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Manufacturers: Pharmstandard-Leksredstva (Russia)
Active ingredients
- Codeine
- Caffeine
- Metamizole sodium
- Paracetamol
- Phenobarbital
Disease class
- Migraine
- Acute upper respiratory tract infection of multiple and unspecified localization
- Joint pain
- Neuralgia and neuritis, unspecified
- Fever of unknown origin
- Headache
- Other constant pain
- Dysmenorrhea, unspecified
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Anti-inflammatory
- Antipyretic
- Analgesic (non-narcotic)
- Analgesic (narcotic)
Pharmacological group
- NSAIDs - Pyrazolones in combinations
Release form and composition
Dosage form - tablets: from white with a cream or yellow tint to white, biconvex in shape, in the form of a capsule with flat side surfaces, on one side there is a risk, on the other there is an engraving “PENTALGIN” (in a cardboard pack of 1 or 2 contour strips 6, 10 or 12 tablets each and instructions for use of Pentalgin-ICN).
Active ingredients in 1 tablet:
- paracetamol – 300 mg;
- caffeine – 50 mg;
- metamizole sodium – 300 mg;
- codeine phosphate – 8 mg;
- phenobarbital – 10 mg.
Auxiliary components in Pentalgin-ICN: potato starch, povidone, stearic acid, calcium stearate.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Pentalgin-ICN, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Pentalgin-ICN is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Pharmacological properties
Pharmacodynamics
Pentalgin-ICN is one of the combination drugs that have antipyretic, analgesic and anti-migraine effects, which is due to the properties of the active components:
- paracetamol: is an analgesic-antipyretic; blocks COX (cyclooxygenase) mainly in the central nervous system by affecting the centers of thermoregulation and pain; has analgesic and antipyretic properties;
- metamizole sodium: is a pyrazolone derivative, an analgesic-antipyretic; has a pronounced analgesic effect;
- caffeine: is a psychostimulant; reduces the severity of headaches of vascular origin (including migraine) and improves well-being;
- phenobarbital: is a barbiturate; increases the analgesic effect of paracetamol and metamizole sodium;
- codeine: has an analgesic property, which is due to the stimulation of opioid receptors in various parts of the central nervous system, which leads to a change in the emotional perception of pain and stimulation of the antinociceptive system.
Pharmacodynamics and pharmacokinetics
This combination drug is characterized by analgesic, antipyretic and anti-inflammatory effects, which is caused by metamizole and naproxen .
Thanks to caffeine, the general well-being of patients improves and headaches . Phenobarbital can increase the effect of treatment with metamizole sodium and paracetamol . Codeine exhibits an antitussive effect by suppressing excitability in the cough center. The analgesic effect of this drug is caused by significant stimulation of opiate receptors in peripheral tissues and the nervous system, which stimulates the antinoceceptive system and changes in emotional pain perception.
Contraindications
Absolute:
- severe liver/renal failure;
- deficiency of glucose-6-phosphate dehydrogenase;
- alcohol intoxication;
- bronchial asthma;
- conditions that are accompanied by respiratory depression;
- leukopenia, anemia;
- acute myocardial infarction;
- cranial hypertension;
- glaucoma;
- arrhythmias;
- age up to 12 years;
- pregnancy and lactation;
- individual intolerance to the components in Pentalgin-ICN.
Relative (Pentalgin-ICN tablets are prescribed under medical supervision):
- arterial hypertension;
- peptic ulcer of the stomach and duodenum in remission;
- elderly age.
Indications for use
As a rule, Pentalgin ICN is prescribed for:
- moderate and mild pain of various origins, affecting joints, muscles, and lumbar region;
- menstrual pain;
- toothache, headache, neuralgia;
- colds that are accompanied by fever.
Side effects
- cardiovascular system: tachycardia, palpitations;
- central nervous system: drowsiness, dizziness;
- hematopoietic system: granulocytopenia, leukopenia, agranulocytosis;
- digestive system: dyspeptic disorders in the form of vomiting, nausea, constipation;
- allergic reactions: itching, rash, urticaria;
- others (in the case of prolonged uncontrolled use of high doses): addiction (manifests itself as a weakening of the analgesic effect), liver/renal failure, drug dependence (to codeine).
Overdose
Long-term use of tablets in high doses can lead to disruption of the liver and kidneys, tachycardia, and a decrease in the speed of psychomotor reactions. In addition, prolonged uncontrolled use of the drug in high dosages is addictive, and the presence of codeine in its composition causes drug dependence.
Typically, an overdose is manifested by nausea, vomiting, gastralgia, tachycardia, arrhythmia, and depression of the respiratory center.
Therapy includes gastric lavage, intestinal adsorbents and other symptomatic treatment.
special instructions
During therapy, athletes may experience changes in the results of doping control tests.
When carrying out long-term treatment (from 7 days), it is necessary to monitor the functional state of the liver and the picture of peripheral blood.
In acute abdominal pain syndrome, taking Pentalgin-ICN may complicate the diagnosis.
The risk of developing hypersensitivity reactions is higher in patients with hay fever and atopic bronchial asthma.
Impact on the ability to drive vehicles and complex mechanisms
While using Pentalgin-ICN, patients should refrain from driving vehicles and activities that require rapid psychomotor reactions and increased concentration.
Reviews of Pentalgin ICN
For many people, taking painkillers is common practice to relieve pain and postpone a visit to the doctor indefinitely. Therefore, reviews of Pentalgin ICN are quite common, since it is one of the most popular painkillers.
These pills are especially actively used by women who are bothered by menstrual pain. It should be noted that this indicates the presence of a menstrual cycle disorder, which requires contacting a gynecologist to identify the causes of pain.
In addition, this remedy helps eliminate headaches and toothaches. However, some users note how quickly this medicine works and how long it took them to find something suitable.
One way or another, the appearance of pain indicates the presence of a deviation in the functioning of the body. Therefore, if pain appears again after taking it, a person should quickly consult a doctor. As you know, timely treatment helps to quickly eliminate the disorder and will not allow it to develop into a more complex form. Therefore, there is no need to be afraid, but it is better to find time and take care of your health.
Drug interactions
- drugs that have a depressant effect on the central nervous system (including sedatives and tranquilizers): the severity of the inhibitory effect on the respiratory center and the sedative effect may be increased;
- non-opioid analgesics: increased toxic effects;
- ethanol: the effect on the psychomotor reaction is enhanced;
- cyclosporine: its concentration decreases (due to metamizole sodium);
- indirect anticoagulants, oral hypoglycemic drugs, glucocorticosteroids, indomethacin: increase in their activity (due to metamizole sodium);
- phenylbutazone, barbiturates and other inducers of microsomal liver enzymes: the effect of metamizole sodium is weakened;
- allopurinol, tricyclic antidepressants, oral contraceptives: the metabolism of metamizole sodium in the liver is disrupted and its toxicity increases.
Oral tablets Pentalgin-ICN (Pentalgin-ICN)
Instructions for medical use of the drug
Description of pharmacological action
Inhibits cyclooxygenase and inhibits the biosynthesis of PGs (analgin and paracetamol), stimulates opiate receptors, activates the antinociceptive system (codeine). Depresses (sedative effect) the central nervous system (phenobarbital). Caffeine increases the permeability of histohematic membranes and increases the concentration of other components in the central nervous system.
Indications for use
— pain syndrome of various origins of weak and moderate intensity (including arthralgia, myalgia, radiculitis, algodismenoria, neuralgia, headache, toothache); - colds and conditions accompanied by fever.
Release form
pills; contour packaging 10 cardboard pack 1; pills; contour packaging 10 cardboard pack 2; pills; contour packaging 12 cardboard packs 1; pills; contour packaging 12 cardboard packs 2; pills; contour packaging 6 cardboard packs 1; pills; contour packaging 6 cardboard pack 2; pills; contour cell packaging 10 cardboard box 500; pills; contour cell packaging 12 cardboard box 500; pills; contour packaging 6 cardboard box 500;
Pharmacodynamics
The combined drug has an analgesic, antipyretic, and anti-migraine effect. Paracetamol is an analgesic-antipyretic. Blocks COX mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effects. Metamizole sodium is an analgesic-antipyretic, a pyrazolone derivative. Has a pronounced analgesic effect. Caffeine is a psychostimulant, improves the well-being of patients and reduces headaches of vascular origin (including migraine). Phenobarbital is a barbiturate that increases the analgesic effectiveness of metamizole sodium and paracetamol. Codeine has an analgesic effect due to the stimulation of opioid receptors in various parts of the central nervous system, leading to stimulation of the antinociceptive system and a change in the emotional perception of pain.
Pharmacokinetics
Data on the pharmacokinetics of the drug Pentalgin-ICN are not provided.
Use during pregnancy
Contraindicated for use during pregnancy and lactation (breastfeeding).
Contraindications for use
- severe liver failure; - severe renal failure; - bronchial asthma; - anemia, leukopenia; - conditions accompanied by respiratory depression; - cranial hypertension; - acute myocardial infarction; - arrhythmias; - glaucoma; - alcohol intoxication; - deficiency of glucose-6-phosphate dehydrogenase; - pregnancy; - lactation period (breastfeeding); - children under 12 years of age; - hypersensitivity to the components of the drug. The drug should be used with caution for gastric and duodenal ulcers in remission, for arterial hypertension, and in elderly patients.
Side effects
From the side of the central nervous system: dizziness, drowsiness. From the cardiovascular system: palpitations, tachycardia. From the digestive system: nausea, vomiting, constipation. From the hematopoietic system: leukopenia, granulocytopenia, agranulocytosis. Allergic reactions: rash, itching, urticaria. Other: with prolonged uncontrolled use in high doses - addiction (weakening of the analgesic effect), drug dependence (codeine), liver and/or kidney failure.
Directions for use and doses
Inside - 1 tablet. 1–3 times a day. The course of treatment depends on the effectiveness of therapy and, as a rule, does not exceed 5 days.
Overdose
Symptoms: nausea, vomiting, gastralgia, tachycardia, arrhythmia, depression of the respiratory center. Treatment: gastric lavage, administration of intestinal adsorbents, and, if necessary, symptomatic therapy.
Interactions with other drugs
Strengthens the inhibitory effect of ethanol on the central nervous system.
Precautions for use
With long-term use, it is necessary to monitor the composition of peripheral blood. Concomitant use of alcohol should be avoided.
Special instructions for use
With long-term (more than 1 week) treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary. When taking the drug Pentalgin-ICN, it is possible to change the results of doping control tests in athletes. Taking the drug Pentalgin®-ICN makes it difficult to establish a diagnosis for acute abdominal pain syndrome. Patients suffering from atopic bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions. Effect on the ability to drive vehicles and operate machinery When using the drug, patients should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Storage conditions
List B.: In a dry place, protected from light.
Best before date
36 months
ATX classification:
N Nervous system
N02 Analgesics
N02B Analgesics and antipyretics
N02BB Pyrazolones
N02BB72 Metamizole sodium in combination with psycholeptics
