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Manufacturers: Pharmcenter Vilar
Active ingredients
- Tetrahydroxyglucopyranosylxanthene
Disease class
- Anogenital herpetic viral infection
- Cytomegalovirus disease
- Herpes simplex virus infections
- Herpetic eczema
- Herpetic gingivostomatitis and pharyngotonsillitis
- Chicken pox [varicella]
- Shingles
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antiviral
- Antibacterial
- Immunomodulatory
- Bacteriostatic
Pharmacological group
- Antiviral (except HIV) drugs
Directions for use and doses
Externally, locally, 4–6 times a day.
For skin lesions, adults are prescribed 5% ointment, children - 2%; on mucous membranes of adults and children - 2% ointment. Apply the ointment in a thin layer and rub in lightly.
The therapeutic effect of the drug is most pronounced when it is prescribed in the initial period of the disease or relapse. The duration of treatment depends on the form and severity of the disease.
For acute and recurrent forms of herpes simplex of extragenital localization (with single rashes), the ointment is applied to the affected area for 3–5 days. In case of widespread rashes, as well as in the presence of fever, lymphadenopathy and other general phenomena, the ointment is used for 5–14 days.
For Kaposi's eczema herpetiformis and CMV infection, the ointment is used in the same age-specific dosages for 7–21 days in complex therapy.
For genital herpes, 2% ointment is applied to the affected areas for 7–10 days.
For viral diseases of the oral mucosa (aphthous stomatitis), the ointment is applied to the affected areas for 5–15 days, for the erosive-ulcerative form of lichen planus of the oral mucosa - for 2–4 weeks.
For diseases caused by Herpes zoster (shingles) and Varicella zoster (chickenpox), 5% ointment is prescribed topically for adults, and 2% for children - 2% on the affected area for 5-21 days. In case of relapses, repeat courses of treatment with the drug are carried out.
Ointment for external use Alpisarin ointment (Alpisarin ointment)
Instructions for medical use of the drug
Description of pharmacological action
An antiviral agent obtained from the herb kopeck.
Indications for use
Herpes simplex (acute and recurrent forms of extragenital and genital localization); Kaposi's eczema herpetiformis; cytomegalovirus infection; viral diseases of the oral mucosa, incl. aphthous stomatitis; shingles; chicken pox.
Release form
ointment for external use 2%; aluminum tube 10 g, cardboard pack 1. ointment for external use 5%; aluminum tube 10 g, cardboard pack 1. ointment for external use 2%; aluminum tube 20 g, cardboard pack 1. ointment for external use 2%; dark glass jar (jar) 10 g, cardboard pack 1. ointment for external use 2%; dark glass jar (jar) 20 g, cardboard pack 1. ointment for external use 5%; aluminum tube 20 g, cardboard pack 1. ointment for external use 5%; dark glass jar (jar) 10 g, cardboard pack 1. ointment for external use 5%; dark glass jar (jar) 20 g, cardboard pack 1. ointment for external use 2%; aluminum tube 10 g, cardboard pack 1. ointment for external use 5%; aluminum tube 10 g, cardboard pack 1. ointment for external use 2%; aluminum tube 20 g, cardboard pack 1. ointment for external use 5%; aluminum tube 20 g, cardboard pack 1.
Pharmacodynamics
It has antiviral activity against herpes simplex viruses, Herpes zoster, Varicella zoster, CMV, and human immunodeficiency virus. The inhibitory effect of Alpizarin® on virus reproduction is especially evident in the early stages. Alpizarin® has a moderate bacteriostatic effect against staphylococcus, Escherichia coli, tuberculous mycobacteria and parasitic protozoa - Entamoeba histolitica and Trichomonas vaginalis. The mechanism of action of the drug is based on the suppression of bacterial nuclease, without a pronounced inhibitory effect on viral neuraminidase. Alpizarin® has anti-inflammatory and immunostimulating properties in relation to cellular and humoral immunity, and the ability to induce the production of interferon gamma in blood cells. Alpizarin® is a low-toxic substance and does not have allergenic, mutagenic, teratogenic or irritating properties.
Pharmacokinetics
Rapidly absorbed into the gastrointestinal tract. In the blood, the unchanged drug is determined in concentrations of 0.05–4.5 μg/ml within 0.5–5 hours after administration, with Cmax (4.5 μg/ml) achieved 1 hour after administration of the drug. Urinary excretion does not exceed 0.1%.
Use during pregnancy
Contraindicated during pregnancy.
Contraindications for use
Individual intolerance; pregnancy.
Side effects
Allergic reactions are possible.
Directions for use and doses
Locally: 4–6 times a day, for skin lesions - 5% ointment for adults, 2% ointment for children; on the mucous membranes of adults and children - only 2% ointment. Apply the ointment in a thin layer and rub in lightly. For acute and recurrent forms of herpes simplex of extragenital localization: for single rashes, the ointment is applied to the affected area for 3–5 days; for widespread rashes, fever, lymphadenopathy - simultaneously in the form of 0.1 g tablets and ointment for 5-14 days. For Kaposi's eczema herpetiformis and cytomegalovirus infection: in complex therapy in the same age-specific dosages for 7–21 days. For genital herpes: apply 2% ointment to the affected areas 4-6 times a day for 7-10 days. In the case of a recurrent course of the disease, additional tablets are prescribed for 5–14 days. For viral diseases of the oral mucosa, incl. aphthous stomatitis, orally in the indicated age dosages and at the same time in the form of an ointment (on the affected areas of the oral mucosa) - 2% ointment for 5–15 days; for erosive-ulcerative form of lichen planus of the oral mucosa - for 2–4 weeks. For diseases caused by Herpes zoster (shingles) and Varicella zoster (chickenpox): tablets (in the same age-specific dosages) and 2% (children) or 5% (adults) ointment on the affected areas for 5–21 days. In case of relapses, repeat courses. To prevent relapses of herpes viral infections, tablets are prescribed 1 month after the end of treatment and then in courses between relapses of 10–14 days.
Interactions with other drugs
Not studied.
Special instructions for use
Tablets are usually prescribed in combination with ointment. The therapeutic effect is most pronounced when prescribed in the initial period of the disease or relapse.
Storage conditions
In a place protected from light, at a temperature of 12–15 °C.
Best before date
60 months
ATX classification:
D Dermatotropic drugs
D06 Antimicrobials for the treatment of skin diseases
D06B Other antimicrobials for external use
D06BB Antiviral drugs
pharmachologic effect
Antiviral, antibacterial (bacteriostatic), immunomodulatory. Affects DNA-containing viruses, suppresses bacterial nuclease, stimulates cellular and humoral immunity, induces the production of interferon gamma. It has anti-inflammatory, cardiotonic and sedative activity. Suppresses the development of herpes simplex virus, Varicella zoster (shingles and chickenpox virus), CMV, human immunodeficiency virus, resistance practically does not arise. Stops the growth of gram-positive and gram-negative bacteria, tuberculous mycobacteria and is active against parasitic protozoa.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before you start using Alpizarin ointment, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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Alpizarin ointment 5% cor 10 g x1
Trade name: Alpisarin ointment International name: Tetrahydroxyglucopyranosilxanten
Release form: ointment for external use 2%, 5% (dark glass jars, aluminum tubes) 10, 20 g
Composition: tetrahydroxyglucopyranosylxanthene 2/5 g - 100 g
Pharmacological group: antiviral agent for topical use
Pharmacological group according to ATK: D06BB (Antiviral drugs)
Pharmacological action: antiviral, antiherpetic,
Indications: Infections of the skin and mucous membranes caused by the Herpes simplex and Varicella zoster viruses: genital herpes, herpes simplex, chickenpox, herpes zoster. Kaposi's syndrome, lichen planus, warts, genital warts.
Dosage regimen: Adults and children over 12 years old are prescribed orally (regardless of food intake) 100-200 mg 3-4 times a day for 5-10 days, children 6-12 years old - 0.1 g 2-3 times a day , children 1-6 years old - 0.05-0.1 g 2-3 times a day. At the same time, local applications of 5% ointment to the skin and 2% ointment to the mucous membranes are prescribed. The ointment is applied to the affected areas of the skin without a bandage 2-6 times a day. The therapeutic effect is more pronounced when used in the early stages of the disease. The duration of treatment is 10-30 days. In case of relapse, the course is repeated. For acute and recurrent forms of Herpes simplex of extragenital localization, for single rashes, the ointment is applied to the affected area 2-3 times a day for 3-5 days. In case of widespread rashes, as well as in the presence of fever, lymphadenopathy is prescribed simultaneously orally and in the form of an ointment for 5-14 days. For eczema herpetiformis, Kaposi is used as part of complex therapy for 7-21 days; for genital herpes, 2% ointment is applied to the affected areas 4-6 times a day for 7-10 days; for recurrent disease - additionally orally for 5- 14 days For viral diseases of the oral mucosa, it is prescribed orally in the same doses and at the same time 2% ointment is applied to the affected areas for 5-15 days, for the erosive-ulcerative form of lichen planus of the oral mucosa - for 2-4 weeks. For diseases caused by Varicella zoster, combination therapy is carried out, including oral administration and local application of 2% (children) or 5% (adults) ointment to the affected area for 5-21 days. To prevent relapses of Herpes simplex, an oral course is prescribed 1 month after the end of treatment and then in inter-relapse periods in courses of 10-14 days.
Contraindications: Hypersensitivity, pregnancy.
Side effects: Allergic reactions.
Pharmacodynamics: Antiviral agent, obtained from the herb kopeck. Active against DNA-containing viruses (Herpes simplex types 1 and 2, Varicella zoster, to a lesser extent CMV and HIV). Suppresses the reproduction of the Herpes virus in the early stages of its development. Suppresses bacterial nuclease without a pronounced inhibitory effect on viral neuraminidase. It has a moderate bacteriostatic effect against gram-positive and gram-negative bacteria, protozoa and mycobacterium tuberculosis. It has an immunostimulating effect on cellular and humoral immunity, induces the production of interferon gamma in blood cells.
Pharmacokinetics: Absorption - high, time of onset of Cmax - 1-3 hours, penetrates well into the organs and tissues of the liver, kidneys, heart, spleen, after 12 hours it is found in small quantities in brain tissue. Excreted by the kidneys and through the gastrointestinal tract.
Drug registration number: 85/507/10
