Skinoclear is an effective drug against acne, pigmentation, rosacea and other skin pathologies. It is used to treat diseases of varying degrees of neglect. The course of therapy is usually long - at least 1-2 months. At the same time, more than 75% of buyers note the real effect of using the product.
Release form and composition
Dosage forms of release of Skinoklir:
- gel for external use 15%: yellowish-white to white, homogeneous, opaque (5, 10, 15, 30 or 50 g in aluminum tubes, 1 tube in a cardboard box);
- cream for external use 20%: white (10 or 30 g in aluminum tubes, 1 tube in a cardboard pack; 10, 15, 20, 25, 30 or 50 g in dark glass jars, 1 jar in a cardboard pack).
Composition of 100 mg Skinoclear gel:
- active substance: azelaic acid – 15 mg;
- auxiliary components: ceramides LS – 0.1 mg; carbomer 980 – 1 mg; disodium edetate dihydrate – 0.1 mg; benzoic acid – 0.1 mg; sodium hydroxide – 0.2 mg; isopropyl myristate – 1 mg; polysorbate 20 – 1.5 mg; propylene glycol – 12 mg; water – up to 100 mg.
Composition of 100 mg Skinoclear cream:
- active substance: azelaic acid – 20 mg;
- auxiliary components: glyceryl stearate and macrogol-30 stearate – 5 mg; benzoic acid – 0.2 mg; glyceryl stearate, cetostearyl alcohol, cetyl palmitate and coconut oil fatty acid glycerides – 7 mg; glycerol – 1.5 mg; cetearyl ethylhexanoate – 3 mg; propylene glycol – 12.5 mg; purified water – up to 100 mg.
Cream "Skinoklir": description, composition
The medicine is produced in the form of a gel or cream of a similar composition, but of different concentrations - the gel contains 15% of the active ingredients by weight, while the cream contains 20%. The drug contains several different substances:
- azelaic acid;
- polyacrylic acid;
- sodium in the form of edetate;
- purified water;
- sodium hydroxide form;
- lecithin;
- triglycerides;
- benzoic acid and others.
The gel is sold in tubes weighing from 5 to 50 g. The cream is produced in tubes weighing 30 g. They should be stored under normal room conditions at temperatures up to 25 degrees Celsius and in the absence of direct sunlight. Access by children should be excluded. The shelf life is 3 years for the gel and 5 years for the cream.
Pharmacological properties
Pharmacodynamics
Due to the inhibition of the synthesis of cellular proteins, azelaic acid causes a moderate cytostatic effect, which manifests itself as the normalization of keratinization processes in the walls of the sebaceous gland follicles.
The drug has the following effects (on the surface of the skin and in the sebaceous glands):
- anti-inflammatory – reduces the metabolism of neutrophil granulocytes and their production of free radical forms of oxygen, which are important factors in maintaining the inflammatory process;
- antimicrobial - mainly against Staphylococcus epidermidis and Propionibacterium acnes.
During a long course, resistance of microorganisms does not develop.
Inhibition of the growth and viability of abnormal melanocytes is dose-dependent.
In hyperpigmentation, the therapeutic effect is due to the suppression of cellular respiration of abnormal melanocytes and/or inhibition of DNA synthesis.
Pharmacokinetics
Azelaic acid, after application to the skin, penetrates the dermis and epidermis. After administration of 1 g of azelaic acid, approximately 4% of the dose is absorbed into the systemic circulation.
Part of the absorbed substance is excreted unchanged by the kidneys, the remaining dose is excreted in the form of dicarboxylic acids (C5, C7), which are formed as a result of beta-oxidation.
Instructions for use of Skinoklir: method and dosage
Skinoclear cream and gel are applied externally.
The maximum duration of the course is determined by the individual picture of the disease and the severity of symptoms.
The drug should be applied 2 times a day (morning and evening) in an even, thin layer to previously cleansed (with water and mild cleansers) and dried areas of the facial skin. For the entire surface of the face, about 2.5 cm of cream/gel is sufficient. Also, if necessary, Skinoclear is applied to the neck and upper chest affected by acne.
The drug should be used regularly throughout the course of treatment.
The minimum duration of melasma therapy is 3 months. During this period, in order to prevent exacerbation of the disease and/or re-pigmentation of the skin under sun exposure, sunscreens (UV A and B) must be used.
A marked improvement in patients with acne vulgaris is usually observed after 4 weeks. In order to obtain the best results, the use of Skinoclear should be continued for several months.
Skinoclear 20% 30g cream for external use
pharmachologic effect
Acne rash treatment.
Composition and release form Skinoclear 20% 30g cream for external use
100 g gel:
- Active substance: azelaic acid - 15.0 g;
- Excipients: carbomer 980 - 1.0 g, benzoic acid - 0.1 g, disodium edetate dihydrate - 0.1 g, ceramides LS - 0.1 g, isopropyl myristate - 1.0 g, polysorbate-20 -1.5 g, propylene glycol - 12.0 g, sodium hydroxide - 0.2 g, water - up to 100.0 g.
Gel for external use 15%.
5, 10, 15, 30 or 50 g in aluminum tubes. Each tube, along with instructions for use, is placed in a cardboard package (pack). It is allowed to pack 2 or 3 cardboard packages (packs) into a group package (shipping container).
Description of the dosage form
Gel for external use. White to yellowish-white, opaque, homogeneous gel.
Directions for use and doses
Externally
The maximum duration of therapy depends on the individual picture of the disease and the severity of symptoms. For adults and children over 12 years of age, apply the gel evenly in a thin layer 2 times a day. (morning and evening) on previously cleansed (with mild cleansers and water) and dried areas of the skin of the face and, if necessary, the neck and upper chest, affected by acne. About 2.5 cm of gel column is sufficient for the entire surface of the face. The drug should be used regularly throughout the course of treatment, the duration of which depends on the severity of the disease.
In patients with acne vulgaris, significant improvement is usually observed after 4 weeks. To obtain the best results, use of the drug should be continued for several months. If symptoms persist, it is recommended to consult a doctor.
Pharmacokinetics
Suction
After application to the skin, azelaic acid penetrates the epidermis and dermis. After applying 1 g of azelaic acid to the skin (corresponding to 5 g of gel), about 3.6% of the dose is absorbed into the systemic circulation.
Removal
Part of the absorbed azelaic acid is excreted by the kidneys unchanged, and part in the form of dicarboxylic acids (C5, C7), formed from azelaic acid as a result of beta-oxidation.
Indications for use Skinoclear 20% 30g cream for external use
- Common acne (acne vulgaris);
- Rosacea.
Contraindications
- Hypersensitivity to azelaic acid and other components of the drug;
- Children's age up to 12 years.
Application of Skinoklir 20% 30g cream for external use during pregnancy and breastfeeding
During pregnancy and breastfeeding, the drug should be used only if the expected benefit to the mother outweighs the possible risk to the fetus and child. It is necessary to avoid applying the gel to the mammary gland area before feeding.
special instructions
The drug is intended for external use only. Avoid contact with the mucous membrane of the eyes, nose, and mouth, as it may cause irritation. If the drug accidentally gets into your eyes, they should be rinsed immediately with running water. In cases of severe skin irritation in the first weeks of treatment, Skinoclear can be used once a day or the amount of gel applied to the skin can be reduced; Short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug at the recommended dose should be resumed.
Dermal melasma is insensitive to treatment with the drug. To carry out differential diagnosis, a Wood's lamp is used.
Skinoclear can be used in combination with other acne treatment methods. In this case, it is possible to adjust the dosage regimen of simultaneously used drugs.
During treatment, it is necessary to protect the skin from the entire spectrum of solar radiation.
Effect on the ability to drive vehicles and operate machinery The drug does not affect driving or engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Overdose
Currently, no cases of overdose have been described.
Side effects Skinoclear 20% 30g cream for external use
Adverse reactions are presented depending on the frequency of development: very often (≥ 1/10); often (≥ 1/100 to
Skin and subcutaneous tissue disorders:
Uncommon: seborrhea, acne, skin depigmentation; Very often: itching, burning, erythema at the site of application;
Common: peeling, dry skin, irritation; Rarely: cheilitis.
General disorders and disorders at the injection site:
Uncommon: paresthesia, dermatitis, discomfort, swelling at the application site;
Rarely: vesicular rash, eczema, feeling of warmth, rash at the site of application;
Common: pain at the site of application. Immune system disorders:
Rarely: allergic reaction, worsening of bronchial asthma.
As a rule, local skin reactions go away on their own during treatment.
If any of the side effects indicated in the instructions worsen, or any other side effects not specified in the instructions are noted, you should immediately inform your doctor.
Drug interactions
The interaction of the drug with other drugs is not known to date.
Side effects
Possible adverse reactions (> 10% - very common; > 1% and < 10% - often; > 0.1% and < 1% - uncommon; > 0.01% and < 0.1% - rare; < 0. 01%, including individual messages - very rarely):
- skin and subcutaneous fat: uncommon – skin depigmentation, acne, seborrhea; rarely - cheilitis;
- immune system: rarely - worsening of bronchial asthma, drug hypersensitivity;
- general disorders (at the site of application): very often – burning, itching, erythema; often – pain, peeling, dryness, discoloration, irritation; uncommon – paresthesia, discomfort, dermatitis, swelling; rarely - a feeling of warmth, eczema, vesicular rash, rash.
Local skin irritations usually go away on their own during treatment.
Side effects
If you have individual intolerance, side effects may also occur, for example:
- burning sensation on the skin;
- itching;
- dryness;
- paresthesia;
- local swelling;
- contact type dermatitis;
- peeling of the surface layer of the skin;
- erythema;
- redness, feeling of heat;
- acne;
- hives.
Mild allergic reactions (itching, burning, redness) disappear without intervention a few days after stopping taking the cream. In other cases (eg, urticaria), symptomatic treatment may be necessary.
special instructions
Skinoclear gel and cream are intended for external use only.
Contact with the mucous membranes of the eyes, mouth and nose should be avoided as this can lead to irritation. In case of accidental contact with eyes, rinse them immediately with running water.
In the first weeks of treatment, if skin irritation is severe, the frequency of use of the drug can be reduced to 1 time per day, or the amount of gel/cream applied to the skin can be reduced. Short-term discontinuation of therapy is also allowed. After symptoms disappear, therapy should be resumed at the recommended dose.
Dermal melasma is insensitive to the action of the drug. To carry out differential diagnosis, a Wood's lamp is used.
Gel "Skinoklir": instructions for use
The drug is taken externally only. It is applied to the affected area of the skin, which must first be washed and dried thoroughly. The ointment or gel is distributed in a thin layer and rubbed in with soft massage movements. It is better to perform the procedure 2 times a day - in the morning and in the evening. The consumption is small: for example, to treat the face, apply a strip up to 2.5 cm long, which is equivalent to 0.5 g of product.
Skinoren is used regularly for several days or weeks in a row until symptoms are completely eliminated. In this case, it is better to coordinate the duration of the course and dosage with a dermatologist.
The total duration depends on the specific disease. For example, for the treatment of rosacea and acne, therapy is continued for 3-4 weeks. The gel is applied every day at least 2 times a day. And even after complete recovery, it is recommended to continue applying the composition for several more weeks. There is proven clinical experience of safe continuous treatment for 12 months.
In the case of melasma, it is better to use a cream. It is applied to the affected area 2 times a day for at least 3 months. If the disease is advanced, you can slightly increase the daily dosage, as well as the total duration.
During treatment, you need to regularly use sunscreen compounds that protect skin tissue from the harmful effects of UV rays. Otherwise, the disease may relapse, and already lightened areas will again acquire characteristic pigmentation. In this case, after each use you should wash your hands thoroughly to avoid getting the joint in your eyes, mouth or nose.
Sometimes the cream can cause skin irritation. Then it is used not 2 times, but once a day. In addition, it is recommended to slightly reduce the amount of composition applied.
If there are no visible signs of improvement after a month of continuous therapy, you should consult a doctor for a possible change in drug. Moreover, if a patient has rosacea, he needs to be treated with the cream for at least 2 months, after which a decision may be made to replace it.
