' condition using the SNAP-IV scale after treatment with adaptol showed a significant decrease in inattention and impulsivity scores (Table 4)
.
The results of the psychophysiological study TOVA confirmed clinical data on a significant decrease in impulsivity after a course of adaptol. At the same time, there was no significant change in attention and reaction time, which is very important in terms of the presence of side effects that often occur when taking tranquilizers (Table 5)
.
After a course of Pantogam, a decrease in the frequency of chronic tics was noted in 17 (42.5%) patients suffering from this disorder. The average frequency of tics on the TSGS scale after the Pantogam course was 3.5±0.7 points. In addition, after the Pantogam course, significant positive dynamics in indicators of inattention and hyperactivity were recorded. There were no changes in anxiety during repeated psychological testing.
After completing the course of adaptol, there was a positive dynamics in the bioelectrical activity of the brain in the form of an increase in the representation of α-activity in the occipital regions. During quantitative assessment, a significant increase in spectral power in the α-range was recorded (Table 6)
.
There were no significant changes in the bioelectrical activity of the brain in the control group.
No undesirable side effects were observed when taking adaptol. While taking Pantogam, manifestations of hyperexcitability were noted in 3 cases. These manifestations were moderate in nature and disappeared after the end of the treatment course.
special instructions
There was no withdrawal syndrome or addiction to the drug. Sometimes, when using homeopathic medicines, a primary deterioration (transient exacerbation of existing symptoms) may occur, requiring temporary cessation of treatment and consultation with a specialist.
The content of absolute ethyl alcohol in Passambra Edas-306 syrup: in 10 ml of the drug (maximum single dose for adults) – 0.62 g; in 30 ml (maximum daily dose for adults) – 1.87 g.
Information for patients with diabetes: 10 ml of syrup (single dose for adults) contains approximately 8.4 g of sucrose (this corresponds to 0.7 XE).
Impact on the ability to drive vehicles and complex mechanisms
During treatment, patients should be careful when driving vehicles and performing other work that requires a high concentration of attention and a quick psychomotor reaction.
Afobazole
An original anxiolytic (anti-anxiety) drug.
Afobazole is a non-benzodiazepine anxiolytic and has a new mechanism of action: through the sigma receptor system, it is able to activate the natural anti-anxiety defense of nerve cells (“endogenous anxiolysis system”).
Afobazole has a special clinical profile that is different from all other anti-anxiety drugs:
- the effect develops from the first week of administration and persists after completion of treatment;
- does not cause daytime sleepiness, dependence and addiction, as well as withdrawal syndrome;
- has not only an anti-anxiety, but also an activating effect;
- suitable for the treatment of sleep disorders associated with anxiety, as well as premenstrual syndrome and withdrawal syndrome when quitting smoking;
- compatible with most other somatotropic drugs, does not interact with ethanol.
Question answer
Is it possible to take Afobazol together with herbal sedatives and glycine?
Afobazole does not interact with herbal sedatives and glycine, so it can be taken together. However, when using combination therapy, you should consult your doctor.
What is the maximum duration of Afobazolm therapy?
Afobazole does not accumulate in the body, does not cause addiction or dependence, which makes it possible to safely carry out long courses of therapy. The duration of a course of drug use is usually 2–4 weeks; if necessary, the duration of treatment can be extended up to 3 months. As a rule, the duration of the course depends on the initial condition, its changes during therapy, concomitant diseases, and the presence of external stress factors. Upon completion of the course of therapy, it is necessary to consult with your doctor to decide on further treatment tactics.
How often can Afobazole courses be repeated? How much break should I take between courses?
Afobazole can be taken without interruption for 3 months. After stopping treatment, the effect of the drug lasts for 1-2 weeks. The duration of breaks between courses of therapy depends on your condition and is determined in each individual case by the attending physician based on the results of an assessment of your condition.
Is Afobazol compatible with alcohol?
The simultaneous use of Afobazole and alcohol is not contraindicated. However, it must be remembered that alcohol can have an adverse effect on the central nervous system, including in the presence of anxiety disorders. In addition, drinking high doses of alcohol is harmful to the body and can increase the symptoms of various diseases.
Hello, is it possible to use Afobazole together with birth control pills?
No interaction between Afobazole and oral contraceptives has been identified; joint use is not contraindicated.
How long before you can plan a pregnancy after stopping the drug?
Afobazole is quickly eliminated from the body. At the same time, after discontinuation of any drug, it is necessary to ensure that the symptoms of the condition for which the drug was prescribed have completely resolved and there is no need to continue treatment with this or any other drug. Therefore, we recommend planning pregnancy no earlier than 2 weeks after discontinuation of the drug.
Tell me, is it possible to take Afobazole during pregnancy? Thank you in advance
During pregnancy, the use of many medications is contraindicated, incl. Afobazole. Despite the fact that, according to experimental studies, Afobazole does not have a negative effect on fetal development in animals, the effects of Afobazole in pregnant women have not been sufficiently studied.
Hello, is it possible to take Afobazole while driving a car?
Afobazole does not have a sedative effect, and also does not cause a deterioration in concentration and speed of psychomotor reactions, therefore it can be taken by people driving vehicles whose activities require increased attention and quick response.
Can the drug be used in children?
According to the approved instructions, Afobazol is not used in children under 18 years of age, because No special studies have been conducted in this category of people.
Hello, is it possible to take Afobazole while taking antidepressants?
The simultaneous use of Afobazole and antidepressants is not contraindicated.
Can the drug help the first time you use it?
The drug Afobazole reduces the severity of anxiety disorders of various origins. The therapeutic effect does not develop immediately, but gradually. And although the first improvement can be felt quite quickly, a noticeable effect occurs on the 5-7th days of treatment. The optimal duration of therapy is 2-4 weeks; if necessary, taking Afobazole can be continued for up to 3 months.
Is it possible to take Afobazol during lactation?
Due to the lack of clinical data on the use of Afobazole during breastfeeding, the drug should not be taken during lactation. If it is necessary to take it, you should consider stopping breastfeeding.
What side effects can Afobazole cause?
Side effects of Afobazole include: allergic reactions; in rare cases, headaches have been described, which usually go away on their own and do not require discontinuation of the drug.
In what cases is the use of Afobazole contraindicated?
Taking Afobazole is contraindicated in case of individual intolerance to the drug, during pregnancy, during breastfeeding, as well as in children under 18 years of age.
Reviews about Passambre Edas-306
According to reviews, Passambra Edas-306 is a good remedy for relieving children's excitability and hysterics, and also helps adults with sleep disorders and stress. Children and adults' sleep normalizes, they become calmer and less excitable. The drug acts gently, has a natural composition, sweet and pleasant taste. The cost of syrup is quite low.
Among the disadvantages, users most often note the overly sweet taste of the drug and weak effect, that is, in case of serious violations, the drug is ineffective.
Description
Passambra Edas-306 is designed for children and adults as a sedative. This is a homeopathic remedy that is available in syrup. It is a clear, thick liquid that smells like valerian. Its color can vary from pale yellow to yellow.
By the way, we recently wrote about whether valerian can be given to children - see here.
Passambra Edas 306 syrup has the following composition of medicinal components:
- Passiflora . Another name for the plant is passion flower. Its active components have a calming effect and help overcome stress. Eliminates symptoms of emotional arousal such as headaches and sleep disturbances. Passionflower normalizes the level of sex hormones in the body, prevents attacks of bronchial asthma, involuntary muscle contractions, and reduces cravings for alcohol and cigarettes. It helps with nervous excitement and insomnia.
- Amber grisea . This substance is formed in the intestines of the sperm whale. It has a positive effect on the nervous system, endocrine glands, and digestive organs. It normalizes sleep; while taking it, the child remembers new information better, and memory problems caused by chronic fatigue disappear. It is recommended to take it for restlessness, anxiety, involuntary twitching of muscles, impaired thinking, weakened memory, insomnia, shallow sleep, nightmares.
- Pulsatilla . This plant is known under such names as meadow lumbago, dream grass, snowdrop. Its active components relieve inflammation, increase immunity, exhibit antimicrobial activity, promote sputum discharge, have a hepatoprotective and diuretic effect, and eliminate signs of depression. It is recommended to take it when mood swings are observed, irritability and tearfulness are replaced by cheerfulness, as well as when there are difficulties falling asleep.
- Valerian tincture . It has a sedative and hypnotic effect. Helps normalize sleep, cope with depression, anxiety, headaches, hysterics.
In addition to these, Edas 306 syrup contains refined sugar and water as additional components.
What is more effective Tenoten for children or Edas 306?
Tenoten for children is available in lozenges. They can be given to patients over 3 years of age with neuroses and hyperactivity. Tablets are contraindicated if their composition is intolerant. The doctor should decide which drug is best depending on the indications and contraindications. Tenoten and Edas-306 are homeopathic medicines, that is, medicines with unproven effectiveness. No good doctor will prescribe these medications.
You can read more about the drug Tenoten here.
