Pharmacological properties of the drug Relief
Phenylephrine hydrochloride is an adrenergic agonist, the use of which leads to a local vasoconstrictor effect. This normalizes the relationship between blood flow to hemorrhoids and blood outflow from them, and also causes a decrease in exudation, swelling, itching, serous discharge in hemorrhoids and other diseases of the anorectal area. Shark liver oil has local anti-inflammatory, hemostatic, wound healing and immunomodulatory effects. Suppository base: cocoa butter; ointments: mineral oil, corn oil, thyme oil, glycerin and vitamin E - a safe base, has a softening effect.
Relief, Advance and Ultra: comparison
Comparing the two drugs Relief and Relief Advance, one can note their different components. The production of the former uses phenylephrine, and the latter - various analgesics.
Therefore, Relief Advance has a stronger analgesic effect, but in terms of the number of adverse reactions it is ahead of other medications in the line.
Among them, it is necessary to highlight drowsiness, dizziness, hypersensitivity (skin itching, redness, swelling), shortness of breath and rapid heartbeat. The classic medicine Relief can be combined with other medications. Advance is not recommended to be taken simultaneously with antihypertensive drugs and antidepressants. In some cases there may be other restrictions.
If we compare Relief and its Ultra form, then in the second case there are several times more indications for use. This drug is justified in the treatment of external and internal hemorrhoids, erosive ulcerations on the mucous membrane, proctitis and paraproctitis, and ulcers of a nonspecific nature. In addition, it is advisable to use the medication in case of fistulas and anal itching caused by dermatitis or eczema. Due to the corticosteroid it contains, Relief Ultra has many contraindications. For people with restrictions on the use of hormones, it is better to choose regular Relief.
Use of the drug Relief
Use the drug after hygiene procedures. The drug in the form of an ointment, using an applicator previously lubricated with a small amount of ointment, carefully apply to the affected areas outside or inside the anus up to 4 times a day, preferably in the evening, in the morning or after each bowel movement. After each use, rinse the applicator thoroughly and place it in a protective cap. Release the suppository from the plastic protective shell and insert it into the anus. Use 1 suppository up to 4 times a day: at night, in the morning and after each bowel movement. Regular use of the drug provides a lasting therapeutic effect and relieves the symptoms of hemorrhoids.
Relief rectal ointment 2.5 mg/g 28.4 g No. 1
Name
Relief.
Description
Yellow ointment without foreign substances with a weak characteristic odor.
Main active ingredient
Shark liver oil + phenylephrine.
Release form
Rectal ointment.
Pharmacological properties
Phenylephrine hydrochloride is an alpha-adrenomimetic, has a local vasoconstrictor effect, which helps reduce exudation, tissue swelling, and itching in the anorectal area.
Indications for use
As a symptomatic remedy for hemorrhoids, anal fissures, anal itching.
Directions for use and doses
Use the drug after hygiene procedures. Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out a small amount of ointment to lubricate the applicator. Apply the ointment carefully through the applicator to the affected areas outside or inside the anus up to 4 times a day (in the morning, at night and after each bowel movement). After each use, rinse the applicator thoroughly and place it in the protective cap. Children under 12 years old - as prescribed by a doctor. The dose used for self-treatment of hemorrhoids in adults and children over 12 years of age should not exceed 2 mg of phenylephrine hydrochloride (1 g of ointment contains 2.5 mg of phenylephrine hydrochloride) per day. It is not recommended to exceed the indicated dose without a doctor's prescription.
Use during pregnancy and lactation
The drug is not recommended for use during pregnancy and lactation.
Impact on the ability to drive vehicles and operate machinery
It is recommended to exercise caution due to the possible development of adverse reactions from the nervous system.
Precautionary measures
For patients with arterial hypertension, cardiovascular diseases, thyroid diseases, angle-closure glaucoma, diabetes mellitus, liver diseases, pancreas diseases, urinary disorders (for example, in the case of prostatic hyperplasia), the drug can be used only after consulting a doctor; during treatment it is necessary doctor's supervision. Before prescribing the drug, the doctor should clarify the allergic history, including allergic reactions to other sympathomimetic drugs. In case of heavy bleeding from the anus or lack of therapeutic effect when using the drug, you should consult a doctor.
Interaction with other drugs
The drug should not be used simultaneously with other vasoconstrictors (regardless of the route of administration), as well as with antihypertensive drugs (13-blockers). Atropine sulfate blocks reflex bradycardia caused by phenylephrine and increases the pressor response to phenylephrine. The simultaneous use of phenylephrine with B-blockers can lead to arterial hypertension and severe bradycardia with possible heart block. Caution should be exercised when using the drug Relief together with thyroid hormones and drugs that affect cardiac conduction (cardiac glycosides, antiarrhythmic drugs). When used simultaneously with drugs that cause potassium excretion (for example, with diuretics such as furosemide), hypokalemia may increase and sensitivity to vasopressor drugs such as phenylephrine may decrease. The simultaneous use of phenylephrine and other sympathomimetic drugs can lead to additional stimulation of the central nervous system, which is accompanied by agitation, irritability, insomnia, and the possible development of a convulsive attack. Relief should not be used simultaneously or within 14 days after stopping treatment with MAO inhibitors.
Contraindications
Hypersensitivity to the components of the drug, severe arterial hypertension, tachysystolic heart rhythm disturbances, decompensated heart failure, cardiac conduction disorders, severe renal and/or liver failure, thyrotoxicosis, acute pancreatitis, thromboembolism (including previous ones), granulocytopenia, simultaneous use with monoamine oxidase inhibitors (MAOIs) or within 14 days after stopping treatment with MAO inhibitors.
Compound
Active ingredient: phenylephrine hydrochloride 2.5 mg/g. Excipients: mineral oil, petrolatum, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), anhydrous lanolin, benzoic acid (E210), corn oil, glycerol, lanolin alcohols, paraffin paraffin (58/60), thyme oil, vitamin E, white wax, purified water.
Overdose
If the recommended single and daily doses are significantly exceeded, a tendency to hypercoagulation may occur. In case of overdose, the following disorders are possible: arterial hypertension, pain and discomfort in the heart, palpitations, respiratory disorders, non-cardiogenic pulmonary edema, agitation, convulsions, sleep disturbances, anxiety, irritability, psychosis with hallucinations, general weakness, anorexia, nausea, vomiting, oliguria, urinary disorders, facial flushing, feeling of coldness in the extremities, paresthesia, hyperglycemia, hypokalemia, decreased blood flow to vital organs, which can lead to deterioration of blood supply to the kidneys, metabolic acidosis, increased workload on the heart due to increased total peripheral resistance. Treatment is symptomatic.
Side effect
The following adverse reactions are possible: From the cardiovascular system: reflex bradycardia, heart rhythm disturbances, increased blood pressure. On the part of the immune system: hypersensitivity reactions, including cross-type reactions in the case of allergic reactions to other sympathomimetic agents, which can manifest as skin rash, itching, angioedema, contact dermatitis. From the nervous system: dizziness, nervousness, headache, tremor, insomnia, anxiety, feeling of hot flashes. From the skin and subcutaneous tissues: contact dermatitis, hyperemia, skin rash, itching, swelling, pain, burning. Reporting Adverse Reactions If you experience any adverse reactions, consult your physician. This recommendation applies to any possible adverse reactions, including those not listed in the package insert. You can also report adverse reactions to the Adverse Drug Events Information Database, including reports of drug failure. By reporting side effects, you can help provide more information about the safety of the drug.
Storage conditions
At a temperature not exceeding 25 °C, out of the reach of children.
Buy Relief ointment rect. 2.5 mg/g in tubes 28.4 g in pack. No. 1 in pharmacy
Price for Relief ointment rect. 2.5 mg/g in tubes 28.4 g in pack. No. 1
Instructions for use for Relief ointment rect. 2.5 mg/g in tubes 28.4 g in pack. No. 1
Special instructions for the use of the drug Relief
In severe forms of hypertension, significant heart rhythm disturbances, severe thyrotoxicosis, and urinary disorders, the use of the drug must be agreed with a doctor. In case of severe bleeding from the anus or if symptoms of the disease persist for more than 7 days from the start of using the drug, you should consult your doctor. Do not use the product if the protective plastic shell is damaged or missing. For children under 12 years of age, during pregnancy and breastfeeding, use the drug after consulting a doctor.
Algorithm for choosing a medication
The presence of several types of Relief suppositories allows you to choose the most effective remedy. Rational use of the drug can delay or prevent colorectal surgery. Thanks to various combinations of components, it is easy to provide a targeted approach to the choice of medication.
| Drug name | Features of application |
| Suppositories Relief | Treatment of stage 1-2 hemorrhoids, which are accompanied by bleeding, swelling and itching. Suitable for long-term use. |
| Relief Advance | Used in the postoperative period, prescribed to relieve pain. |
| Relief Ultra | They are used in the treatment of anal fissures and erosions, and for stage 2-3 hemorrhoids. |
| Relief Pro | Prescribed for chronic hemorrhoids with severe pain, inflammation, and accumulation of tumor infiltrate. |
It is not possible to correctly answer the question which candles from the Relief line are better. First of all, it is necessary to be guided by the clinical picture and disturbing symptoms. Based on this, after consultation with a doctor, you can choose the most effective option.
High efficiency of the drug
Relief suppositories are used in the treatment of all forms of hemorrhoids, as well as other diseases of the anus. The drug helps reduce the severity of painful attacks and speed up the healing process of ulcers and cracks. It is also advisable to use it in the pre- and postoperative period to relieve irritation. There are 4 medications in the Relief line of suppositories. Each of them has its own therapeutic focus, which allows patients to choose the most effective option to eliminate the problem.
Popular analogues
It happens that suppositories from the Relief line are not suitable for the patient. In this case, the doctor prescribes an analogue. It must be a drug with a similar therapeutic effect or composition. However, the release form may differ. Some patients opt for all-natural remedies or Ayurvedic preparations.
One of the popular analogues is Proctosan. Used for the treatment of dental fissures. Patients usually tolerate Proctosan well. In isolated cases, allergic reactions in the form of swelling and redness are observed. Among other analogues of Relief candles, it is necessary to highlight:
- Heparin ointment
. This is the cheapest treatment option for hemorrhoids. It is used for local treatment of affected areas every time pain occurs. - Gepatrombin G
. It has an anti-inflammatory and wound-healing effect, promotes the resorption of hemorrhoidal blood clots and prevents the formation of the latter. - Procto-Glyvenol
. Available in the form of suppositories and ointments. The latter has a venotonic effect and helps well in the treatment of hemorrhoids.
Proctosedyl is a hormonal analogue of Relief. It is an emergency aid for exacerbation of hemorrhoids. Can be used as ointment or suppositories.
