Composition and release form
- Spray 50 ml in bottles with a sprayer, 1 bottle in a cardboard box.
- Solution 125 ml in bottles, 1 bottle in a cardboard package.
100 ml of Givalex solution contains:
- Hexetidine – 100 mg;
- Choline salicylate – 500 mg;
- Chlorobutanol hemihydrate – 250 mg;
- Excipients, including ethyl alcohol.
100 ml of Givalex spray contains:
- Hexetidine – 100 mg;
- Choline salicylate – 500 mg;
- Chlorobutanol hemihydrate – 250 mg;
- Excipients, including ethyl alcohol.
Price
Average price in Russia:
- spray (50ml bottle with dispenser) – 230 rubles;
- rinse solution (125 ml bottle with measuring cup) – 190 rubles.
You can purchase Givalex without a prescription in all stationary and online pharmacies in the country.
In Ukrainian pharmacies the spray can be purchased for 85 hryvnia. You will be offered a rinse solution for an average of 102 hryvnia.
PHARMACOLOGICAL PROPERTIES
A remedy used for diseases of the oral cavity and pharynx. The effect of the drug is due to three active ingredients.
Antibacterial and antifungal activity
Hexetidine (INN - hexetidinum) exhibits antibacterial activity against both gram-positive and gram-negative strains of microorganisms - both aerobes and anaerobes. It should be noted that it acts mainly bacteriostatically on strains of aerobic microorganisms; the bactericidal effect is weak. Hexetidine has a pronounced bactericidal effect on strains of anaerobic microorganisms. The mechanism of action is based on the competitive replacement of thiamine (the structure of hexetidine is similar to the structure of thiamine), which is necessary for the growth of microorganisms.
Anti-inflammatory activity
Choline salicylate is used due to its analgesic, antipyretic and anti-inflammatory effects.
Analgesic activity
Chlorobutanol is used in otolaryngological (nasal drops, rinses) and dental practice (applications and irrigations) mainly as an anesthetic. Classically used as an anesthetic.
The active substances are fixed on the oral mucosa, from where they are gradually released.
APPLICATION
Topically for irrigation and rinsing of the mouth and pharynx.
Givalex spray:
- adults and children over 15 years of age - 1 spray 4-6 times a day;
- children aged 12 to 15 years - 1 spray 2-3 times a day.
Givalex solution:
For one mouth rinse for adults and children over 6 years of age: place the drug in a measuring cup to the 10 ml mark and add warm water to the 50 ml mark or dissolve 2 teaspoons of the drug in ¼ glass of warm water. Do not swallow. The course of treatment is 5 days.
Analogs
There are many analogues of this drug, but you should not make an independent decision about a replacement. A doctor’s advice in this matter will not be superfluous.
Substitutes for Givalex:
- Stopangin. This antiseptic is also available in the form of a spray and rinse solution. Can be used by children from 8 years of age.
- Inhalipt is available in the form of a spray. The effect of treatment with this drug is much lower, due to the fact that the active substance included in Ingalipt (sulfanilamide) belongs to the 1st generation of antibiotics.
- Strepsils is a local antiseptic. Oral lozenges. Can be used during pregnancy and lactation.
- Falimint is an antiseptic drug produced in the form of lozenges. Well tolerated by patients of all ages. Recommended for use during pregnancy and breastfeeding.
- Angilex is a spray for topical use for irrigation of the oral cavity.
- Hepilor is an analgesic and antiseptic. Effective for the treatment of sore throat, pharyngitis, stomatitis, tonsillitis, laryngitis. Often prescribed as a hygienic oral care product.
SPECIAL INSTRUCTIONS
When using Givalex, do not swallow and avoid contact with eyes as it contains ethanol.
Long-term use is not recommended as the natural microbial balance of the mouth and throat may be altered and there is a risk of bacterial and fungal spread.
If general clinical signs of a bacterial infection occur, general antibacterial therapy should be provided.
If symptoms persist for more than 5 days and/or elevated body temperature, it is necessary to reconsider treatment tactics.
During pregnancy and breastfeeding. During pregnancy and lactation, the drug is used only as prescribed by a doctor and only when the benefit of its use for the mother outweighs the risk to the fetus.
Children. The drug should not be used in children under 6 years of age (solution) and under 12 years of age (spray).
The ability to influence reaction speed when driving vehicles and working with other mechanisms. Unknown.
Interaction with other drugs
Doctors do not recommend using Givalex together with similar topical antiseptic drugs. This may lead to increased irritation of the oral mucosa.
If the disease is complex, Givalex can be combined with antibacterial drugs in the form of tablets and injections. Due to the low percentage of absorption of the substance and the low concentration of its components in the blood plasma, this medicine combines well with other drugs.
Cases of allergic reactions are very rare. This should serve as a reason to cancel this drug.
Note!
The description of the drug Givalex on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use. Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug).
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Givalex
Name: Givalex Pharmacological action: Givalex is a drug with pronounced antibacterial, antifungal, anti-inflammatory and analgesic effects, used in dental and ENT practice. The drug contains three active components - hexetidine, choline salicylate and chlorobutanol. The mechanism of action and therapeutic effects of the drug are based on the pharmacological properties of the active components included in its composition: Hexetidine is an antibacterial drug, the mechanism of action of which is based on the ability of the hexetidine molecule to competitively replace thiamine, as a result of which bacterial growth is impaired. The drug is active against gram-positive and gram-negative aerobic and anaerobic microorganisms. Hexetidine has a predominantly bacteriostatic effect against aerobic bacteria and a bactericidal effect against anaerobic bacteria.
Chlorobutanol is an antibacterial and antifungal drug used as part of combination medications used in dental and ENT practice. Chlorobutanol also has some local anesthetic activity. Choline salicylate is a non-steroidal anti-inflammatory drug that is highly active when applied topically. Choline salicylate reduces the synthesis of pro-inflammatory cytokines by inhibiting cyclooxygenase. The drug has a pronounced anti-inflammatory, antipyretic and analgesic effect. After spraying or rinsing the mouth with the drug, the active components are fixed on the mucous membrane and are gradually released, providing a long-lasting therapeutic effect.
Indications for use: The drug is used as a means of local therapy in patients suffering from infections of the oral cavity and pharynx caused by microorganisms sensitive to the action of the drug Givalex, including: Sore throat, acute and chronic laryngitis, tonsillitis, pharyngitis. Gingivitis, canker sores, stomatitis. The drug can also be used as a prophylactic agent in patients who have undergone dental surgery.
Directions for use: Givalex in spray form: The drug is intended for topical use. The spray is used to irrigate the oral cavity and pharynx. After using the drug, it is not recommended to eat for at least 10 minutes. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient. Adults and adolescents over the age of 15 years are usually prescribed 1 spray of the drug 4 to 6 times a day, depending on the severity of the disease. Children aged 12 to 15 years are usually prescribed 1 spray of the drug 2-3 times a day, depending on the severity of the disease. The duration of treatment is 5 days, unless the attending physician prescribes otherwise.
Givalex in solution form: The drug is intended for topical use. The solution is used diluted to rinse the mouth. Immediately before use, pour 10 ml of the drug into a measuring cup and add water to the 50 ml mark (if there is no measuring cup, then dilute 2 teaspoons of the drug in a quarter glass of water). The recommended water temperature for diluting the drug is 30-35 degrees Celsius. Do not swallow the drug. The duration of the course of treatment and frequency of use of the drug is determined by the attending physician individually for each patient. Adults and children over 6 years of age are usually prescribed 2 to 4 rinses per day, at regular intervals. The duration of treatment is 5 days, unless the attending physician prescribes otherwise. Avoid contact of the drug with the eyes. In case of development of symptoms of a general bacterial infection, the drug is used in combination with oral or parenteral antimicrobial drugs. If symptoms of the disease persist within 5 days or the patient experiences an increase in body temperature, re-diagnosis should be carried out and the treatment regimen should be reconsidered.
Side effects: The drug is usually well tolerated by patients, in some cases the development of irritation of the oral mucosa, changes in taste and impaired sense of smell were noted. It is also possible to develop skin allergic reactions. If any side effects develop, you should contact your doctor, who should review the treatment regimen. With prolonged use of the drug, superinfection may develop.
Contraindications: Increased individual sensitivity to the components of the drug. The drug in spray form is not used to treat children under 12 years of age. The drug in the form of a solution for rinsing the mouth is not used to treat children under the age of 6 years.
Pregnancy: At the moment there is no reliable data on the safety of the drug in women during pregnancy and lactation. The drug can be prescribed by the attending physician during pregnancy if the expected benefit to the mother is higher than the potential risks to the fetus. If it is necessary to use the drug during lactation, you should consult with your doctor and decide on the possible interruption of breastfeeding.
Interaction with other drugs: The drug should not be used in combination with other antiseptic drugs.
Overdose: When using the drug according to the instructions, no overdose was observed in patients. If you accidentally take the drug orally, you should consult a doctor as soon as possible.
Release form: 50 ml spray in bottles with a sprayer, 1 bottle in a cardboard box. Solution 125 ml in bottles, 1 bottle in a cardboard package.
Storage conditions: It is recommended to store the drug in a dry place away from direct sunlight at a temperature of 15 to 25 degrees Celsius. The shelf life, regardless of the form of release, is 3 years.
Composition: 100 ml of Givalex solution contains: Hexetidine – 100 mg; Choline salicylate – 500 mg; Chlorobutanol hemihydrate – 250 mg; Excipients, including ethyl alcohol.
100ml of Givalex spray contains: Hexetidine – 100 mg; Choline salicylate – 500 mg; Chlorobutanol hemihydrate – 250 mg; Excipients, including ethyl alcohol.
Attention! The description of the drug " Givalex " on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
