How does a hepatoprotector work?
The liver has a natural ability to heal itself. However, in some cases, cell regeneration is too slow. In this case, a hepatoprotector is needed, that is, a “liver protector.” This is precisely the function that Esslial Forte, containing phospholipids, performs for the body - compounds similar to those that are part of liver cells.
Firstly, the drug dissolves excess cholesterol so that the liver works more efficiently and recovers faster. Secondly, it normalizes blood clotting and provides optimal conditions for regeneration. Phospholipids, the main “building material” of cells, are integrated into the structure of cells and help them recover.
Why is this drug better than others?
It is impossible not to mention that one of the main advantages of Esslial Forte is its price, which is more favorable than that of many analogues. But liver health is not an area where you should rely solely on financial considerations. There are several other significant benefits.
The phospholipids that this drug contains are of completely natural origin. They are obtained from soybeans - unlike many production technologies, where phospholipids are synthesized artificially. The drug does not cause allergies or other unpleasant side effects.
This hepatoprotector is prescribed to different groups of patients - children and adults, men and women. Hepatologists recommend Esslial Forte for people over 12 years of age with liver diseases and poisoning. Contraindications include only individual intolerance to soy and drug components. In all other cases it is allowed to be taken.
Esslial forte caps 300 mg x100
Esslial forte caps 300 mg x100 Ozone
Registration number:
LP-002933
Trade name of the drug:
Esslial forte
International nonproprietary name or generic name:
phospholipids
Dosage form:
capsules
Compound:
1 capsule contains: Active substance: lipid PPL-400 – 400.0 mg, in terms of polyunsaturated phospholipids from soy lecithin (PPL fraction) – 300.0 mg, with an average content of L-α-phosphatidylcholine 76% – 228.0 mg . Excipients: ethyl alcohol 95% – 4.0 mg. Hard gelatin capsules No. 0: Capsule body composition: black iron oxide dye – 0.01%, red iron oxide dye – 0.01%, yellow iron oxide dye – 0.1714%, titanium dioxide – 3%, gelatin – up to 100 %, Composition of the capsule cap: black iron oxide dye – 0.53%, red iron oxide dye – 0.93%, yellow iron oxide dye – 0.2%, titanium dioxide – 0.3333%, gelatin – up to 100%
Description:
Hard gelatin capsules No. 0. The capsule body is light brown with a beige tint, the capsule cap is dark brown. The contents of the capsules are a yellow-brown or brown homogeneous mass from a paste-like to denser consistency with a characteristic odor.
Pharmacotherapeutic group:
hepatoprotective agent.
ATX code:
A05C.
Pharmacological properties
Pharmacodynamics Essential phospholipids are the main elements of the structure of the cell membrane and cellular organelles of the liver. In liver diseases, there is always damage to the membranes of liver cells and their organelles, which leads to disruptions in the activity of associated enzymes and receptor systems, deterioration in the functional activity of liver cells and a decrease in the ability to regenerate. The phospholipids that make up the drug Esslial forte correspond in their chemical structure to endogenous phospholipids, but are superior to endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids. The integration of these high-energy molecules into damaged areas of hepatocyte cell membranes restores the integrity of liver cells and promotes their regeneration. The cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes; the density of the phospholipid structure of the cell membranes of hepatocytes decreases, which causes an increase in their fluidity and elasticity, and improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on membranes and contribute to the normal physiological pathway of the most important metabolic processes. Phospholipids, which are part of the drug Esslial forte, regulate the metabolism of lipoproteins, transferring neutral fats and cholesterol to sites of oxidation, mainly by increasing the ability of high-density lipoproteins to bind to cholesterol. Thus, there is a normalizing effect on the metabolism of lipids and proteins, on the detoxification function of the liver and phospholipid-dependent enzyme systems, which ultimately prevents the formation of connective tissue in the liver and promotes the natural restoration of liver cells. With the excretion of phospholipids into the bile, the lithogenic index decreases and the bile is stabilized.
Pharmacokinetics More than 90% of phospholipids taken orally are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 50% of which is immediately reverse acetylated into polyunsaturated phosphatidylcholine during the absorption process in the intestinal mucosa. This polyunsaturated phosphatidylcholine enters the bloodstream through the lymph, and from there, mainly bound to high-density lipoproteins, enters the liver. Pharmacokinetic studies in humans were conducted using radiolabeled dilinoleyl-phosphatidylcholine (3H and 14C). The choline moiety was labeled with 3H, and the linoleic acid residue was labeled with 14C. The maximum concentration of 3H is achieved 6-24 hours after administration and is 19.9% of the prescribed dose. The half-life of the choline component is 66 hours. The maximum concentration of 14C is reached 4-12 hours after administration and is up to 27.9% of the prescribed dose. The half-life of this component is 32 hours. Both isotopes are more than 90% absorbed in the intestine.
Indications for use
Chronic hepatitis, cirrhosis of the liver, fatty liver of various etiologies, toxic liver damage, alcoholic hepatitis, liver dysfunction in other somatic diseases. Toxicosis of pregnancy, prevention of recurrence of gallstones, psoriasis (as an adjuvant therapy), radiation syndrome.
Contraindications
Individual intolerance to phosphatidylcholine or other auxiliary components of the drug. Soy intolerance. Children under 12 years of age (lack of sufficient evidence base).
Directions for use and doses
Inside. Capsules should be taken whole with a sufficient amount of water (approximately 1 glass). For adolescents over 12 years of age and weighing more than 43 kg, as well as for adults, Esslial Forte is recommended to take 2 capsules - 3 times a day with meals. As a rule, the duration of use is not limited.
Side effect
Esslial forte is usually well tolerated by patients. To assess the frequency of side effects, the following definitions are used: very often (>.1/10), often (>.1/100 - <.1/10), not often (>.1/1000 - <.1/100) , rare (>.1/10000 - <.1/1000), very rare (<.1/10000), unknown frequency (from the available data it is impossible to determine the frequency of occurrence). From the gastrointestinal tract: rarely - discomfort in the epigastric region, loose stools, nausea, gastralgia. Allergic reactions: very rarely - rash, exanthema, urticaria, unknown frequency - itching.
Overdose
No information available.
Interaction with other drugs
No information available.
Impact on the ability to drive vehicles and operate machinery
Does not affect.
Release form
Capsules 300 mg. 5, 6, 10 capsules in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil. 10, 20, 30, 40, 50, 60, 90 or 100 capsules in polyethylene terephthalate jars or polymer jars for medicines. One can or 1, 2, 3, 4, 5, 6, 9 or 10 blister packs along with instructions for use are placed in a cardboard package (pack). It is allowed to pack 2 or 3 cardboard packages (packs) into a group package (shipping container) made of cardboard for consumer packaging.
Storage conditions
In a place protected from light at a temperature not exceeding 25 ºС. Keep out of the reach of children.
Best before date
3 years. Do not use after the expiration date stated on the package.
Vacation conditions
Available without a prescription.
Legal address: 445351, Russia, Samara region, Zhigulevsk, st. Pesochnaya, 11 Address of place of production (address for correspondence, including for receiving claims): 445351, Russia, Samara region, Zhigulevsk, st. Gidrostroiteley, 6
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Cost benefit when using
A separate positive point is the absence of overpayments. Compared to well-known analogues at Esslial Forte, the price is approximately one and a half times more favorable. You can easily verify this by simply comparing prices for different medications in any pharmacy or online catalogue.
Immediately after examination by a doctor, you can begin treatment. In combination with other drugs, a therapeutic diet and other measures to combat the disease, the hepatoprotector provides the desired result.
The drug "Esslial Forte" can be bought in St. Petersburg, Novosibirsk, Yekaterinburg, Nizhny Novgorod, Kazan, Chelyabinsk, Krasnodar, Ufa and other cities of Russia.
Essel Forte E capsules No. 10x3
Writing
Essel forte e.
Release forms
Capsules.
INN
Phospholipids.
FTG
Hepatoprotective agent.
Compound
Each capsule contains: active ingredients: essential phospholipids - 300.0 mg, nicotinamide - 30.0 mg, vitamin B1 (thiamine mononitrate) - 6.0 mg, vitamin B2 (riboflavin) - 6.0 mg, vitamin B6 (pyridoxine hydrochloride ) - 6.0 mg, vitamin B12 (cyanocobalamin) - 0.006 mg, vitamin E (alpha-tocopheryl acetate) - 6.0 mg; excipients: talc, magnesium stearate, corn starch, anhydrous colloidal silicon dioxide, disodium salt of ethylenediaminetetraacetic acid; composition of the capsule shell: gelatin, glycerin, titanium dioxide E-171, sodium lauryl sulfate, sunset yellow E-110, purified water.
Description
Hard gelatin capsules No. 0, cylindrical in shape with hemispherical ends; white body, orange cap. The contents of the capsules are an oily mass from yellow to orange. The presence of particles ranging from yellow-white to brown is acceptable.
pharmachologic effect
A combined drug whose effect is determined by the properties of its constituent components. “Essential phospholipids” are complex substances of natural origin, which are diglyceride esters of phosphatidic and unsaturated fatty acids (mainly oleic and linolenic). They are an important structural element of cell membranes and membranes of hepatocyte organelles. Phospholipids regulate membrane permeability and the activity of membrane-bound enzymes, ensuring normal processes of oxidative phosphorylation. The drug normalizes the biosynthesis of phospholipids and general lipid metabolism in case of damage to hepatocytes of various etiologies. Restores hepatocyte membranes through structural regeneration and through competitive inhibition of oxidative processes: being embedded in biomembranes, unsaturated fatty acids are able to take on toxinogenic effects instead of membrane lipids. Promotes the regeneration of liver cells, stabilizes the physical and chemical properties of bile. Thiamine mononitrate (vitamin B1) as a coenzyme is involved in carbohydrate metabolism. Riboflavin (vitamin B2) is the most important catalyst for cellular respiration processes. Pyridoxine hydrochloride (vitamin B6) as a coenzyme takes part in the metabolism of amino acids and proteins. Cyanocobalamin (vitamin B12), together with folic acid, is involved in the synthesis of nucleotides. Nicotinamide is involved in the processes of tissue respiration, fat and carbohydrate metabolism. Alpha tocopheryl acetate (vitamin E) has antioxidant properties and protects unsaturated fatty acids in membranes from lipoprotection.
Pharmacokinetics
When taken orally, more than 90% of phospholipids are absorbed from the gastrointestinal tract. The main amount is broken down to 1-acyl-LYSO-phosphatidylcholine, 50% of which is converted into polyunsaturated phosphatidylcholine in the small intestine. Next, polyunsaturated phosphatidylcholine in combination with HDL is transported to the liver. The maximum concentration of phospholipids in the blood plasma is achieved after 6 hours. Metabolism occurs in the kidneys and liver. They are excreted from the body in feces and, to a lesser extent, in urine.
Indications for use
· lipid metabolism disorders of various origins; · acute and chronic hepatitis; cirrhosis of the liver; · alcohol and drug intoxication; · poisoning (including medicinal); · dysfunction of hepatocytes (as a complication of other diseases); · radiation damage to the liver; psoriasis (as part of combination therapy).
Contraindications
Hypersensitivity to the components of the drug, cholestasis, empyema of the gallbladder, nephrolithiasis, peptic ulcer of the stomach and duodenum in the acute stage.
Pregnancy and lactation
Data on the safety and effectiveness of the drug during pregnancy and lactation are not provided.
Directions for use and doses
Inside, during meals; Capsules should be swallowed whole with plenty of water. The medicine is prescribed 2 capsules 2-3 times a day. Duration of treatment is at least 5 months; if necessary, longer use of the drug or repeated courses of treatment are possible. For psoriasis, the drug is used as an adjuvant therapy, 2 capsules 3 times a day for 2 weeks.
Side effect
The drug is usually well tolerated. Very rarely, flatulence, nausea, diarrhea, dark yellow urine, discomfort in the stomach, hypersensitivity reactions, skin rashes, urticaria, and itching may occur.
Overdose
Currently, there are no known cases of overdose.
Interaction with other drugs
Multivitamin medicines: The vitamin content of Essel Forte E should be taken into account to prevent vitamin overdose. Tocopherol acetate enhances the effect of steroidal and non-steroidal anti-inflammatory drugs (diclofenac sodium, ibuprofen, prednisolone). Tocopherol acetate should not be taken with iron or silver preparations; with agents that exhibit an alkaline reaction (sodium bicarbonate, trometamol), indirect anticoagulants (dicoumarin, neodicoumarin). Pyridoxine may weaken the effect of levodopa and reduce toxic effects when using isoniazid and other anti-tuberculosis drugs. Pyridoxine hydrochloride enhances the effect of diuretics. Isoniazid, penicillamine, pyrazinamide, hydralazine, immunosuppressants, estrogens (including oral contraceptives containing estrogens) act as pyridoxine antagonists or enhance the renal excretion of the latter. Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline, lincomycin). Tricyclic antidepressants, imipramine and amitriptyline inhibit riboflavin metabolism. Thiamine may weaken the curare-like effect. Antacids slow down the absorption of thiamine. The action of thiamine is inactivated by 5-fluorouracil, since the latter competitively inhibits the phosphorylation of thiamine to thiamine pyrophosphate. Cholestyramine: reduces the absorption of nicotinamide; An interval of 4-6 hours between taking these medications is recommended. Rifampicin: decreased bilirubin synthesis and increased protein synthesis. Paracetamol: decreased levels of serum transaminases.
Precautionary measures
The use of the drug requires caution in the following cases: in patients with allergic diseases, with a history of gastric and duodenal ulcers, with heart and blood diseases. If an allergic reaction to the drug occurs, you should stop taking it. For patients with chronic gastritis, additional use of products containing digestive enzymes is recommended to facilitate the digestion of gelatin capsules. Children. The drug is used to treat children over 12 years of age.
Release form
30 capsules in a polymer jar with a pull-on lid with first opening control or 10 capsules in a blister pack; jar or 3 blisters along with an insert in a cardboard pack.
Storage conditions
Store in a place protected from moisture and light at a temperature not exceeding 25 °C. Keep out of the reach of children.
Best before date
Shelf life: 3 years. Do not use after the expiration date stated on the packaging.
Conditions for dispensing from pharmacies
Without a doctor's prescription.
Buy Essel Forte E caps. in container pack No. 10x3 in the pharmacy
Price for Essel Forte E caps. in container pack No. 10x3
Instructions for use for Essel Forte E caps. in container pack No. 10x3
