A new look at the pathogenesis and treatment of androgenetic alopecia

HomeGenerolon for baldness

GENEROLON® is able to stimulate hair growth, regardless of the cause of hair loss. It is effective for all types and causes of hair loss (after eliminating the factor that caused hair loss).

Generalon Spray 2% is recommended for use in women with hair loss problems.
Generalolon Spray 5% is used as a basic treatment for all types of alopecia in men.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

When applied locally, minoxidil has been shown to accelerate hair growth in patients with androgenetic alopecia . Strengthens microcirculation, activates the transition of hair cells to the growing phase, transforms the effect of male hormones on hair follicles. Suppresses the synthesis of 5-alpha-dehydrosterone , which is involved in the formation of baldness.

It has the greatest effect at a young age, with a short duration of the disease (up to 10 years), with a parietal bald spot of up to 10 cm, and the presence of more than 100 hairs in the center of the bald spot. Signs of growth may be observed after four months of using the drug. The severity and speed of onset of the effect varies depending on individual characteristics. Generolon 5% stimulates hair growth more strongly than a 2% solution of the drug. After completing the use of the drug Generalolon, hair growth stops; after 3-4 months, restoration of the original state is possible.

The mechanism of action in the treatment of androgenic alopecia is unknown. The drug is ineffective for medicinal alopecia or baldness caused by poor diet and “tight” hair styling.

Pharmacokinetics

When used externally, it is poorly absorbed through intact skin: about 1.5% of the applied dose reaches the systemic bloodstream. 95% of the substance that enters the bloodstream is eliminated after 4 days.

The mechanisms of biotransformation are not fully understood. The drug does not bind to plasma proteins and is evacuated by the kidneys. Does not pass through the blood-brain barrier.

ACTIVE COMPONENTS OF THE PREPARATION:

• The vasodilator epigenin (citrus fruit extract) dilates blood vessels and stimulates microcirculation of the hair papillae.

It has been proven that for effective therapeutic effects for alopecia, it is necessary to stimulate blood circulation in the scalp for at least 8 hours a day. (For comparison: pepper, mustard, ginger stimulate blood circulation for no more than 1 hour!) It is this effect in the drug that is achieved with the help of non-essential oil epigenin, which prevents any allergic reactions.

Redness is possible (as superficial vasodilation occurs) when applied to the skin of the face or in the morning when rinsing the hair, which disappears after 5–10 minutes.

• Biotinyl tripeptide is a recombinant peptide that is a growth factor. Accelerates hair growth in length up to 40% (when using a 3-month course) and in width, increasing root volume.
• Oleanolic acid (extract from olive leaves). Normalizes testosterone metabolism in the skin and increases hair thickness.
• Ozonides – olive oil saturated with ozone.

Contraindications: pregnancy, active oncology, frequent epileptic seizures.

Side effects

• Local effects: dermatitis of the scalp, itching , folliculitis , allergic contact dermatitis , hypertrichosis, seborrhea , accelerated hair loss (stops within two weeks).
• Systemic effects (if the product is swallowed): nonspecific allergic phenomena , facial swelling shortness of breath , allergic rhinitis , vertigo , headache , thoracalgia, neuritis , pressure fluctuations, arrhythmia , rapid heartbeat, edema.

Instructions for use (Method and dosage)

Instructions for use of Generalolon prescribe external use of the drug.

Regardless of the size of the affected area, 1 ml of spray should be applied using a dispenser (seven pumps) twice a day, starting from the central area. After use, wash your hands well. The total daily dosage is up to 2 mg.

Patients who do not experience strong hair growth when using a 2% spray, and those who need accelerated hair growth, are allowed to use the 5% spray version.

For men, this remedy is most effective for baldness on the crown, for women - for baldness in the area of ​​the middle parting. Generolon is applied exclusively to dry skin of the scalp and does not require rinsing.

The first signs of increased hair growth may appear after using the product twice a day for four months or more. The severity, onset of growth and quality vary from patient to patient.

According to rare reports, after stopping use of the drug Generalolon, hair growth stops, and after 3-4 months it is possible that the original state will be restored.

The duration of therapy is on average 1 year.

Preparation for use

Remove the cap and put on the measuring pump. Attach the spray nozzle to the top of the pump. Press the spray nozzle several times, after which the spray can be used.

Features of use

Using a mesoscooter

The use of mesoscooters is designed to improve the penetration of minoxidil into the skin, enhance its penetration and effect on the hair follicles. Mesoscooters are used both for the scalp and to stimulate the growth of stubble on the face. It is most reasonable to use a device with short needles - no more than 0.5 mm. This needle size is considered less traumatic, providing stimulation that increases blood circulation. Before purchasing a mesoscooter, you must be aware of the risks associated with its use: there is a danger of injuring (puncture) the skin and introducing or spreading an existing infection. In addition, when tissue damage increases the likelihood of minoxidil penetrating not into the hair follicles, but into the bloodstream, which is fraught with side effects. In some cases, when using a mesoscooter, users note increased sebum secretion and the appearance of dandruff. This is due to damage to the sebaceous glands and stimulation of sebum production, combined with the rapid development of a conditionally pathogenic microorganism - the fungus Pityrosporum. The microorganism “wakes up” only when there is a disturbance in the activity of the sebaceous glands, and its development leads to the appearance of oily dandruff.

If you decide to use a mesoscooter, then after each procedure it must be washed, stored in an airtight case, and treated with an antiseptic before use to minimize the likelihood of introducing and multiplying an infection.

Dandruff - a reaction to the base of the drug

All minoxidil-based drugs have a medicinal “base” consisting of ethanol, water and propylene glycol polyhydric alcohol, in which minoxidil is dissolved. It is to this base that some patients experience a reaction in the form of dandruff, sometimes accompanied by itching and irritation. If such a problem occurs, stop using the drug for a few days and then resume its use. If the itching and irritation is very pronounced, it is advisable to apply Belosalik spray to the scalp for 3-5 days, and also use sulsena shampoo or shampoo containing clobetasol to wash your hair. After this, resume regular use of Generolon.

The phenomenon of “synchronization” in AGA

Approximately 2 weeks after starting use, increased hair loss may be observed.
The duration of the phenomenon is approximately 1-1.5 weeks. This is a normal reaction and one of the signs that the drug has begun to work. The reason for this phenomenon is that the hair follicles “revitalized” and began to synthesize new hair, which pushes out the old obsolete hair that is in the terminal stage from the follicles. During this period, it is important not to be afraid of what is happening and not to stop using Generolon! The second wave of hair loss may occur approximately 2 months after the start of treatment. Some hair may leave your head again. This phenomenon is also associated with a new phase of hair growth and renewal. It is important to understand and feel physically that new short “young” hair is growing. This will give you confidence that you are doing everything right. Treatment with Generalolon must be continued. The severity of “synchronization” is different for everyone and depends on many factors, but primarily on the number of follicles initially in the stage. Another, final stage of hair loss usually occurs at 6-7 months of using minoxidil. As a rule, this is a less pronounced loss. Further, all hair that can grow from existing living follicles will grow, strengthen, and thicken!

“Withdrawal syndrome” that doesn’t exist

Minoxidil does not have a “withdrawal syndrome” - this is a myth. But if you stop using it, it stops working - the process of stimulating the follicles stops, and the hair that grew solely under its influence will gradually regress and fall out. In a few months you will get the same picture on your head that you would have had if you had not started using Generalolon spray at all. This is typical when diagnosed with AGA.

If you do not want to lose your hair again, continue to use GENEROLON® every day until you value your hair and want to keep the hair on your head. And remember that there is no other product in the world that is just as effective and safe.

Detailed video instructions for using GENEROLON®:
Buy Generalolon

Overdose

Accidental use of the drug Generalolon orally can provoke systemic side effects due to the vasodilatory ability of minoxidil .

Signs: decreased blood pressure, fluid retention, tachycardia .

Overdose therapy: prescribing diuretics to eliminate water retention; Beta blockers are used to treat tachycardia . For hypotension, 0.9% sodium chloride . It is not recommended to prescribe sympathomimetic drugs that have strong cardiac stimulating activity.

Interaction

There is a theoretical possibility of increased symptoms of orthostatic hypotension in individuals receiving concomitant therapy with peripheral vasodilators.

minoxidil may interact with topical medications. The combined use of topical minoxidil betamethasone leads to suppression of the systemic absorption of the former.

Concomitant use of a cream containing tretinoin results in increased absorption of minoxidil .

The combined application of Generalolon to the skin and drugs for external use such as Tretinoin and Dithranol , which cause changes in the barrier functions of the skin, leads to an increase in the adsorption of minoxidil.

REASONS FOR THE DEVELOPMENT OF AGA

The development of AGA is based on genetically determined features of androgen metabolism in the hair follicle.

The most significant factor in men is increased activity of the enzyme 5α-reductase type II, which in genetically predisposed hair follicles metabolizes testicular testosterone to dihydrotestosterone (DHT).

In addition to the local metamorphoses of androgens in women, similar to those in men, in the pathogenesis of AGA, as a rule, a decrease in the activity of aromatase, which transforms

ovarian testosterone circulating in the blood into 17 beta-estradiol.

An increase in local DHT concentration leads to a progressive contraction of anagen due to a longer telogen phase (Fig. 3) and is accompanied by a progressive miniaturization of hair follicles. The latter is carried out due to relatively sharp reductions in the number of cells of the dermal papilla and dermal membrane.

In addition to androgen-dependent changes in the pathogenesis of AGA, the involvement of follicular microinflammation with the formation of fibrosis, provoked by the presence of bacterial flora, toxins and oxidative stress, has been proven.

special instructions

The drug is applied exclusively to dry scalp in the hairy area after bathing or 4 hours before bathing. It is forbidden to let your head get wet before the specified time. The drug should not be applied to areas of the body other than the head.

When using the drug, it is recommended to wash your hair as usual.

While using the drug, it is allowed to use hairspray and other hair care tools. Before applying care products, you must first use Generolon and wait until the treated area is completely dry. There is no information that perming, coloring hair or using softeners may reduce the effectiveness of the product. However, to prevent possible irritation of the scalp, it is necessary to completely rinse the drug from the scalp before using the above chemicals.

Before starting treatment with Generalolon, patients must undergo an examination, including clarification and study of the medical history, and the doctor must make sure that there are no diseases of the scalp.

If systemic side effects or severe skin reactions develop, patients should stop using the drug and consult their doctor.

Generalolon contains ethanol , which can cause irritation and inflammation of the eyes. If the product gets on sensitive surfaces (irritated skin, eyes, mucous membranes), rinse them with plenty of water.

It is recommended to avoid inhaling the product when spraying, and wash your hands well after using the product.

EPILOGUE

In conclusion, I would like to place special emphasis on two aspects.

Firstly, the use of all of the above treatment methods does not change the genetic program of the hair follicles, therefore the therapeutic successes of these measures are temporary and should be repeated regularly throughout the patient’s life. It is also necessary to exclude internal factors (for example, iron deficiency anemia, endocrine diseases, etc.), which, together with AGA, worsen the condition of the hair and lead to chronic diffuse thinning.

Secondly, for skeptics, we note that the innovative DECOPILL passed strict dermatological control in clinics in Europe and the USA, while demonstrating its effectiveness and safety as a result of clinical tests, which objectively revealed:

• activation of hair growth by 121%,
• significant delay in hair aging by 46%,
• improvement in encoring (fixation in the skin) of the hair shaft by 73%.

Analogs

Level 4 ATX code matches:
Badyaga Forte

Badyaga

Rogaine

Capsiol

Vulnuzan

Skin cap

Petrolatum

Alerana

Apilak

Solcoseryl

Tsinocap

Silocast

Alerana, Cosilon, Alopexi, Minoxidil, Eucapil, Rogaine, Revogen, Simone Dixidox De Luxe Forte, Revasil.

Generalolon price, where to buy

The price of Generalolon 2% spray in Russia starts at 360 rubles, and buying a similar form of product in Ukraine will cost 350-510 hryvnia.

• Online pharmacies in RussiaRussia

ZdravCity

• Spray Generalolon for external use 2% 60 mlIndustrial Pharmaceutical Cantabria S.A./Belupo
  579 rub.order
• Spray Generalolon 5% for external use 60 ml 2 pcs. BELUPO, Medicines and cosmetics d.d.

  1206 rub. order

• Spray Generalolon for external use 5% 60 mlIndustrial Pharmaceutical Cantabria S.A/Belupo

  RUR 689 order

• Spray Generalolon 5% for external use 60 ml 3 pcs. BELUPO, Medicines and cosmetics d.d.

  RUB 1,708 order