Advantan for infants: how to apply the ointment correctly, side effects and reviews from mothers

A rash is a modified area of ​​skin that differs from healthy dermis in appearance, texture and shade. It may appear as blisters, papules, localized spots or blisters. Only a pediatrician or dermatologist can make the correct diagnosis.

Pharmacies are overflowing with specialized medications that promise to quickly relieve the baby from an unpleasant illness. When choosing medications for newborns, it is important to be guided by 2 criteria - effectiveness and safety. And in this context, the drug Advantan for infants, recommended by many dermatologists and pediatricians, deserves special attention.

Compound

Release form

Dosage forms of Advantan:

• ointment 0.1% (tubes 15 g);
• fatty ointment 0.1% (tubes 5 and 15 g);
• cream 0.1% (tubes 5 and 15 g);
• cutaneous emulsion 0.1% (tubes of 10, 20 and 50 g).

Ointment 0.1% is a white or slightly yellowish homogeneous opaque mass. Fatty ointment 0.1% is translucent, white or white with a slightly yellowish tint. Cream 0.1% for external use is white or slightly yellowish, opaque. Emulsion is an opaque white substance.

Pharmacodynamics

The active component of Advantan®, methylprednisolone aceponate, is a non-halogenated steroid. When applied externally, Advantan® suppresses inflammatory and allergic skin reactions, as well as reactions associated with increased proliferation, which leads to a reduction in objective symptoms of inflammation (including erythema, swelling, weeping) and subjective sensations (including itching, irritation, pain).

When methylprednisolone aceponate is used topically at the recommended dose, the systemic effect is minimal in both humans and animals. After repeated application of the drug Advantan® to large surfaces (40–60% of the skin surface), as well as application under an occlusive dressing, no dysfunction of the adrenal glands is observed: the level of cortisol in plasma and its circadian rhythm remain within normal limits, and there is no decrease in the level of cortisol in daily urine is happening.

During clinical studies, when using the drug Advantan® for up to 12 weeks in adults and up to 4 weeks in children (including young children), the development of skin atrophy, telangiectasia, stretch marks and acne-like rashes was not detected.

Methylprednisolone aceponate (especially its main metabolite, 6α-methylprednisolone-17-propionate) binds to intracellular GCS receptors. The steroid receptor complex interacts with specific regions of the DNA of immune response cells, thereby causing a series of biological effects. In particular, binding of the steroid receptor complex to DNA cells of the immune response leads to the induction of macrocortin synthesis. Macrocortin inhibits the release of arachidonic acid and thereby the formation of inflammatory mediators such as PG and LT.

GCS inhibition of the synthesis of vasodilating PGs and potentiation of the vasoconstrictor effect of adrenaline lead to a vasoconstrictor effect.

Reviews about Advantan

Reviews of Advantan cream, as well as reviews of Advantan ointment, are quite contradictory: some call these products a salvation for skin prone to inflammatory and allergic diseases , others not only do not see an improvement in the condition, but, on the contrary, believe that the use of the drug only worsened the course of the disease.

However, based on the fairly high rating of the product on specialized sites (an average of 4.2-4.3 on a five-point scale), we can conclude that the cream, ointments, and emulsion are effective medications, but they must be prescribed by a doctor . Moreover, supplementing external therapy with general treatment in order to eliminate not only the symptoms, but also the cause of the pathological process.

In reviews of Advantan cream for children, many mothers write that the drug quickly copes with itching and unpleasant skin rashes, but in order to consolidate the result and prevent relapses, it is necessary not only to undergo a course of treatment, but also to review the diet and eliminate all possible allergens.

Pharmacokinetics

Methylprednisolone aceponate is hydrolyzed in the epidermis and dermis. The main and most active metabolite is 6α-methylprednisolone-17-propionate, which has a significantly higher affinity for GCS receptors in the skin, which indicates the presence of its bioactivation in the skin.

The intensity of percutaneous absorption for ointments and creams depends on the condition of the skin, dosage form and method of application (on an open area of ​​skin or under an occlusive dressing). Percutaneous absorption in children and adults with atopic dermatitis (neurodermatitis) and psoriasis was no more than 2.5%, which is only slightly higher than in healthy volunteers (0.5–1.5%).

After entering the systemic circulation, 6α-methylprednisolone-17-propionate is rapidly conjugated with glucuronic acid and is thus inactivated in the form of 6α-methylprednisolone-17-propionate-21-glucuronide. Metabolites of methylprednisolone aceponate are eliminated mainly by the kidneys with a T1/2 of about 16 hours. Methylprednisolone aceponate and its metabolites do not accumulate in the body.

Advantan's analogs

Level 4 ATC code matches:
Gistan-N

Sinalar

Avecourt

Mesoderm

Momederm

Betazon

Silkaren

Elokom

Flucinar

Sinaflan

Celestoderm

Cutivate

Betamethasone

Beloderm

Mometasone Furoate

Uniderm

Momat

Analogues of Advantan are the drugs Akriderm , Beloderm , Cutivate , Momat , Monovo , Sinoderm , Celestoderm-B , Elokom , Betliben .

Under the indicated names, both cream analogs and ointment substitutes are produced.

The price of ointment analogues is from 105 Russian rubles.

What is better - Advantan or Elokom?

Advantan and Elokom are analogue drugs. The basis of the first is methylprednisolone , the second contains mometosone furoate .

Methylprednisolone penetrates the systemic circulation in smaller quantities than mometosone and is considered safer for use in pediatrics.

Mometosone is well absorbed by the body through the skin, which can cause quite serious side effects in the child (muscle weakness, weight gain, swelling, etc.), as well as, in the case of long-term use, growth retardation.

Unlike Advantan, which can be prescribed even to 4-month-old children, Elokom is indicated only from 2 years of age.

Side effects

The drug is usually well tolerated.

Very rarely (less than 0.01% of cases) local reactions may be observed, such as itching, burning, erythema, and the formation of a vesicular rash. If the drug is used for more than 4 weeks and/or on an area of ​​10% or more of the body surface, the following reactions may occur: skin atrophy, telangiectasia, stretch marks, acneiform skin changes, systemic effects due to the absorption of GCS. During clinical studies, none of the above side effects were noted when using Advantan® for up to 12 weeks in adults and up to 4 weeks in children.

In rare cases (0.01–0.1%), folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, and allergic reactions to one of the components of the drug may occur.

Overdose

In studies aimed at studying the acute toxicity of Advantan, no risk of acute intoxication was established either with a single external use of the drug in an excessively high dose or with accidental ingestion.

Excessively long treatment with glucocorticosteroids , as well as intensive local use of these agents, can cause thinning and atrophy of the skin, the appearance of stretch marks and telangiectasia .

Treatment involves discontinuation of the drug.

Directions for use and doses

For all dosage forms

Externally.

Adults and children from 4 months of age.

The drug is applied once a day in a thin layer to the affected areas of the skin. As a rule, the duration of continuous daily treatment with Advantan® should not exceed 12 weeks for adults and 4 weeks for children.

Additionally for ointment for external use

For subacute or chronic inflammatory skin diseases that are not accompanied by weeping, a dosage form with a balanced ratio of fat and water is necessary. Advantan® ointment has a therapeutic effect, also helping to eliminate dry skin and restore its normal oil content.

Additionally for cream for external use

For subacute and acute inflammation without significant weeping, a dosage form with a low fat content and high water content is required. Advantan® cream ensures the elimination of the inflammatory process both on smooth skin and on the scalp, incl. on skin prone to oily skin.

For children

Advantan is prescribed for children for allergic and inflammatory skin diseases .

Advantan for infants and older children is prescribed in the form of an ointment or cream, since there is currently no accurate data regarding the safety of using the emulsion.

Mothers often have questions: “Is Advantan ointment hormonal or not?” or “Is the cream hormonal or not?” The active substance of Advantan - methylprednisolone - is a synthetic glucocorticosteroid , that is, the drug is hormonal .

Since the medicine contains hormones, it should be prescribed very carefully (this is especially true for infants). However, in the presence of severe clinical symptoms of allergy , the remedy can be recommended starting from the age of four months.

In accordance with the instructions, both cream and ointment can be used in a child for no more than 4 weeks. The medicine should be applied to the skin once a day.

When prescribing a topical glucorticoid (GC) to a child for external use, doctors usually adhere to the following rules:

• these drugs are used taking into account the biorhythms of children (in order for GC to imitate the daily rhythm of the function of the adrenal cortex , the drug should be used in the morning);
• use an individual approach to each child, taking into account the extent of skin damage, age, severity of the process, clinical form of the disease, duration of previous treatment using similar agents, etc.;
• change the concentration of hormones in the dosage form, diluting it in different proportions with indifferent creams (for infants, dermatologists often advise diluting the drug with baby cream or petroleum jelly in a ratio of 1:10, the optimal proportion for children under three years of age is 1:7, for children three - five years old - 1:4, for children 5-10 years old - 1:3, for children over 10 years old - 1:1);
• external therapy with GC drugs is complemented by other types of local and systemic treatment

Advantan is effective for diathesis in children and other allergic skin reactions even in critical skin conditions. However, it should be borne in mind that for a very young child, as well as in the presence of significant skin lesions, it is recommended to apply it very carefully, since methylprednisolone , being absorbed through the skin into the systemic bloodstream, can cause side effects .

The drug is hormonal, so it is necessary to stop treatment gradually.

What is better - cream or ointment?

The choice of dosage form is determined by the condition of the skin: for dry skin, the optimal choice is a fatty ointment; for normal skin (not dry, and without weeping elements of the rash) - ointment; for diseases characterized by weeping , doctors recommend using cream, and for the treatment of sunburn and photodermatitis, it is best to use an emulsion.

special instructions

In the presence of bacterial complications and/or dermatomycosis, in addition to therapy with Advantan®, it is necessary to carry out specific antibacterial and/or antimycotic treatment.

Avoid contact of the drug with the eyes.

As with the use of systemic corticosteroids, glaucoma may develop after external use of corticosteroids (for example, when using large doses or very long-term use of occlusive dressings or application to the skin around the eyes).

Impact on the ability to drive vehicles and operate machinery. Not found.

Contraindications

Advantan should not be prescribed for:

• the presence of manifestations of syphilis on the skin in the area of ​​application of the product;
• skin tuberculosis;
• viral skin diseases with localization of lesions in the area of ​​application of cream, ointment or emulsion (for example, herpes zoster or chicken pox );
• perioral dermatitis or rosacea in the area where the medication is applied;
• skin reactions to the vaccine;
• hypersensitivity to the components included in the drug.

In pediatrics, the drug is used to treat children over 4 months of age.

Causes of rashes in babies

Allergic dermatitis is a common skin disease characteristic of newborns and young children. Despite the fact that the rash can be effectively and quickly gotten rid of, it causes a lot of inconvenience for both the little ones themselves and their parents. The first sign of concern is redness of the baby's bottom or cheeks.

Pediatricians identify several reasons that can trigger a rash in babies:

• inappropriate nutritional mixture (typical with artificial feeding);
• the presence of active allergens in mother’s breast milk;
• diaper rash that occurs when wearing diapers;
• sweat rash;
• deficiency of fluid in the toddler’s body (often observed when feeding formulas);
• unsuitable air freshener, washing powder, bedding or clothing fabric.

Doctors recommend using Advantan ointment for children in each of the listed cases. It effectively and quickly eliminates the rash and accompanying symptoms, and promotes the formation of resistance to external irritants and allergens.

Advantana price, where to buy

How much an ointment, cream or emulsion costs depends on the pharmacy through which the drug is sold. On average, the price of Advantan cream 15 g is 370 rubles, the price of Advantan ointment 15 g is 350 rubles, fatty ointment 15 g is 350 rubles, the price of Advantan emulsion is from 355 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Advantan oily ointment 0.1% 15g Intendis Manuf.Spa/Bayer Healthcare Manufacturing S.r.l
  571 rub.order
• Advantan cream 0.1% 15 gLEO Pharma Manufacturing Italy S.r.l.

  RUR 571 order

• Advantan ointment 0.1% 15g Intendis Manuf.Spa/Bayer Healthcare Manufacturing S.r.l.

  RUR 571 order

• Advantan emulsion for external use. approx. 0.1% 20g Bayer Healthcare Manufacturing S.R.L.

  RUR 571 order

• Advantan ointment 0.1% 50g Intendis Manuf.Spa/Bayer Healthcare Manufacturing S.r.l.

  RUB 1,246 order

Pharmacy Dialogue

• Advantan cream tube 0.1% 15gIntendis Manufakturing

  RUR 621 order

• Advantan ointment (tube 0.1% 15g)Intendis Manufakturing

  RUR 597 order

• Advantan emulsion tube 0.1% 20gIntendis Manufakturing

  RUR 599 order

• Advantan ointment tube 0.1% 50gIntendis Manufakturing

  RUB 1,269 order

• Advantan ointment tube 0.1% 15g fattyBayer

  RUR 558 order

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Pharmacy24

• Advantan 0.1% 15 g No. 1 cream Bayer Healthcare Manufacturing S.R.L., Italy
  255 UAH.order
• Advantan 0.1% 15 g ointment Bayer Healthcare Manufacturing S.R.L., Italy

  255 UAH order

• Advantan 0.1% 20 g No. 1 emulsion Bayer Healthcare Manufacturing S.R.L., Italy

  255 UAH order

PaniPharmacy

• Advantan liquid Advantan emul. 0.1% 20g Italy, Bayer Healthcare Manufacturing

  284 UAH order

• Advantan cream Advantan cream 0.1% 15g Italy, Bayer Healthcare Manufacturing

  269 ​​UAH. order

• Advantan ointment Advantan ointment 0.1% 15g Italy, Bayer Healthcare Manufacturing

  291 UAH order

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