What is Nurofen syrup and tablets for?
The action of Nerofen is explained by the presence of ibuprofen in the composition, which, by acting on the thermostat in the brain, relieves fever and returns the temperature to normal values.
In addition, ibuprofen inhibits the synthesis of prostaglandins, which are mediators of pain. Which explains its analgesic effect. This is why Nurofen is indicated for:
- high body temperature;
- toothache;
- headache;
- muscle pain;
- for adverse reactions after DTP.
Adverse reactions and overdose
If Nurofen is used for painful periods, toothache or fever for several days, then no adverse reactions should occur. With prolonged use, adverse reactions may occur:
- from the digestive system: stomach ulcer, constipation, anorexia, indigestion, pain in the mouth, hepatitis;
- from the central nervous system: headache, lethargy, drowsiness, stress, emotionality, insomnia;
- from the cardiovascular system: increased blood pressure, heart failure;
- from the senses: the appearance of tinnitus, deterioration of vision and hearing, swelling of the eyelids;
- from the hematopoietic system: leukopenia, anemia;
- from the respiratory system: bronchospasm, shortness of breath.
Other effects include allergies such as urticaria, angioedema, itching and excessive sweating.
If Nurofen is taken continuously for a long time, ulceration of the gastric mucosa may occur and bleeding may begin.
In case of overdose, a delayed reaction, drowsiness, stress, headache, and high blood pressure appear.
If the permissible dose is exceeded, you need to rinse your stomach, drink activated charcoal and engage in symptomatic therapy.
After how many hours can Nurofen be given?
Due to the fact that the drug is quickly and almost completely absorbed from the gastrointestinal tract, its maximum concentration in human plasma is reached after 30 minutes. This suggests that after taking the drug on an empty stomach, the patient’s temperature should begin to decrease within 40 minutes. When taking a single dose of the drug after a meal, the antipyretic effect should appear after an hour.
If the temperature has not started to decrease after an hour, you can give another antipyretic drug. In this case, it is better to give preference to paracetamol. Nurofen can be taken again no earlier than 4 hours after the first use.
The same dosage regimen also applies in the opposite direction, when the question arises of how long after paracetamol can be taken Nurofen. If taking paracetamol after an hour does not work, you can switch to ibuprofen.
NUROFEN oral suspension (strawberry), 100mg/5ml 100ml bottle
The simultaneous use of ibuprofen with the following drugs should be avoided: · Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (not more than 75 m by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increased incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen).Other NSAIDs, including selective COX-2 inhibitors: the simultaneous use of two or more drugs from the group of NSAIDs should be avoided -due to a possible increase in the risk of side effects.Use with caution simultaneously with the following drugs: · Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs. · Antihypertensives (ACE inhibitors and angiotensin II antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs. · Glucocorticosteroids: increased risk of gastrointestinal ulceration and gastrointestinal bleeding. · Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding. · Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma. · Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs. · Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs. · Cyclosporine: increased risk of nephrotoxicity with simultaneous administration of NSAIDs and cyclosporine. · Mifepristone: NSAIDs should be started no earlier than 8-12 days after taking mifepristone, as NSAIDs may reduce the effectiveness of mifepristone. · Tacrolimus: When NSAIDs and tacrolimus are co-administered, the risk of nephrotoxicity may increase. · Zidovudine: Concomitant use of NSAIDs and zidovudine may lead to increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen. · Quinolone antibiotics: In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may be increased.
If Nurofen does not bring down the temperature: what to do
When the thermometer rises above 39˚C, absorption of substances from the stomach may stop. This means that taking medications orally may not have an effect. This happens especially often when the patient washes down the tablet or syrup with cold water. Once in the stomach, cold liquid forces the vessels of the gastric walls to contract, as a result of which they cannot fully pass substances through their walls.
In this case, doctors recommend giving preference to rectal suppositories at high temperatures exceeding 39˚C. The suppository, once in the rectum, quickly dissolves, and ibuprofen immediately enters the bloodstream through the intestinal walls. After 30-40 minutes, the patient’s temperature begins to decrease.
Description of the drug NUROFEN FOR CHILDREN
With simultaneous use, ibuprofen reduces the effect of antihypertensive drugs (ACE inhibitors, beta-blockers), diuretics (furosemide, hydrochlorothiazide).
When used simultaneously with anticoagulants, their effect may be enhanced.
When used simultaneously with GCS, the risk of side effects from the gastrointestinal tract increases.
When used simultaneously, ibuprofen can displace indirect anticoagulants (acenocoumarol), hydantoin derivatives (phenytoin), and oral hypoglycemic drugs, sulfonylurea derivatives, from compounds with blood plasma proteins.
When used simultaneously with amlodipine, a slight decrease in the antihypertensive effect of amlodipine is possible; with acetylsalicylic acid - the concentration of ibuprofen in the blood plasma decreases; with baclofen - a case of increased toxic effects of baclofen has been described.
When used simultaneously with warfarin, an increase in bleeding time is possible; microhematuria and hematomas were also observed; with captopril - the antihypertensive effect of captopril may be reduced; with cholestyramine - a moderate decrease in the absorption of ibuprofen.
When used simultaneously with lithium carbonate, the concentration of lithium in the blood plasma increases.
When used simultaneously with magnesium hydroxide, the initial absorption of ibuprofen increases; with methotrexate - the toxicity of methotrexate increases.
The simultaneous use of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.
There is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.
With simultaneous use of NSAIDs and cyclosporine, the risk of nephrotoxicity increases.
NSAIDs may reduce the effectiveness of mifepristone, so taking NSAIDs should be started no earlier than 8-12 days after stopping mifepristone.
Concomitant use of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
Concomitant use of NSAIDs and zidovudine may lead to increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen.
In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may increase.
In patients receiving concomitant NSAIDs and myelotoxic drugs, hematotoxicity increases.
With the simultaneous use of ibuprofen and cefamandole, cefoperazone, cefotetan, valproic acid, plicamycin, the incidence of hypoprothrombinemia increases.
With the simultaneous use of ibuprofen and drugs that block tubular secretion, there is a decrease in excretion and an increase in plasma concentration of ibuprofen.
With the simultaneous use of ibuprofen and inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), there is an increase in the production of hydroxylated active metabolites and an increased risk of developing severe intoxications.
How many times can Nurofen be given to a baby?
The effect of the drug begins an hour after the first dose. The decrease in temperature can continue for up to half an hour until the values drop to normal levels. The antipyretic effect can last up to 8 hours. However, with severe inflammatory processes, the fever may return after 4-5 hours. An infant can be re-given a single dose of the drug both in the form of suppositories and in the form of syrup after 4 hours if the temperature begins to rise again. A baby can receive up to 5 permissible single doses per day.
Instructions for use
It is better to use the medicine only after consultation with a specialist and as prescribed.
Tablets can be given to adults and children over 12 years of age, no more than 200 mg 3-4 times a day. The drug is taken after meals. For faster and more noticeable results, you can double the dose and take it 3 times a day.
The ointment is intended for external use. Can only be used by persons over 12 years of age. No more than 125 mg of the main active ingredient can be used at a time. The gel can be applied no more than 4 times a day, with an interval of at least 4 hours. If after 12-14 days the condition does not improve, then you should stop taking the drug.
Which is safer Nurofen or paracetamol
Ibuprofen, which is part of the drug, is contraindicated for people with chronic bronchial diseases, in particular asthma. In addition, Nurofen should not be taken by patients with intolerance to the active substance, pregnant women, patients with heart failure, diagnosed liver failure and gastrointestinal bleeding.
Contraindications to taking paracetamol are the neonatal period, individual intolerance to the drug, and gastric ulcers, including erosion and inflammation of the gastrointestinal mucosa.
Components and release form
The drug is produced in 2 forms: gel and tablets. The tablets are coated with a light film and have a round shape. Sold in packages.
Nurofen in gel form is intended for external use. It has a colorless and homogeneous consistency with an inherent odor of alcohol.
The main component is ibuprofen. The tablets contain auxiliary elements: croscarmellose sodium, colloidal silicon dioxide, stearic acid.
Additional components in the gel are: sodium hydroxide, isopropyl alcohol, water.
