Klion-D 100: instructions for use. Price and reviews of the drug

Pharmacodynamics and pharmacokinetics

The effect of the drug is due to the complex effect on the vaginal microflora of its constituent components.

Miconazole is an antifungal agent that destroys dermatophytes and yeasts , but does not disturb the pH or destroy healthy microflora in the vagina. The substance directly affects the synthesis of lipid components in the fungal membrane, thereby destroying it. It does not penetrate into the blood and is not found in the kidneys and products of the excretory organs; 90% remains in the vagina. The maximum concentration is after 8 hours.

Metronidazole is an antibiotic . It inhibits the process of RNA and DNA of destructive bacteria by restoring the 5-nitro group by transport proteins inside the cell. After entering the vagina, it penetrates into the blood. Its maximum concentration in the blood (half of the administered dose) can be detected after 9 hours.

Pharmacological properties of the drug Klion-d 100

Combined drug for intravaginal use for infections caused by Trichomonas vaginalis and/or pathogenic fungi. The active ingredients of the drug are metronidazole (1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole) and miconazole (1-[2,4-dichloro-β-((2,4-dichlorobenzyl)oxy)-phenethyl]- imidazole). Metronidazole has antiprotozoal and antibacterial effects. Active against Trichomonas vaginalis , Entamoeba histolytica , obligate anaerobes, including anaerobic gram-negative bacilli ( Bacteroides spp. Bacteroides fragilis group , Fusobacterium spp. ), anaerobic gram-positive bacilli ( Clostridium spp. and sensitive strains of Eubacterium ), anaerobic gram-positive cocci cove ( including Peptococcus spp. and Peptostreptococcus spp. ). Metronidazole penetrates into microorganisms, where its nitro group is converted into hydroxylamine, which enhances the effect of the drug on the DNA of microorganisms, leading to their death. Miconazole nitrate has an antifungal (fungicidal) effect. Active (when used intravaginally) mainly against Candida albicans . When administered intravaginally, metronidazole is absorbed and enters the systemic circulation, the maximum concentration in the blood plasma is observed after 6-8 hours. It is about 50% of the maximum concentration achieved 1-3 hours after a single oral dose of the same dose. When administered intravaginally, miconazole is absorbed and enters the systemic circulation in small quantities.

Interaction

The medicine is not combined with ethanol, disulfiram , non-depolarizing muscle relaxants, cimetidine, and lithium preparations .

When taking indirect anticoagulants , it is worth additionally monitoring the prothrombin index .

The effectiveness of metronidazole is reduced when combined with phenobarbital and phenytoin .

Vaginal tablets Klion-D 100 (Klion-D 100)

Instructions for medical use of the drug

Description of pharmacological action

The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms. Metronidazole is a broad-spectrum antimicrobial and antiprotozoal agent. Active against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis as well as against obligate anaerobes (spore-forming and non-spore-forming) - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., sensitive strains of Eubacterium. Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole. Miconazole has antifungal activity against common dermatophytes, yeasts and various other fungi and antibacterial activity against certain gram-positive bacteria. Miconazole inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, which leads to the death of fungal cells. Quickly relieves itching that often accompanies infections caused by yeast and dermatophytes. Does not change the composition of the microflora and pH of the vagina.

Indications for use

Trichomonas, candidal and nonspecific vaginitis (local treatment).

Release form

vaginal tablets; contour packaging without cells 10, cardboard pack 1; vaginal tablets 100 mg + 100 mg; strip 10, cardboard pack 1; vaginal tablets 100 mg + 100 mg; strip 10, box 100; Composition Vaginal tablets 1 table. metronidazole 100 mg miconazole nitrate 100 mg excipients: sodium lauryl sulfate; colloidal silicon dioxide; magnesium stearate; povidone; sodium bicarbonate; tartaric acid; sodium carboxymethyl starch (type A); crospovidone; hypromelose; lactose monohydrate in contour-free packaging 10 pcs.; in a cardboard pack 1 package.

Pharmacodynamics

Pharmacokinetics

Metronidazole. When administered intravaginally, it is absorbed into the systemic circulation. Cmax in the blood is determined after 6–12 hours and is approximately 50% of the Cmax that is achieved (after 1–3 hours) after a single dose of metronidazole orally. Miconazole. Systemic absorption of miconazole nitrate after intravaginal use is limited. 8 hours after application of the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.

Use during pregnancy

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindications for use

- hypersensitivity to the components of the drug (including other nitroimidazole derivatives); - blood diseases, leukopenia (including history); — impaired coordination of movements, organic lesions of the central nervous system (including epilepsy); - liver failure (in case of prescribing large doses); - pregnancy; - period of breastfeeding. With caution: - diabetes mellitus; - microcirculation disturbance.

Side effects

Local: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge without odor or with a faint odor, frequent urination; a burning sensation or irritation of the penis in a sexual partner. From the gastrointestinal tract: nausea, changes in taste, “metallic” taste and dry mouth, loss of appetite, cramping pain in the abdominal cavity; vomiting, constipation or diarrhea. Allergic reactions: urticaria, itching of the skin, rash. From the nervous system: headache, dizziness. Other: leukopenia or leukocytosis. In rare cases, urine is colored red-brown (due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole).

Directions for use and doses

Intravaginally (deeply), after moistening the tablet with water. Trichomonas vaginitis - 1 table. per day for 10 days in combination with oral metronidazole. Nonspecific vaginitis or candidal vaginitis - 1 table. 2 times a day for 10 days, if necessary in combination with oral metronidazole. Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

Interactions with other drugs

Like disulfiram, it causes ethanol intolerance. Concomitant use with disulfiram can lead to the development of various mental disorders and depression of consciousness. Strengthens the effect of indirect anticoagulants (warfarin, etc.), which leads to an increase in the time of prothrombin formation. It is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide). Co-administration with barbiturates may accelerate the elimination of metronidazole, resulting in a decrease in its effect. Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects. When taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase.

Special instructions for use

Simultaneous treatment of the sexual partner is recommended, regardless of whether he has manifestations of the disease. During the treatment period you should abstain from sexual intercourse. If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or with its long-term use, monitoring of a general blood test is necessary. Metronidazole can immobilize treponemes, leading to a false-positive Nelson test. Use with caution while working for drivers of vehicles and people whose profession is associated with increased concentration of attention (dizziness associated with taking the drug may occur).

Storage conditions

List B.: In a dry place, protected from light, at a temperature of 15–30 °C.

Best before date

60 months

ATX classification:

G Genitourinary system and sex hormones

G01 Antiseptics and antimicrobials for the treatment of gynecological diseases

G01A Antiseptics and antimicrobials for the treatment of gynecological diseases (excluding combinations with corticosteroids)

G01AF Imidazole derivatives

G01AF20 Combinations of imidazole derivatives

Analogs

Level 4 ATX code matches:
Gainomax

Sertaconazole

Ornisis

Metrogil Plus

Livarol

Flagyl

Ginofort

Zalain

Ketoconazole

Candide B6

Candide

Gyno-Travogen Ovulum

Kanizon

Metromicon-Neo

Lomexin

Neo-Penotran

Gyno-Pevaril

Ginesol

Antifungol

Analogs of suppositories are: Metromicon-Neo, Ginalgin, Clomezol, Neo-Penotran Forte, Clevazol, Pulsitex, Candibene, Ketodin, Candide, Ketonazole, Livarol, Metronidazole, Clotrimazole, Trichopolum, Econazole.

What is the difference between Klion and Klion-D 100?

Klion tablets contain metronidazole and have a wider range of applications. Usually, to combat trichomoniasis, oral intake of tablets alone is not enough, for which Klion-D 100 suppositories are prescribed.

Vaginal tablets Gedeon Richter Klion-D 100 - reviews

Lilya
https://lekotzyvy.com/preparat/k/klion-d-100/

Effective, but causes a lot of inconvenience

Advantages: Effective, relatively inexpensive

Disadvantages: Causes a burning sensation, leaks heavily, turns urine brick-colored

I was treated with it quite recently, just a couple of months ago. I had a mixed infection - both vaginitis and thrush, so the gynecologist gave me a choice of several complex medications. I chose Klion because it turned out to be the best price, plus a friend also used it and was very pleased. I can say the same because I was cured of both diseases in just 8 days. The symptoms did not recur, tests showed that the inflammation and fungus were eliminated, so in terms of effectiveness, I can give Klion an “excellent” rating. But regarding the convenience and comfort of treatment, everything is not so smooth. The tablets cause quite a strong burning sensation, especially in the first days. I introduced them at night, because of this, sometimes I lay awake until midnight and suffered from unpleasant sensations. I also didn’t like the fact that Klion leaks a lot. Even if you use it at night, foamy discharge occurs in a very large volume during the next day, and you cannot do without pads. The last unpleasant moment even scared me a little, because by the end of the treatment my urine began to resemble rust in color. Okay, after finishing the treatment it went away, but I still didn’t understand what it was connected with.

Guest
https://www.otzyvua.net/klion-d/review-571580

After treatment with a wedge, I had colpitis, this time nonspecific. The doctor said that in order for this not to happen, it is necessary to be treated with complex medications like Metrogyl Plus. Why then is Klion needed?

marusya1988
https://otzovik.com/review_1869939.html

Advantages:

convenient to use

Flaws:

eliminated the discharge, but not the disease

Every time I take tests, or rather a smear, every time the doctor says that the smear is bad, they diagnose vaginitis, I’m already tormented, it doesn’t go away, in addition to vaginitis there are also unpleasant ailments, so there was also antibiotic therapy, at least for me Klion-D and antibiotics were prescribed together. A package of “Klion-D” costs 270 rubles for 10 tablets, it’s a bit expensive, of course, but when you want to be cured, you just go and buy it, because firstly, you don’t know what analogue they have, and even during pregnancy it’s scary to use analogues, you already trust in such a situation to the doctor. The tablets are packed in a foil blister, by the way, it’s inconvenient to take the tablet, you have to carry scissors with you to carefully cut it, otherwise I tore off the first tablet with my hands and broke it, I had to insert it inside in parts. The tablet is drop-shaped, which in principle makes it easier to administer. Many people write that the tablet is inserted like sandpaper, probably because they do not wet it in water; when you wet it in water, it is inserted easily and simply, although you need to wet it quickly so that the tablet does not melt much, otherwise most of the tablet will remain on your hands, I I usually wet half the tablet so that it doesn’t fall apart. You need to insert it as deeply as possible, that is, as far as your finger goes in. In principle, I did not feel any inconvenience with the introduction. As for the discomfort during treatment, when I took the first tablet there was a slight burning sensation that went away within half an hour, but it did not cause any discomfort, I happily forgot about it and fell asleep. And the pill needs to be taken at night, usually it should come out in the morning or by the morning, but I put it in bed quickly, as it begins to seem that the pill is already leaking. There were no other unpleasant sensations at all, I mean itching. There was also no red staining of urine, as indicated as a side effect in the instructions. I wonder if this has ever happened to anyone... Well, now, actually, about the effect. The finale had been brewing for a long time, almost two weeks had passed since the treatment, I had a smear, and as a result, the smear was still bad, they prescribed another suppository - Hexicon. On the plus side, the unpleasant discharge has almost stopped, but there are no more pluses for me. They didn't help me. From the reviews I see that they help 50/50.

rushana24
https://otzovik.com/review_1586298.html

Advantages:

Just the thing for masochists

Flaws:

Unpleasant sensations, burning sensation.

I used it for the first time in the 9th month of pregnancy, the nurse administered it 7 times, then I went to give birth but didn’t continue the course, maybe that’s why the thrush didn’t go away. The second time I purchased it 3 years later, my local gynecologist prescribed it along with an antibiotic like flucostat (my husband and I took it), after the course tests also showed this candida infection. That's why I don't recommend it. And in general, a relative recommended douching with yarrow - this was the only way she got rid of the never-ending thrush. Health to everyone!

NatashaMax
https://otzovik.com/review_5357801.html

Advantages:

Flaws:

cons in everything

Klion-D doesn’t help at all, I’ve been using it for five days but there’s no improvement, there’s not even any relief, I’m suffering day and night ((((the itching is terrible and after taking the first suppository there was more discharge, burning and pain in the lower abdomen. I don’t recommend these suppositories to my friends I will, I will dissuade you. This is money down the drain. For that amount you can buy pimafucin relief from the first suppository and much more with a better effect. Today I will change suppositories. I can’t stand it anymore. I’m disappointed ((( I bought them only because there were other medications for There was no thrush in the pharmacy, the doctor prescribed clotrimazole, I will look in other pharmacies. It’s a very Pity.

Mne_nik_ne_nuzhen
https://irecommend.ru/content/ochen-silno-zhzhet-i-zudit-k-tomu-zhe-neudobnye-v-primenenii-eshche-kroshitsya

These pills are probably the worst that can be used in the treatment of thrush! (By the way, thrush can appear if you eat a lot of sugar and other junk foods for a long time). Microflora is disrupted. Both in the intestines and “there”.

If you have severe symptoms of thrush and everything “there” is already very unpleasant, then after the administration of this pill there will be just blood pressure . Severe burning and itching. (And it seems to hiss inside you:) haha. But in reality it was far from funny. The second and third time (when the thrush has been defeated a little, it doesn’t hurt so much) the fourth time it just hisses. (I don’t know what it is. An allergy, or just a reaction when the mucous membrane is unhealthy.) But it is assumed that we are not inserting the tablets into healthy mucous membranes))

And before inserting the tablet, it must be moistened in water. Inconvenient. After you wet it, it will begin to hiss and dissolve in your hands. Hands are dirty. Then she stains her laundry. (Although, to be fair, I note that candles do too).

And now I took out the tablet to take a photo, and it crumbled in half. Expiration date is normal

There are 10 tablets in a package, the price is about 330 rubles.

There are other more comfortable products (and the composition is the same, except that the concentration is different), for example Neo-Penotran or its analogue Metromicon-Neo. (These are suppositories, not tablets). They are comfortable (no need to soak them in water) and there is no burning or itching from them. Absolutely not. Neither for the first use, nor for subsequent ones.

I will never buy Klion-D again in my life.

Satira-live
https://irecommend.ru/content/yavno-ne-dlya-vsekh-ostorozhno

Hello! I will not attach photos and instructions, because... there are so many of them here. I want to say only one thing, this is bullying of the body. The gynecologist prescribed it to me for adnexitis. I read reviews about these candles and decided that since they were prescribed, I had to take a risk. Well, I used one at night, so to speak, and am waiting for the promised burning sensation to set in... Half an hour passed, I didn’t feel anything.. I thought, “How great!” and went to bed. after 10 minutes, the pulse jumped to 90 beats per minute... well, I didn’t pay attention.. I drank valerian and continued to sleep... but that was not the case, the skin of my arms and chest began to burn, and later my face. I wanted to apply ice. the heat was growing. I went into the shower to douse myself with cold water and saw in the mirror that all the skin was red, with spots, if you touched, then in this place there were white marks from the touch, which then disappeared .. the entire sternum, part of the arms and cheeks were red, the cheeks were still and started to itch. In the end, I realized that the tachycardia was not accidental. I developed a severe allergy. and there were no antihistamines in the house... and you can’t run anywhere to get them at three o’clock in the morning. I had to wash everything out if possible and apply cold water. In the morning there was a slight tachycardia and the skin itched in places. The redness subsided. I think this is the end of my acquaintance with this drug and it will go in the trash. So be careful, and better yet, don’t get sick!

Reviews about Klion-D 100

Reviews on forums: Overall good. Many people used Klion-D 100 for thrush and were satisfied with the result. Some women complain of severe side effects. The drug is quite effective not only against thrush, but also against other types of vaginitis .

Reviews during pregnancy: Despite the fact that the use of the product during pregnancy is not recommended, women are often prescribed suppositories. Reviews of Klion-D 100 suppositories were divided; some women tolerated the medication well and it did not affect their children in any way. Many experienced severe burning, itching, abdominal pain and voluntarily stopped taking the drug.

Use of the drug Klion-d 100

Locally, for vaginitis caused by Trichomonas vaginalis , 1 tablet of the drug, moistened with water, is injected deep into the vagina once a day, in the evening before bed. The course of treatment is 10 days. At the same time, metronidazole is prescribed for oral administration (1 tablet during or immediately after meals, 2 times a day in the morning and evening). It is advisable to simultaneously treat the sexual partner with metronidazole (orally). If the effectiveness is insufficient, local treatment is continued for another 10 days. For candidal vaginitis, 1 tablet of the drug, moistened with water, is injected deep into the vagina once a day, in the evening before bed. The course of treatment is 10 days.

Price Klion-D 100 (where to buy)

On average, the price of Klion-D 100 suppositories in Ukraine is 100 UAH for 10 vaginal tablets.

How much does it cost to buy medicine in Kyiv? About 120 UAH for 10 pieces.

Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

Pharmacy24

Klion-D 100 N10 tablets VAT "Gedeon Richter", Ugorshchina
201 UAH. order

PaniPharmacy

Klion-D 100 tablets Klion D tab. vag. No. 10 Hungary, Gedeon Richter
212 UAH order

Klion-D 100

Klion-D 100 (metronidazole + miconazole) is a combined two-component drug for use in gynecological practice. Indicated for combined inflammation of the vagina caused by Trichomonas and Candida. Itching and hyperemia in the genital area, pain during urination, vaginal discharge and an unpleasant odor are constant companions to inflammation of the vagina (vaginitis), which most often develops as a result of trichomoniasis and candidiasis. The causative agent of candidiasis is the microscopic fungus candida. The balance between saprophytic and potentially pathogenic vaginal microflora is maintained by lactic acid bacteria (lactobacteria). They inhibit the growth and reproduction of candida by releasing lactic acid and hydrogen peroxide. However, under the influence of a number of factors (weakened immunity, hormonal imbalance, pregnancy, increased psycho-emotional stress), this balance can be disrupted, resulting in the development of candidiasis. Subsequently, other infections may join it, which greatly complicates treatment. In this regard, gynecologists currently prefer combination drugs for the treatment of vaginal infections, the components of which are active against both fungi (candida) and bacteria. A striking example of such a drug is Klion-D 100 from the Hungarian pharmaceutical company, the effect of which is determined by the components included in its composition.

Metronidazole is active against protozoa and bacteria, because is able to penetrate the cell wall of the pathogen, causing its death. Miconazole is effective for fungal infections of the vagina, incl. candidiasis Klion-D 100 ensures balance in the qualitative and quantitative composition of the vaginal microflora and brings the acid-base balance to the physiological norm. The drug reduces the risk of complications after abortion and implantation of an intrauterine device by 4.83 times. The use of Klion-D 100 before gynecological surgical interventions shortens recovery time and reduces the risk of developing postoperative complications. The high effectiveness of the drug makes it possible to exclude the use of systemic anti-inflammatory drugs, which have a large number of unwanted side effects. Kliona-D 100 is well tolerated and has a favorable safety profile. The drug is active against Trichomonas, Garnerella, Bacteroides, Fusobacteria, Velionella, Prevotella, Clostridia, Peptococcus and a number of other bacteria. In pediatric practice, the drug can be used starting from the age of 12. Single dose – 1 vaginal tablet. The duration of the drug course is 10 days in combination with additional oral administration of metronidazole drugs. Klion-D 100 is not compatible with alcohol. During treatment it is necessary to abstain from sexual activity.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Klion-D 100, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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