Pharmacodynamics and pharmacokinetics
Pharmacodynamics
A drug with a combined effect. It has anti-inflammatory, antiseptic, antiparasitic and antifungal effects. The effect of Naftalan oil on the skin is manifested by a resolving, softening, disinfecting and mild analgesic effect.
Sulfur, in the process of interaction with substances of organic origin, forms complex compounds that have antiparasitic and antimicrobial effects. Tar increases the blood supply to tissues, improves the process of regeneration of the epidermis and the process of its keratinization, and has disinfectant properties.
Pharmacokinetics
Since the adsorption of the active components of the drug into the systemic circulation is insignificant, the pharmacokinetics of the drug have not been described.
Side effects
A large number of reviews from patients who were treated with Wilkinson's Ointment indicate that this external agent is generally well tolerated and does not have any side effects if the recommended dosage regimen and duration of therapy are followed. This fact is confirmed by doctors, because In clinical practice, no cases of any serious side effects have been reported. Very rarely there are complaints of dermatitis. With long-term use there is a risk of arthropathy (joint disease).
In individual cases - in the presence of hypersensitivity or intolerance to one or another component of the medication - allergic reactions may develop.
Solcoseryl ointment for external use. approx. in a tube 20g in a pack. No. 1
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MEDA Pharmaceuticals Switzerland GmbH, Switzerland manufactured by Legacy Pharmaceuticals Switzerland GmbH
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Solcoseryl
Dosage form: gel for external use and ointment for external use
Composition per 1 g:
Solcoseryl gel and Solcoseryl ointment contain:
Active component: Solcoseryl (deproteinized dialysate from the blood of dairy calves), in terms of dry matter 4.15 mg/g and 2.07 mg/g, respectively
Excipients:
Solcoseryl gel - methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), sodium carmellose, propylene glycol, calcium lactate pentahydrate, water for injection, lactic acid and/or sodium hydroxide.
Solcoseryl ointment - methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), cetyl alcohol, cholesterol, white petrolatum, water for injection.
Description
Solcoseryl gel
Homogeneous, almost colorless, transparent gel of dense consistency. The characteristic light smell of Solcoseryl (the smell of meat broth).
Solcoseryl ointment
A homogeneous, fatty mass from white to white with a yellowish tint. The characteristic light smell of Solcoseryl (the smell of meat broth) and Vaseline.
Pharmacotherapeutic group
Means for the treatment of wounds and ulcers. Other wound healing agents.
ATX code: D03AX
Pharmacological properties
Solcoseryl is a deproteinized hemodialysate that contains a significant amount of low-molecular components of cells and blood serum of calves (dialysis/ultrafiltration, maximum molecular weight 5000 Da), the chemical and pharmacological properties of which are only partially described to date.
A study of the drug on various cell and tissue cultures, organs, as well as animal bodies showed that Solcoseryl:
— maintains and/or restores aerobic energy metabolism, as well as oxidative phosphorylation processes in cells deprived of sufficient amounts of nutrients, thereby maintaining and/or restoring the supply of high-energy phosphates,
- increases oxygen uptake (in vitro), as well as glucose transport in hypoxic and metabolically depleted tissues and cells,
– improves repair and regeneration processes in damaged tissues and/or tissues deprived of sufficient nutrients,
– prevents and/or reduces secondary degeneration and pathological changes in reversibly damaged cellular systems,
– enhances collagen synthesis in in-vitro models, as well as
— stimulates cell proliferation and migration in-vitro.
Thus, Solcoseryl protects tissues prone to hypoxia and/or substrate depletion. This stimulates the restoration of functions in reversibly damaged tissue, and also accelerates the healing of lesions and improves the quality of this process.
Indications for use
Solcoseryl gel/ointment is used in the following cases:
- minor damage (abrasions, scratches, cuts)
— 1st and 2nd degree burns (sunburn, thermal burns)
- frostbite
- difficult-to-heal wounds (including trophic ulcers and bedsores).
For the treatment of trophic lesions of tissues of various origins, Solcoseryl is used only after removal of necrotic tissue from the wound.
Solcoseryl gel is used in the initial stage of treatment and is applied to fresh wounds, wounds with wet discharge or ulcers with weeping phenomena.
Solcoseryl ointment is used primarily for the treatment of dry (non-wetting) wounds.
Contraindications
Hypersensitivity to one of the components of the drug.
Use with caution if you are predisposed to allergic reactions.
Directions for use and doses
Solcoseryl is used topically.
Apply a thin layer to the wound 2 times a day.
Experience with use has shown that Solcoseryl gel is especially suitable for wounds with wet discharge or ulcers with weeping phenomena, while the ointment is especially suitable for dry wounds.
Children and teenagers:
The literature describes cases of the use of Solcoseryl in children. In children, it is preferable to use Solcoseryl ointment.
Side effects
— In rare cases, allergic reactions in the form of urticaria and marginal dermatitis may develop at the site of application of Solcoseryl. In this case, you must stop using the drug and consult a doctor.
— A short-term burning sensation may be observed at the site of application of Solcoseryl gel. If the burning sensation does not go away for a long time, the use of Solcoseryl gel should be abandoned.
Overdose (intoxication) of the drug
There is no information on the effects of an overdose of Solcoseryl gel/ointment.
Interaction with other drugs
The interaction of Solcoseryl with other topical medications has not been established.
Use during pregnancy and breastfeeding
Animal studies have shown no risk to the fetus. Studies of the effect of Solcoseryl on the course of pregnancy and the fetus in women have not been conducted. The use of Solcoseryl during pregnancy and breastfeeding is undesirable and is possible only if the benefit exceeds the risk, under the supervision of a physician.
Impact on the ability to drive vehicles and operate machinery
No studies have been conducted.
Precautionary measures
Solcoseryl should not be applied to a contaminated wound, since it does not contain antimicrobial components;
— If you experience pain, redness of the skin near the site where Solcoseryl was applied, secretion from the wound, or increased temperature, you must immediately consult a doctor;
— If, when using Solcoseryl, healing of the affected area is not observed within 2-3 weeks, you should consult a doctor.
Release form
Solcoseryl gel for external use. Solcoseryl ointment for external use.
20 g in aluminum tubes. The tube along with instructions for use are placed in a cardboard box.
Storage conditions
At a temperature not higher than 30°C.
Keep out of the reach of children.
Best before date
5 years from the date of production. Do not use after the expiration date stated on the package.
The shelf life of an opened tube is 28 days when stored at room temperature (15-25°C).
Conditions for dispensing from pharmacies
Over the counter.
Analogs
Benzyl benzoate ointment
Analogues of Wilkinson's ointment are:
- Benzyl benzoate ointment. Used for head lice and scabies. After hygiene procedures, apply to the hands, and then throughout the body from top to bottom without affecting the facial and scalp. Price – 10-42 rubles.
- Spregal. An analogue is available in the form of an aerosol. Helps in the treatment of scabies. Price from 950 to 1200 rubles.
- Bensocryl. The composition includes benzyl benzoate, which is classified as an anti-itch agent. Price – 25-75 rubles.
- Hellebore water. It is an alcohol tincture of hellebore root. Used to treat skin parasites of the scalp and face. According to the instructions, it has antiparasitic and antibacterial effects. Stimulates hair growth. Price – 85-120 rubles.
- Sulfur-tar ointment. Indicated for fungal infections and scabies. It has antimycotic, antiseptic, insecticidal and stimulating effects. Price – 55-74 rubles.
- Solution according to Demyanovich. Based on hydrochloric acid and sodium thiosulfate, after application to the skin the liquid part evaporates, leaving crystals of substances that are rubbed into the scabies. Price – 70 rub.
It is not recommended to independently select analogues of Wilkinson's ointment; this can provoke a worsening of the disease and the appearance of severe complications, according to reviews of specialized specialists.
Contraindications
Wilkinson's ointment
Based on the instructions, Wilkinson's ointment is contraindicated in the acute period of eczematous manifestations, new rashes, and severe weeping. It is not recommended for use in persons with impaired renal blood flow and renal failure.
The product is contraindicated in case of individual intolerance to one of the components. With caution in case of a burdened allergic history, in case of immediate type allergies: Quincke's edema, anaphylactic shock, urticaria.
Contraindicated for use in pediatric practice for children under two years of age. Not recommended for women during pregnancy to avoid an allergic reaction.
Composition and pharmacological action
Wilkinson's ointment consists of several main components that complement each other's action. Compound:
- Tar – has an antiseptic effect. Helps restore normal microcirculation. Softens crusts and other keratinized structures, improves the regeneration of damaged epidermis and dermis.
- Green soap - when treating damaged areas, creates a disinfecting effect.
- Naftalan oil – softens the skin, disinfects wound defects, and has a resolving effect.
- Purified sulfur - penetrating into the wound, it is activated, special biochemical compounds appear that have antibacterial and antiparasitic effects.
- Calcium carbonate – performs an adsorbing effect.
- Distilled water.
Wilkinson's ointment is brown in color, dense in consistency, and has a characteristic odor. Designed for outdoor use.
The pharmacological action is to eliminate pathogenic microflora, relieve inflammation, eliminate mycotic infections and destroy skin parasites.
Indications
Wilkinson's ointment
According to the instructions for use, Wilkinson's ointment is indicated:
- Trichophytosis (ringworm) is an infectious skin disease caused by fungi.
- Scabies - caused by a skin parasite, affects the folds of the epidermis between the fingers, forearms, and abdomen in the umbilical area.
- Trophic ulcers due to venous insufficiency, atherosclerotic lesions of the arteries, diabetic neuroangiopathy, infectious skin lesions.
- Domestic wounds (cuts, scratches, abrasions), professional (knife, gunshot, stab wounds).
- Bedsores are tissue necrosis due to constant pressure on them, as a result of which trophism and innervation deteriorate.
- Indicated for chronic skin eczema.
- As a restorative therapy, it helps with psoriatic skin lesions.
Wilkinson's ointment is widely used in dermatology and is indicated for persons with dermatomycosis in complex therapy.
