Composition per 1 tablet:
Active substance:
Pancreatin - 100 mg The amount of pancreatin is indicated for a substance with an amylolytic activity of at least 1700 FIP units; lipolytic activity of at least 3000 FIP units; total proteolytic activity of at least 130 FIP units.
Excipients:
calcium stearate - 3.2 mg, potato starch - 7.4 mg, croscarmellose sodium - 1.2 mg, lactose monohydrate - to obtain an uncoated tablet weighing 320 mg
Excipients of the coating to obtain a tablet with a coating weighing 335 mg: titanium dioxide - 0.933 mg, azorubine dye (acid red dye 2C) - 0.025 mg, methacrylic acid and ethyl acrylate copolymer (1:1) - 6.948 mg, macrogol 4000 - 1.044 mg, talc - 4.184 mg, povidone - 1.866 mg.
How to take Pancreatin correctly
The medicine in any form is used orally. It should be drunk with meals. Do not chew or dissolve. It is best to drink plenty of water or tea.
It is better to divide the permissible dose per day into several doses corresponding to the number of meals.
The doctor can determine the appropriate dose of the medicine after examining the patient. His condition and age category are taken into account.
In the absence of any indications, the drug should be taken 1-2 tablets per day. For the problems and diseases described above, the medicine is prescribed 2-4 tablets per day. According to the doctor's recommendations, the dosage may be increased. This is possible if necessary to reduce the symptoms of a disease.
A child aged 6-8 years can be given 1 tablet per day, children from 8 to 10 years old can be prescribed up to 2 tablets per day, children over 10 years old can be given 2 tablets per day.
Description:
Tablets coated with a pink or dark pink color interspersed with a specific odor, biconvex in shape, two layers visible on the cross section.
Pharmacotherapeutic group:
digestive enzyme agent.
ATX code
: A09AA02.
Pharmaceutical action
Pancreatin compensates for the insufficiency of the exocrine function of the pancreas and has proteolytic, amylolytic and lipolytic effects.
The enzymes included in pancreatin (lipase, alpha-amylase, trypsin, chymotrypsin) help break down proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides.
Improves the functional state of the gastrointestinal tract, normalizes digestion processes.
Trypsin inhibits stimulated pancreatic secretion and has an analgesic effect.
Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, since they are protected from the action of gastric juice by the membrane.
The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
What are Pancreatin tablets for?
The instructions describe the conditions and diseases for which you can take the drug:
- exocrine insufficiency of the intestine, liver, stomach, gall bladder;
- late pancreatitis that appeared after transplantation;
- problems with the gastrointestinal tract caused by prolonged immobilization of the patient;
- chronic diseases of the liver and biliary tract;
- feeling of fullness in the stomach;
- excessive accumulation of gases in the stomach;
- stabilization of the stomach in a healthy person, if it has been disrupted as a result of eating unhealthy and too fatty foods, overeating, a passive lifestyle or pregnancy;
- before performing an ultrasound of the digestive system.
Indications for use
Replacement therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, Roemheld syndrome (gastrocardiac syndrome), cystic fibrosis; flatulence, diarrhea of non-infectious origin.
Impaired digestion of food (condition after resection of the stomach and small intestine); to improve food digestion in people with normal gastrointestinal function in case of errors in nutrition (eating fatty foods, large amounts of food, irregular meals) and in cases of chewing dysfunction, sedentary lifestyle, prolonged immobilization.
Preparation for X-ray examination and ultrasound of the abdominal organs.
Pancreatin-Belmed tablets po enteric-soluble 25 units No. 10x5
Name
Pancreatin-Belmed tablet coated. k/r vol. 25 units per contact. cell pack №10x5
Description
Film-coated tablets, yellow to yellow-brown in color, with a biconvex surface. Unevenness and inclusions are allowed on the surface. When breaking the tablet, a specific smell is felt. The cross section shows two layers.
Main active ingredient
Pancreatin
Release form
Pills
Dosage
25 units
pharmachologic effect
Digestive enzyme agent. The pancreatic enzymes included in the composition (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins into amino acids, fats into glycerol and fatty acids, starch into dextrins and monosaccharides, improve the functional state of the gastrointestinal tract, and normalize digestive processes. Trypsin suppresses stimulated pancreatic secretion, producing an analgesic effect. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.
Indications for use
Disorders of the exocrine function of the pancreas (chronic pancreatitis, pancreatectomy), achylia. Preparation for X-ray examination and ultrasound of the abdominal organs.
Directions for use and doses
The drug is taken orally 3-6 times a day, during meals, without chewing and with plenty of liquid (water, fruit juices). The dose is set individually, depending on the age and severity of the digestive disorder. Adults and children over 14 years of age: the usual single dose is 50-100 units (2-4 tablets); the daily dose is 200-400 units (8-16 tablets). The average single dose for children 6-7 years old is 3 units (1 tablet), 8-9 years old – 25-50 units (1-2 tablets), 10-14 years old – 50 units (2 tablets). The duration of treatment can vary from several days (for indigestion, dietary errors) to several months and even years (if constant replacement therapy is necessary).
Use during pregnancy and lactation
The use of the drug during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms
The drug does not have a negative effect on the ability to drive a car or drive potentially dangerous machinery.
Precautionary measures
With long-term use, iron supplements are prescribed simultaneously.
Interaction with other drugs
Forms insoluble complexes with folates, as a result of which their absorption is significantly reduced. Reduces iron absorption (especially with long-term use). Concomitant use of antacids containing calcium carbonate and/or magnesium hydroxide may lead to a decrease in the effectiveness of pancreatin.
Contraindications
Hypersensitivity to the components of the drug, acute pancreatitis, exacerbation of chronic pancreatitis. Patients with hereditary diseases such as galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take Pancreatin-Belmed.
Compound
Each tablet contains: active substance: pancreatin - 25 units; excipients: calcium stearate (E - 470), methylcellulose (E - 461), lactose monohydrate, acrylic 93 A (methacrylic acid copolymer, quinoline yellow aluminum varnish, yellow iron oxide (E -172), black iron oxide (E -172), anhydrous colloidal silicon dioxide (E - 551), talc (E - 553), sodium lauryl sulfate (E - 487), sodium bicarbonate (E - 500), titanium dioxide (E -171)), triethyl citrate (E - 1505).
Overdose
Symptoms: hyperuricosuria, hyperuricemia. Children have constipation. Treatment: drug withdrawal, symptomatic therapy.
Side effect
Allergic reactions, rarely - diarrhea or constipation, nausea, discomfort in the epigastric region. With long-term use in high doses - hyperuricosuria, hyperuricemia, structures in the ileocecal region and in the ascending colon. If the above adverse reactions or adverse reactions not listed in these instructions for medical use of the drug occur, you should consult a doctor.
Storage conditions
In a place protected from moisture and light at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Side effects
Allergic reactions. In some cases - diarrhea, constipation, discomfort in the stomach, nausea (the cause-and-effect relationship between the development of these reactions and the effect of pancreatin has not been established, since these phenomena refer to symptoms of exocrine pancreatic insufficiency). With prolonged use in high doses, perianal irritation and irritation of the oral mucosa may occur. Patients with cystic fibrosis may develop strictures in the ileocecal region and in the ascending colon.
Contraindications and adverse reactions
Like other medications, Pancreatin has several contraindications for use. These include:
- people with acute and aggravated chronic pancreatitis;
- excessive sensitivity to the constituent substances of the drug;
- intestinal obstruction;
- acute hepatitis.
In very rare cases, the drug can provoke the appearance of adverse reactions, which manifest themselves in the form of allergies to the constituent ingredients.
Long-term use of the drug at an increased dose can provoke hyperuricosuria.
It is extremely rare for the digestive system to experience problems associated with excessive excretion of uric acid in the urine (especially when the dosage is increased).
There may be cases of drug overdose, which is manifested by high levels of uric acid in the urine or blood.
special instructions
The safety of using pancreatin during pregnancy has not been sufficiently studied. Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
In cystic fibrosis, the use of pancreatin in high doses is not recommended due to the increased risk of strictures (fibrotic colonopathy). The dose should be adequate to the amount of enzymes necessary for the absorption of fats, taking into account the quality and quantity of food consumed.
With long-term use, iron supplements are prescribed simultaneously.
Can pregnant women take Pancreatin?
While carrying a child, many women experience problems with the functioning of the digestive system. Violations are manifested by discomfort in the stomach, constipation, nausea and vomiting. Since the action of Pancreatin is aimed at improving digestive processes, many pregnant women ask questions about the possibility of taking the medicine during pregnancy.
Since constipation in pregnant women is associated with problems with the motility of the digestive organs, the drug will not be able to cope with them. Taking medication can only make the situation worse. The same applies to other manifestations, such as heartburn and vomiting.
Clinical studies have not been conducted on pregnant women, so it is impossible to give an exact answer about the possibility of taking Pancreatin and its safety.
Directions for use and doses
- The dose (in terms of lipase) depends on age and the degree of pancreatic insufficiency. The average dose for adults is 150,000 units/day. In case of complete insufficiency of exocrine pancreatic function - 400,000 units/day, which corresponds to the daily requirement of an adult for lipase. The maximum daily dose is 15,000 units/kg.
- Children under 1.5 years old - 50,000 units/day; over 1.5 years - 100,000 units/day. The duration of treatment can vary from several days (if the digestive process is disrupted due to errors in the diet) to several months and even years (if constant replacement therapy is necessary).
How much to drink
When prescribing a medication, doctors use an indicator of lipolytic activity, which is converted into tablets.
Depending on how many times a person eats a day, the number of Pancreatin doses is divided into 5-6 parts. The intestines should not be left without enzymes even with a small snack. The doctor can prescribe up to 18 tablets of medication per day. Most often, a single dose varies from 2 to 4 tablets.
The medication should be taken before eating or immediately after eating. The tablets do not need to be chewed. The effect of the medication can be felt only an hour after taking it, the effect will last approximately 4 hours.
Is it possible for pregnant women
Before deciding to take Pancreatin, pregnant women should consult their doctor. It may not be necessary to take the drug.
The instructions for the medication do not indicate whether the medicine can be taken at such a crucial moment in life.
In the course of the studies, it became known that the use of Pancreatin at any stage of pregnancy does not have any effect on the development and growth of the intrauterine fetus.
Doctors usually prescribe medicine to pregnant women for:
- Gastritis with decreased production of gastric juice
- Chronic pancreatitis
- Disorders of the pancreas
