Azithromycin is a macrolide antibiotic that belongs to the azalide group. The molecule is formed as a result of the introduction of a nitrogen atom into the lactone ring of erythromycin A. The mechanism of action of azithromycin is to suppress bacterial protein synthesis due to binding to the 50 S-subunit of ribosomes and inhibition of peptide translocation.
When taken, azithromycin is distributed throughout the body. Pharmacokinetic studies have shown that the concentration of azithromycin in tissues is significantly higher (50 times) than in plasma, indicating strong binding of the drug to tissues.
Indications for use
Infections caused by microorganisms sensitive to azithromycin:
- ENT organs (bacterial pharyngitis/tonsillitis, sinusitis, otitis media);
- respiratory tract infections (bacterial bronchitis, community-acquired pneumonia);
- infections of the skin and soft tissues, erythema migrans (initial stage of Lyme disease), erysipelas, impetigo, secondary pyodermatoses, acne vulgaris (acne vulgaris) of moderate severity;
- sexually transmitted infections: uncomplicated genital infections caused by Chlamydia trachomatis.
Buy Azitrox powder for oral suspension 200mg/5ml 15.9g in pharmacies
Buy Azitrox in pharmacies Azitrox in the medicine directory DOSAGE FORMS powder for the preparation of suspension for oral administration 200 mg/5ml
MANUFACTURERS Pharmstandard (Russia)
GROUP Antibiotics - macrolides and azalides
COMPOSITION Active substance - azithromycin.
INTERNATIONAL NON-PROPENTED NAME Azithromycin
SYNONYMS Azivok, Azimicin, Azitral, Azithromycin, Azithromycin Zentiva, Azithromycin Forte, Azithromycin-OBL, Azithromycin-Akos, AzitRus, AzitRus forte, Azicide, Vero-Azithromycin, Zetamax retard, Zi-Factor, Zimax, Zitrolide, Zitrolide forte, Zithrocin, Sumazid, Sumamed forte, Sumamecin, Sumamox, Sumatrolide Solutab, Hemomycin, Ecomed
PHARMACOLOGICAL ACTION Pharmacological action - antibacterial. Suppresses protein biosynthesis, slowing down the growth and reproduction of bacteria; at high concentrations, a bactericidal effect is possible. Stable in an acidic environment, lipophilic, quickly absorbed from the gastrointestinal tract. The maximum concentration is created after 2-3 hours, the half-life is 68 hours. Stable plasma levels are achieved after 5-7 days. Easily passes histohematic barriers and enters tissues. Concentrations in tissues and cells are 10-50 times higher than in plasma, and at the site of infection - 24-34% higher than in healthy tissues. A high level (antibacterial) remains in tissues for 5-7 days after the last injection. Excreted unchanged in bile (50%) and in urine (6%). The spectrum of action is wide and includes gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, streptococci of groups C, F, G, Streptococcus viridans ), except for those resistant to erythromycin, and gram-negative (Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Campylobacter jejuni, Legionella pneumophila, Neisseria gonorrhoeae, Gardnerella vaginalis) microorganisms, anaerobes (Bacteroides bivius, Peptostreptococcus spp., Peptococcus, Clostridium perfringens) , chlamydia (Chlamydia trachomatis, Chlamydia pneumoniae), mycobacteria (Mycobacteria avium complex), mycoplasma (Mycoplasma pneumoniae), ureoplasma (Ureaplasma urealyticum), spirochetes (Treponema pallidum, Borrelia burgdorferi).
INDICATIONS FOR USE Infections of the upper and lower respiratory tract (streptococcal pharyngitis and tonsillitis, bacterial exacerbation of chronic obstructive pneumonia, interstitial and alveolar pneumonia, bacterial bronchitis), ENT organs (otitis media, laryngitis and sinusitis), genitourinary system (urethritis and cervicitis), skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses), chronic stage of erythema migrans (Lyme disease).
CONTRAINDICATIONS Hypersensitivity to macrolides, severe liver dysfunction, pregnancy, lactation.
SIDE EFFECTS Nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea, melena, cholestatic jaundice, chest pain, palpitations, weakness, drowsiness, headache, dizziness, nephritis, vaginitis, candidiasis, neutropenia or neutrophilia, pseudomembranous colitis, photosensitivity , rash, angioedema, eosinophilia; in children, in addition, hyperkinesia, agitation, nervousness, insomnia, conjunctivitis.
INTERACTIONS Antacids containing aluminum or magnesium hydroxide reduce absorption and maximum concentrations.
METHOD OF APPLICATION AND DOSAGE Orally, 1 hour before meals or 2 hours after meals, 1 time per day.
OVERDOSE No information available.
SPECIAL INSTRUCTIONS Use with caution in cases of severe dysfunction of the liver, kidneys, and cardiac arrhythmias. After discontinuation of treatment, hypersensitivity reactions may persist in some patients, which requires specific therapy under medical supervision.
STORAGE CONDITIONS List B. Store in a dry place, protected from light, at room temperature, out of reach of children.
Directions for use and doses
Azithromycin should be used as a single daily dose, regardless of meals. Swallow the tablets without chewing. If you miss 1 dose of the drug, the missed dose should be taken as soon as possible, and subsequent doses should be taken at intervals of 24 hours.
Adults and children weighing ≥45 kg.
For infections of the ENT organs, respiratory tract, skin and soft tissues
(except for chronic migratory erythema), the total dose of azithromycin is 1500 mg (500 mg 1 time per day). The duration of treatment is 3 days.
For acne vulgaris, the recommended total dose of azithromycin is 6 g, which should be taken according to the following regimen: 500 mg once a day for 3 days, followed by 500 mg once a week for 9 weeks. The second week's dose should be taken 7 days after the first tablet is taken, and the 8 subsequent doses should be taken at 7-day intervals.
For erythema migrans, the total dose of azithromycin is 3 g, which should be taken according to the following regimen: 1000 mg on the first day, followed by 500 mg once a day for 5 days.
For sexually transmitted infections, the recommended dose of azithromycin is 1000 mg.
Azitrox powder for the preparation of suspension for oral administration 200 mg/5 ml 20 ml in Bryansk
Take orally
, 1 hour before or 2 hours after meals, 1 time per day.
To prepare the suspension, add 9.5 ml of water (distilled or boiled and cooled) to the bottle with the powder. Measure the water using the dosing pipette included with the bottle. Shake the contents of the bottle thoroughly until a homogeneous suspension is obtained. The actual volume of the prepared suspension will be 20 ml.
The suspension must be shaken before each use.
To dispense the finished suspension, use a dosing pipette or measuring spoon. Immediately after taking the suspension, you need to drink a few sips of water to rinse and swallow the drug remaining in the mouth.
After use, a measuring spoon or pipette, which is previously disassembled, washed with running water, dried and stored with the drug.
Children over 6 months For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues (except for erythema migrans):
at the rate of 10 mg/kg body weight 1 time per day for 3 days (course dose 30 mg/kg). Children weighing up to 10 kg are recommended to take the drug in powder form to prepare an oral suspension with a concentration of 100 mg/5 ml.
- For patients weighing 6 kg - 1.5 ml (60 mg) suspension,
- For patients weighing 7 kg - 1.8 ml (70 mg) suspension,
- For patients weighing 8 kg - 2 ml (80 mg) suspension,
- For patients weighing 9 kg - 2.3 ml (90 mg) suspension,
- For patients weighing 10-14 kg - 2.5 ml (100 mg) suspension,
- For patients weighing 15-24 kg - 5 ml (200 mg) suspension,
- For patients weighing 25 - 34 kg - 7.5 ml (300 mg) suspension,
- For patients weighing 35 -44 kg - 10 ml (400 mg) suspension,
- For patients weighing more than 45 kg (doses for adults are prescribed) 12.5 ml (500 mg) suspension.
When treating the initial stage of Lyme disease (erythema migrans):
1st day:
- For patients weighing 6 kg - 3 ml (120 mg) suspension,
- For patients weighing 7 kg - 3.5 ml (140 mg) suspension,
- For patients weighing 8 kg - 4 ml (160 mg) suspension,
- For patients weighing 9 kg - 4.5 ml (180 mg) suspension,
- For patients weighing 10-14 kg - 5 ml (200 mg) suspension,
- For patients weighing 15-24 kg - 10 ml (400 mg) suspension,
- For patients weighing 25 - 34 kg - 15 ml (600 mg) suspension,
- For patients weighing 35 -44 kg - 20 ml (800 mg) suspension,
- For patients weighing more than 45 kg (doses for adults are prescribed) 25 ml (1.0 g) suspension.
From 2nd to 5th day:
- For patients weighing 6 kg - 1.5 ml (60 mg) suspension,
- For patients weighing 7 kg - 1.8 ml (70 mg) suspension,
- For patients weighing 8 kg - 2 ml (80 mg) suspension,
- For patients weighing 9 kg - 2.3 ml (90 mg) suspension,
- For patients weighing 10-14 kg - 2.5 ml (100 mg) suspension,
- For patients weighing 15-24 kg - 5 ml (200 mg) suspension,
- For patients weighing 25 - 34 kg - 7.5 ml (300 mg) suspension,
- For patients weighing 35 -44 kg - 20 ml (800 mg) suspension,
- For patients weighing more than 45 kg (doses for adults are prescribed) 12.5 ml (500 mg) suspension.
Adults.
For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues (except for erythema migrans):
500 mg once a day for 3 days (course dose - 1.5 g).
For uncomplicated urethritis/cervicitis - once 1.0 g (25 ml)
For the treatment of acne (acne vulgaris) of moderate severity.
On days 1, 2 and 3 of treatment, take 500 mg (12.5 ml) once a day, then take a break from the fourth to the seventh day, from the eighth day of treatment take 500 mg once a week for 9 weeks (course dose 6.0 g).
Patients with impaired renal function.
If renal function is impaired (creatinine clearance more than 40 ml/min), no dose adjustment is required.
Patients with impaired liver function.
For moderate liver dysfunction, no dose adjustment is required.
Features of application
Use during pregnancy or breastfeeding
Pregnancy.
The study of the effect on the reproductive function of animals was carried out with the introduction of doses corresponding to moderate toxic doses for the maternal body. These studies provided no evidence of toxic effects of azithromycin on the fetus. However, there are no adequate and well-controlled studies in pregnant women. Since studies of the effect on reproductive function in animals do not always correspond to the effect in humans, azithromycin should be prescribed during pregnancy only for health reasons.
Breastfeeding.
Azithromycin has been reported to pass into breast milk, but there have been no adequate and well-controlled clinical studies to characterize the pharmacokinetics of azithromycin excretion into breast milk. The use of azithromycin during breastfeeding is possible only if the expected benefit to the mother outweighs the potential risk to the child.
Fertility.
Fertility studies were performed on rats; pregnancy rates decreased after administration of azithromycin. The relevance of these data to humans is unknown.
Children
The drug should be used in children weighing ≥45 kg. For children weighing less than 45 kg, it is recommended to use other dosage forms of azithromycin, such as suspension.
The ability to influence the reaction rate when driving vehicles or other mechanisms
There is no evidence that azithromycin can impair the ability to drive vehicles or use other mechanisms, but the possibility of adverse reactions such as dizziness, drowsiness, and blurred vision should be taken into account.
Note!
Description of the drug Azitrox table. p/o 500 mg No. 3 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
