The action of aminazine and the effects it causes
Antipsychotic
. Reduces or completely eliminates hallucinations and delusions, especially in endogenous diseases.
Sedative
. Relieves overexcitation (psychomotor agitation), reduces the severity of affect (fear, anger, melancholy), stops aggressiveness.
Antiemetic
. Regardless of the cause of vomiting (poisoning, inflammation of the gastrointestinal tract, psychosomatic reactions, gestosis, etc.), it has an effect that reduces gag reflexes. Also relieves (or reduces) hiccups.
Hypotensive
. Reduces blood pressure, as a result of which tachycardia (increased heart rate) often develops.
Other actions: extrapyramidal (muscle tone changes), hypothermic (body temperature decreases), antipruritic (itching decreases), antiallergic, anticonvulsant, hypnotic, analgesic.
Aminazine, 10 pcs., 2 ml, 25 mg/ml, solution for intravenous and intramuscular administration
Aminazine weakens the vasoconstrictor effect of ephedrine.
May mask some manifestations of ototoxicity (tinnitus, dizziness) of ototoxic drugs, especially antibiotics.
Reduces the antiparkinsonian effect of levodopa (due to the blockade of dopamine receptors), as well as the effects of amphetamines, clonidine and guanethidine. Strengthens the anticholinergic effects of other drugs, while its own antipsychotic effect may decrease.
With the simultaneous use of Aminazine with prochlorperazine, which is related in chemical structure, an overdose and prolonged loss of consciousness may occur. Compatible with other antipsychotic drugs, anxiolytics and antidepressants.
Long-term combination with analgesics and antipyretics is undesirable (possible development of hyperthermia).
When used simultaneously with other drugs that have a depressant effect on the central nervous system (general anesthesia, anticonvulsants, narcotic analgesics, ethanol and drugs containing it, barbiturates and other hypnotics, anxiolytic drugs (tranquilizers) and others), it is possible to enhance and prolongation of the depressive effect, as well as respiratory depression. Prescription together with tricyclic antidepressants, maprotiline or monoamine oxidase inhibitors increases the risk of developing neuroleptic malignant syndrome.
With drugs for the treatment of thyrotoxicosis, the risk of developing agranulocytosis increases.
With other drugs that cause extrapyramidal reactions, Aminazine increases the frequency and severity of extrapyramidal disorders.
With antihypertensive drugs, it increases the severity of the decrease in blood pressure in orthostasis.
Antacids, antiparkinsonian drugs, lithium preparations can interfere with the absorption of Aminazine.
Hepatotoxic drugs when used together with Aminazine increase the risk of developing toxic effects on the liver.
During treatment with Aminazine, the administration of epinephrine should be avoided (due to the possibility of distorting the effect of epinephrine and further reducing blood pressure). Drugs that inhibit bone marrow hematopoiesis increase the risk of myelosuppression.
Aminazine recipe in Latin
Rp.: Sol. Chiorpromazini 2.5% - 2.0 Dtd No. 10 in amp. S. 2.0 intramuscularly 2 times a day. Rp.: Tab. Chiorpromazini 0.05 Dtd No. 50 S. 1 tablet 3 times a day.
The main difference between chlorpromazine and other antipsychotics is its strong and quickly onset sedative (calming) effect. Therefore, in practice, it is widely used only as an “ambulance” remedy for psychosis, nervous breakdowns, aggression, etc.
Due to its side effects, it is used extremely rarely for permanent or long-term use (only in cases where other means are not effective).
Like any medicine, aminazine should be used only after examination by a doctor and determination of indications and contraindications.
Compound
Contains the active substance chlorpromazine hydrochloride .
The dragee contains 50 or 100 mg of this substance. Auxiliary elements: sunflower oil, talc, gelatin, sucrose, wax, starch syrup, titanium dioxide, iron oxide.
The solution contains 25 mg of chlorpromazine per 1 ml.
Tablets contain 25, 50 or 100 mg of active substance in the form of hydrochloride. Auxiliary elements are: magnesium stearate, cellulose, copovidone, starch, lactose monohydrate, croscarmellose sodium.
Indications for use of Aminazin
In psychiatric practice, the drug is used in the treatment of psychomotor agitation in patients with schizophrenia . The drug is prescribed for chronic psychosis, hypomanic agitation, acute delusional states, psychopathy, insomnia, anxiety, mental illnesses accompanied by agitation, anxiety, fear, for which tablets are often used.
Also, indications for the use of Aminazin are: alcoholic psychosis , persistent hiccups , “indomitable” vomiting, nausea. For persistent pain, the drug enhances the effect of analgesic medications.
The medicine is prescribed for diseases accompanied by increased muscle tone: tetanus (combination therapy with barbiturates), after suffering cerebrovascular accidents.
Previously, Aminazine was used as part of “lytic” mixtures (for artificial hypothermia ).
In anesthesiology, medication is prescribed to potentiate general anesthesia and for premedication .
In dermatological practice, the drug is used for itchy dermatoses . The drug is prescribed for the treatment of acute “intermittent” porphyria .
Side effects of Aminazine
Let's look at the side effects of Aminazine. At the first stages of therapy, dry mouth, increased drowsiness , accommodation paresis, constipation, dizziness, appetite disturbances, tachycardia, a severe form of orthostatic hypotension, decreased potency, urinary retention, sleep disorders, allergic reactions , frigidity , drop in blood pressure are noted.
Long-term therapy with chlorpromazine causes neuroleptic depression , cramps of the tongue, neck muscles, floor of the mouth, extrapyramidal disorders , akathisia, akineto-rigid phenomena, delayed reaction to stimuli, mental changes, amenorrhea , hypercoagulation, inhibition of bone marrow hematopoiesis, cardiac arrhythmias, cholestatic jaundice, gynecomastia, hyperplolactinemia , galactorrhea, skin pigmentation, oliguria, diarrhea, vomiting, neuroleptic malignant syndrome. When administered intramuscularly, infiltrates may form; with intravenous infusion - phlebitis .
Overdose
An overdose is manifested by blurred visual perception, hyperreflexia or areflexia . Cardiotoxic effects in the form of shock, drop in blood pressure, development of heart failure , arrhythmia, cardiac arrest, ventricular fibrillation, and changes in the QRS complex on the electrocardiogram are also noted
Neurotoxic effects include coma, stupor, drowsiness, disorientation , convulsions, confusion, agitation, respiratory depression, pulmonary edema, vomiting, muscle rigidity, hypothermia, or hyperpyrexia .
The administration of enterosorbents and gastric lavage are required. When arrhythmia develops, phenytoin is administered intravenously; when heart failure develops, the use of cardiac glycosides . When blood pressure drops, vasopressors ( phenylephrine , norepinephrine) are given intravenously. Diazepam is indicated for the development of seizures. Diphenhydramine and diphenyltropine are effective for parkinsonism For five days, control over the functioning of the cardiovascular system and respiratory system is required, and consultation with a psychotherapist is required. Dialysis has not proven effective.
Pharmacodynamics and pharmacokinetics
The active component is a phenothiazine derivative. The drug has antiemetic, sedative, antipsychotic, weak hypothermic, vasodilating, local irritant, and moderate anticholinergic effects.
The antipsychotic effect is achieved by blockade of dopamine D2 receptors in the mesocortical and mesolimbic systems. The antipsychotic effect is manifested in the elimination of delusions, hallucinations and other productive symptoms of psychosis.
Aminazine helps relieve various types of psychomotor agitation, reduces the severity of psychotic fear and aggressiveness. The sedative effect is achieved by blocking the adrenergic receptors of the reticular pharmacy, located in the brain stem.
The drug inhibits conditioned reflex activity (especially motor-defensive receptors), reduces the spontaneity of motor activity, reduces sensitivity to exogenous and endogenous stimuli while maintaining consciousness, and relaxes skeletal muscles. Prescribing large dosages causes drowsiness.
Blockade of dopamine D2 receptors in the vomiting center in the trigger zone , as well as blockade of the vagus nerve in the gastrointestinal tract provide an antiemetic effect. Aminazine has a weak effect on m-cholinergic receptors, a pronounced effect is observed on alpha-adrenergic receptors.
The medication is able to completely eliminate the effects caused by epinephrine . The hypothermic effect is provided by blockade of dopamine receptors located in the hypothalamus. The medication increases heart rate, lowers blood pressure, has a pronounced cataleptogenic effect , a weak antihistamine effect, and reduces the permeability of capillary walls. When dopamine receptors are blocked, the production of prolactin by the pituitary gland increases. With intramuscular administration, the sedative effect develops after 15 minutes, with oral administration - after 2 hours. Tolerance to the hypotensive and sedative effects develops after 1 week.
When taken orally, the antipsychotic effect is observed on days 4-7. The most pronounced therapeutic effect lasts from 6 weeks to six months.
Instructions for use of Aminazin (Method and dosage)
The drug is taken orally, administered intramuscularly, intravenously.
Aminazine tablets, instructions for use
The initial daily dosage in psychiatric practice is 25-100 mg (for 1-4 doses). Gradually, the amount of the drug is increased every 3-4 days by 25-50 mg until the desired effect is achieved. In case of anxiety before surgical interventions, the medication is prescribed 2-3 hours before surgery. The maximum one-time intake is 300 mg, per day - 1.5 g.
Solution
A 2.5% solution is administered intravenously and intramuscularly.
The initial dose is 25-50 mg. Before intramuscular administration, the drug solution is diluted in 2-5 ml of procaine (0.25-0.5%), or in a 0.9% sodium chloride solution. Aminazine is administered deeply intramuscularly. Before surgical interventions in cases of anxiety, patients are administered the drug intramuscularly at the rate of 0.55 mg per 1 kg of weight 2 hours before the intended surgical treatment. For tetanus, 0.55 mg/kg is administered intramuscularly every 8 hours, the infusion rate is 1 mg/2 minutes.
Maximum one-time intramuscular injection is 150 mg, per day - 1 g.
The maximum one-time intravenous dose is 100 mg, per day - 250 mg.
In pediatric practice, only special, pediatric forms of the drug are used.
Aminazine price, where to buy
A package of 10 ampoules of 2 ml 25 mg/ml costs approximately 60 rubles.
10 tablets of 25 mg cost about 150 rubles.
The price of Aminazin in tablets is approximately 70 rubles per package of 10 pieces of 100 mg.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Aminazine solution for intravenous and intramuscular administration.
2.5% 2ml 10 pcs. JSC Novosibkhimpharm 197 rub. order - Aminazine tablets p.p.o. 25 mg 10 pcs. PJSC Valenta Pharm/JSC Valenta Pharmaceuticals/JSC Valenta Pharm
160 rub. order
Pharmacy Dialogue
- Aminazine (tab.p.pl/vol. 50 mg No. 10) Valenta Pharmaceuticals OJSC
220 rub. order
- Aminazine (tab.p.pl/vol. 25 mg No. 10) Valenta Pharmaceuticals OJSC
146 RUR order
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Pharmacy24
- Aminazine 2.5% 2 ml N10 injection solution PAT "Galichfarm", Ukraine
34 UAH. order
PaniPharmacy
- Aminazine ampoule Aminazine solution d/in. 2.5% amp. 2ml No. 10 Ukraine, Galichfarm JSC
30 UAH order
- Aminazine tablet. p/o 0.1g No. 10 in pack.
61 UAH order
- Aminazine ampoule Aminazine solution d/in. 2.5% amp. 2ml No. 10 Ukraine, Health of the people LLC
25 UAH order
- Aminazine tablets Aminazine tablets. p/o 0.025g No. 20 Ukraine, Health LLC
52 UAH order
- Aminazine tablets Aminazine tablets. p/o 0.1g No. 10 Ukraine, Health LLC
44 UAH order
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Contraindications
Aminazine is not used in comatose states of any etiology, with severe depression of the functions of the nervous system, with severe pathology of the cardiovascular system, with intolerance to the active substance, with progressive diseases of the spinal cord and brain of a systemic nature, with breastfeeding, with ulcerative lesions of the digestive tract .
Due to the risk of developing hepatotoxic reactions, Aminazine is prescribed with caution for alcoholism. For breast cancer, pathological changes in the blood, prostatic hyperplasia , angle-closure glaucoma, Parkinson's disease, myxedema, epilepsy, vomiting, cachexia, Reye's syndrome, and elderly patients, the drug is prescribed with caution.
Reviews about Aminazine
The drug has a very powerful effect, helping to eliminate signs of psychomotor agitation. However, reviews of Aminazine are very different.
Some people maintain that the drug is very effective for schizophrenia, Alzheimer's disease, epilepsy, psychosis, and relieves stress and anxiety. Others consider the drug sometimes even simply terrible; they say that it provokes epileptic seizures, hand tremors, a state of increased drowsiness, and various personality disorders.
In any case, this medication should only be used under the supervision of a physician.
