Pradaxa is a drug belonging to the group of anticoagulants. Many substances belonging to the same group are included in cheap analogues of Pradaxa. The drug is produced in oblong capsules with a dosage of 75, 110 or 150 mg of active substance per capsule. The active substance is dabigatran etexilate, which has a positive effect on the clotting factor of blood plasma, and also affects the aggregation function of platelets and fibrin clots.
The medicine is prescribed under the supervision of the attending physician, who sets the required dosage. Used in people who have undergone orthopedic surgery to help prevent the development of venous thromboembolism. Pradaxa is also used to prevent strokes and in atrial fibrillation to prevent cardiovascular crises.
The drug has a significant list of contraindications:
- renal failure;
- bleeding of various origins;
- diathesis of hemorrhagic nature;
- simultaneous use together with ketoconazole;
- age less than 18 years;
- liver failure;
- disturbances in the functioning of internal organs, accompanied by bleeding;
- coagulopathy.
Note! During pregnancy, the medicine can only be used in situations that directly threaten the life of the mother. As a precaution, breastfeeding should be stopped during treatment.
pharmachologic effect
Manufacturer: BOEHRINGER INGELHEIM INTERNATIONAL (Germany)
Release form: capsules
Active ingredient: dabigatran etexilate
Analogues: Clexane, Trombo ACC, Rivaroxaban
The mechanism of action of Pradaxa is based on inhibition of thrombin activity, which leads to an obstacle to the formation of a blood clot. The active substance included in the drug effectively reduces the prothrombin index. The concentration of the drug increases, reaching its maximum, within 1–2 hours from the moment the drug is taken.
Description of the drug
The capsules are oblong in shape with a soft creamy shell. The main active ingredient is dabigatran etexilate. You can buy it in any dosage - 75; 100; 150 mg. Excipients are hypromellose, tartaric acid, gum arabic, carrageenan, potassium chloride.
The main element of Pradaxa reduces blood clotting. The mechanism of action occurs through the suppression of thrombin, which involves a strain in the form of a serine protease, which initiates the process of blood clotting with modification of soluble fibrinogen. After taking the medication, the active substance is instantly absorbed from the intestine into the plasma. Its pharmaceutical concentration in the circulatory system is achieved 2 hours after consumption.
The drug is excreted unchanged in the urine by the kidneys after about 14 hours. In elderly people or with kidney pathologies with low activity, the half-life may increase (this must be taken into account when prescribing the dosage of the drug).
Indications for use of Pradaxa
Prescribing Pradaxa allows you to avoid serious health complications. The drug is indicated for use as a prophylactic agent to prevent:
- venous thromboembolism after orthopedic interventions;
- ischemic stroke against the background of cerebral atherosclerosis;
- mortality of patients suffering from atrial fibrillation;
- recurrent deep vein thrombosis;
- pulmonary embolism.
Pradaxa is used not only as a prophylaxis, but also for the treatment of acute conditions that have already occurred in the patient (deep vein thrombosis or pulmonary embolism).
Pradaxa - instructions for use
According to the instructions for use of Pradaxa, the dosage and duration of the course of therapy is determined by the doctor, taking into account the type of disease and the activity of the pathological process. On average, the drug is prescribed 1 capsule 1-2 times a day. The dosage of Pradaxa is subject to adjustment in patients with kidney disease, elderly and senile patients (over 80 years).
How to take Pradaxa
Pradaxa capsules are taken orally. Their intake is not related to the time of eating. Take the medicine with a glass of water to make it easier to pass through the esophagus and dissolve in the stomach. It is not recommended to open the medication capsule.
Analogues of Pradaxa
The Russian pharmacological market is represented by a wide range of analogues and substitutes for Pradaxa, the use of which gives results similar to the base drug. The pharmacy chain offers them in the form of:
- synonyms;
- generics;
- combination medications.
The variety of Pradaxa analogues from domestic and foreign pharmaceutical manufacturers allows doctors to choose and prescribe competent treatment for a patient, taking into account all the nuances of his health condition. The price of Pradaxa analogues varies widely depending on the composition of the drug and the pharmacological company.
Table of Pradaxa analogues with price and country of origin
Analogue | Cost in rubles | Manufacturer country |
Pradaxa | 1780-10000 | Germany |
Clexane | 570-4500 | France |
Thrombo ACC | 40-135 | Russia |
Aspirin | 80-160 | Germany |
Cardiomagnyl | 115-270 | Russia |
Sylt | 500-1450 | Russia |
Wessel Due F | 2700-3000 | Italy |
Eliquis | 900-2500 | USA |
Among a large number of medicines of different price categories, you can buy analogues of Pradaxa cheaper, but with similar effectiveness compared to the basic drug.
Various analogues of the drug Prodax, recommended by a doctor, will help prevent complications of serious diseases that are a threat to the patient’s life.
You can supplement this list of drugs with analogues of Pradaxa from domestic manufacturers:
- Rivaroxaban;
- Warfarin;
- Fraxiparine forte;
- Magnicor;
- Thrombogel 1000;
- Lavenum.
A large selection of medications presented in the pharmacy chain allows the patient to choose cheaper analogues of Pradaxa. The cost of the medicine is an important point for the patient, since anticoagulants have to be used for a long time.
Pradaxa or Xarelto - which is better and safer, reviews from doctors
Manufacturer: BAYER (Germany)
Release form: tablets
Active ingredient: rivaroxaban
Pradaxa and Xarelto have equivalent indications and are used for the prevention and treatment of thrombosis. They have different active ingredients, which determine the different mechanism of action of the drugs.
If there is increased blood clotting and treatment is prescribed, there is something to replace Prodax 110 mg. This is its analogue, Xarelto, which works better for thrombosis, as it has a rapid effect on the mechanism of thrombus formation.
Taking Pradaxa will be preferable for aortic valve bioprosthesis, since the drug is more effective in recurrent forms of blood clots, and it does not affect atrial fibrillation.
According to doctors, both drugs are highly effective. But for varicose veins and other vascular disorders, preference is given to the Pradaxa analogue Xarelto, since this medication has fewer contraindications.
Xarelto or Pradaxa – what to choose
Xarelto, an analogue of Pradaxa, is an anticoagulant with a direct inhibitory effect on blood clotting factor 10. The active component of the drug is rivaroxaban. Xarelto inhibits clotting factor 10, eliminating the so-called thrombin burst, which prevents the formation of blood clots.
Rivaroxaban is used to prevent blood clots during leg surgery (joint replacement), to prevent recurrent pulmonary embolism or deep thrombosis.
Xarelto is not prescribed for the treatment of pregnant and lactating women, patients under 18 years of age, allergies, significant bleeding, severe liver and kidney dysfunction, and carbohydrate metabolism disorders. Rivaroxaban is not used concomitantly with other drugs with similar effects.
Xarelto can cause hyperreactivity reactions, hemorrhages, anemia, increased heart rate, decreased blood pressure, leg pain, hematuria, and increased activity of liver enzymes.
Xarelto is taken orally, once. Drug doses range from 10 mg to 30 mg. A large dose can be divided into 2 doses.
Xarelto is manufactured by Bayer (Germany). The package may contain tablets of 2.5 mg, 10 mg, 15 mg and 20 mg of the drug. Prices for Xarelto are cheaper, ranging from 1300-10000 rubles.
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Pradaxa or Warfarin - which is better?
Manufacturer: Ozone LLC
Release form: tablets
Active ingredient: warfarin sodium
What is a cheaper alternative to Prodaksa, but still get the expected equivalent result? This drug may be its analogue Warfarin.
Both medications are anticoagulants and have common indications for use. According to doctors, it is preferable to use a Russian medicine, since its mechanism of action is well studied, has been used in therapeutic practice for more than 60 years and is affordable. In any case, only a professional will have to choose the best drug for treatment.
Pradaxa or Eliquis - which is better?
Manufacturer: PFIZER (USA)
Release form: tablets
Active ingredient: alixaban
Pradaxa and Eliquis are direct-acting anticoagulants and have similar indications for the treatment and prevention of thrombosis of various locations. When prescribing therapy and there is a risk of developing an embolism, a stroke or dysfunction of the excretory system, the doctor has the option of replacing Pradaxa 110 mg.
This analogue could be Eliquis, which gives fewer complications in the form of bleeding, since the drug blocks only 1 stage of coagulation, unlike similar drugs. According to doctors, Eliquis will be the best in the medical practice of patients with atrial fibrillation or after stenting.
It is convenient for a fixed dose of medication without the need for laboratory monitoring and dosage adjustment for older patients.
"Warfarin"
It is an antagonist of vitamin K and belongs to the antithrombotic drugs of the group of indirect anticoagulants. Reduces the likelihood of blood clots. Used for treatment and prophylactic purposes for thrombosis, as well as embolism of blood vessels.
"Warfarin" is dispensed from pharmacies in tablet form at 2.5; 3; 5 milligrams. Capsules are distributed into blisters. The active ingredient is warfarin sodium clathrate. Warfarin is a cheap analogue of Pradaxa (110 mg).
If the drug is prescribed to a patient for the first time, the average dosage should be 5 milligrams per day for four days. Subsequently, based on the patient’s condition and indicators, a maintenance dose is prescribed, usually ranging from 2.5 to 7.5 milligrams.
If a person has used the drug before, for the first two days the medicine is used in a dosage that doubles the known maintenance dosage. Then a maintenance dose is used for three days. On the fifth day, it is necessary to monitor the indicators and adjust the dosage. The cost of the drug is 180 rubles.
Clexane
Manufacturer: SANOFI-AVENTIS FRANCE (France)
Release form: solution for parenteral administration
Active ingredient: enoxaparin sodium
Clexane belongs to the group of direct-acting anticoagulants. The active substance of the Pradaxa analogue is low molecular weight hemoglobin. The drug is used as a prophylaxis to prevent venous thrombosis and embolism after orthopedic and general surgical interventions.
The drug is recommended for use by patients who are on constant bed rest due to acute or chronic pathology of internal organs. The analogue is administered subcutaneously according to indications.
The dosage of the Pradaxa substitute is calculated individually, depending on the degree of risk of thrombosis or thromboembolism, and is 20–40 mg once a day and a course of administration for 7–10 days.
How to take the drug correctly?
Capsules are used only for adult patients. They are consumed orally with water, one to two times a day, regardless of diet. Before taking tablets, you must ensure that the tablet is intact, since this changes the rate of absorption of the active microelement. The dosage and regimen of medication directly depend on the disease and certain conditions, for example:
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For kidney disease, which is accompanied by a moderate decrease in kidney function, the dosage of tablets is reduced to 150 milligrams per day. If thromboembolic complications in atrial fibrillation are being prevented, the dosage is not reduced and is 300 milligrams per day. In patients of retirement age, dosage is adjusted after assessing renal function.
Depending on the prescription, as well as the severity of the age-related decrease in the functional activity of the kidneys, the dosage of Pradaxa can vary between 150-300 milligrams per day. If a concomitant lesion occurs, which may lead to an increased risk of bleeding, the dose is reduced to 220 milligrams per day. If the patient's weight is low (less than 50 kilograms), he is monitored and there is no need to adjust the dosage.
Thrombo ACC
Manufacturer: VALEANT (Russia)
Release form: tablets
Active ingredient: acetylsalicylic acid
Thrombo ACC, a substitute for Pradaxa, is an antiplatelet drug that reduces the activity of platelets in gluing with their subsequent adhesion to the vessel wall. This process can trigger the formation of a blood clot.
Taking Thrombo ACC normalizes the properties of blood, improving its fluidity. The analogue is effective when taken in small doses for a long time. This property of the drug is used in the prevention and treatment of:
- myocardial infarction;
- IHD (coronary heart disease);
- complication of varicose veins of various locations;
- for atherosclerosis of cerebral vessels to prevent cerebral catastrophe;
- after surgical interventions.
The Thrombo ACC analogue is prescribed at a dose of 50–100 mg once a day, depending on the indications and activity of the pathological process. The course of treatment is long, the duration of which is determined by the doctor.
Sinkumar
Sinkumar is an anticoagulant, one of the analogues of the drug Pradaxa, which suppresses the activity of prothrombin and other factors of the blood coagulation system that depend on vitamin K. The active component is acenocoumarol.
Sinkumar is prescribed in case of pulmonary embolism, thrombosis of the arteries of the heart and venous vessels of the lower extremities. List of contraindications:
- Severe liver pathologies.
- Peptic ulcer of the stomach and duodenum.
- Bleeding, hemorrhagic diathesis.
- There is no need to use acenocoumarol if you are allergic to it.
Sinkumar can cause the following side effects: increased risk of hemorrhages, dyspeptic reactions.
The drug is taken orally, once, in a dose of 4 mg - 8 mg. Sinkumar is produced by MEDA (Germany) in 2 mg tablets. The cost is in the range of 500-700 rubles.
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Aspirin
Manufacturer: Bayer (Germany)
Release form: tablets
Active ingredient: acetylsalicylic acid
Pradaxa substitute Aspirin belongs to a group of non-steroidal medications that have antiplatelet, anti-inflammatory, analgesic and antipyretic properties. Thanks to the action of the active substance of this analogue of Pradaxa, blood parameters (prothrombin index) improve, which leads to the prevention of blood clots.
Aspirin is used as a symptomatic treatment for pain of various etiologies, for colds and infectious-inflammatory diseases. The analogue is taken 1-2 tablets (100 mg) 1 time per day. The course of treatment is determined by the indications and activity of the disease.
Cardiomagnyl
Manufacturer: TAKEDA PHARMACEUTICALS (Russia)
Release form: tablets
Active ingredient: acetylsalicylic acid, magnesium hydroxide
The drug Cardiomagnyl is an inhibitor of platelet aggregation in combination with magnesium, which protects the gastric mucosa from the aggressive effects of acetylsalicylic acid. This Russian Pradaxa substitute has a positive effect on the vascular system, warning:
- development of myocardial infarction;
- ischemic stroke;
- acute heart failure due to diabetes mellitus, arterial hypertension, obesity.
Mandatory prescription of the drug during surgical procedures, which is carried out before and after surgery, will avoid serious complications. A cheaper analogue of Pradaxa 150 mg, Cardiomagnyl, is recommended for use from 150 to 450 mg per day, depending on the type of pathology and its activity.
Contraindications
Pradaxa capsules also have restrictions on use, for example:
In addition, there are a number of other prohibitions on the use of Pradaxa, which can cause bleeding:
Before starting to use the drug, you should ensure that there are no contraindications.
Sylt
Manufacturer: KRKA-RUS (Russia)
Release form: tablets
Active ingredient: clopidogrel
The medication belongs to the group of antiplatelet drugs that help prevent complications of vascular atherosclerosis of any location, especially cerebral, coronary and peripheral arteries.
A substitute for Pradaxa tablets, the drug Zilt, is used for secondary prevention in patients who have suffered a myocardial infarction or stroke in the early recovery period. In therapeutic practice, it is used in combination with acetylsalicylic acid. The dosage of Zilt is calculated according to the scheme individually, depending on the indications.
Clopidogrel
Clopidogrel is an antiplatelet agent, the active metabolite of which is formed after ingestion. This drug can replace taking dabigatran. The mechanism of action is based on inhibition of platelet aggregation by influencing the glycoprotein complex.
List of indications: Clopidogrel is prescribed for the prevention of thrombosis in patients who have suffered acute coronary syndrome, as well as during the acute period of myocardial infarction. Contraindications: individual intolerance, severe acute bleeding, carbohydrate metabolism disorders, severe liver and kidney failure, pregnancy and lactation, age under 18 years.
Possible side effects:
- Hyperreactivity reactions.
- Hemorrhages.
- Cephalgia, dizziness.
- Dyspepsia.
- Angina, hypotension.
- Pain in muscles and joints.
Clopidogrel is available in 75 mg and 300 mg tablets. The drug is taken orally, once, the dose can be 75 mg, 150 mg and 300 mg per day. Prices depend on the manufacturer (Russian or foreign). The cost can be in the range of 200-2000 rubles.
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