Cevicap drops 100 mg/ml 10 ml (ascorbic acid) @


Pharmacological properties of the drug Cevicap

Ascorbic acid (vitamin C). Vitamin C has strong restorative properties. Ascorbic acid affects immunological reactions, detoxification processes, the conversion of folic acid into its active form - folinic acid, affects the metabolism of cholesterol, promotes the absorption of iron, and also suppresses peroxidation processes. Ascorbic acid takes part in the biosynthesis of connective tissue components (collagen, elastin and proteoglycans), due to which it participates in maintaining the intracellular structure of all body tissues. Ascorbic acid (vitamin C) is a water-soluble vitamin that is not synthesized in the human body. During infectious and inflammatory diseases, the concentration of vitamin C in leukocytes decreases sharply, and for the normal functioning of the body's immune system, sufficient saturation of tissues with ascorbic acid is important (the concentration of ascorbic acid in the blood plasma decreases due to an increase in its uptake by leukocytes). Vitamin C deficiency in the body leads to the development of hypo- and avitaminosis C, manifested by increased irritability, tachypnea, dyspepsia, anorexia, gingivitis, impaired dentin formation, low-grade fever, anemia, sluggish healing of wounds and fractures, Meller-Barlow disease (radiological changes in tubular bones, hyperostosis and pain in the area of ​​the epiphyses), scurvy.

CEVICAP DROPS 100MG/ML 10ML

Instructions

Trade name of the drug: Cevikap®
Active ingredients: Ascorbic acid

Pharmacotherapeutic group: Vitamins., Vitamins.

Release form:

10 ml or 30 ml in dark glass bottles with a dropper inside and a screw cap with a guarantee ring. 1 bottle with instructions for use in a cardboard box.

Dosage form: Drops for oral administration 100 mg/ml 10 ml, 30 ml (dropper bottle)

Compound:

1 ml contains: Active substance: ascorbic acid (vitamin C) 100 mg Excipients: anhydrous glycerin, purified water.

Pharmacological properties:

Due to its strong restorative properties, vitamin C is involved in many metabolic exchanges that take place in the human body. Ascorbic acid is capable of transporting electrolytes and enzymes. Ascorbic acid affects the immune system, detoxification processes, the conversion of folic acid into its active form - folinic acid, cholesterol metabolism, iron absorption, and also prevents peroxidation processes. Taking part in the biosynthesis of collagen, elastin and proteoglycans, ascorbic acid also participates in the formation of connective tissue, due to which it integrates and maintains the intracellular structure of all body tissues. Collagen, which makes up 30-40% of the body's proteins, is the main building component of connective tissue. It is part of the skin, endothelium of blood vessels, ligaments, tendons, bones, teeth, cornea, as well as the intercellular substance that binds cells. Affects the healing process of wounds, diaper rash, bone fractures. Ascorbic acid - vitamin C - is a water-soluble vitamin that is not synthesized in the human body. Ascorbic acid is very sensitive to the action of many factors and is subject to breakdown under the influence of light, high temperature and oxygen contained in the air. Optimal saturation of tissues with ascorbic acid is essential for the proper functioning of the body’s defense system. Due to the increased uptake of ascorbic acid by leukocytes, its concentration in the blood decreases. The use of vitamin C already at the first symptoms of a cold causes a significant increase in its concentration in the blood, from where it is captured in the tissues by phagocyte cells. It has been proven that the use of vitamin C reduces and softens the course of colds by an average of 23%. Lack of ascorbic acid leads to the formation of scurvy. Symptoms of vitamin C deficiency: increased irritability, tachypnea, dyspepsia, loss of appetite causing a characteristic position of the legs, swelling and subperiosteal hemorrhage, inflammatory changes in the gums, abnormal dentin structure, radiological changes in long bones, painful hyperostosis in the epiphyseal region (Möller-Barlow disease) . In this case, a low-grade fever, anemia, and delayed healing of wounds and fractures are observed. Symptoms stop after taking vitamin C.

Pharmacokinetics:

After oral administration, ascorbic acid is well absorbed from the gastrointestinal tract. About 25% binds to plasma proteins and is transported in the form of compounds with albumin. It quickly penetrates from the blood into almost all tissues and biological fluids (including through the placental barrier and into the milk of nursing women). The concentration of ascorbic acid in the blood plasma of a healthy person is 0.8–1.5 mg/100 ml. The concentration in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations. Ascorbic acid is reversibly oxidized to form dehydroascorbic acid, some is metabolized to form ascorbate-2-sulfate (inactive) and oxalic acid and is excreted in the urine. The excretion of ascorbic acid is controlled by the renal threshold, which for vitamin C is 1.5 mg/100 ml. Vitamin C taken in excessive quantities is quickly excreted unchanged in the urine.

Indications for use:

Cevicap - a solution of vitamin C in the form of drops is specially designed for children, this makes it possible to take small children's doses of ascorbic acid. • In complex therapy: - infectious diseases with fever, as well as viral recurrent infections of the upper respiratory tract - in inflammatory conditions • Conditions of increased need for vitamin C - convalescence - reduced immunity - playing sports or intense physical exercise  For the preventive purpose of hypovitaminosis C in case: - artificial feeding of children - malnutrition - anorexia - malabsorption (for diseases of the gastrointestinal tract).

Mode of application:

Orally. Drops can be given in one or more doses, preferably with meals. For infants, it is recommended to dissolve the drops in water, tea, juice or add to food. One drop contains 5 mg of vitamin C. Preventive doses: - infants and children of the 1st year of life: 5-8 drops (approx. 25-40 mg) per day; - children from 2 to 11 years: 10 drops (approx. 50 mg) per day; - adolescents from 12 to 17 years: 15 – 20 drops (approx. 75-100 mg) per day. Therapeutic doses are 2-5 times higher than prophylactic doses (depending on the indications).

Side effects:

The drug used in recommended doses is well tolerated. With long-term use of large doses, the following may appear: - increased excretion of oxalic acid in the urine, crystallization of urates and citrates, which increases the risk of kidney stones in the urinary system - in persons with glucose-6-phosphate dehydrogenase deficiency it can cause hemolysis - hyperglycemia, glycosuria - dyspeptic disorders (regurgitation, vomiting) - hemorrhages. - long-term use of high doses of ascorbic acid can lead to addiction

Contraindications:

Hypersensitivity to ascorbic acid and/or other components of the drug.

Drug interactions:

Iron. Ascorbic acid increases the absorption of non-heme iron from the digestive tract by 2-4 times, especially in individuals with a low supply of iron in tissues. Deferroxamine. In patients with excess iron in the body, the use of deferroxamine in combination with ascorbic acid in the initial phase of detoxification or treatment may increase iron toxicity. Acetylsalicylic acid. Large doses of acetylsalicylic acid reduce the bioavailability of ascorbic acid. Vitamin E. Both vitamins exhibit a synergistic antioxidant effect. Ascorbic acid reactivates tocopherol, preventing its inactivation both in vitro and in vivo. Co-trimoxazole. Large doses of ascorbic acid may increase the risk of crystalluria of the sulfomide component of co-trimoxazole. Medicines of an acidic and alkaline nature. Large doses of ascorbic acid (2 g/day or more) acidify the urine, which can affect the reduced excretion of acidic drugs in the urine, and therefore enhance their effect (eg nitrofuratonin, salicylates), as well as weaken the effect of alkaline drugs ( etc. antidepressant drugs, phenothiazine derivatives) due to their accelerated exclusion.

Special instructions:

Do not mix with preparations containing iron and copper due to its restorative properties. It is recommended to take ascorbic acid in a dose of no more than 100 mg per day for patients with kidney stones, hyperoxaluria or a tendency to form kidney stones (especially oxalate or uric acid), as well as with excess iron in the body, i.e. patients with hemochromatosis, sickle cell anemia, thalassemia and iron poisoning, persons with pre-existing hyperoxaluria or a predisposition to its formation, as well as in patients with recurrent kidney stones or renal failure accompanied by a metabolic defect in the conversion of oxalic and ascorbic acids. Ascorbic acid, consumed in large doses, can distort the results of laboratory tests performed by oxide-reduction methods (for example, testing for the presence of blood hidden in the stool, determining the concentration of glucose and creatinine in the blood and urine). Impact on the ability to drive vehicles and maintain mechanical equipment. Does not affect. The drug should not be used after the expiration date and should be stored out of the reach of children. The drug can be used during pregnancy. The recommended daily intake of vitamin C for pregnant women (including dietary intake) is 80 mg. The use of large doses of vitamin C by pregnant women leads to the manifestation of symptoms of its deficiency in the newborn due to the induction of metabolic processes under the influence of large doses of vitamin C. The drug can be used during breastfeeding. The recommended daily intake of vitamin C for breastfeeding women (including dietary intake) is 100 mg. The ascorbic acid content in mother's milk is 30-55 mg/l, which is sufficient for a breastfed infant (Goodman & Gilman's 1996). Large doses of vitamin C should be avoided due to the risk of overdose of this compound in infants

Overdose:

There are no data regarding overdose. The use of high doses of vitamin C (more than 1000 mg = 200 drops per day) can lead to an overdose with increased side effects. Treatment is symptomatic.

Storage conditions: Store in a carefully closed bottle at a temperature not exceeding 25°C. Protect from light.

Shelf life: 2 years.

Dispensing conditions: Without a prescription.

Manufacturer: Medana Pharma SA, Poland

Use of the drug Cevicap

Orally during or after meals, for preventive purposes - 1 time per day, for therapeutic purposes - 3 times per day. For infants, it is recommended to dilute the drops with water, tea, juice or add to food. 1 drop contains 5 mg of vitamin C. For prevention: children under 1 year of age: 5–8 drops (25–40 mg) per day; children aged 2–11 years: 10 drops (50 mg) per day; children aged 12–17 years: 15–20 drops (75–100 mg) per day. Therapeutic doses are 2–5 times higher than prophylactic doses (depending on the indications). Doses and duration of treatment are determined by the doctor individually.

Vaccination of children against COVID-19

Table of contents

  • How is children vaccinated against coronavirus in Russia?
  • Pros and cons of vaccinating children against covid
  • Is it mandatory to vaccinate children?
  • At what age is vaccination required?
  • Advantages of contacting MEDSI

Vaccinations against coronavirus infection are currently underway. More than several tens of millions of people have already completed the procedure in Russia. For now, vaccinations are only available to people over 18 years of age.
This is due to the fact that clinical trials on minor patients have not been completed.

Will children be vaccinated against COVID-19? When will it start? Will procedures be carried out in kindergartens and schools? We'll look into all the issues.

How is children vaccinated against coronavirus in Russia?

Vaccinations against coronavirus infection in our country began in January 2021. At the moment, the procedure is carried out only for adults. Vaccination of children and adolescents from 12 to 18 years of age against Covid has not yet begun. This is due to the fact that clinical trials are still ongoing and will last about a year. However, adolescents can begin to be immunized as early as September 20. This is due to the fact that they plan to register the special Sputnik V vaccine by September 15, 2021. In parallel with this, vaccination of schoolchildren will most likely begin. It is possible that the timing of mass procedures will be shifted.

Important! Vaccination of children and adolescents against Covid will be carried out exclusively with the approval of parents. At the same time, it is important for mothers and fathers to understand that a timely procedure will significantly reduce the incidence of coronavirus infection, severe complications after it and mortality. This is due to the fact that children, although they do not get severely ill (as a rule), are carriers of the disease.

Pros and cons of vaccinating children against covid

Advantages

  • The developed drugs increase the body's resistance to the infectious agent and help in the formation of artificial immunity. They are the most important means of protecting children from disease
  • Vaccination reduces the risk of infection. After vaccination, even a sick child will more easily survive the infection.
  • Complications after vaccinations are always less significant than complications after the disease

Flaws

  • Vaccination leads to the formation of artificial immunity, which can reduce natural
  • Vaccination does not guarantee 100% protection against the disease.
  • After the drug is administered, the child may feel unwell for several hours or days.

Is it mandatory to vaccinate children?

The parents or legal representatives of the child themselves answer this question. But everyone should understand that vaccination allows you to protect your child from complications or even death. It ensures that even if the child gets sick, he will survive the infection in a milder form than he could without the vaccine.

In addition, one should take into account the bans on entry into a number of countries without prior vaccination (providing a certificate or a special certificate about it).

At what age is vaccination required?

Vaccinations are possible from a very early age. On the first day of a newborn’s life, for example, a drug against viral hepatitis B is administered. As for the vaccination of children against covid, its timing has not yet been determined; perhaps it will be carried out in schools and kindergartens.

Advantages of contacting MEDSI

Attention! At the moment, vaccination of children against coronavirus is not carried out at MEDSI clinics. As soon as this opportunity becomes available, we will notify you about it. However, clinics perform other vaccinations: in accordance with the National Calendar or an individually compiled schedule.

  • Experienced specialists.
    Vaccination is carried out by paramedical personnel (nurses) with the necessary knowledge and skills
  • Diagnostic capabilities.
    Before getting vaccinated, you can perform the necessary examinations, undergo examinations by doctors and consult with them.
  • Immunization preparation programs
  • Comfortable conditions for the procedure.
    Vaccination is carried out without queues or long waits, on a convenient day. To undergo the procedure, each patient can choose the clinic closest to him

If you want to clarify the specifics of vaccination against coronavirus for children and adolescents or sign up for vaccination, call +7 (495) 7-800-500. Our specialist will answer all questions. You can also register for a clinic using the SmartMed application.

Side effects of the drug Cevicap

The drug is well tolerated in recommended doses. With long-term use of the drug in high doses, side effects may occur. From the urinary system: crystalluria, formation of urate and/or oxalate stones in the kidneys. From the endocrine system: in case of glucose-6-phosphate dehydrogenase deficiency, the use of vitamin C can cause hemolysis, hyperglycemia, and glycosuria. From the gastrointestinal tract: dyspeptic disorders (heartburn, vomiting). From the cardiovascular system : hypertension (arterial hypertension), myocardial dystrophy. From the blood system: thrombocytosis, hyperprothrombinemia, anemia, neutrophilic leukocytosis. From the side of the central nervous system: excitement. Metabolic disorders: metabolic disorders of zinc and copper. Long-term use of ascorbic acid in high doses can lead to addiction.

Special instructions for the use of Cevicap

Do not exceed the recommended dose. Do not mix with preparations containing iron and copper, as ascorbic acid has a restorative effect. It is recommended to use ascorbic acid in a dose of no more than 100 mg/day for patients with urolithiasis, hyperoxaluria or a predisposition to the formation of kidney stones (especially oxalate or uric acid), as well as with excess iron in the body (hemochromatosis, sickle cell anemia, thalassemia, intoxication with iron preparations), as well as in patients with renal failure, with metabolic disorders of oxalic and ascorbic acids. Ascorbic acid, used in high doses, can affect the results of laboratory tests that are carried out using redox methods (for example, conducting the Gregersen reaction, determining the concentration of glucose and creatinine in blood plasma and urine). Prescribe with caution to patients with diabetes. During pregnancy and breastfeeding. The drug can be used during pregnancy. The daily requirement for ascorbic acid during pregnancy is 80 mg. However, the use of ascorbic acid in high doses during pregnancy leads to the development of symptoms of its deficiency in the newborn due to the induction of metabolic processes. The drug can be used during breastfeeding. The daily requirement for ascorbic acid during breastfeeding is 100 mg. The concentration of ascorbic acid in mother's milk is 30–55 μg/ml. High doses of vitamin C should be avoided during breastfeeding due to the risk of overdose in a breastfed baby. Does not affect reaction speed when driving vehicles or operating other mechanisms. Children. Cevicap is a solution of vitamin C in the form of drops, specially designed for use in children.

Cevicap 100 mg/ml 30 ml drops for oral administration

Instructions for use of the medicinal product for consumers (insert summary) Cevicap Trade name Cevicap International nonproprietary name Ascorbic acid Dosage form Drops for oral administration 100 mg/ml Composition 1 ml contains the active substance - ascorbic acid (vitamin C) 100 mg excipients: disodium edetate 0.5 mg, anhydrous glycerin, purified water up to 1 ml. Description Transparent, light yellow or yellow liquid with a sweet and sour taste. Pharmacological properties Due to its strong restorative properties, vitamin C is involved in many metabolic exchanges that take place in the human body. Ascorbic acid is capable of transporting electrolytes and enzymes. Ascorbic acid affects the immune system, detoxification processes, the conversion of folic acid into its active form - folinic acid, cholesterol metabolism, iron absorption, and also prevents peroxidation processes. Taking part in the biosynthesis of collagen, elastin and proteoglycans, ascorbic acid also participates in the formation of connective tissue, due to which it integrates and maintains the intracellular structure of all body tissues. Collagen, which makes up 30-40% of the body's proteins, is the main building component of connective tissue. It is part of the skin, endothelium of blood vessels, ligaments, tendons, bones, teeth, cornea, as well as the intercellular substance that binds cells. Affects the healing process of wounds, diaper rash, bone fractures. Ascorbic acid - vitamin C - is a water-soluble vitamin that is not synthesized in the human body. Ascorbic acid is very sensitive to the action of many factors and is subject to breakdown under the influence of light, high temperature and oxygen contained in the air. Optimal saturation of tissues with ascorbic acid is essential for the proper functioning of the body’s defense system. Due to the increased uptake of ascorbic acid by leukocytes, its concentration in the blood decreases. The use of vitamin C already at the first symptoms of a cold causes a significant increase in its concentration in the blood, from where it is captured in the tissues by phagocyte cells. It has been proven that the use of vitamin C reduces and softens the course of colds by an average of 23%. Lack of ascorbic acid leads to the formation of scurvy. Symptoms of vitamin C deficiency: increased irritability, tachypnea, dyspepsia, loss of appetite causing a characteristic position of the legs, swelling and subperiosteal hemorrhage, inflammatory changes in the gums, abnormal dentin structure, radiological changes in long bones, painful hyperostosis in the epiphyseal region (Möller-Barlow disease) . In this case, a low-grade fever, anemia, and delayed healing of wounds and fractures are observed. Symptoms stop after using vitamin C. Indications for use Cevicap - a solution of vitamin C in the form of drops is specially designed for children - it makes it possible to take small, children's doses of ascorbic acid. · In complex therapy: — infectious diseases with elevated temperature, as well as viral recurrent infections of the upper respiratory tract — in inflammatory conditions · Conditions of increased need for vitamin C — convalescence — reduced immunity — sports or intense physical exercise § For the preventive purpose of hypovitaminosis C in case: - artificial feeding of children - malnutrition - anorexia - malabsorption (for diseases of the gastrointestinal tract). Method of administration and dosage: Oral. Drops can be given in one or more doses, preferably with meals. For infants, it is recommended to dissolve the drops in water, tea, juice or add to food. One drop contains 5 mg of vitamin C. Preventive doses: - infants and children of the 1st year of life: 5-8 drops (approx. 25-40 mg) per day; - children from 2 to 11 years: 10 drops (approx. 50 mg) per day; - adolescents from 12 to 17 years: 15 – 20 drops (approx. 75-100 mg) per day. Therapeutic doses are 2-5 times higher than prophylactic doses (depending on the indications). Side effects The drug used in recommended doses is well tolerated. With long-term use of large doses, the following may appear: - increased excretion of oxalic acid in the urine, crystallization of urates and citrates, which increases the risk of kidney stones in the urinary system - in persons with deficiency of glucose - 6 - phosphate dehydrogenase can cause hemolysis - hyperglycemia, glycosuria - dyspeptic disorders (regurgitation, vomiting) - hemorrhages. - long-term use of high doses of ascorbic acid can lead to addiction. Contraindications Hypersensitivity to ascorbic acid and/or other components of the drug. Drug interactions Iron. Ascorbic acid increases the absorption of non-heme iron from the digestive tract by 2-4 times, especially in individuals with a low supply of iron in tissues. Deferroxamine. In patients with excess iron in the body, the use of deferroxamine in combination with ascorbic acid in the initial phase of detoxification or treatment may increase iron toxicity. Acetylsalicylic acid. Large doses of acetylsalicylic acid reduce the bioavailability of ascorbic acid. Vitamin E. Both vitamins exhibit a synergistic antioxidant effect. Ascorbic acid reactivates tocopherol, preventing its inactivation both in vitro and in vivo. Co-trimoxazole. Large doses of ascorbic acid may increase the risk of crystalluria of the sulfomide component of co-trimoxazole. Medicines of an acidic and alkaline nature. Large doses of ascorbic acid (2 g/day or more) acidify the urine, which can affect the reduced excretion of acidic drugs in the urine, and therefore enhance their effect (eg nitrofuratonin, salicylates), as well as weaken the effect of alkaline drugs ( etc. antidepressant drugs, phenothiazine derivatives) due to their accelerated exclusion. Special instructions Do not mix with preparations containing iron and copper due to its reducing properties. It is recommended to take ascorbic acid in a dose of no more than 100 mg per day for patients with kidney stones, hyperoxaluria or a tendency to form kidney stones (especially oxalate or uric acid), as well as with excess iron in the body, i.e. patients with hemochromatosis, sickle cell anemia, thalassemia and iron poisoning, persons with pre-existing hyperoxaluria or a predisposition to its formation, as well as in patients with recurrent kidney stones or renal failure accompanied by a metabolic defect in the conversion of oxalic and ascorbic acids. Ascorbic acid, consumed in large doses, can distort the results of laboratory tests performed by oxide-reduction methods (for example, testing for the presence of blood hidden in the stool, determining the concentration of glucose and creatinine in the blood and urine). Pregnancy and lactation The drug can be used during pregnancy. The recommended daily intake of vitamin C for pregnant women (including dietary intake) is 80 mg. The use of large doses of vitamin C by pregnant women leads to the manifestation of symptoms of its deficiency in the newborn due to the induction of metabolic processes under the influence of large doses of vitamin C. The drug can be used during breastfeeding. The recommended daily intake of vitamin C for breastfeeding women (including dietary intake) is 100 mg. The content of ascorbic acid in mother's milk is 30-55 mg/l, which is sufficient for a breastfed infant (Goodman & Gilman's 1996). Large doses of vitamin C should be avoided due to the risk of overdose of this compound in infants. Effect on the ability to drive vehicles and operate mechanical equipment. No effect. Overdose There are no data on overdose. The use of high doses of vitamin C (more than 1000 mg = 200 drops per day) can lead to an overdose with increased side effects. Treatment is symptomatic. Release form Drops for oral administration 100 mg/ml. 10 ml or 30 ml in dark glass bottles with a dropper inside and a screw cap with a guarantee ring. 1 bottle with instructions for use in a cardboard box. Storage conditions Store in a carefully closed bottle at a temperature of 15°C to 25°C. Protect from light. Keep out of the reach of children! Shelf life: 2 years Do not use after the expiration date indicated on the package. Conditions for dispensing from pharmacies Without a prescription Manufacturer MEDANA PHARMA TERPOL GROUP Joint Stock Company 98-200 Sieradz, st. Warcka 3, POLAND

Drug interactions Cevicap

Iron. Ascorbic acid increases the rate of absorption of non-heme iron in the gastrointestinal tract by 2–4 times, especially in individuals with iron deficiency. Deferoxamine. In patients with excess iron in the body, the use of deferoxamine in combination with ascorbic acid at a dose of 150–250 mg/day increases its excretion; the use of higher doses does not contribute to additional excretion of iron compounds. Acetylsalicylic acid. Acetylsalicylic acid in high doses reduces the bioavailability of ascorbic acid. Vitamin E. Vitamins E and C are synergistic in terms of antioxidant action. Ascorbic acid has an antioxidant effect in the presence of α-tocopherol both in vitro and in vivo. Co-trimoxazole. When used simultaneously with ascorbic acid, the risk of crystalluria increases. The use of ascorbic acid in high doses (≥2 g/day) leads to a decrease in urine pH, which can affect the reduction in the urinary elimination of drugs with an acidic reaction, and therefore enhances their effect (nitrofurantoin, salicylates), and also weaken the effect of drugs with an alkaline reaction (antidepressants, phenothiazine derivatives) due to the acceleration of their elimination.

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