Photo: UGC During the autumn-winter period, the lack of vitamins is especially acute. When there are not enough vegetables and fruits to replenish them, you should turn to vitamins from the pharmacy. One of the most popular is ascorbic acid, the pills of which are easy to use and available for sale.
Attention! The material is for informational purposes only. You should not resort to the treatment methods described herein without first consulting your doctor.
What is ascorbic acid
Ascorbic acid is an organic compound with the formula C6H8O6.
It is necessary for the normal functioning of all systems and organs of the body, therefore it must be present in the human diet every day.
The vitamin also has antioxidant, regenerative and metabolic effects.
Visually, ascorbic acid looks like a white crystalline powder with a sour taste.
This powder dissolves well in water and alcohol.
Ascorbic acid is found in sufficient quantities in most vegetables and fruits.
The main effect of ascorbic acid is anti-oxidation - it suppresses the activity of free radicals, which leads to proper reduction, oxidation and metabolic processes in the body.
Ascorbic acid is a kind of protector of cell membranes from various damages.
Functions
Vitamin C has a beneficial effect on the entire body:
- Stimulates the immune system and protective functions of the body;
- It has a preventive effect against infectious diseases, and also successfully helps to overcome existing infections;
- Strengthens immunity to allergic manifestations and inflammatory processes;
- Destroys toxic and harmful substances present in the blood;
- Improves the process of hemoglobin formation;
- Removes “bad” cholesterol, leaving “good”;
- Improves the quality of blood clotting;
- Enhances absorption of iron by the small intestine;
- Normalizes the formation and production of bile;
- Neutralizes the effect of toxic substances on the liver;
- Plays an important role in the connection of hormones;
- Activates the excretory activity of the pancreas;
- Improves the functioning and performance of the thyroid gland.
Indications for the use of ascorbic acid
Ascorbic acid has many benefits for people who have gas poisoning. In case of severe poisoning, vitamin C helps restore the natural internal environment in the body and normalize oxidative processes.
The recommended dosage of ascorbic acid for poisoning is no more than 0.25 ml per kilogram of a person’s weight. Another indication for prescribing ascorbic acid is seasonal deficiency of vitamins.
You can provide your body with vitamin C through pharmaceutical preparations or by eating natural fruits and vegetables. They should be present in the daily diet and in sufficient quantities. With the correct dosage, ascorbic acid will protect against colds. An increased dose of vitamin C is necessary for people who smoke.
Ascorbic acid has invaluable benefits: it restores the acidic environment. As prescribed by a doctor, this useful element is often prescribed to pregnant women. According to scientific research, during the period of bearing a child, a girl should drink about a third more vitamin C than before conception.
You can get recommendations from specialists on the use of certain medications and vitamins based on the results of a Check-up at the Anadolu Clinic.
Find out about check-up
Calorie content
The calorie content of modern ascorbic acid tablets and dragees is provided by glucose or sugar , which are almost always contained in the drug.
How many calories are in 1 tablet
For example, consider ascorbic acid “Sesana”. A plastic jar contains 200 dragees, small round yellow balls.
The weight of one dragee is 0.25 g. The packaging states that the calorie content of the drug is 283 kcal/100 g, respectively, the calorie content of 1 pill will be 0.7 kcal .
Ascorbic acid tablets with glucose
The calorie content of ascorbic acid with glucose, which is sold in rolled packs of 10 large tablets, is usually approximately 380 kcal/100g.
The mass of one such tablet is 3 grams, respectively, its calorie content will be 11.4 kcal .
Energy value of 1 pack of tablets
One pack of ascorbic acid with glucose consists of 10 tablets, rolled into a candy shape. The weight of such a pack is 30 g, and the calorie content is 380 kcal/100 g.
Accordingly, such a package will contain approximately 114 kcal .
Can it be used for weight loss?
Vitamin C is without a doubt essential in the fight against excess weight; But ascorbic acid by itself is not able to cope with the problem of obesity; an integrated approach to eliminating the problem is needed - nutrition, training and vitamins.
Ascorbic acid actively helps restore the body's internal resources after physical training or illness.
In order to get the maximum benefit from a vitamin, you need to figure out when and how to take it correctly.
If you take ascorbic acid before meals , it will help slightly reduce your appetite.
If you take a vitamin after a meal , on the contrary, your appetite increases and a strong feeling of hunger awakens - this can lead to a violation of your diet or eating regimen.
Reference! Many cafes in fitness centers offer various vitamin cocktails with ascorbic acid. Undoubtedly, there will be benefits from them, but if you abuse such cocktails, the sugar they contain can adversely affect the process of losing weight.
Recommended daily dose
The daily dose of ascorbic acid varies from 0.05 mg to 100 mg , depending on age, physical and mental stress, etc.
increases significantly if a person:
- experiences increased stress on the body,
- engages in heavy physical labor,
- is under prolonged mental stress,
- experiencing emotional disturbances
- susceptible to infection or pain.
Reference! The dosage of vitamin C increases during pregnancy .
Daily dosage of vitamin C for preventive purposes :
- For adults - 50-100 mg (1-2 tablets of 50 mg), 3-5 times a day, after meals;
- For children (from 5 years old) - 50 mg (1 tablet), 2-3 times a day, after meals.
Maximum doses
The maximum single dose for adults is no more than 200 mg, the daily dose is no more than 500 mg .
For children, the daily dosage is significantly less:
- 0-6 months - 30 mg;
- 6-12 months - mg;
- 1-3 years - 40 mg;
- 4-10 years - 45 mg;
- 11-14 years - 50 mg.
For pregnant
Throughout pregnancy and breastfeeding, a woman should receive an increased dosage of vitamin C - about 300 mg/day (6 tablets).
Ascorbic acid (Vitamin C) dietary supplement tablets 50 mg N 100
Pharmacological properties Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.
Indications for use Prevention and treatment of hypo- and avitaminosis of vitamin C. As an adjuvant: hemorrhagic diathesis, nasal, uterine, pulmonary bleeding; overdose of anticoagulants; diseases of the gastrointestinal tract accompanied by impaired absorption of vitamin C; slowly healing wounds. Increased physical and mental stress, pregnancy and breastfeeding, recovery period after serious long-term illnesses.
Contraindications Hypersensitivity to the components of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus. With caution: Hyperoxalaturia, renal failure, hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia, glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, progressive malignant diseases, pregnancy.
Method of administration and dosage The drug is taken orally after meals. For prevention: adults 0.05-0.1 g (1-2 tablets) per day, children over 5 years old 0.05 g (1 tablet) per day. For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years old 0.05-0.1 g (1-2 tablets) 2-3 times a day day. During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for 10-15 days, then 0.1 g (2 tablets per day) per day.
Side effects From the central nervous system (CNS): headache, feeling of fatigue, with long-term use of large doses - increased excitability of the central nervous system, sleep disturbances. From the digestive system: irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps. From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria). From the urinary system: when used in high doses, hyperoxalaturia and the formation of urinary stones from calcium oxalate. From the cardiovascular system: thrombosis, when used in high doses - increased blood pressure, development of microangiopathies, myocardial dystrophy. Allergic reactions: skin rash, rarely - anaphylactic shock. Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia. Other: hypervitaminosis, feeling of heat, with prolonged use of large doses - sodium (Na+) and fluid retention, metabolic disorders of zinc (Zn2+), copper (Cu2+).
Overdose
When taking more than 1 g per day, heartburn, diarrhea, difficulty urinating or red urine, and hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible. If any side effects occur, you should stop taking the drug and consult a doctor. Interaction with other drugs Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol. Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body. Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, and glucocorticosteroids with long-term use deplete ascorbic acid reserves. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction. In high doses, it increases the renal excretion of mexiletine. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotics (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.
Special instructions Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure. With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment. In patients with high iron levels in the body, ascorbic acid should be used in minimal doses. Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH). Use during pregnancy and breastfeeding The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. The minimum daily requirement during breastfeeding is 80 mg. A mother's diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).
Storage conditions: In a dry place, protected from light, at a temperature not exceeding 25°C.
Overdose and side effects
If you significantly exceed the dosage of ascorbic acid, its effectiveness will not increase.
On the contrary, it can aggravate some problems of the body, or create new ones.
In addition, excessive consumption of vitamin C increases the feeling of hunger and appetite, and accordingly increases cravings for unhealthy and high-calorie foods.
Abuse of ascorbic acid can lead to disorders from:
- CNS - headaches, fatigue, malaise, increased excitability and sleep disturbances
- Digestive system - nausea, vomiting, stomach cramps, stool upset, irritation of the gastrointestinal mucosa
- Endocrine system - disruption of the pancreas - hyperglycemia, glycosuria
- Urinary system - formation of stones in the bladder, excess of oxalic acid (hyperoxalaturia)
- Cardiovascular system - increased blood pressure, thrombosis, development of microangiopathy, myocardial dystrophy
In addition, an overdose can cause various allergic reactions , including anaphylactic shock (extremely rare), and affect laboratory parameters - erythropenia, hypokalemia, hypoprothrombinemia, thrombocytosis, neutrophilic leukocytosis.
Other side effects are a feeling of heat, hypovitaminosis, fluid retention with sodium salts, disruption of the metabolic processes of copper and zinc.
Important! If any adverse symptoms appear and an overdose is suspected, you should stop taking the drug and consult a doctor for advice.
Hypervitaminosis
A significant overdose (more than 1000 mg/day) is manifested by the following symptoms :
- Diarrhea;
- Heartburn;
- Difficulty urinating;
- Red coloration of urine;
- Hemolysis (destruction of red blood cells) - in people with glucose-6-phosphate dehydrogenase deficiency.
Overdose is treated systematically.
Buy Ascorbic acid FST etc. 50 mg No. 200 in pharmacies
Trade name:
Ascorbic acid
International nonproprietary name:
ascorbic acid
Dosage form:
dragee
Composition per tablet
Active substance:
Ascorbic acid (vitamin C) - 50.0 mg.
Excipients:
sucrose - 177.5 mg, starch syrup - 7.2 mg, wheat flour - 15.0 mg, sunflower oil - 0.05 mg, beeswax - 0.04 mg, talc - 0.14 mg, orange flavor - 0.02 mg, quinoline yellow dye - 0.05 mg.
Description
Dragee is yellow to greenish-yellow in color and has a regular spherical shape. The surface of the dragee should be even, smooth, and uniform in color.
Pharmacotherapeutic group:
Vitamin
Pharmacological properties
Pharmacodynamics
Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food.
It is a cofactor in some hydroxylation and amidation reactions - it transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of carnitine synthesis), oxidation of folic acid to folinic acid, drug metabolism agents in liver microsomes and hydroxylation of dopamine with the formation of norepinephrine.
Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands. Restores ferric ions to ferrous ions in the intestine, promoting its absorption.
The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.
In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.
Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body.
Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.
Pharmacokinetics
Absorption
Absorbed in the gastrointestinal tract (GIT) (mainly in the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). The time to reach maximum concentration (TCmax) after oral administration is 4 hours. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine. .
Distribution
The normal plasma ascorbic acid concentration is approximately
10-20 mcg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day. Communication with plasma proteins - 25%.
Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, the concentration in leukocytes decreases later and more slowly and is considered a better criterion for assessing deficiency than plasma concentration.
Metabolism
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.
Removal
It is excreted by the kidneys, through the intestines, with sweat, with breast milk unchanged and in the form of metabolites.
When high doses are used, the rate of elimination increases sharply. Smoking and ethanol consumption accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.
Indications for use
Treatment and prevention of hypo- and avitaminosis of vitamin C and related conditions.
Contraindications
Hypersensitivity to ascorbic acid and/or any excipient in the composition of the drug, thrombophlebitis, tendency to thrombosis, diabetes mellitus, sucrose/fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption syndrome.
If you have one of the diseases/conditions or risk factors listed above, you should consult your doctor before using the drug.
Carefully
Sideroblastic anemia, sickle cell anemia, urolithiasis, renal failure, progressive malignant diseases, polycythemia, leukemia, oxalosis. Thalassemia, hemochromatosis, hyperoxaluria, glucose-6-phosphate dehydrogenase deficiency.
If you have one of the diseases/conditions or risk factors listed above, you should consult your doctor before using the drug.
Use during pregnancy and breastfeeding
Pregnancy
The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop a “withdrawal” syndrome.
During pregnancy, the dose of ascorbic acid should not exceed 300 mg per day.
Breastfeeding period
Ascorbic acid passes into breast milk. The minimum daily requirement during breastfeeding is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in the infant.
Directions for use and doses
The drug is taken orally after meals.
For prevention: adults 0.05-0.1 g (1-2 tablets) per day, children from 5 years old 0.05 g
(1 tablet) per day.
For treatment: adults 0.05-0.1 g (1-2 tablets) 3-5 times a day, children from 5 years old 0.05-0.1 g (1-2 tablets) 2-3 times a day day.
During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for
10-15 days, then 0.1 g (2 tablets) per day.
Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.
Side effect
If any side effects occur, you should stop taking the drug and consult a doctor.
Nervous system disorders: headache, fatigue
Gastrointestinal disorders: irritation of the mucous membrane of the gastrointestinal tract (GIT); depression of the pancreatic insular apparatus (hyperglycemia, glycosuria).
Vascular disorders: thrombosis
Immune system disorders: skin rash, hyperemia.
Laboratory and instrumental data: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
If you experience any undesirable reactions indicated in the instructions or they get worse, or you notice any other undesirable reactions not listed in the instructions, inform your doctor.
Overdose
Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, spastic abdominal pain, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.
Treatment: symptomatic, forced diuresis.
In case of overdose, consult a doctor.
Interaction with other drugs
Absorption of ascorbic acid is reduced with simultaneous use of oral contraceptives, acetylsalicylic acid, consumption of fresh fruit and vegetable juices, and alkaline drinks.
Ascorbic acid, when taken orally, increases the absorption of penicillin and iron, reduces the effectiveness of heparin and indirect anticoagulants, and increases the risk of developing crystalluria when treated with salicylates.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
With long-term use or use in large doses, it may interfere with the interaction of disulfiram and ethanol.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.
If you are using the above or other medications (including over-the-counter medications), consult your doctor before using Ascorbic Acid.
special instructions
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor kidney function and blood pressure.
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
The use of ascorbic acid in patients with rapidly proliferating and intensely metastasizing tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (plasma concentrations of glucose, bilirubin, transaminase activity, lactate dehydrogenase).
Impact on the ability to drive vehicles and machinery
The use of the drug does not affect the ability to drive vehicles and machinery.
Release form
Dragee, 50 mg. 200 tablets in polymer jars. The jars are sealed with screw-on lids. Each polymer jar, together with instructions for use, is placed in a pack of cardboard, or 32 polymer jars, together with the corresponding number of instructions for use, are placed in shrink film.
Storage conditions
In a place protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Best before date
1 year 6 months.
Do not use after the expiration date stated on the package.
Vacation conditions
Available without a prescription.
