Nosological classification (ICD-10)
- M02.3 Reiter's disease
- M06.9 Rheumatoid arthritis, unspecified
- M07.3 Other psoriatic arthropathies (L40.5+)
- M19.9 Arthrosis, unspecified
- M45 Ankylosing spondylitis
- M54 Dorsalgia
- M54.1 Radiculopathy
- M71 Other bursopathies
- M77.9 Enthesopathy, unspecified
- M79.1 Myalgia
- M79.2 Neuralgia and neuritis, unspecified
- T14 Injury of unspecified location
- T14.3 Dislocation, sprain and damage to the capsular-ligamentous apparatus of a joint of an unspecified area of the body
- T14.9 Injury, unspecified
Ketonal's analogs
Level 4 ATC code matches:
Voltaren Emulgel
Ultrafastin
Indomethacin
Dicloran
Dicloran Plus
Dolgit
Nise
Ketorol
Febrofeed
Fastum gel
Diclofenac
Finalgel
Bystrumgel
Deep Relief
Butadion
Diklovit
Artrosilene
Olfen
Fanigan Fast
Analogs of Ketonal in tablets and capsules - Artrum , Ketoprofen , Indomethacin , Ibuprofen , Osteoartisi Active Plus , Artron Complex , Flamax Forte , Denebol , Ketoprofen MV , Chondra-Sila , Flexen , Bystrumkaps , Oruvel , Ultrafastin , Profenid and others.
Analogues of Ketonal in the form of a solution are Artrosilene , Diclofenac , Denebol , OKI , Emodol , Oruvel , Flamax , Flexen , Chondrolone and others.
Analogs of cream and gel Ketonal - Artrosilen , Ketoprofen , Voltaren , Febrofid , Bystrumgel , F-gel , Fastum- , Ketoprom , Oruvel , Ketum-gel , Reanimator Thermo-gel , Valusal , Arthropod , Ultrafastin , Fort-gel , Profenid , Flexen .
Analogues of Ketonal in the form of suppositories are Artrum , Oruvel , Flexen , Artrosilen .
The price of analogues may differ significantly from the cost of Ketonal. When replacing the drug, you should consult a specialist.
Indications for the drug Ketonal®
Symptomatic treatment of painful and inflammatory processes of various origins, including:
rheumatoid arthritis and periarthritis;
ankylosing spondylitis (Bechterew's disease), psoriatic arthritis, reactive arthritis (Reiter's syndrome);
osteoarthritis of various localizations;
tendonitis, bursitis, myalgia, neuralgia, radiculitis;
injuries of the musculoskeletal system (including sports), bruises of muscles and ligaments, sprained ligaments, rupture of ligaments and muscle tendons.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Ketoprofen inhibits the activity of cyclooxygenase , which inhibits the process of prostaglandin .
The drug also inhibits the synthesis of bradykinin , lipoxygenase , stabilizes lysosomal membranes in the cell and suppresses the production of enzymes that are involved in the inflammatory process. Ketoprofen does not have a negative effect on the condition of articular cartilage.
Pharmacokinetics
The process of absorption of ketoprofen in the body is very slow and it practically does not accumulate in the body. Bioavailability - 5%. The drug penetrates well and reaches therapeutic concentrations in synovial fluid, muscles, ligaments, and subcutaneous tissue. Its concentration in blood plasma is insignificant. Metabolized in the liver to form conjugates. Excreted in urine. Slowly.
Contraindications
hypersensitivity to ketoprofen or other components of the drug, as well as salicylates, tiaprofenic acid or other NSAIDs, fenofibrate, UV blockers, fragrances;
a history of attacks of bronchial asthma after the use of NSAIDs and salicylates;
pregnancy (III trimester);
children's age (up to 15 years);
violation of the integrity of the skin (eczema, weeping dermatitis, open or infected wound);
history of photosensitivity reactions;
exposure to sunlight, incl. indirect sunlight and UV irradiation in a solarium throughout the entire treatment period and for another 2 weeks after stopping treatment with the drug.
With caution: impaired liver and/or kidney function, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure.
Interaction
Ketoprofen reduces the effectiveness of antihypertensive drugs and diuretics , enhances the effect of hypoglycemic oral drugs and a number of anticonvulsants ( phenytoin ).
Concomitant use with anticoagulants , antiplatelet agents and thrombolytics increases the risk of bleeding. Taking Ketonal with salicylates , other NSAIDs , ethanol and corticosteroids increases the risk of developing gastrointestinal complications.
Ketonal increases the concentration in the blood of lithium drugs , cardiac glycosides , CCBs , methotrexate , cyclosporine , and when administered simultaneously with potassium-sparing diuretics , ACE inhibitors , tacrolimus , low molecular weight heparins and trimethoprim hyperkalemia increases .
Side effects
The most common manifestations associated with the use of a cream containing ketoprofen are local manifestations.
Classification of adverse reactions according to the frequency of their detection: very often (≥1/10); often (≥1/100, <1/10); uncommon (≥1/1000, <1/100); rare (≥1/10000, <1/1000); very rare (<1/10000).
Allergic reactions: very rarely - angioedema, anaphylaxis.
From the skin and skin appendages: infrequently - erythema, itching, burning, eczema, mild transient dermatitis; rarely - urticaria, rash, photosensitivity, bullous dermatitis, purpura, erythema multiforme, lichenoid dermatitis, skin necrosis, Stevens-Johnson syndrome; very rarely - a single case of severe contact dermatitis (due to poor hygiene and insolation), a single case of severe generalized photodermatitis, toxic epidermal necrolysis.
From the respiratory system: very rarely - asthmatic attacks as a variant of an allergic reaction.
From the urinary system: very rarely - deterioration of renal function in patients with chronic renal failure.
Release form
- Solution 50 mg/ml for intravenous and intramuscular administration - in dark glass ampoules of 2 ml, in a blister of 5 and 10 ampoules in cardboard packaging No. 10.2
- Gel 2.5% - for external use, colorless, transparent, homogeneous in an aluminum tube of 50, 100 g in a cardboard package.
- Cream 5% - for external use, homogeneous, white in aluminum tube, 30, 50 g in a cardboard package.
- Ketonal tablets 50 mg are biconvex round, film-coated in dark glass bottles of 20 pcs. in cardboard packaging.
- Capsules 50 mg with modified release - blue in blister in cardboard packaging No. 20, 30.
- Rectal suppositories are smooth, white, homogeneous in a blister of 6 suppositories in a cardboard package No. 12.
special instructions
Avoid contact of the cream with mucous membranes and eyes. If any side effects occur, you should stop using the drug and consult a doctor.
If the patient forgets to apply the cream, it should be applied at the time the next dose is due, but not double it.
Cream for external use Ketonal® can be used in combination with other dosage forms of Ketonal® (capsules, tablets, suppositories). The total daily dose, regardless of the dosage form, should not exceed 200 mg.
If skin reactions occur, incl. developed during combined use with octocrylene-containing drugs, treatment should be stopped immediately. To reduce the risk of developing photosensitivity, it is recommended to protect the areas of skin treated with the cream with clothing from exposure to UV radiation throughout the entire treatment period and for another 2 weeks after stopping use. Do not use as occlusive dressings.
You should wash your hands thoroughly after each application of the drug.
Effect on ability to concentrate. There is no data on the effect of Ketonal® cream on psychophysical activity.
Compound
- Solution - ketoprofen , propylene glycol, ethanol, benzyl alcohol, sterile water.
- Gel - ketoprofen, trolamine, carbomer , ethanol, lavender essential oil, sterile water.
- Cream - ketoprofen, isopropyl myristate, methylhydroxybenzoate, propylene glycol, propylhydroxybenzoate, white petrolatum, magnesium sulfate, elphacos ST9, propylene glycol oleate, glyceryl, water.
- Tablets - silicon dioxide, magnesium stearate, talc, corn starch, lactose, macrogol , hypromellose, titanium dioxide, indigo carmine, wax, talc.
- Capsules - ketoprofen, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, povidone, polysorbate, purified water, eudragit, triethyl citrate, talc, yellow iron oxide, purified water, silicon dioxide, titanium dioxide, gelatin.
- Suppositories - ketoprofen, solid fat, glyceryl caprylocaprate.
Reviews about Ketonal
On the Internet you can find numerous reviews about Ketonal, mostly favorable. The most favorable reviews about Ketonal in tablets and injections:
- “... I had a kidney stone pass, hellish pain, neither baralgin nor other analgesics helped. The emergency doctor gave Ketonal injections and the pain went away almost immediately. An excellent pain reliever, not a narcotic and affordable.”
- “... I had a tooth removed. During extraction, the tooth crumbled and when they began to pull out the roots, there was hellish pain. But after the Ketonal injection I stopped feeling pain. A good cure for toothache."
- “... I suffer from osteochondrosis, for which I take Ketonal tablets and use cream, it helps a lot.”
Many patients leave good reviews about Ketonal cream and often call it “ointment”: “...my mother has been using Ketonal ointment for arthrosis for quite a long time. The drug relieves pain in the knee joints well and quickly. It’s not the cheapest drug, but it’s very effective.”
There are also negative reviews: “... I ride a horse. After the fall, my ankle began to hurt severely. I used the cream for a month. It didn’t help, the joint continued to hurt. We got “horse balm” at the hippodrome – excellent results.”
Those who are not familiar with the drug ask the question: “what is Ketonal ointment for?” It is successfully used for injuries to the ligamentous apparatus and muscles, which is very important for people leading an active lifestyle. What else can the ointment be used for? Local treatment in the forms of cream, ointment, gel is very effective for inflammation of the veins (phlebitis). In this case, NSAIDs are prescribed in parallel with venotonics and thrombolytics.
Reviews about the gel are also positive, and it is noted that this dosage form is absorbed more easily and quickly, without leaving marks on the skin and clothing; the use of the gel is more economical.
There are also numerous positive reviews about suppositories in gynecology: “... For me, the beginning of the menstrual cycle is almost always accompanied by severe pain. Whatever I drank. The emergency doctor recommended Ketonal suppositories and the pain subsided. Of course, the application procedure is not very pleasant. After inserting the suppository, I feel some discomfort (slight burning and itching), but they quickly relieve the pain and the effect lasts the whole day. Excellent product."
Ketonal price, where to buy
The price of Ketonal depends on the form of the drug.
The price of Ketonal in injections (ampoules 2 ml 100 mg) No. 10 varies from 230 to 305 rubles per pack; Ketonal ampoules No. 50 – 957 – 1490 rubles.
The price of Ketonal in tablets 100 mg No. 20 ranges from 200 to 210 rubles; tablets Ketonal Retard 150 mg No. 20 –235 – 302 rubles.
The cost of Ketonal in capsules 50 mg No. 25 is 105 – 115 rubles.
The price of Ketonal cream 5% in a 30 g tube varies from 230 to 297 rubles; 50 g – from 310 to 395 rubles.
The price of Ketonal gel 2.5% in a 100 g tube ranges from 338 to 466 rubles per package.
The price of Ketonal in candles No. 12 pieces varies from 283 to 345 rubles.
You can purchase medications without difficulty in most pharmacies in Moscow and other cities.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Ketonal solution for intravenous and intramuscular administration.
50 mg/ml 2 ml 10 pcs. Lek dd 240 rub. order - Ketonal tablets p.p.o. 100 mg 20 pcs Lek dd
RUB 153 order
- Ketonal gel 2.5% 50gLek dd/Salutas Pharma GmbH
RUR 366 order
- Ketonal gel 2.5% 100g Salutas Pharma GmbH
RUR 515 order
- Ketonal cream 5% 50gLek dd/Salutas Pharma GmbH
455 rub. order
Pharmacy Dialogue
- Ketonal gel (tube 2.5% 100g)Salutas Pharma GmbH
RUR 523 order
- Ketonal (solution intravenously and intravenously 50 mg/ml 2 ml No. 5)Lek
108 RUR order
- Ketonal (tab.p.pl/vol. 100 mg No. 20)Lek
RUB 139 order
- Ketonal cream (tube 5% 50g)Salutas Pharma GmbH
427 RUR order
- Ketonal 2.5% gel 50gSalutas Pharma GmbH
RUB 342 order
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Pharmacy24
- Ketonal 100 mg 2 ml No. 10 injection solution Lek pharmaceutical company d.d., Slovenia
204 UAH.order - Ketonal forte 100 mg No. 20 tablets Lek pharmaceutical company d.d., Slovenia
133 UAH order
- Ketonal 100 mg No. 12 suppositories Lek pharmaceutical company d.d. Slovenia / Sandoz Ilac Sanay ve Ticaret A.S., Turecchina
149 UAH order
- Ketonal retard 150 mg No. 2 tablets Lek pharmaceutical company d.d., Slovenia
182 UAH order
- Ketonal 2.5% 50 g gel Salutas Pharma GmbH, Nimechchina
93 UAH order
PaniPharmacy
- Ketonal capsule Ketonal capsules 50 mg No. 25 Slovenia, Lek
117 UAH. order
- Ketonal suppository Ketonal suppository 100 mg No. 12 Slovenia, Lek
152 UAH order
- Ketonal retard tablets Ketonal retard tablets 150 mg No. 20 Slovenia, Lek
198 UAH order
- Ketonal duo capsule Ketonal DUO capsules 150 mg No. 20 Slovenia, Lek
192 UAH order
- Ketonal forte tablets Ketonal forte film-coated tablets 100 mg No. 20 Slovenia, Lek
144 UAH order
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