Amitriptyline-nycomed Tablets, 50 pcs., 25 mg
special instructions
Use with caution for ischemic heart disease, arrhythmia, heart block, heart failure, myocardial infarction, arterial hypertension, stroke, chronic alcoholism, thyrotoxicosis, and during therapy with thyroid drugs. During amitriptyline therapy, caution is required when suddenly moving to a vertical position from a lying or sitting position. If you stop taking it abruptly, withdrawal syndrome may develop. Amitriptyline in doses of more than 150 mg/day reduces the seizure threshold; the risk of developing epileptic seizures in predisposed patients should be taken into account, as well as in the presence of other factors that increase the risk of developing convulsive syndrome (including brain damage of any etiology, simultaneous use of antipsychotic drugs, during the period of ethanol withdrawal or drug withdrawal, having anticonvulsant activity). It should be taken into account that patients with depression may experience suicide attempts. Should only be used in combination with electroconvulsive therapy under close medical supervision. In predisposed patients and elderly patients, it can provoke the development of drug-induced psychoses, mainly at night (after discontinuation of the drug, they disappear within a few days). May cause paralytic ileus, primarily in patients with chronic constipation, the elderly, or those forced to bed rest. Before performing general or local anesthesia, the anesthesiologist should be warned that the patient is taking amitriptyline. With long-term use, an increase in the incidence of caries is observed. The need for riboflavin may increase. Amitriptyline can be used no earlier than 14 days after discontinuation of MAO inhibitors. Should not be used simultaneously with adrenergic and sympathomimetics, incl. with epinephrine, ephedrine, isoprenaline, norepinephrine, phenylephrine, phenylpropanolamine. Use with caution simultaneously with other drugs that have anticholinergic effects. Avoid drinking alcohol while taking amitriptyline. Impact on the ability to drive vehicles and operate machinery: During the treatment period, you should refrain from potentially hazardous activities that require increased attention and rapid psychomotor reactions.
Indications for use of Amitriptyline
What are tablets and solution usually prescribed for?
The drug is indicated:
- for depression (agitation, anxiety, sleep disturbances, alcohol withdrawal, organic brain damage, neurotic withdrawal);
- for behavioral disorders, mixed emotional disorders, nocturnal enuresis , chronic pain syndrome (for cancer pathology, postherpetic neuralgia );
- for bulimia nervosa ;
- for migraine (for prevention);
- for ulcerative lesions of the digestive system .
Indications for the use of Amitriptyline in tablets and in other forms of release are the same.
Amitriptyline, instructions for use (Method and dosage)
The medicine is taken orally immediately after eating, without chewing, which ensures the least irritation of the stomach walls. The initial dosage is 25-50 mg at night for adults. Within 5 days, the amount of the drug is increased to 200 mg per day in 3 doses. If there is no effect within 2 weeks, the dose is increased to 300 mg.
Solutions are administered slowly intravenously and intramuscularly, 20-40 mg 4 times a day with a gradual transition to oral administration. The course of therapy is no more than 8 months. For prolonged headaches, for migraines, chronic pain syndrome of neurogenic origin, for migraines, 12.5-100 mg per day is prescribed.
Instructions for use of Amitriptyline Nycomed are similar. Before use, be sure to familiarize yourself with the contraindications for the drug.
Contraindications
According to the annotation, the medicine is not used:
- for myocardial infarction ;
- intolerance to the main component;
- for angle-closure glaucoma ;
- acute intoxication with psychoactive, analgesic, hypnotics;
- for acute alcohol intoxication;
- during breastfeeding;
- severe disturbances of intraventricular conduction and antioventricular conduction;
- with pathology of the cardiovascular system;
- with suppression of bone marrow hematopoiesis;
- manic-depressive psychoses;
- bronchial asthma;
- chronic alcoholism;
- decreased motor function of the digestive system;
- stroke;
- liver and kidney pathologies;
- intraocular hypertension;
- urinary retention;
- prostatic hyperplasia;
- with hypotension of the bladder;
- thyrotoxicosis;
- pregnancy.
For epilepsy , Amitriptyline is prescribed with caution.
Overdose
Manifestations from the nervous system: coma, stupor, increased drowsiness, anxiety, hallucinations, ataxia, epileptic syndrome, choreoathetosis, hyperreflexia, dysarthria, muscle tissue rigidity, confusion, disorientation, impaired concentration, psychomotor agitation.
Manifestations of an overdose of Amitriptyline from the cardiovascular system: disturbance of intracardiac conduction, arrhythmia, tachycardia, drop in blood pressure, shock, heart failure, rarely - cardiac arrest.
Anuria , oliguria, increased sweating, hyperthermia , vomiting, shortness of breath, depression of the respiratory system, and cyanosis are also noted Possible drug poisoning.
To avoid the negative consequences of an overdose, emergency gastric lavage and administration of cholinesterase inhibitors are required in case of severe anticholinergic manifestations. It is also required to maintain water and electrolyte balance, blood pressure levels, control over the functioning of the cardiovascular system, and carry out resuscitation and anticonvulsant measures if necessary. Forced diuresis, as well as hemodialysis, have not proven effective in treating an overdose of Amitriptyline.
Side effects of Amitriptyline
Nervous system: agitation, hallucinations, disorientation , fainting, asthenia, drowsiness, anxiety, hypomanic state, increased depression, depersonalization , motor restlessness, increased epileptic seizures, extrapyramidal syndrome , ataxia, myoclonus, paresthesia in the form of peripheral neuropathy, tremor of small muscles, headache.
Anticholinergic effects: increased intraocular pressure, blurred vision, mydriasis, dry mouth, tachycardia , difficulty urinating, paralytic ileus, delirium, confusion, decreased sweating.
Cardiovascular system: instability of blood pressure, intraventricular conduction disorders , arrhythmia, orthostatic hypotension , dizziness, palpitations, tachycardia.
Digestive tract: darkening of the tongue, diarrhea, changes in taste perception, vomiting, heartburn , gastralgia, hepatitis, cholestatic jaundice.
Endocrine system: galactorrhea, hyperglycemia , decreased potency or increased libido, increased size of the mammary glands, gynecomastia , testicular swelling, syndrome of inappropriate ADH secretion, hyponatremia. Hypoproteinemia , pollakiuria, urinary retention, enlarged lymph nodes, hyperpyrexia, swelling, tinnitus, and hair loss are also noted
When discontinuing the drug, unusual agitation, sleep disturbances, malaise, headache, diarrhea, nausea, unusual dreams, restlessness, and irritability are noted. When administered intravenously, a burning sensation, lymphangitis , thrombophlebitis , and an allergic response .
Reviews of the side effects of Amitriptyline are quite frequent. When using the drug, addiction may also occur.
Amitriptyline price, where to buy
The price of Amitriptyline in 25 mg tablets in Russia is about 30-40 rubles for 50 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Amitriptyline solution for intravenous and intramuscular administration.
10 mg/ml 2 ml 10 pcs. Federal State Unitary Enterprise Moscow Endocrine Plant 50 rub. order - Amitriptyline tablets 25 mg 50 pcs. OzonOzon LLC
67 RUR order
Pharmacy Dialogue
- Amitriptyline (25 mg tablet No. 50) Ozone LLC
62 RUR order
- Amitriptyline (25 mg tablet No. 50) Ozone LLC
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- Amitriptyline (25 mg tablet No. 50) Moscow Endocrine Plant
30 rub. order
- Amitriptyline (25 mg tablet No. 50) DHF JSC
62 RUR order
- Amitriptyline (amp. 10 mg/ml 2 ml No. 10) Moscow Endocrine Plant
47 RUR order
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Pharmacy24
- Amitriptyline 25 mg No. 50 tablets PrAT “Technolog”, Uman, Cherkasy region, Ukraine
20 UAH. order - Amitriptyline 25 mg N25 tablets TOV Doslidniy, Ukraine/TOV FC Zdorovya, Ukraine
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PaniPharmacy
- Amitriptyline tablets Amitriptyline h/x tablets. w/o 0.025g No. 50 control. cell unitary enterprise Ukraine, OZ GNTsLS LLC
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- Amitriptyline ampoule Amitriptyline liquid solution d/in. 10mg/ml amp. 2ml No. 10 Ukraine, Health of the people LLC
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- Amitriptyline tablets Amitriptyline h/x tablets. 0.025g No. 25 Ukraine, OZ GNTsLS LLC
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- Amitriptyline liquid solution d/in. 1% amp. 2ml No. 10 Ukraine, OZ GNTsLS
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- Amitriptyline tablets Amitriptyline h/x tablets. 0.025g No. 50 Ukraine, Health of the people LLC
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