Pharmacodynamics and pharmacokinetics
Multicomponent product.
Acetylsalicylic acid has an antipyretic and anti-inflammatory effect, reduces pain, and also moderately suppresses platelet and thrombus formation processes, improves perfusion at the site of inflammation.
Paracetamol has an analgesic, antipyretic and weak anti-inflammatory effect, which is associated with its effect on the thermoregulation center and a weak ability to suppress the biosynthesis of prostaglandins.
Caffeine increases the excitability of the spinal cord, vasomotor and respiratory centers, dilates the kidneys, blood vessels of the muscles, brain, heart, and reduces platelet aggregation; reduces the feeling of fatigue, drowsiness , increases performance.
In this combination, it has almost no stimulating effect on the brain, but helps regulate cerebral vascular tone and accelerate perfusion.
What does Askofen help with?
The composition of this medicine is similar to Citramon, only different proportions are used. The drug helps relieve pain, inflammation, and it also normalizes the temperature if it is elevated. Due to the fact that it contains caffeine, the effect of which is described above, the excitability of the central nervous system increases, fatigue goes away to some extent, and the person becomes more active. Askofen increases blood pressure if it is low. It should be taken for hypotension in the amount of 2 tablets, but it does not help everyone, and its effect is short-lived (relates to increasing blood pressure). Continuous use of the drug is not recommended.
Contraindications
- Lesions of the digestive tract of an erosive-ulcerative nature.
- "Aspirin" asthma.
- Hypersensitivity.
- Bleeding from the digestive organs.
- Hemophilia.
- Hypoprothrombinemia.
- Vitamin deficiency K.
- Pregnancy or lactation .
- Severe coronary heart disease.
- Kidney failure.
- Lack of glucose-6-phosphate dehydrogenase.
- Severe arterial hypertension.
- Glaucoma.
- Sleep disorders.
- Portal hypertension.
- Surgical interventions with expected bleeding.
- Increased excitability.
- Hemorrhagic diathesis.
- Age up to 15 years.
It is recommended to take Coficil-Plus with caution if you have gout or liver disease.
Does pu-erh increase blood pressure?
Pu-erh is a dark variety of tea, but not black, as the manufacturing technology is different. Budget options for this tea are ready-made Pu-erh (Shu) and raw Pu-erh (Shen). At reduced pressure, the second of them is used. Thanks to it, the body’s tissues receive more nutrition, and digestion is normalized to some extent.
Shu Pu'er should not be drunk in large quantities. It lowers cholesterol in the blood, is used to prevent vascular and heart diseases, and removes harmful substances and toxins from the body. Pu-erh increases blood pressure, so if the norm is exceeded, short-term hypertension may occur. To avoid affecting blood pressure, drink it not so strong or in the amount of 1-2 cups per day. It is better to avoid consumption at night.
Side effects
Nausea, gastralgia, hepatotoxicity , vomiting, erosive-ulcerative lesions of the digestive system, tachycardia , allergic reactions , nephrotoxicity , increased blood pressure , bronchospasm.
dizziness , tinnitus, weakened platelet aggregation, hypocoagulation, deafness, headache , Reye's syndrome , hemorrhagic syndrome are possible .
Ascorbic acid and blood pressure
Ascorbic acid (vitamin C) affects blood clotting and capillary permeability. This drug may increase blood pressure in some people. If you self-medicate, exceed the frequency of use or dosage of the medicine, it is likely that your blood pressure will increase and kidney function will be impaired. An increase in blood pressure when taking ascorbic acid is considered a side effect. Vitamin C is not prescribed to influence blood pressure.
Instructions for use Coficil-Plus (Method and dosage)
Instructions for use Coficil-Plus prescribes taking the drug orally, during or after meals, 1 tablet every four hours; for pain, take 1-2 tablets; the usual daily dose is 3-4 tablets, the highest daily dose is 8 tablets. The duration of therapy should not exceed 7-10 days.
The medicine should not be taken for more than five days as an analgesic and for more than three days as an antipyretic. Other dosages and patterns of use are determined by the doctor.
Medicines for high blood pressure
If non-drug methods of increase do not produce results, you need to resort to the use of medications. A common remedy is caffeine sodium benzoate (tablets). This stimulant is known throughout the world and is added to energy drinks. However, they increase blood pressure, but negatively affect the functioning of the gastrointestinal tract. Therefore, drinking energy drinks is not recommended!
Caffeine is also known as trimethylxanthine. This is a powder that has a bitter taste. This substance is also a diuretic; it dilates peripheral blood vessels. It increases blood pressure only for a while. With normal blood pressure, the readings may not change when taking caffeine. You should follow the dosage prescribed by your doctor (or indicated in the instructions for the drug). In large doses, the drug can negatively affect some organs; it is also rare, but it causes addiction.
The second popular remedy is lemongrass tincture. 25 drops are diluted in 100 ml of water. Give to the patient 15 minutes before meals, 2-3 times a day. It is not recommended to take this alcohol infusion at night. If you have insomnia, try using it only in the morning and at lunchtime, and after 16:00 do not drink lemongrass tincture to increase blood pressure.
Ginseng tincture is the third most popular remedy for increasing blood pressure in hypotensive patients. The drug is also believed to strengthen the immune system. Do not use this medicine in the evening as it will make it difficult to fall asleep. This remedy is also not suitable for pregnant and breastfeeding women. One dose delivers an average of 20 drops.
Eleutherococcus is also a popular remedy for raising blood pressure. It relieves accumulated fatigue and is used in frequent stressful situations. After long illnesses, the body is weakened, so the doctor may also prescribe a tincture of Eleutherococcus. But this is not only a tincture; the drug is available in capsules and tablets. There is also dry raw material that is brewed and drunk. The most popular is the liquid extract of Eleutherococcus. Take 1-3 times a day, 15-30 drops (depending on the age and weight of the patient). The course of treatment for hypotension is 30 days.
Leuzea extract normalizes blood pressure, tones the body and strengthens the body's defenses. Thanks to this remedy, the body adapts to heavy loads. Take 1-3 times a day, twenty or thirty drops. This drug is also available in tablet form, take a maximum of 3 times a day, 1-2 tablets.
All the drugs mentioned above stimulate, to a greater or lesser extent, the activity of the heart, blood vessels and nervous system. Thus, after taking one of these drugs, a person’s vascular tone increases, which is why blood pressure increases. Below we will describe how other drugs that people periodically use to treat hypotension affect blood pressure readings.
Overdose
Signs of overdose: nausea, ringing in the ears, gastralgia, vomiting, dizziness, lethargy, collapse, drowsiness , bronchospasm , convulsions, difficulty breathing, anuria , respiratory acidosis , bleeding.
Treatment of overdose: monitoring pH balance and electrolyte balance; depending on the level of metabolism, the use of sodium citrate, sodium lactate or sodium bicarbonate is recommended.
Pressure and Cordiamine
The drug is an analeptic; it stimulates the CENS and chemoreceptors. This medicine increases your blood pressure. Breathing, accordingly, becomes more frequent and deeper, consciousness becomes clearer. Cordiamine can be used in case of a sharp decrease in blood pressure, for example, with suffocation or fainting.
Cordiamine is available in drops that need to be taken orally. Also available as a solution that is administered by injection. You need to take drops 1-3 times a day, 20-40 drops. And by injection (into the muscles, into the veins) it is administered in an amount of 1 to 2 ml. Among the side effects caused by overdose, researchers name overexcitement and seizures. You cannot prescribe this drug to yourself!
Interaction
Combined use with other anti-inflammatory non-steroidal drugs, Methotrexate increases the likelihood of developing undesirable effects.
Reduces the effectiveness of Spironolactone, Furosemide, antihypertensive and anti-gout drugs that promote the evacuation of uric acid.
Metoclopramide enhances the absorption of Paracetamol .
Salicylamide, barbiturates, Rifampicin, antiepileptic drugs and other inducers of microsomal oxidation enhance the synthesis of toxic derivatives of Paracetamol , which affect liver function.
The simultaneous use of Paracetamol and ethanol increases the risk of hepatotoxic effects.
Under the influence of Paracetamol, the half-life of Chloramphenicol is extended fivefold.
Caffeine enhances the absorption of ergotamine.
Pentalgin - does it lower blood pressure?
This is a drug for pain, which contains naproxen, paracetamol, drotaverine, caffeine, pheniramine. If the pressure is normal or below normal, the values on the tonometer will not change when taking Pentalgin. Since the drug contains caffeine, the blood vessels may narrow, which means that the pressure will not increase by much. In severe hypertension, the drug is contraindicated.
Pentalgin increases blood pressure if taken in excess of the norm or for long courses. You can take no more than 4 tablets per day, and the duration of the course is a maximum of 5 days.
special instructions
With long-term use of the drug, monitoring of blood counts and liver condition is necessary.
Children are prohibited from being prescribed medications containing acetylsalicylic acid , since in case of infection they can increase the risk of Reye's syndrome ( encephalopathy , vomiting, hepatomegaly ).
Acetylsalicylic acid in small doses weakens the evacuation of uric acid.
Acetylsalicylic acid has a teratogenic effect.
Coficil-plus, 0.3 g+0.05 g+0.1 g, tablets, 10 pcs.
Are common
This medicine should not be taken at the same time as medicines containing ASA or paracetamol.
As with other migraine treatments, caution should be exercised to rule out other potentially serious neurological disorders before initiating treatment for suspected migraine in patients who have not previously been diagnosed with migraine or in those whose migraine presents with atypical symptoms.
If patients vomit during > 20% of migraine attacks or require bed rest during > 50% of migraine attacks, the drug should not be used.
If the migraine does not stop after taking the first two tablets of the drug, you should seek medical help.
The drug should not be used if the patient has had more than 10 headache attacks per month for at least the last three months. In this case, headache due to excessive use of drugs should be suspected and treatment should be discontinued. Additionally, patients should seek medical attention. Caution should be used in patients with risk factors for dehydration, such as vomiting, diarrhea, or before or after major surgery.
Due to its pharmacodynamic properties, the drug can mask the signs and symptoms of infection.
Due to the content of acetylsalicylic acid in the drug
The drug should be used with caution in patients with gout, impaired renal or hepatic function, dehydration, uncontrolled hypertension, glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus.
Due to ASA inhibition of platelet aggregation, the drug may lead to an increase in bleeding time during and after surgical interventions (including minor ones, such as tooth extraction).
The drug should not be used simultaneously with anticoagulants and other drugs that interfere with blood clotting, without medical supervision (see section “Interaction with other drugs”). Patients with bleeding disorders should be closely monitored. Caution should be exercised in case of metro- or menorrhagia.
If a patient develops bleeding or ulceration of the gastrointestinal tract while taking the drug, it must be discontinued immediately. Potentially fatal bleeding, ulceration, and perforation of the gastrointestinal tract may occur at any time during treatment with any NSAID, with or without a history of precursors and severe gastrointestinal complications. These complications tend to be more severe in older patients. Alcohol, glucocorticosteroids and NSAIDs may increase the risk of gastrointestinal bleeding (see section "Interaction with other drugs").
The drug may contribute to the development of bronchospasm and the occurrence of exacerbation of bronchial asthma (including bronchial asthma caused by intolerance to analgesics) or other hypersensitivity reactions. Risk factors include bronchial asthma, seasonal allergic rhinitis, nasal polyposis, chronic obstructive pulmonary disease, chronic respiratory tract infections (especially those associated with symptoms characteristic of allergic rhinitis). Such effects may also occur in patients with allergic reactions (eg, skin reactions, including itching and urticaria) to other substances. Particular caution is recommended in such patients.
Children under 18 years of age should not be prescribed medications containing acetylsalicylic acid as an antipyretic, since in the case of a viral infection they can increase the risk of developing Reye's syndrome. Symptoms of Reye's syndrome are hyperpyrexia, prolonged vomiting, metabolic acidosis, nervous system and mental disorders, hepatomegaly and liver dysfunction, acute encephalopathy, respiratory failure, convulsions, coma.
ASA may interfere with the results of laboratory tests of thyroid function due to false-positive low concentrations of levothyroxine (T4) and triiodothyronine (T3) (see section "Interactions with other drugs").
Due to the content of paracetamol in the preparation
Caution should be exercised when prescribing the drug to patients with impaired renal or hepatic function, or alcohol dependence.
The risk of paracetamol poisoning is increased in patients taking other potentially hepatotoxic drugs or drugs that induce liver microsomal enzymes (eg, rifampicin, isoniazid, chloramphenicol, hypnotics and anticonvulsants including phenobarbital, phenytoin and carbamazepine). Patients with a history of alcoholism are at particular risk for liver damage (see section “Interaction with other drugs”).
When using the drug, serious skin reactions may develop, such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, which can be fatal. Patients should be informed of the signs of serious skin reactions. The drug should be discontinued at the first manifestation of skin reactions or any other signs of hypersensitivity.
Due to the caffeine content of the product
The drug should be prescribed with caution to patients with gout, hyperthyroidism and arrhythmia.
When using the drug, you should limit your consumption of products containing caffeine, since excess caffeine intake can lead to nervousness, irritability, insomnia and, in some cases, increased heart rate.
Effect on laboratory tests
High doses of ASA can distort the results of a number of clinical and biochemical laboratory studies.
The use of paracetamol may affect the results of determining uric acid using the phosphotungstic acid method and glycemia using the glucose oxidase/peroxidase method.
Caffeine may reverse the effects of dipyridamole on myocardial blood flow, thereby confounding the results of this study. During the study, it is necessary to refrain from taking caffeine for 8–12 hours.
Impact on the ability to drive vehicles and machinery
While using the drug, you should refrain from driving vehicles and operating other mechanisms, because caffeine, which is part of the drug, can cause problems with concentration and reaction speed, and acetylsalicylic acid, also included in the drug, can in rare cases cause dizziness.
Analogs
Level 4 ATC code matches:
Acetylsalicylic acid
Aspirin-S
Citropak
Aspirin
Citramon
Farmadol
Askofen-P
Cefekon N
Aquacitramon
Upsarin UPSA
Citrapack
Alca Prim
Thrombopol
Citrapar
Askofen-P, Aquacitramon, Acepar, Migrenol Extra, Acifein, Citramarin, Citramon Ultra, Citramon P, Citrapar, Excedrin.
Price, where to buy
The price of a package of drug No. 10 in Russia is 9-10 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Koficil-Plus tablets 10 pcs. JSC Pharmstandard (ICN) Leksredstva, Kursk
18 rub. order - Koficil-Plus tablets 20 pcs. Pharmstandard-Leksredstva OJSC
51 RUR order
Pentalgin and blood pressure
Pentalgin is taken to relieve pain, inflammation, and the drug also has an antispasmodic and fever-reducing effect. It contains paracetamol, naproxen, caffeine, drotaverine, pheniramine, etc. It is recommended to use 1 tablet per day. One tablet contains 50 mg of caffeine, which may increase blood pressure. But drotaverine dilates blood vessels, so the pressure generally remains normal. Pentalgin may increase your blood pressure if it is below normal when you take the drug. But pressure indicators change only after taking 2 tablets at a time. The medicine is not used to treat hypotension.
Don't wonder which medications increase blood pressure. Consult a doctor who will help eliminate the cause of this symptom, and you will not have to spend money on medications and poison your body with unknown drugs. Before taking medications that increase blood pressure, you need to double check your blood pressure monitor.
