"Acyclovir" is an ointment for the treatment of herpes on the lips, intimate areas and other areas of the skin. Apply 4-5 times a day until symptoms are completely eliminated. After this, a control appointment is indicated for 3 days. It works quite quickly and at the same time has a very affordable price.
Acyclovir ointment: description, composition
"Acyclovir" is a medicine containing the component of the same name, which has antiviral activity. Available in the form of ointments and other dosage forms:
- pills;
- lyophilisate for preparing a solution;
- cream;
- eye ointment.
It has an antiherpetic effect, slows down the synthesis of viral DNA, prevents its reproduction and leads to the death of pests. This helps control the rash and reduces the likelihood of complications associated with pain, external scabs and other symptoms. Partially gives an immunostimulating effect.
The ointment is absorbed only by the affected skin. Healthy areas of the skin do not absorb the active or auxiliary components, so it should be applied only when the corresponding symptoms appear.
They are produced in metal tubes weighing 5, 10, 20 g. They can be stored under normal conditions at temperatures up to +25°C. The place should be dry, without direct sunlight. Access by children should be excluded. The shelf life is 3 years - after this period the ointment cannot be used.
Contraindications and side effects
The ointment is used exclusively externally, so it has few contraindications, with the exception of individual intolerance and possible allergic reactions. Can be used during pregnancy and breastfeeding with caution. It is advisable to consult your doctor first.
Side effects are rare and are mainly associated with the injection and tablet forms of the drug. They are mainly associated with allergic reactions:
- skin rash;
- redness;
- itching
If any of the described symptoms occur, stop taking it and consult a doctor. It may be necessary to change therapy.
Acyclovir-Akrikhin, tablets 200 mg, 20 pcs.
Manufacturer
Akrikhin KhFK JSC, Russia
Compound
Active ingredient:
acyclovir 200 mg.
pharmachologic effect
The antiviral drug is a synthetic analogue of thymidine nucleoside.
In infected cells containing viral thymidine kinase, phosphorylation occurs and is converted to acyclovir monophosphate. Under the influence of acyclovir guanylate cyclase, monophosphate is converted into diphosphate and, under the action of several cellular enzymes, into triphosphate. High selectivity of action and low toxicity to humans are due to the absence of the necessary enzyme for the formation of acyclovir triphosphate in intact cells of the macroorganism.
Acyclovir triphosphate, “incorporating” into the DNA synthesized by the virus, blocks the reproduction of the virus. The specificity and very high selectivity of the action are also due to its predominant accumulation in cells affected by the herpes virus.
Highly active against Herpes simplex virus types 1 and 2; the virus that causes chickenpox and herpes zoster (Varicella zoster); Epstein-Barr virus (types of viruses are indicated in increasing order of the MIC value of acyclovir).
Moderately active against CMV.
In case of herpes, it prevents the formation of new rash elements, reduces the likelihood of skin dissemination and visceral complications, accelerates the formation of crusts, and reduces pain in the acute phase of herpes zoster. Has an immunostimulating effect.
Indications
- Treatment of primary and recurrent severe genital herpes (including in patients with impaired immunity) - orally and parenterally; - prevention of frequently recurrent (6 or more cases per year) genital herpes (including in patients with impaired immunity) - orally; - treatment of primary and recurrent herpes simplex with damage to the skin and mucous membranes, caused by the Herpes simplex virus types 1 and 2, in patients with impaired immunity - orally, parenterally; - prevention of herpes simplex in patients with impaired immunity (including after transplantation and taking immunosuppressive drugs, HIV-infected patients, during chemotherapy) - orally; — encephalitis caused by the Herpes simplex virus types 1 and 2 — parenterally; - treatment of herpes zoster caused by the Varicella zoster virus, in adults - orally; in patients with impaired immunity and with generalized herpes zoster in patients with unimpaired immunity - parenterally; - prevention of herpes zoster caused by the Varicella zoster virus, after the initial period of using acyclovir for parenteral use in all patients with impaired immunity (including after transplantation and when taking immunosuppressive drugs, HIV-infected patients, during chemotherapy) - orally; - herpes zoster with eye damage - orally, parenterally; - generalized infection in newborns caused by the Herpes simplex virus - parenterally; - chicken pox in patients with unimpaired immunity within 24 hours after the appearance of a typical rash - orally, in patients with impaired immunity - parenterally.
Use during pregnancy and breastfeeding
Use during pregnancy is only possible if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to use the drug during lactation, breastfeeding should be stopped.
Contraindications
Hypersensitivity (including to valacyclovir), children under 3 years of age (for solid dosage forms).
Carefully. Pregnancy, lactation period.
Side effects
From the digestive system: in isolated cases - abdominal pain, nausea, vomiting, diarrhea; rarely - transient increase in liver enzyme activity, hyperbilirubinemia.
From the hematopoietic system: rarely - leukopenia, erythropenia.
From the side of the central nervous system: rarely - headache, weakness; in some cases - tremor, dizziness, increased fatigue, drowsiness, hallucinations.
Allergic reactions: skin rash; rarely - allergic dermatitis (when using ointment).
Local reactions: when using the ointment, redness, itching, peeling, burning or tingling are possible.
Other: rarely - alopecia, fever, increased levels of urea and creatinine.
Interaction
When used simultaneously with probenecid, the average half-life of acyclovir increases and the clearance of acyclovir decreases.
When taken simultaneously with nephrotoxic drugs, the risk of developing renal dysfunction increases.
How to take, course of administration and dosage
The dosage regimen is set individually depending on the severity of the disease.
In the treatment of infections of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2, for adults and children over 2 years of age, Acyclovir is prescribed 200 mg 5 times a day for 5 days at intervals of 4 hours during the day and at intervals of 8 hours at night. . In more severe cases of the disease, it is possible to increase the course of treatment.
As part of complex therapy for severe immunodeficiency, including with a full-blown clinical picture of HIV infection (including early clinical manifestations of HIV infection and the stage of AIDS), after bone marrow implantation, 400 mg is prescribed 5 times a day.
To prevent relapses of infections caused by Herpes simplex virus types 1 and 2, patients with normal immune status and in case of relapse of the disease are prescribed 200 mg 4 times a day every 6 hours.
For the prevention of infections caused by the Herpes simplex virus types 1 and 2, in adults and children over 2 years of age with immunodeficiency, the drug is prescribed 200 mg 4 times a day every 6 hours, the maximum dose is 400 mg 5 times a day.
When treating infections caused by the Varicella zoster virus, adults are prescribed 800 mg 5 times a day at 4-hour intervals during the day and at 8-hour intervals at night. The duration of treatment is 7-10 days. Children over 2 years old are prescribed 20 mg/kg body weight 4 times a day for 5 days; children weighing more than 40 kg are prescribed the drug in the same dosage as adults.
In the treatment of herpes zoster (Herpes zoster), adults are prescribed 800 mg 4 times a day every 6 hours for 5 days. Children over 6 years old - 800 mg 4 times a day; 2-6 years - 400 mg 4 times a day; under 2 years - 200 mg 4 times a day. More precisely, the dose can be determined at the rate of 20 mg/kg, but not more than 800 mg 4 times/day. The course of treatment is 5 days.
In patients with severe renal impairment (KK) in the treatment and prevention of infections caused by the Herpes simplex virus, the drug is prescribed 200 mg 2 times a day at intervals of 12 hours.
When treating infections caused by the Varicella zoster virus, patients with CC are prescribed the drug 800 mg 2 times a day at intervals of 12 hours; with CC from 10 to 25 ml/min - 800 mg 3 times a day at intervals of 8 hours.
The drug should be taken during or immediately after meals and washed down with enough water.
Overdose
Ingestion of 20 g of acyclovir has been reported. Symptoms: agitation, coma, convulsions, lethargy. Precipitation of acyclovir in the renal tubules is possible if its concentration exceeds the solubility in the renal tubules (2.5 mg/ml).
Overdose with parenteral administration (with bolus administration, or use in high doses, or in patients whose water and electrolyte balance is not properly controlled): increased urea nitrogen, hypercreatininemia, impaired renal function, lethargy, convulsions, coma.
Treatment: maintenance of vital functions, hemodialysis.
Special instructions
Acyclovir should be prescribed with caution to patients with impaired renal function and elderly patients due to an increase in the half-life of acyclovir. When using the drug, it is necessary to ensure the supply of a sufficient amount of fluid.
Release form
Pills.
Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Best before date
4 years.
Active substance
Acyclovir
Conditions for dispensing from pharmacies
On prescription
Dosage form
pills
Purpose
For adults as prescribed by a doctor, Children over 2 years old, Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor, Pregnant women as prescribed by a doctor
Indications
Herpes, Cold
Information in the State Register of Medicines
Go
Barcode and weight
Barcode: 4601969000177, 4601969007237 Weight: 0.015 kg
Instructions for use "Acyclovir"
The ointment is applied only externally to the affected areas of the skin 4-5 times a day (with an interval of 4-5 hours). The skin surface is first washed and dried. Then squeeze out a small volume (half a pea) and rub into a thin layer.
The eye ointment is applied in a small strip to a clean finger and placed in the lower eye bag from the conjunctival side. The frequency of doses is the same - 4-5 times a day with an interval of 4-5 hours. Therapy lasts until complete recovery. In this case, there is no need to immediately stop treatment - after eliminating obvious symptoms, the ointment continues to be applied for another 3-4 days.
Acyclovir-Akrikhin
The drug is taken orally, during or immediately after a meal, with a sufficient amount of water.
The dosage regimen is set individually depending on the severity of the disease.
When treating infections of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2, adults are prescribed 200 mg 5 times a day (every 4 hours while awake, excluding night sleep) for 5 days; when treating genital herpes - 10 days. If necessary, the duration of treatment can be increased.
As part of complex therapy for severe immunodeficiency, incl. with a developed clinical picture of HIV infection (including early clinical manifestations of HIV infection and the stage of AIDS), after bone marrow transplantation, 400 mg is prescribed 5 times a day.
To prevent relapses of infections caused by Herpes simplex viruses types 1 and 2, in patients with normal immune status, adults are prescribed 200 mg 4 times a day every 6 hours. The course duration is from 6 to 12 months.
To prevent infections caused by the Herpes simplex virus types 1 and 2, in patients with immunodeficiency, adults are prescribed 200 mg 4 times a day every 6 hours, the maximum dose is up to 400 mg of acyclovir 5 times a day, depending on the severity of the infection.
When treating herpes zoster - 800 mg 5 times a day (every 4 hours while awake, excluding night sleep) for 7-10 days.
For children over 3 years of age, the drug is prescribed in the same dose as for adults.
When treating chickenpox, adults and children over 6 years of age are prescribed 800 mg 4 times a day; children aged 3-6 years - 400 mg 4 times a day. More accurately, the dose can be determined at the rate of 20 mg/kg. The course of treatment is 5 days.
In patients with impaired renal function, dose adjustment and dosage regimen are necessary depending on the amount of CC and the type of infection. When treating an infection caused by Herpes simplex, with CC less than 10 ml/min, the daily dose of the drug should be reduced to 400 mg, divided into 2 doses (with intervals between them of at least 12 hours, i.e. 200 mg 2 times a day ). In the treatment of infections caused by Varicella zoster, and during maintenance therapy in patients with severe immunodeficiency - patients with CC 10-25 ml/min are prescribed the drug 800 mg 3 times a day with an interval of 8 hours, with CC less than 10 ml/min - according 800 mg 2 times a day with an interval of 12 hours.
Overdose
Symptoms: agitation, coma, convulsions, lethargy. Precipitation of acyclovir in the renal tubules is possible if its concentration exceeds the solubility in the renal tubules (2.5 mg/ml).
Treatment: symptomatic therapy.
Cases of overdose
If the described dosages are observed, the drug is safe for health. However, if the ointment gets inside, the following consequences may occur:
- diarrhea;
- convulsions;
- nausea;
- vomit;
- kidney disorders;
- coma;
- headaches;
- disorders of the nervous system;
- lethargy.
In these cases, you need to do a gastric lavage, take several tablets of activated carbon, crush them and drink water. Treatment is symptomatic; you may need to consult a doctor.
