Pharmacological properties of the drug Nurofen™ for children
The mechanism of action is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and temperature response. The drug has analgesic, antipyretic and anti-inflammatory effects, inhibits platelet aggregation. After oral administration, it is quickly and almost completely absorbed from the digestive tract. The maximum concentration of the active substance in the blood plasma is achieved 1–2 hours after administration. Ibuprofen is 90–99% bound to plasma proteins and penetrates into the synovial fluid. Metabolized in the liver to two inactive metabolites, which are quickly and almost completely excreted by the kidneys. A certain amount (10%) is excreted unchanged. The half-life is 2 hours.
Children's syrup Nurofen - reviews
Ekaterina
https://alfatabs.ru/protivovospalitelnye/nurofen-dlya-detej.html
At one time it was given to my elder as an antipyretic - it worked, but not for long at high temperatures (no more than 4 hours). Over time, this drug was abandoned as a panacea for fever. I consider the more pronounced effect of Nurofen to be pain relief - it helps the younger one when teething.
Doctors recommend alternating Nurofen with drugs containing paracetamol at temperatures. Well, no one has canceled the instructions - you should not abuse Nurofen. If possible, it is better for children in the form of candles.
Leaf
https://otzovik.com/review_813020.html
There is an opinion that ibuprofen is a better antipyretic than paracetamol. After hearing him, I decided to buy a drug based on ibuprofen, or rather Nurofen, to try.
Its price is almost similar to drugs with paracetamol. But the action is a little different. Since more often we had to use such drugs for pain relief than for the purpose of relieving high fever, it was not suitable for us. It lowers the temperature similarly to Efferalgan, but has weak pain relief. The teething was long and painful, there were frequent screams, not just whimpers. Especially at night. In mild cases, we made do with Kalgel, and when it didn’t help, we took painkillers. But this particular one acted very slowly, the child screamed for up to half an hour from toothache, while biting everything and everyone around him, before relief finally came. Of course, I didn’t like this and we bought another product.
As for the measuring spoon, there is a measuring syringe instead. In some cases it is much more convenient than a spoon, in others it is not. It all depends on your child. If he lies quietly and waits for the hooting sound when you give him the medicine, then this process of sticking the syringe into the neck of the bottle, turning the bottle of medicine along with the syringe into a vertical position and drawing up the medicine will be very easy for you. And if your baby is screaming like crazy and doesn’t want to wait for a second, then it would be more convenient for you to simply open the medicine, pour it into a spoon and give it to the baby! And it’s not very convenient to squeeze the medicine into a child’s mouth; if you press a little harder, a lot of medicine flows out. Moreover, at this time the child does not hide his dissatisfaction with the fact that instead of taking him in your arms and feeling sorry for him, you shove some nonsense into his mouth! In a word, from a variety of different antipyretic and analgesic drugs, you will have to choose the ideal one for you and your baby yourself. I can only describe my impressions, but I don’t know whether they will coincide with yours.
It tastes good. I didn't notice any particular bitterness. Didn't cause any allergies.
Alena Shevchuk
https://xn--80avnr.xn--p1ai/%D0%9C%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0/%D0% 9D%D1%83%D1%80%D0%BE%D1%84%D0%B5%D0%BD_%D0%B4%D0%BB%D1%8F_%D0%B4%D0%B5%D1%82% D0%B5%D0%B9
It's time for my youngest son to start teething, and his temperature rises from time to time. As a rule, I don’t bring the temperature down to 39, but recently I still had to. In the evening the temperature jumped over 39, closer to 40. I immediately gave Nurofen. Literally 20 minutes later the temperature began to drop. The child fell asleep. An hour later his forehead was already cold. After 8-10 hours, the temperature began to rise again and again reached 39. Nurofen again came to the rescue. Fortunately, it tastes good and the child took it well. That day she gave Nurofen again at night. On the third day there was no more fever, but everything was covered in small red spots on the tummy and back. I didn’t introduce any new foods, I only ate breast milk. We didn't have anything like this before. Therefore, it was only a reaction to Nurofen, and specifically I think to the excipients and flavorings in the syrup.
(kira22) kira
https://www.imho24.ru/recommendation/797/
Previously, I often used this drug to reduce high fever during colds for my first daughter aged 1 to 6 years. She accepted it normally and drank the suspension with pleasure, preferring the strawberry taste. However, when treating my youngest daughter (aged 1 to 2 years), I was faced with the fact that when taking this medicine in the form of a suspension, she immediately developed a gag reflex. In my opinion, this is either due to the viscous consistency or the cloying taste, which my youngest daughter does not like. But I can note that in those cases when I managed to give her Nurofen (as a rule, in a sleepy state, when I had to wake her up to take medication), the result was as always: a rapid decrease in high temperature (from 39 to 37 degrees ). In addition, this drug can be alternated with antipyretic drugs of another series (containing paracetamol), which for me is necessary, for example, if the temperature after taking the antipyretic drug quickly begins to rise again, before the required minimum interval between doses has expired. In any case, in my personal experience of using any means to effectively reduce fever, this drug occupies one of the leading places.
Tanya110
With our older child, Nurofen syrup has become a kind of lifesaver for us. As soon as a high temperature rose (a cold, after a vaccination, when teething, etc.), I immediately gave the child the amount of syrup indicated in the instructions or on the bottle itself and the temperature dropped over 15-20 minutes. Moreover, the fever disappeared for 8-10 hours.
The syrup has a pleasant sweet taste. It is very convenient to use because a measuring syringe comes in the package along with a bottle of syrup. The bottle has a special hole into which it is firmly inserted and thus the required amount of syrup is collected.
If the syrup gets into the hands of a baby, a special lid that rotates will save it from opening. To open Nurofen you need to press the lid firmly and twist it.
But with my youngest son, things didn’t work out with Nurofen :(
She gave it for the first time at 4 months, he threw it up. Then, about a month later, the need arose to lower the temperature - history repeated itself. Now we are 10 months old, during this period I tried to give it several more times - the child already accepted it normally, but the temperature did not go down, I had to put candles on.
This is our experience. With my eldest son it helps 100%, but with my younger son there is no result. As for my friends, almost everyone uses Nurofen to relieve fever and pain in their children.
Use of Nurofen™ for children
Oral only. The dose for children depends on the age and body weight of the child. Single dose - 5–10 mg/kg. The maximum daily dose should not exceed 30 mg/kg. Children aged 3 to 6 months - 2.5 ml of suspension (50 mg) every 8 hours, but not more than 7.5 ml (150 mg) per day. Children aged 6 to 12 months - 2.5 ml of suspension (50 mg) every 6 hours and no more than 10 ml (200 mg) per day. Children aged 1 to 3 years - 5 ml of suspension (100 mg) every 8 hours and no more than 15 ml (300 mg) per day. Children aged 4 to 6 years - 7.5 ml of suspension (150 mg) 3 times a day (450 mg). Children aged 7 to 9 years - 10 ml of suspension (200 mg) 3 times a day (600 mg). Children aged 10 to 12 years - 15 ml of suspension (300 mg) 3 times a day (900 mg). For fever after immunization (children aged 3–6 months) - 2.5 ml, if necessary - another 2.5 ml after 6 hours, but not more than 5 ml over 24 hours. The duration of use depends on the course of the disease and is usually 3 days
Nurofen for children
Nurofen for children (active ingredient ibuprofen) is a nonsteroidal anti-inflammatory drug (NSAID) used in pediatric practice as an analgesic and antipyretic. The drug non-selectively blocks the enzyme cyclooxygenase types 1 and 2 (COX-1 and COX-2), as a result of which the process of synthesis of mediators of pain and inflammation, prostaglandins, is inhibited. In addition, ibuprofen inhibits platelet aggregation (sticking together). The effect of Nurofen for children lasts about 8 hours. It is necessary to note the special place of ibuprofen among all NSAIDs. The PAIN study, which compared the effectiveness and safety of ibuprofen, paracetamol and aspirin, found that patient tolerability of ibuprofen was similar to paracetamol and much better than aspirin. At the same time, the incidence of unwanted side reactions from the digestive tract when using ibuprofen was significantly lower than that of aspirin. The data obtained as a result of this study dispelled all doubts that ibuprofen (and Nurofen, as well as Nurofen for children, are the original preparations of ibuprofen) can be considered as a first-line drug for relieving pain and reducing elevated body temperature during febrile conditions . Before entering the pharmaceutical market, the drug Nurofen for children was carefully studied to identify possible side effects. As part of this large-scale research work, about 85 thousand children were examined. The results of the study demonstrated a favorable safety profile of the drug, which allows its widespread use in pediatrics.
Nurofen for children, as its name suggests, was developed exclusively for the youngest patients. The drug is available in two dosage forms: oral suspension and rectal suppositories. The dose is calculated based on the child’s body weight. For pain and febrile body temperature, Nurofen for children is prescribed 5-10 mg per 1 kg 3-4 times a day.
In this case, the daily maximum should not exceed 30 mg per 1 kg. Duration of the drug course: no more than three days as an antipyretic and no more than five days as an analgesic. If there is no proper therapeutic response within the specified period of time, you should consult a doctor. Nurofen for children in the form of a suspension must be shaken thoroughly before use. To ensure dosing accuracy, a measuring syringe is included in the package with the drug. In order to draw the suspension into the syringe, the bottle should be turned upside down and the piston should be carefully withdrawn. Before removing the syringe, the bottle returns to its original position. To administer the suspension, a syringe is placed in the oral cavity. The introduction should be done smoothly. After completing all the above manipulations, the syringe must be washed in warm water. The possibility of using the drug is considered by the doctor individually in the following cases: if there is a history of gastritis, arterial hypertension or heart failure; if the patient receives other painkillers, for kidney and/or liver diseases, for helicobacteriosis; during treatment with antihypertensive drugs, glucocorticosteroids, diuretics, indirect anticoagulants, antiplatelet agents; for bronchial asthma, defecation disorders, autoimmune connective tissue diseases. Combining Nurofen for children with anticoagulants can enhance the effect of the latter and lead to increased bleeding. Co-administration of the drug with antihypertensive drugs and diuretics reduces the effectiveness of the latter. In addition, diuretics may increase the nephrotoxicity of NSAIDs. Glucocorticosteroids in combination with Nurofen for children increase the risk of erosive and ulcerative lesions of the gastrointestinal tract. Concomitant use of Nurofen for children with cardiac glycosides may cause exacerbation of heart failure.
Side effects of Nurofen™ for children
Hypersensitivity may manifest itself as a nonspecific allergic reaction and anaphylaxis; exacerbation of asthma, bronchospasm; various skin rashes. From the gastrointestinal tract : nausea, vomiting, discomfort or pain in the epigastric region, laxative effect, possible exacerbation or development of gastric ulcer, bleeding. From the nervous system : headache, dizziness. From the hematopoietic organs : anemia, thrombocytopenia, agranulocytosis, leukopenia. From the urinary system : impaired renal function. If any side effect occurs, discontinue the drug immediately and provide proper care.
Nurofen for children, 1 piece, 200 ml, 100 mg/5 ml, oral suspension, strawberry
The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.
Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg/day. When treating chronic conditions and with long-term use, other adverse reactions may occur.
The incidence of adverse reactions was assessed based on the following criteria; very often (≥1/10); often (from ≥1/100 to <1/10); uncommon (from ≥1/1000 to <1/100); rare (from ≥1/10000 to <1/1000); very rare (<1/10000); frequency unknown (no frequency estimates available).
From the blood and lymphatic system:
very rare - hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
From the immune system:
infrequently - hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis, Lyell's syndrome, Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia; very rare - severe hypersensitivity reactions, incl. swelling of the face, tongue and larynx, shortness of breath, tachycardia, arterial hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).
From the gastrointestinal tract:
uncommon - abdominal pain, nausea, dyspepsia; rarely - diarrhea, flatulence, constipation, vomiting; very rarely - peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, ulcerative stomatitis, gastritis; frequency unknown - exacerbation of ulcerative colitis and Crohn's disease.
From the liver and biliary tract:
very rarely - liver dysfunction.
From the kidneys and urinary tract:
very rarely - acute renal failure (compensated and decompensated), especially with long-term use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, papillary necrosis.
From the nervous system:
infrequently - headache; very rarely - aseptic meningitis (in patients with autoimmune diseases).
From the SSS side:
frequency unknown - heart failure, peripheral edema, with long-term use there is an increased risk of thrombotic complications (for example, myocardial infarction, stroke), increased blood pressure.
From the respiratory system and mediastinal organs:
frequency unknown - bronchial asthma, bronchospasm, shortness of breath.
Other:
very rarely - swelling, incl. peripheral.
Laboratory indicators:
hematocrit or Hb (may decrease); bleeding time (may increase); plasma glucose concentration (may decrease); creatinine clearance (may decrease); plasma creatinine concentration (may increase); liver transaminase activity (may increase). If side effects occur, you should stop taking the drug and consult a doctor.
Special instructions for the use of Nurofen™ for children
The drug should be used with caution when:
- systemic connective tissue diseases;
- hypertension (arterial hypertension) and/or heart disease;
- liver and/or kidney failure.
If gastrointestinal bleeding or ulcers develop, the drug should be discontinued immediately. In patients with severe dehydration, ensure sufficient fluid intake. Particular caution must be exercised when used in children with severe dehydration due to diarrhea, after major surgical interventions, with cardiac, hepatic and renal failure, when using diuretics. In these cases, careful monitoring of diuresis and renal function is necessary.
Interactions of Nurofen™ for children
Concomitant use with:
- acetylsalicylic acid or with other NSAIDs and GCS drugs (the risk of side effects from the gastrointestinal tract increases);
- anticoagulants (increasing the effect of oral anticoagulants and increasing the risk of bleeding).
Use cautiously simultaneously with:
- antihypertensive drugs and diuretics (increased risk of developing a reaction from the kidneys);
- methotrexate and lithium drugs (increased levels of these drugs in the blood plasma);
- cyclosporines (drug interactions are possible, which can lead to an increased risk of nephrotoxicity).
Overdose of Nurofen™ for children, symptoms and treatment
Increasing the dose to 400 mg/kg may cause acute intoxication, which may be accompanied by nausea, vomiting, abdominal pain, dizziness, headache, drowsiness, nystagmus, blurred vision, tinnitus and, rarely, decreased blood pressure, metabolic acidosis, and renal failure. and loss of consciousness. When the first signs of overdose appear, you should immediately stop using the drug and carry out symptomatic therapy. There is no specific antidote.
