To treat psoriasis, neurodermatitis, eczema and other skin diseases, various ointments are used, including those based on hydrocortisone. Such drugs include Lokoid cream. It has a quick effect and is safe for health. Suitable for both adults and children aged 6 months and older. You can buy the product at an affordable price and without a prescription.
Lokoid cream: description
The drug is a thick, translucent ointment for external use only. The composition includes the active ingredient hydrocortisone in the form of butyrate - a concentration of 1 mg per 1 g or 0.1%. Auxiliary components are a base with petroleum jelly and polyethylene.
The ointment is packaged in aluminum tubes weighing 30 g. It can be stored under normal room conditions at temperatures up to 25 degrees Celsius. It is necessary to exclude access to direct sunlight and also keep it away from children. The ointment can be used within the general shelf life of 5 years from the date of production.
How are we being treated? Lokoid. The Curse of Multifunctionality
That's why the manufacturers of Lokoid chose the ointment. It contains hydrocortisone in the form of butyrate. WHO classifies this compound as class five out of seven (and hydrocortisone itself in its pure form – even class seven). The first class causes capillaries to contract the most, and class I drugs are considered the most highly active. But again, everything is relative: they not only act most strongly as intended, but also threaten with the most powerful side effects, so they cannot be used for more than 2-3 weeks. In addition, activity depends on the form: ointments are on average more effective than lotions and creams. The effect of corticosteroid ointments is enhanced under closed bandages, as well as in areas of diaper rash.
Indicator.Ru recommends: for short-term use
Lokoid contains a real steroid hormone - cortisol. The almighty corticosteroids can give you life and health in the same way - and take it away. They can weaken your immune system, save you from allergies and asthma, inflammation and anaphylactic shock, pain and rheumatoid arthritis, and also ruin your bones, cause diabetes or infection with fungi and bacteria, change your mood - and even make you moon-faced (and believe me, you won’t like it ). It is safer to use it in the form of an ointment or cream: this way, most likely, it will not affect the entire body, but only the desired area of the skin.
Hydrocortisone (this is the pharmaceutical name for the same cortisol) is a relatively weak medicine based on corticosteroids, so its topical use, even for a month, is unlikely to cause side effects. Therefore, as a one-time treatment (for example, against itching and redness during allergic reactions), it is quite safe for most patients. It helps against psoriasis, atopic and seborrheic dermatitis (which, by the way, often causes dandruff).
Those who suffer from chronic diseases should be the most attentive and careful. For example, for dermatitis and psoriasis, when the ointment needs to be applied daily for months. But although it can help about 70% of patients in these cases (and also relieve ulcers from systemic lupus erythematosus), it still does not provide relief for some people.
And remember: if the doctor does not recommend applying the ointment under the bandage, do not do it, such use will enhance the effects of the drug - and not only the desired ones, but also the side effects. Children also need to be careful: chronic use of corticosteroids can impair bone development (although this is better proven for inhalations than for ointments).
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Pharmacodynamics
The components of the drug esterify the hydrocortisone molecule, combining with butyric acid. This leads to a significant increase in chemical activity compared to native compounds. The product inhibits inflammatory processes, reduces itching and swelling.
If the dosage is observed, the drug acts safely for health and does not suppress the hypothalamic, pituitary and adrenal systems. Moreover, if used in large doses for a long period, the content of cortisol in the bloodstream may increase. But as a rule, this does not lead to a deterioration in the functioning of the pituitary gland and adrenal glands. In addition, stopping treatment almost immediately normalizes cortisol synthesis.
After use, the active substance quickly accumulates in the superficial tissues of the skin, mainly in the granular layers of the epidermis. Penetration into the bloodstream is negligible. The substance is processed mainly in the tissues of the skin, and is partially excreted in the urine and through the intestines in the same form.
Indications
Lokoid is a hormone belonging to the group of glucocorticoids. Use only under close medical supervision. The main indications for use are:
- psoriasis (as an additional therapeutic measure);
- neurodermatitis;
- barley;
- eczema;
- allergic reactions;
- conjunctivitis;
- reaction to insect bites;
- itching of the skin of various nature;
- shock - treatment and preventive measures.
Contraindications and side effects
In some cases the drug cannot be used:
- bacterial skin infections;
- viral infectious skin lesions;
- fungal infections;
- syphilis;
- tuberculosis;
- infections associated with parasites;
- skin tumors of various natures, including cancer;
- period after vaccination;
- wounds, ulcers;
- individual intolerance to components;
- all stages of pregnancy;
- feeding period.
The drug is safe for health, but in some cases it can cause allergic reactions, including itching and irritation. They do not require treatment and go away on their own after you stop taking them.
Also, during long-term treatment, systemic side effects are possible. The risks of their occurrence are not as high compared to the use of fluorinated steroids.
Signs of hypercortisolism may occur, including:
- the skin becomes very sensitive;
- wounds and bruises take a long time to heal, poorly;
- menstrual irregularities;
- skin rash;
- increased hair growth;
- general weakness;
- rapid weight gain;
- increase in pressure;
- anxiety, mood disorders;
- depressive states;
- sleep disorders.
Such symptoms appear rarely and only after prolonged use. If at least one of the described effects is detected, you should stop therapy and immediately consult a doctor to prescribe a course of treatment.
Buy Locoid ointment 0.1% 30g in pharmacies
Instructions for use Lokoid ointment 0.1% 30g
Dosage forms ointment 0.1% 30g Group Drugs with glucocorticosteroid activity International nonproprietary name Hydrocortisone Composition Active substance: Hydrocortisone. Manufacturers : Temmler Italy S.r.L (Italy), Yamanouchi Europe B.V. (Netherlands) Pharmacological action Anti-inflammatory, antiallergic, antishock, desensitizing, immunosuppressive, antiexudative, antipruritic. Well absorbed after oral administration. The maximum concentration is reached after 1 hour. Penetrates well through mucous membranes and histohematic barriers. After application to the skin, it accumulates in the epidermis. Intensively metabolized in the liver. The absorbed portion is metabolized in the epidermis and then in the liver. Metabolites and a small part of hydrocortisone are excreted in urine or bile. Inhibits hypersensitivity reactions, proliferative and exudative processes in connective tissue, at the site of inflammation. Reduces local hyperemia and hyperthermia of the skin. It disrupts the synthesis of prostaglandin and the release of macrophage chemotactic factor, inhibits the activation of tissue kinins. Reduces the migration of macrophages and lymphocytes to the site of inflammation. Suppresses alteration, exudation and proliferation. Inhibits the production of collagenase and activates the synthesis of protease inhibitors. Blocks the synthesis and release of histamine and other biologically active substances from sensitized mast cells and basophils, suppresses various stages of immunogenesis without having a mitozostatic effect. Increases the level of glycogen in the liver, inhibits the release of sodium and water, increases potassium, affects protein (causes a negative nitrogen balance due to increased catabolism) and lipid metabolism. Increases the volume of circulating blood, the hydrophilicity of tissues, and increases blood pressure. With long-term use, atrophy of the adrenal cortex develops, the formation of ACTH and thyroid-stimulating hormone of the pituitary gland is inhibited. Side effects: Headache, dizziness, euphoria, insomnia, depression, psychosis; allergic reactions (up to anaphylaxis); with long-term use: edema syndrome, skin itching, hyperpigmentation, convulsions, Cushing's syndrome, decreased glucose tolerance, hyperglycemia, steroid diabetes, adrenal insufficiency, menstrual irregularities, hypokalemia, hypokalemic alkalosis, hyperuricemia (especially in acute leukemia), memory loss , increased intracranial pressure, myopathy, arthralgia, arthropathy, osteoporosis, arterial hypertension, vasculitis, exacerbation of gastric and duodenal ulcers, formation of posterior subcapsular cataracts, glaucoma with possible damage to the optic nerve and increased risk of viral and fungal eye infections, activation of latent foci of infection . With prolonged topical use, especially with impermeable dressings or over large areas of skin: systemic side effects, local irritation may occur. Indications for use : Seasonal allergic rhinitis, severe attack of bronchial asthma, asthmatic condition, serum sickness, hypersensitivity reactions to drug administration; emergency conditions - spontaneous and orthostatic hypotension, collapse in Addison's disease, myocardial infarction, hemorrhagic stroke, Morgagni-Adams-Stokes syndrome, coma due to cerebrovascular accident and inflammatory diseases of the brain, hypothyroid and hepatic coma, acute adrenal insufficiency (Waterhouse-Friderichsen syndrome) , multiple bleeding, acute liver failure in case of poisoning, swelling of the larynx in allergic and inflammatory lesions, burns and injuries, poisoning with vitamin D, strong acids, organophosphates, quinine, chlorine, post-transfusion complications, Mendelssohn's syndrome, snake and scorpion bites, anaphylactic, hemorrhagic , cardiogenic and traumatic shocks; endocrine diseases - primary or secondary adrenal insufficiency (preferably natural cortisone and hydrocortisone, synthetic analogues should be used in combination with mineralocorticoids), adrenogenital syndrome with sodium loss, thyroiditis, hypercalcemia associated with cancer; rheumatic diseases - psoriatic, rheumatoid, juvenile rheumatoid and acute gouty arthritis, ankylosing spondylitis, acute and subacute bursitis, glenohumeral periarthritis, etc., systemic lupus erythematosus, acute rheumatic carditis, dermatomyositis; inflammatory and allergic skin diseases, incl. eczema, dermatitis: allergic and atopic, bullous herpetiformis, exfoliative, seborrheic, contact; itchy dermatoses, pemphigus, Stevens-Johnson syndrome, mycosis fungoides, psoriasis; in ophthalmology: allergic conjunctivitis, blepharitis, eyelid dermatitis, keratitis, corneal ulcer, herpes zoster, iritis, iridocyclitis, chorioretinitis, inflammation of the anterior segment, diffuse posterior uveitis and choroiditis, optic neuritis, sympathetic ophthalmia, condition after surgery; sarcoidosis, Loeffler's syndrome, berylliosis, fulminant or disseminated pulmonary tuberculosis, aspiration pneumonitis; idiopathic thrombocytopenic purpura in adults, autoimmune hemolytic and congenital hypoplastic anemia, erythroblastopenia, palliative therapy of leukemia and lymphomas in adults, acute leukemia in children; nephrotic syndrome without signs of uremia (to reduce proteinuria and induce diuresis), severe exacerbations of ulcerative colitis and Crohn's disease, tuberculous meningitis with subarachnoid block, trichinosis with neurological and myocardial manifestations, acute manifestations of multiple sclerosis, disseminated lung cancer (additional therapy). Intra-articular and periarticular administration (hydrocortisone acetate): reactive synovitis (including with deforming osteoarthritis), rheumatoid arthritis, acute and subacute bursitis, acute gouty arthritis, epicondylitis, acute nonspecific tenosynovitis, carpal tunnel syndrome, post-traumatic osteoarthritis. I/C for keloids, localized hypertrophic, infiltrative, inflammatory lesions, lichen planus, psoriatic plaques, granuloma annulare, neurodermatitis, discoid lupus erythematosus, diabetic lipid necrobiosis, alopecia areata, cystic tumors of the aponeurosis and tendons; differential diagnosis of idiopathic and drug-induced leukopenia. Contraindications Hypersensitivity, systemic fungal infections, acute psychoses, severe forms of arterial hypertension, severe decompensated diabetes mellitus, gastric and duodenal ulcers in the acute stage, infectious (tuberculosis, mycosis, viral diseases, syphilis, etc.) and ulcerative skin lesions, wounds, tumor diseases of the skin, osteoporosis, Cushing's disease, thrombophilic conditions, renal failure, herpetic fever, viral and fungal eye diseases, ocular tuberculosis, trachoma, damage to the ocular epithelium, AIDS, previous arthroplasty, conditions after intestinal anastomosis, pregnancy, breast feeding, younger children. Overdose No information available. Interaction Barbiturates, antiepileptics and antihistamines reduce effectiveness. NSAIDs increase the risk of ulceration in the gastrointestinal tract, paracetamol - hepatotoxicity. Reduces the activity of salicylates, antidiabetic agents, increases - anticoagulants. Cardiac glycosides and non-potassium-sparing diuretics potentiate hypokalemia, anabolic steroids increase tissue hydrophilicity. When combined with amphotericin B, the development of dilated myocardial damage and heart failure is possible. Special instructions During the treatment period, vaccination is not recommended. Administration of large doses is permissible for no more than 48-72 hours. Intra-articular administration should be carried out no more than once every 3 weeks. During long-term therapy, monitoring of potassium levels in the blood and regular ECG studies are recommended. To prevent the development of secondary hypocortisolism caused by discontinuation of treatment, the dose should be reduced gradually. Glucocorticoids can mask some manifestations of the infectious process; new infections may occur due to a decrease in resistance. When treated with corticosteroids or their combination with other drugs that suppress cellular, humoral immunity or neutrophil function, various viral, bacterial, fungal, protozoal infections and helminthic infestations that were previously latent may appear. The risk of infection and its more severe course increases in proportion to the increase in the dose of the drug. Storage conditions At a temperature of 5-15 °C.
special instructions
The product should not be applied to the area near the eyes (eyelids), as this may lead to the development of glaucoma. If the drug constantly gets on the conjunctiva, this can cause an increase in intraocular pressure.
If dry eyes are severe, hyperkeratosis is observed, the drug is used only in the form of an ointment, lipocrem is also available. The ointment should not be used if atrophic changes in the skin are diagnosed.
It should be remembered that the risk of side effects increases when applied to large areas of the body, as well as during prolonged use.
If the therapeutic effect does not occur within 2 weeks (reception is carried out in a row), therapy should be discontinued and consult a doctor to clarify the diagnosis.
Use in pediatrics
The ointment can be prescribed to children from 6 months, but only under the supervision of a doctor. If the product is applied using occlusive dressings or on the skin of the face, the course of therapy should be reduced to a minimum. In this case, the maximum area of the treated cover should be less than 20% of the entire surface.
It should be noted that in children, adrenal suppression may manifest itself more quickly. A decrease in the synthesis of growth hormone is also often observed. If you use the ointment for a long time, it is important to monitor the child’s weight and monitor the concentration of cortisol in the blood, which is only possible with the participation of a doctor.
There is research data according to which children who received 7-8 g of ointment daily for a month did not experience side effects. The adrenal cortex worked normally in all those observed.
Lokoid
Lokoid (hydrocortisone 17-butyrate) is a topical synthetic glucocorticosteroid drug for use in dermatological practice. Used to treat eczematous skin lesions, dermatitis, scaly lichen (psoriasis). It has a rapidly developing anti-inflammatory, antiexudative, antipruritic effect. The use of the drug in the doses stated by the manufacturer does not inhibit the hypothalamic-pituitary-adrenal axis. Submaximal and maximum doses of Lokoid when used over a long period (including when using the drug under an airtight bandage) can increase the level of the stress hormone cortisol in the blood, but this does not affect the activity of the pituitary-adrenal system, and after the end of the drug course The secretion of cortisol is normalized as soon as possible. After hydrocortisone is absorbed through the skin, 17-butyrate undergoes a series of metabolic transformations to hydrocortisone and a number of other metabolites. It is excreted from the body by the kidneys and intestines. Lokoid is contraindicated in cases of rosacea, acne, localized on the face, dermatitis in the perioral area, itching in the genital and anal area, dermatitis with concomitant bacterial, viral or fungal infection, individual intolerance to the active or auxiliary components. The use of the drug during pregnancy and breastfeeding is allowed only after assessing the benefit/risk ratio.
Frequency of use: 1-3 times a day. If the clinical situation develops positively, the frequency of dosing is reduced to 1-3 times a week. To improve the absorption of the drug, its application is carried out with repeated massage movements. In case of a pathological process that is resistant to therapeutic effects (for example, in the presence of psoriasis in the elbows and knees), the drug is used under an airtight bandage. The maximum weekly dose is 30-60 g. Adverse effects when using the drug are skin irritation. With prolonged use or application over large areas, Lokoid may provoke the development of systemic side effects characteristic of glucocorticosteroids, however, this drug will have a lower risk than halogenated glucocorticosteroids. Using the drug under a sealed bandage increases the risk of systemic side effects. Lokoid is suitable for use in pediatric practice from the age of six months. If Lokoid is intended to be used on the skin of the face or under an airtight bandage, then the duration of the medication course is recommended to be reduced. When using the drug in pediatric practice, patients may experience inhibition of growth hormone secretion. The use of Lokoid in patients of this age group involves monitoring anthropometric parameters and the level of cortisol in the blood.
