BETALOK ZOK delayed-release film-coated tablets 25 mg No. 14

Pharmacodynamics and pharmacokinetics

The active ingredient Betaloc reduces or eliminates the stimulating effect of catecholamines during stress and exercise, reduces myocardial contractility and cardiac output, reduces high blood pressure and heart rate. In addition, metoprolol reduces myocardial oxygen demand and prolongs diastole.

The drug may slightly increase TG levels and also slightly reduce HDL fractions and free fatty acid levels in the blood plasma.

The tablets are characterized by a delayed release of the active substance, so the concentration of the drug in the blood plasma remains unchanged, which ensures a stable clinical effect for a day or more. The drug is better tolerated than its analogues, and the risk of developing unwanted side effects is significantly reduced.

Betaloc ZOK is completely absorbed. Absorption does not depend on the timing of meals. The degree of connection with blood plasma proteins is 5-10%. The active substance is metabolized in the liver to form three metabolites without beta-blocking activity.

About 95% of the drug is excreted in the urine, the remaining amount remains unchanged. The half-life averages 3-4 hours.

Comparison

Each of the drugs is effective in the treatment of diseases of the cardiovascular system. When taking medications based on metoprolol, it is possible to normalize blood pressure and significantly improve the patient’s condition.

If you conduct a comparative analysis of the drugs, you can note that the active ingredients are the same, but have a different chemical formula. There are differences in the degree of influence on the cardiovascular system. Betaloc is available in only one dosage, but Betaloc Zok is produced in three different dosages: 25 mg, 50 mg and 100 mg. Thanks to this, it is possible to select the optimal treatment regimen for the patient.

The list of indications for medications is the same; one drug or another is prescribed taking into account the patient’s medical history and the effectiveness of previous treatment.

It must be taken into account that Betaloc can provoke more adverse reactions, this is due to the specific properties of the active substance. The second drug is much better tolerated, since the active substance is not released immediately, but gradually, ensuring a constant plasma level. Although there is still a possibility of negative symptoms occurring.

Each of the medications is sold strictly according to your prescription.

If you choose which of these drugs is better, you should first determine the purpose of the treatment, only after that the doctor can recommend the use of the first or second drug.

Indications for use

What are Betaloc ZOK tablets for? First of all, they are prescribed to patients with:

• arterial hypertension;
• heart rhythm disturbances;
• angina pectoris;
• functional disorders of the heart, which are accompanied by tachycardia .

As an element of therapy, the drug is used for chronic heart failure . In addition, Betaloc ZOK is used to reduce mortality and the likelihood of recurrent infarction after the acute phase of myocardial infarction , as well as as a prophylactic against migraine .

Contraindications

This drug is contraindicated in cases of atrioventricular block II-III degree, therapy with inotropic agents to activate beta-adrenergic receptors, sick sinus syndrome, peripheral arterial circulation disorders, heart failure in the decompensation phase, clinically significant sinus bradycardia , cardiogenic shock , as well as hypersensitivity to beta-adrenergic blockers and any component of the drug.

In addition, Betaloc ZOK is not suitable for patients with acute myocardial infarction with a heart rate less than 45 per minute, systolic blood pressure less than 100 mm Hg. Art. or the duration of the P-Q interval on the ECG is more than 0.24 s.

Possible side effects

Before using this medicine, you should carefully study information about all possible side effects using the official instructions in the package. Since the drug directly affects the heart rate, in a short time it can significantly reduce the pulse and lower blood pressure, the side effects of taking it should be taken seriously.

"Betaloc ZOK" can affect various organs and systems of the body, for example:

• from the sensory organs, vision impairment, dry eyes, and tinnitus may occur;
• possible disorders in the functioning of the central nervous system, such as slow motor and mental reactions, headaches;
• when large doses of the drug are prescribed, respiratory dysfunction may occur - bronchospasm, shortness of breath, nasal congestion;
• from the dermatological side, various rashes, skin itching, urticaria, photodermatosis, psoriasis-like reactions are possible.

If any changes in well-being occur or if symptoms similar to those described above occur, cardiologists advise that you must notify your doctor.

Side effects

As a rule, when used correctly, the medicine is well tolerated by patients to whom it is prescribed. Side effects are minor or easily reversible.

Cardiovascular system: bradycardia , coldness of the extremities, increased manifestations of heart failure , orthostatic hypotension , cardiogenic shock , edema, pain in the heart, fainting, palpitations, first degree atrioventricular block arrhythmia .

Gastrointestinal tract: nausea , diarrhea , vomiting , abdominal pain, constipation .

Skin: rash, increased sweating.

Metabolism: increased body fat.

CNS: increased fatigue, headache , convulsions, problems concentrating, insomnia , dizziness , paresthesia , depression , drowsiness , nightmares.

Respiratory organs: shortness of breath , bronchospasm .

In rare cases, when taking the drug, the following are possible:

• gangrene;
• increased nervous excitability;
• memory impairment;
• hallucinations;
• anxiety;
• depression;
• dryness of the oral mucosa;
• hepatitis;
• hair loss;
• exacerbation of psoriasis ;
• liver dysfunction;
• photosensitivity;
• rhinitis;
• visual impairment;
• conjunctivitis;
• taste disturbances;
• irritation and/or dry eyes;
• tinnitus;
• arthralgia;
• thrombocytopenia;
• impotence , sexual dysfunction .

Composition and release form

Active substance: metoprolol tartrate 25 mg

• Excipients:
• lactose monohydrate;
• magnesium stearate;
• sodium carboxymethyl starch;
• anhydrous colloidal silicon dioxide;
• povidone.

Nosological classification (ICD-10)

• I21 Acute myocardial infarction
• I25 Chronic ischemic heart disease
• I47.1 Supraventricular tachycardia
• R00.0 Tachycardia, unspecified
• R07.2 Pain in the heart area

Description of the dosage form

Solution for intravenous administration: clear, colorless liquid.

Tablets: biconvex, round, white, scored and engraved A/mE on one side.

pharmachologic effect

Pharmacological action - antiarrhythmic, hypotensive, antianginal.

Indications for Betaloc®

arterial hypertension: lowering blood pressure and reducing the risk of cardiovascular and coronary death (including sudden death);

angina pectoris;

cardiac arrhythmias, including supraventricular tachycardia;

after myocardial infarction (in complex therapy);

functional disorders of cardiac activity accompanied by tachycardia;

prevention of migraine attacks;

hyperthyroidism (complex therapy).

Contraindications

known hypersensitivity to metoprolol and its components or to other beta-blockers;

AV block II and III degrees, heart failure in the stage of decompensation, clinically significant sinus bradycardia, sick sinus syndrome, cardiogenic shock, severe peripheral circulatory disorders, arterial hypotension;

patients with acute myocardial infarction with a heart rate of less than 45 beats per minute, a PQ interval of more than 0.24 s, or a blood pressure of less than 100 mm Hg;

In patients receiving β-blockers, the administration of “slow” calcium channel blockers such as verapamil is contraindicated.

serious peripheral vascular diseases (with the threat of gangrene);

age under 18 years (efficacy and safety have not been established).

Patients receiving long-term or intermittent therapy with inotropic agents acting on β-adrenergic receptors.

With caution: 1st degree AV block, Prinzmetal's angina, COPD (emphysema, chronic obstructive bronchitis, bronchial asthma), diabetes mellitus, severe renal failure.

Use during pregnancy and breastfeeding

Pregnancy

Like most drugs, Betaloc® should not be prescribed during pregnancy and breastfeeding, unless the expected benefit to the mother outweighs the potential risk to the fetus. Like other antihypertensive agents, beta-blockers may cause side effects such as bradycardia in the fetus, neonates, or breastfed children, and therefore particular caution should be exercised when prescribing beta-blockers in the last trimester of pregnancy and immediately before birth. .

Lactation period

The amount of metoprolol excreted in breast milk and the β-adrenergic blocking effect in a breastfed child (when the mother takes metoprolol in therapeutic doses) are insignificant.

Side effects

Betaloc® is well tolerated by patients, and side effects are mostly mild and reversible.

As a result of clinical studies or with the use of Betaloc® (metoprolol tartrate) in clinical practice, the following undesirable side effects have been described. In many cases, a cause-and-effect relationship with treatment with Betaloc® has not been established. The following criteria were used to assess the frequency of cases: very common (>10%), common (1–9.9%), uncommon (0.1–0.9%), rare (0.01–0.09%) and very rare (<0.01%).

From the cardiovascular system: often - bradycardia, postural disturbances (very rarely accompanied by fainting), coldness of the extremities, palpitations; uncommon - temporary increase in symptoms of heart failure, cardiogenic shock in patients with acute myocardial infarction, AV block of the first degree; rarely - other cardiac conduction disorders, arrhythmias; very rarely - gangrene in patients with previous severe peripheral circulatory disorders.

From the side of the central nervous system: very often - increased fatigue; often - dizziness, headache; uncommon - paresthesia, convulsions, depression, loss of attention, drowsiness or insomnia, nightmares; rarely - increased nervous excitability, anxiety, impotence/sexual dysfunction; very rarely - amnesia/memory impairment, depression, hallucinations.

From the gastrointestinal tract: often - nausea, abdominal pain, diarrhea, constipation; infrequently - vomiting; rarely - dry mouth.

From the skin: infrequently - rash (in the form of urticaria), increased sweating; rarely - hair loss; very rarely - photosensitivity, exacerbation of psoriasis.

From the liver: rarely - liver dysfunction.

From the respiratory system: often - shortness of breath with physical effort; uncommon - bronchospasm in patients with bronchial asthma; rarely - rhinitis.

From the senses: rarely - visual disturbances, dryness and/or irritation of the eyes, conjunctivitis; very rarely - ringing in the ears, disturbances of taste.

From the side of metabolism: infrequently - weight gain.

From the musculoskeletal system: very rarely - arthralgia.

From the blood system: very rarely - thrombocytopenia.

For tablets additionally

From the liver: very rarely - hepatitis.

Directions for use and doses

Inside, both with food and on an empty stomach.

Arterial hypertension

100–200 mg of Betaloc® once in the morning or in 2 divided doses; in the morning and in the evening. If necessary, the dose can be increased or another antihypertensive agent added.

Long-term antihypertensive therapy of 100–200 mg of Betaloc® per day can reduce overall mortality, including sudden death, as well as the incidence of cerebral strokes and coronary circulatory disorders in patients with arterial hypertension.

Angina pectoris

100–200 mg/day in 2 divided doses; in the morning and in the evening. If necessary, another antianginal drug may be added to therapy.

Heart rhythm disturbances

100–200 mg/day in 2 divided doses; in the morning and in the evening. If necessary, another antiarrhythmic drug may be added to therapy.

Maintenance therapy after myocardial infarction

The maintenance dose is 200 mg/day in 2 divided doses; in the morning and in the evening. Prescribing Betaloc® at a dose of 200 mg/day can reduce mortality in patients who have suffered a myocardial infarction and reduce the risk of developing a recurrent myocardial infarction (including in patients with diabetes mellitus).

Functional cardiac disorders accompanied by tachycardia

100 mg of Betaloc® 1 time per day, it is recommended to take the tablet in the morning. If necessary, the dose can be increased.

Preventing migraine attacks

100–200 mg/day in 2 divided doses; in the morning and in the evening.

Hyperthyroidism

150–200 mg/day in 3–4 doses.

Renal dysfunction

There is no need to adjust the dose in patients with impaired renal function.

Liver dysfunction

Usually, due to the low degree of binding to plasma proteins, no dose adjustment of metoprolol is required. However, in severely impaired liver function (in patients with severe liver cirrhosis or portacaval anastomosis), a dose reduction may be required.

Elderly age

There is no need to adjust the dose in elderly patients.

Children.

Experience with the use of Betaloc® in children is limited.

Overdose

Symptoms: the consequences of an overdose of Betaloc® can be a pronounced decrease in blood pressure, sinus bradycardia, AV block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impaired consciousness/coma, nausea, vomiting and cyanosis.

Concomitant use of alcohol, antihypertensive drugs, quinidine or barbiturates may worsen the patient's condition.

The first signs of overdose may appear within 20 minutes to 2 hours after taking the drug.

Treatment: administration of activated carbon, and, if necessary, gastric lavage. In case of a pronounced decrease in blood pressure, bradycardia, or the threat of heart failure, a β1-adrenergic agonist (for example, dobutamine) should be administered intravenously at intervals of 2–5 minutes or by infusion until a therapeutic effect is achieved. If a selective β1-agonist is not available, IV dopamine or atropine sulfate can be administered to block the vagus nerve.

If therapeutic effect is not achieved, other sympathomimetics such as dobutamine or norepinephrine can be used.

Glucagon can be administered at a dose of 1–10 mg. Sometimes it may be necessary to use a pacemaker. To relieve bronchospasm, a β2-adrenergic agonist should be administered intravenously.

It must be taken into account that the doses of antidotes required to eliminate the symptoms that occur with an overdose of β-blockers are much higher than therapeutic doses, since β-adrenergic receptors are bound to the β-blocker.

special instructions

Patients taking β-blockers should not be administered intravenous calcium channel blockers such as verapamil.

When using β1-blockers, the risk of their influence on carbohydrate metabolism or the possibility of masking hypoglycemia is significantly less than when using non-selective β-blockers.

In patients with chronic heart failure in the stage of decompensation, it is necessary to achieve a stage of compensation both before and during treatment with the drug.

Non-selective β-blockers are not recommended for patients suffering from Prinzmetal's angina.

Very rarely, patients with impaired atrioventricular conduction may experience deterioration (a possible outcome is AV block). If bradycardia develops during treatment, the dose of Betaloc® should be reduced. Metoprolol may worsen symptoms of peripheral arterial circulation disorders, mainly due to a decrease in blood pressure. Caution should be exercised when prescribing the drug to patients suffering from severe renal failure, metabolic acidosis, and co-administration with cardiac glycosides.

Patients suffering from pheochromocytoma should be prescribed an α-blocker in parallel with Betaloc®.

In case of surgery, the anesthesiologist should be informed that the patient is taking a beta-blocker.

In patients taking β-blockers, anaphylactic shock occurs in a more severe form.

Patients suffering from obstructive pulmonary disease are not recommended to prescribe β-blockers. In case of poor tolerance to other antihypertensive drugs or their ineffectiveness, metoprolol can be prescribed, since it is a selective drug. It is necessary to prescribe the minimum effective dose; if necessary, a β2-adrenergic agonist may be prescribed.

In patients with liver cirrhosis, the bioavailability of metoprolol increases.

Abrupt withdrawal of the drug should be avoided. If it is necessary to discontinue the drug, withdrawal should be carried out gradually. In most patients, the drug can be discontinued within 14 days. The dose of the drug is reduced gradually, in several doses, until a final dose of 25 mg is reached once a day. Patients with coronary artery disease should be closely monitored by a physician during drug withdrawal.

Impact on the ability to drive a car and operate technical devices. When using the drug, episodes of dizziness or general weakness are possible, and therefore it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

A comment

Before using the drug, you must read the instructions for use.

Conditions for dispensing from pharmacies

• On prescription.

Storage conditions for Betaloc®

• In a place protected from light, at temperatures below 25 °C.
• Keep out of the reach of children.

Shelf life of Betaloc®

• 5 years.
• Do not use after the expiration date stated on the package.

Instructions for use of Betaloc ZOK (Method and dosage)

Instructions for use of Betaloc ZOK include taking the drug once daily, regardless of meals (preferably in the morning). Tablets should not be crushed or chewed. During dosage selection, heart rate should be monitored.

Arterial hypertension : 50 mg per day (if the therapeutic effect is not achieved, the dose can be gradually increased to 100-200 mg per day, while Betaloc ZOK tablets, instructions for use, can be combined with other antihypertensive drugs).

Stable chronic heart failure of functional class III-IV : to begin with, a dosage is prescribed - 12.5 mg per day (1/2 tablet of 25 mg). If necessary, the dose is gradually increased, but this must be done strictly under the supervision of a doctor. After 14 days, the initial dosage is increased to 25 mg per day; after another 2 weeks, 50 mg per day can be prescribed. Thus, every 14 days the dose can be doubled until a maximum dosage of 200 mg is reached. However, the dose should not be increased until there is clear evidence that the patient is stable. Kidney function needs to be monitored.

Stable chronic heart failure of functional class II : at the beginning, a dose of 25 mg is prescribed. After the first 2 weeks, it can be increased to 50 mg per day, and then doubled every 14 days until a therapeutic effect is achieved. The maximum dosage is 200 mg per day.

For migraine prevention, 100–200 mg per day is prescribed.

For angina pectoris, 100–200 mg per day is prescribed (can be combined with other drugs for the treatment of angina pectoris).

For arrhythmia, 100–200 mg per day is prescribed.

Cardiac disorders with palpitations: 100 mg per day (if necessary, the dosage can be increased to 200 mg).

Reviews from doctors about this drug

On numerous forums, cardiologists speak quite well about this drug. One of its main advantages is the ability of the drug to effectively reduce blood pressure. Since this medication is much less expensive than its analogues, for many hypertensive patients this medicine truly becomes a panacea.

This drug also deserves good reviews from doctors because, according to the results of many studies, its main component, metaprolol, has the property of prolonging life. Despite the fact that this drug has a fairly good reputation among cardiologists, there is a certain category of people who are advised by doctors to take additional safety measures while taking these pills. Among these recommendations are:

1. Regularly checking blood glucose levels in people with diabetes. It is necessary to take into account the fact that, being a beta-blocker, “Betaloc ZOK can mask tachycardia that occurs due to hypoglycemia. At the beginning of taking the pills, cardiologists recommend that every patient measure their blood pressure and monitor their pulse daily. In cases where, when taking Betalok ZOK, the heart rate is less than 50 beats per minute, cardiologists strongly recommend seeking medical advice.
2. For elderly patients who take this medicine, doctors recommend monitoring kidney function at least once every 6 months.

Overdose

There are cases where, at a dosage of 7.5 g, the drug caused severe intoxication with a fatal outcome in an adult. At doses of 1.4 and 2.5 g, respectively, there was moderate and severe intoxication.

An overdose of this drug can lead to respiratory depression, atrioventricular block I–III degrees, decreased blood pressure, heart failure, bradycardia , asystole , weak peripheral perfusion , cardiogenic shock , apnea . In addition, Betaloc ZOK in increased doses can cause impairment of consciousness, tremor , excessive sweating and fatigue, bronchospasm , vomiting, hypoglycemia or hyperglycemia , renal impairment, loss of consciousness, convulsions, paresthesia , nausea, as well as esophageal spasm and hyperkalemia .

Initial signs of a drug overdose will be noticeable 20-120 minutes after administration.

Activated carbon is prescribed as treatment , as well as gastric lavage if necessary.

Depending on the manifestations of overdose, symptomatic treatment is carried out. So, you may need intubation and adequate ventilation, ECG monitoring, blood volume replenishment and glucose infusions. If necessary, Atropine (before gastric lavage) is administered intravenously 1-2 mg. For myocardial depression, Dobutamine or Dopamine . It is possible to use Glucagon intravenously at a dosage of 50–150 mcg per 1 kg of weight. In some cases, Adrenaline , terbutaline (to relieve bronchospasm ), as well as an artificial pacemaker, help. For arrhythmia and an extensive ventricular complex, a sodium solution is injected. Resuscitation measures may be necessary.

General description of the drug

"Betalok ZOK", the price of which differs depending on the dosage and number of tablets in the package, is classified as one of the types of cardioselective beta-blockers. Externally, these tablets are enteric-coated. "Betalok ZOK", reviews from cardiologists, whose effects are mostly positive, is a long-acting drug. Due to its shell, the medicine has a delayed release. However, it does not have sympathomimetic internal activity.

The main active ingredient of the drug is metoprolol, a substance that has the following effects on the body:

• antihypertensive;
• antianginal;
• antiarrhythmic.

Also, this drug quite effectively reduces the excitability of the myocardium, reducing its need for oxygen.

Interaction

When using the drug Betaloc ZOK and other beta-adrenergic receptor blockers, as well as MAO inhibitors and ganglion blockers, strict medical supervision is required.

The drug should not be combined with Propafenone , Verapamil . When taking Diltiazem and/or antiarrhythmic drugs, a negative ino- and chronotropic effect may develop. When using inhalational anesthetics, the cardiodepressive effect is enhanced.

It is possible that inducers or inhibitors of microsomal liver enzymes may influence the content of the active substance Betaloc ZOK in the blood plasma. Its concentration is reduced when combined with Rifampicin or increased when taken simultaneously with Cimetidine , hydralazine , phenytoin , and serotonin .

When discontinuing clonidine, Betaloc ZOK must be discontinued several days before.

In combination with COX inhibitors, the antihypertensive effect of the drug may be reduced. Dosage adjustments of oral antidiabetic agents may also be necessary when administered concomitantly.

Interaction with other drugs

Also, the doctor prescribing Betaloc ZOK should be informed about all the medications that the patient is using at the time of prescription. There are substances the use of which is strictly contraindicated when using Betalok ZOK. When taking it, it is strictly forbidden to inject Verapamil into a person. When using Betalok ZOK, you should be very careful when prescribing drugs similar to Reserpine (which, by their action, reduce the reserves of catecholamines). Such simultaneous administration can provoke an attack of bradycardia and a rapid drop in blood pressure in the patient.

Analogues of Betalok ZOK

Level 4 ATC code matches:
Biol

Metocard

Metozok

Nebilet

Nebilong

Betaxolol

Bisogamma

Aritel

Cordinorm

Vasocardin

Corvitol

Bidop

Bisoprolol

Nebivolol

Biprol

Bisoprol

Concor Cor

Lokren

Concor

Niperten

The following analogues of Betalok ZOK are sold in pharmacies:

• Betalok
• Egilok
• Metoprolol
• Metocard
• Metocore
• Serdol
• Azoprol Retard
• Vasocardin
• Corvitol

Reviews about analogues of Betalok ZOK are quite different. Some of them are almost as good as him, and some are of a fairly low level. So the price of analogs of this product, as well as their manufacturers, deserves special attention. To finally decide which medicine is best for each specific case, you should consult a doctor. In addition, before use, be sure to read the instructions.

Reviews of Betaloka ZOK

Reviews of Betalok ZOK indicate that quite often after its use undesirable symptoms occur. Thus, patients often report cases of rhinitis . Some also complain of irregular pulse and unstable blood pressure. Because of this, specialists prescribe additional medications that are designed to eliminate these side effects. However, it should be noted that most people still tolerate this medication easily.

In addition, reviews of Betalok ZOK draw attention to the fact that the selection of dosages should be approached with particular care. The patient’s condition must be constantly monitored and the danger of deterioration must be eliminated in a timely manner.

Compatibility

The drugs have the same composition, so taking two drugs will not lead to an increase in therapeutic effectiveness, but rather may harm the patient, aggravating the course of the disease. If necessary, another drug may be additionally prescribed, which will help relieve negative symptoms and stabilize the patient’s condition.

You should not self-medicate; before taking a medication that affects the functioning of the cardiovascular system, you should definitely consult a cardiologist. Take care of your own health; if you experience any side symptoms during treatment, you should inform your doctor.

This article was written by specialists with medical education from the team. You can read the original instructions on the manufacturer’s website: Betalok and Betalok Zok.

Betaloka ZOK price, where to buy

The average price of Betaloc ZOK 50 mg is about 250 rubles, the price of 25 mg is about 150 rubles, and the average cost of 100 mg of the drug is about 400 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

ZdravCity

• Betaloc ZOK tablets p.p.o.
  with deceleration release 100 mg 30 pcs. AstraZeneca AB / Astra Zeneca Industries LLC 409 rub. order
• Betaloc ZOK tablets p.p.o. with deceleration release 50 mg 30 pcs. Astra Zeneca AB/LLC Astra Zeneca Industries

  RUB 284 order

• Betaloc ZOK tablets p.p.o. with deceleration release 25 mg 14 pcs. AstraZeneca AB / ZiO-Zdorovye / Astra Zeneca Industries LLC

  147 RUR order

Pharmacy Dialogue

• Betaloc Zok tablets 25 mg No. 14Astra Zenesa/AstraZeneca Industries

  134 RUR order

• Betaloc Zok tablets 50 mg No. 30Astra Zenesa/AstraZeneca Industries

  280 rub. order

• Betalok Zok (tablet p/o 100 mg No. 30)Astra Zeneсa/AstraZeneca Industries

  RUB 385 order

• Betalok Zok (tablet p/o 50 mg No. 30)Astra Zeneca/ZIO Health

  RUB 279 order

show more

Pharmacy24

• Betaloc Zok 100 mg N30 Astra Zeneca AB, Sweden
  199 UAH order
• Betaloc Zok 50 mg N30 tablets Astra Zeneca AB, Sweden

  142 UAH order

• Betaloc Zok 25 mg No. 14 tablets Astra Zeneca AB, Sweden

  80 UAH order

Average cost of the drug

"Betalok ZOk", the price of which depends on the number of tablets in the package and on the markup of the final seller, costs on average from 130 to 460 rubles. The cheapest are 25 mg tablets, which are packaged in 14 pieces. in a pack. Their price is about 130-150 rubles.

The most expensive is Betalok ZOK with a dosage of 100 mg, which is packaged in 30 pieces. into bottles. It costs about 420–480 rubles.