Septanazal 0.1mg+5mg/dose 10ml metered nasal spray

Compound

Pharmacodynamics

Xylometazoline is a local vasoconstrictor (decongestant) with alpha-adrenomimetic activity that causes constriction of the blood vessels of the nasal mucosa, restores the patency of the nasal passages, eliminates nasal congestion, and facilitates nasal breathing. The effect of xylometazoline usually occurs within a few minutes after its use and lasts up to 10 hours.

Dexpanthenol is a B vitamin, a derivative of pantothenic acid.

Dexpanthenol is converted in the body into pantothenic acid, which is a component of coenzyme A (CoA), and is involved in the processes of acetylation, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins, stimulates the restoration of skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers. It has a regenerating, metabolic and mild anti-inflammatory effect.

Septanazal 0.1mg+5mg/dose 10ml metered nasal spray

Release form

nasal spray

Package

Bottle 10 ml

pharmachologic effect

Xylometazoline is a local vasoconstrictor (decongestant) with alpha-adrenomimetic activity that causes constriction of the blood vessels of the nasal mucosa, restores the patency of the nasal passages, eliminates nasal congestion, and facilitates nasal breathing. The effect of xylometazoline usually occurs within a few minutes after its use and lasts up to 10 hours.

Dexpanthenol is a B vitamin, a derivative of pantothenic acid.

Dexpanthenol is converted in the body into pantothenic acid, which is a component of coenzyme A (CoA), and is involved in the processes of acetylation, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins, stimulates the restoration of skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers. It has a regenerating, metabolic and mild anti-inflammatory effect.

Indications

- acute respiratory diseases with symptoms of rhinitis;

- acute allergic rhinitis;

- vasomotor rhinitis;

- sinusitis;

- otitis media (as part of combination therapy to reduce swelling of the nasopharyngeal mucosa);

— to facilitate rhinoscopy, restoration of impaired nasal breathing after surgical interventions in the nasal cavity.

Contraindications

Common to both dosage forms:

- hypersensitivity to any of the components of the drug;

- arterial hypertension;

- tachycardia;

- severe atherosclerosis;

- glaucoma;

- atrophic rhinitis;

- hyperthyroidism;

— surgical interventions on the meninges (history);

- prostatic hyperplasia;

- simultaneous use with MAO inhibitors and tricyclic antidepressants;

- pregnancy;

- period of breastfeeding.

For nasal spray dosed additionally

- porphyria;

- children under 6 years of age.

For nasal spray dosed additionally for children

- dry rhinitis;

- children under 2 years of age.

Common to both dosage forms:

With caution: diabetes mellitus, pheochromocytoma, cardiovascular diseases (including coronary heart disease, angina), increased sensitivity to the action of adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

Directions for use and doses

Intranasally. One dosed spray into each nasal passage 3-4 times a day.

Dosed dosed spray for nasal use - for adults and children over 6 years of age.

Spray for nasal use, dosed for children - for children from 2 to 6 years old.

Before use, remove the protective cap. Before using the spray for the first time or after a long break, you must press the pump dispenser several times until a uniform spray appears.

Insert the tip of the bottle vertically into the nasal passage, inhale slowly through the nose, while simultaneously pressing the pump dispenser once. Repeat the procedure in the other nasal passage. After use, the tip should be wiped with a paper napkin and covered with a protective cap. Duration of therapy is 3–5 days.

Side effects

With frequent and/or prolonged use: irritation and/or dryness of the mucous membrane of the nasopharynx, burning, tingling, sneezing, hypersecretion, allergic reactions, swelling of the nasal mucosa, nausea, vomiting, headache, dry rhinitis, palpitations, increased blood pressure, tachycardia, insomnia, blurred vision, depression (with long-term use of high doses).

Pharmacokinetics

Xylometazoline is practically not absorbed when applied topically. Concentrations in blood plasma are so low that they cannot be determined by modern analytical methods.

When applied topically, dexpanthenol is quickly absorbed by the skin and converted into pantothenic acid and binds to blood plasma proteins (mainly beta-globulin and albumin). Its concentration in the blood is 0.5-1 mg/l, in the blood serum - 100 μg/l. Pantothenic acid is not metabolized in the body (except for inclusion in CoA) and is excreted unchanged.

pharmachologic effect

A remedy for treating nasal diseases.

Xylometazoline is a local vasoconstrictor (decongestant) with alpha-adrenomimetic activity that causes constriction of the blood vessels of the nasal mucosa, restores the patency of the nasal passages, eliminates nasal congestion, and facilitates nasal breathing. The effect of xylometazoline usually occurs within a few minutes after its use and lasts up to 10 hours.

Dexpanthenol is a B vitamin, a derivative of pantothenic acid.

Dexpanthenol is converted in the body into pantothenic acid, which is a component of coenzyme A (CoA), and is involved in the processes of acetylation, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins, stimulates the restoration of skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers. It has a regenerating, metabolic and mild anti-inflammatory effect.

Contraindications

Common to both dosage forms:

hypersensitivity to any of the components of the drug;

arterial hypertension;

tachycardia;

severe atherosclerosis;

glaucoma;

atrophic rhinitis;

hyperthyroidism;

surgical interventions on the meninges (history);

prostatic hyperplasia;

simultaneous use with MAO inhibitors and tricyclic antidepressants;

pregnancy;

breastfeeding period.

For nasal spray dosed additionally

porphyria;

children under 6 years of age.

For nasal spray dosed additionally for children

dry rhinitis;

children under 2 years of age.

Common to both dosage forms:

With caution: diabetes mellitus, pheochromocytoma, cardiovascular diseases (including coronary heart disease, angina), increased sensitivity to the action of adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

Septanasal for children nasal spray 0.5 mg/50 mg/1 ml 10 ml No. 1

Name

Septanasal for children.

Release forms

Dosed nasal spray.

INN

Xylometazoline + dexpanthenol.

FTG

A remedy for nasal diseases.

Compound

1 ml of nasal spray contains 0.5 mg of xylometazoline hydrochloride and 50 mg of dexpanthenol. 1 dose with a single press is 0.1 ml of nasal spray and contains 0.05 mg of xylometazoline hydrochloride and 5.0 mg of dexpanthenol. Excipients: potassium dihydrogen phosphate, disodium phosphate dodecahydrate, purified water.

Classification code

Sympathomimetics, combinations, excluding corticosteroids. ATX code: R01AB06.

Pharmacological properties

SeptaNazal® for children is a nasal spray containing the active substances xylometazoline hydrochloride and dexpanthenol. Xylometazoline hydrochloride has a vasoconstrictor effect, thus eliminating swelling of the nasal mucosa. Dexpanthenol is a B vitamin, a derivative of pantothenic acid, has a protective effect and promotes the healing of damage to the mucous membrane.

Indications for use

The drug is recommended: to reduce swelling of the nasal mucosa in acute respiratory diseases with symptoms of rhinitis (runny nose) and as a maintenance treatment for healing damage to the nasal mucosa, to alleviate the condition of vasomotor rhinitis, to restore nasal breathing after surgery in the nasal cavity. The drug is recommended for children from 2 years of age.

Directions for use and dosage

Intranasally. Children from 2 to 6 years old - one injection of SeptaNazal® for children in each nasal passage up to 3 times a day. For children over 6 years of age, SeptaNazal® nasal spray for adults is recommended, containing a higher dose of the active substance. Dosage depends on individual sensitivity and clinical effectiveness. Do not use the drug for more than 7 days. A repeated course is possible after a break of several days.

Mode of application

Remove the protective cap from the sprayer. Before the first use, and also if the spray has not been used for a long period of time, you should press the sprayer several times until the optimal flow appears. The upper part (tip) of the sprayer should be inserted in as vertical a position as possible into the nasal passage and press the sprayer once. At the time of injection, the patient should inhale lightly through the nose. If necessary, the procedure should be repeated with another nasal passage. After each use, wipe the spray tip with a paper towel and close the cap. Long-term use of high doses of the drug can lead to chronic swelling and subsequent atrophy of the nasal mucosa. If you have increased intraocular pressure (glaucoma), especially angle-closure glaucoma, consult your doctor before use. Take with food and drinks The drug can be used regardless of meals. If you miss the next dose of the drug, you should not take a double dose to make up for the missed dose. Stopping the use of the drug You can stop using the drug at any time convenient for you. If you need more information or advice, consult your doctor or pharmacist.

Side effect

Like any medicine, in isolated cases the drug may cause side effects. Classification of the frequency of side effects according to the World Health Organization: very common (≥1/10) frequent (≥1/100 to

Contraindications

Hypersensitivity to the active substances or to any of the excipients of the drug. Dry inflammation of the nasal mucosa. Surgical removal of the pituitary gland or other surgical interventions on the meninges (history). SeptaNazal® for children is contraindicated in children under 2 years of age.

Overdose

When used intranasally, systemic effects are unlikely, since local narrowing of the lumen of blood vessels leads to decreased absorption. In case of exceeding recommended doses or accidental ingestion of large quantities of the drug orally, the following undesirable effects are possible: constriction of the pupils (miosis), dilation of the pupils (mydriasis), fever, increased sweating, pallor of the skin, bluish coloration of the lips (cyanosis), nausea , convulsions, disorders of the cardiovascular system (increase or decrease in heart rate, cardiac arrhythmia, cardiac arrest, hypertension), respiratory disorders (pulmonary edema, respiratory dysfunction), mental disorders. In addition, if recommended doses are exceeded or if large quantities of the drug are accidentally taken orally (orally), drowsiness, decreased body temperature, decreased blood pressure, impaired respiratory function, and coma are possible. If any of these symptoms appear, you should immediately consult a doctor.

Precautionary measures

Before use, consult a doctor: if the patient is receiving therapy with monoamine oxidase inhibitors (MAOIs) and other drugs that potentially increase blood pressure, with increased intraocular pressure (glaucoma), especially with angle-closure glaucoma, with severe heart and circulatory diseases (for example, coronary disease heart disease, high blood pressure), pheochromocytoma, metabolic disorders (for example, hyperthyroidism, diabetes), porphyria, prostatic hyperplasia. The use of the drug in cases of chronic rhinitis is possible only under the supervision of a doctor, since there is a possibility of developing atrophy of the nasal mucosa. Incorrect use and overdose of the drug can lead to side effects, especially in children. The simultaneous use of the spray and: medicines for the treatment of influenza, medicines for the runny nose and cough containing sympathomimetics (for example, pseudoephedrine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, tramazoline, naphazoline, aminoheptane) is not recommended. With concomitant use, the risk of side effects from the cardiovascular and central nervous systems increases. Avoid contact of the drug with the eyes.

Use in children

Do not exceed recommended doses. It is recommended to consult with a doctor regarding therapy and dosage features in children. SeptaNazal® for children is intended for children from 2 to 6 years old. For children over 6 years of age, SeptaNazal® for adults is recommended, containing a higher dose of the active substance. The use of the drug in children should be carried out under adult supervision. If after 3 days of treatment there is no improvement in the child's condition, or the child feels worse, you should consult a doctor.

Pregnancy and lactation

During pregnancy and lactation, you should consult your doctor before taking any medications. It is not recommended to use the drug during pregnancy due to the lack of sufficient safety data. It is not recommended to use the drug during lactation, since it is unknown whether xylometazoline hydrochloride is excreted into breast milk.

Effect on the ability to drive a car or use other machinery

When used in accordance with the recommendations, the drug does not affect the ability to drive vehicles or operate complex machinery.

Interaction with other drugs

Before you start taking it, you must tell your doctor that you are taking or have recently taken any medications. Concomitant use of drugs for the treatment of depression (monoamine oxidase inhibitors of the tranylcypromine type or tricyclic antidepressants), as well as drugs that increase blood pressure, may lead to an increase in blood pressure. When used simultaneously with medications for the treatment of influenza, as well as sympathomimetics contained in cold and cough medications (for example, pseudoephedrine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, tramazoline, naphazoline, tuaminoheptane), the risk of cardiovascular side effects increases. vascular and central nervous systems.

Conditions and shelf life

Before opening the bottle No special storage conditions are required. After opening the bottle, store at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date

2 years. After opening the bottle, the drug should be used within 3 months. Do not use after the expiration date stated on the package. The expiration date refers to the last day of the month.

Vacation conditions

Without a doctor's prescription.

Package

White plastic bottle (HDPE) with white pump and red plastic cap: 10 ml nasal spray, in a box, with leaflet. 10 ml nasal spray corresponds to 100 sprays.

Buy Septanazal spray for children, dosage. 0.5mg/50mg/1ml per bottle. 10ml in pack No. 1 in the pharmacy

Price for Septanazal spray for children, dosage no. 0.5mg/50mg/1ml per bottle. 10ml in pack No. 1

Instructions for use for Septanazal for children, spray, dosage. 0.5mg/50mg/1ml per bottle. 10ml in pack No. 1

Directions for use and doses

Intranasally. One dosed spray into each nasal passage 3-4 times a day.

Dosed dosed spray for nasal use - for adults and children over 6 years of age.

Spray for nasal use, dosed for children - for children from 2 to 6 years old.

Before use, remove the protective cap. Before using the spray for the first time or after a long break, you must press the pump dispenser several times until a uniform spray appears.

Insert the tip of the bottle vertically into the nasal passage, inhale slowly through the nose, while simultaneously pressing the pump dispenser once. Repeat the procedure in the other nasal passage. After use, the tip should be wiped with a paper napkin and covered with a protective cap. Duration of therapy is 3–5 days.

Septanasal for adults nasal spray 1mg/50mg/1ml 10ml No.1

Name

Septanasal.

Release forms

Dosed nasal spray.

INN

Xylometazoline + dexpanthenol.

FTG

A remedy for nasal diseases.

Description

Transparent, colorless liquid.

Compound

1 ml of nasal spray contains 1 mg of xylometazoline hydrochloride and 50 mg of dexpanthenol. 1 dose with a single press is 0.1 ml of nasal spray and contains 0.1 mg of xylometazoline hydrochloride and 5.0 mg of dexpanthenol. Excipients: potassium dihydrogen phosphate, disodium phosphate dodecahydrate, purified water.

Drug classification code

Combinations of sympathomimetics, excluding corticosteroids. ATX code: R01AB06.

Pharmacological properties

SeptaNazal® for adults is a nasal spray containing the active substances xylometazoline hydrochloride and dexpanthenol. Xylometazoline hydrochloride has a vasoconstrictor effect, thus eliminating swelling of the nasal mucosa. Dexpanthenol is a B vitamin, a derivative of pantothenic acid, has a protective effect and promotes the healing of damage to the mucous membrane.

Indications for use

The drug is recommended: - to reduce swelling of the nasal mucosa in acute respiratory diseases with symptoms of rhinitis (runny nose) and as a maintenance treatment for the healing of damage to the nasal mucosa, - to alleviate the condition of vasomotor rhinitis, - to restore nasal breathing after surgical intervention in the nasal cavity cavities. The drug is recommended for children over 6 years of age and adults.

Directions for use and dosage

Intranasally. Children over 6 years old - one injection of SeptaNazal® for adults in each nasal passage, up to 3 times a day. It is recommended to consult with your doctor regarding the duration of therapy and dosage specifications in children. For children under 6 years of age, SeptaNazal® nasal spray for children, which contains a lower dose of the active substance, is recommended. Adults - one injection of SeptaNazal® for adults in each nasal passage, up to 3 times a day. Dosage depends on individual sensitivity and clinical effectiveness. In the absence of other instructions from the attending physician, the duration of therapy is up to 7 days. A repeated course is possible after a break of several days.

Mode of application

Remove the protective cap from the sprayer. Before the first use, and also if the spray has not been used for a long period of time, you should press the sprayer several times until the optimal flow appears. The upper part (tip) of the sprayer should be inserted in as vertical a position as possible into the nasal passage and press the sprayer once. At the time of injection, the patient should inhale lightly through the nose. If necessary, the procedure should be repeated with another nasal passage. After each use, wipe the spray tip with a paper towel and close the cap. Long-term use of high doses of the drug can lead to chronic swelling and subsequent atrophy of the nasal mucosa. If you have increased intraocular pressure (glaucoma), especially angle-closure glaucoma, consult your doctor before use. Take with food and drinks The drug can be used regardless of meals. If you miss the next dose of the drug, you should not take a double dose to make up for the missed dose. Stopping the use of the drug You can stop using the drug at any time convenient for you. If you need more information or advice, consult your doctor or pharmacist.

Side effect

Like any medicine, in isolated cases the drug may cause side effects. Classification of the frequency of side effects according to the World Health Organization: - very frequent (≥ 1/10) - frequent (≥ 1/100 to

Contraindications

Hypersensitivity to the active substances or to any of the excipients of the drug. Dry inflammation of the nasal mucosa. Surgical removal of the pituitary gland or other surgical interventions on the meninges (history). SeptaNazal® for adults is contraindicated in children under 6 years of age.

Overdose

When used intranasally, systemic effects are unlikely, since local narrowing of the lumen of blood vessels leads to decreased absorption. In case of exceeding recommended doses or accidental ingestion of large quantities of the drug orally, the following undesirable effects are possible: constriction of the pupils (miosis), dilation of the pupils (mydriasis), fever, increased sweating, pallor of the skin, bluish coloration of the lips (cyanosis), nausea , convulsions, disorders of the cardiovascular system (increase or decrease in heart rate, cardiac arrhythmia, cardiac arrest, hypertension), respiratory disorders (pulmonary edema, respiratory dysfunction), mental disorders. In addition, if recommended doses are exceeded or if large amounts of the drug are accidentally taken orally (orally), drowsiness, decreased body temperature, decreased blood pressure, respiratory arrest, and coma may occur. If any of these symptoms appear, you should immediately consult a doctor.

Precautionary measures

Before use, consult a doctor: - if the patient is receiving therapy with monoamine oxidase inhibitors (MAOIs) and other drugs that potentially increase blood pressure, - with increased intraocular pressure (glaucoma), especially with angle-closure glaucoma, - with severe diseases of the heart and circulatory system (eg , coronary heart disease, high blood pressure), - with pheochromocytoma, - with metabolic disorders (for example, hyperthyroidism, diabetes), - with porphyria, - with prostate hyperplasia. The use of the drug in case of chronic rhinitis is recommended only under the supervision of a doctor, since there is a possibility of developing atrophy of the nasal mucosa. Incorrect use and overdose of the drug can lead to side effects, especially in children. The simultaneous use of the spray and: - medicines for the treatment of influenza, - medicines for colds and coughs containing sympathomimetics (for example, pseudoephedrine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, tramazoline, naphazoline, tuaminoheptane). With concomitant use, the risk of side effects from the cardiovascular and central nervous systems increases. Avoid contact of the drug with the eyes.

Use in children

Do not exceed recommended doses. It is recommended to consult with your doctor regarding the duration of therapy and dosage specifications in children. In the absence of other instructions from the attending physician, the duration of therapy is up to 7 days. A repeated course is possible after a break of several days. SeptaNazal® for adults is recommended for children over 6 years of age and adults. For children under 6 years of age, SeptaNazal® nasal spray for children, which contains a lower dose of the active substance, is recommended. The use of the drug in children under 12 years of age should be carried out under adult supervision. If after 3 days of treatment there is no improvement in the child's condition, or the child feels worse, you should consult a doctor.

Pregnancy and lactation

Before taking any medications, you should consult your doctor. The drug is not recommended during pregnancy and lactation due to the lack of sufficient data on use in this category of patients.

Effect on the ability to drive a car or use other machinery

When used in accordance with the recommendations, the drug does not affect the ability to drive vehicles or operate complex machinery.

Interaction with other drugs

Before you start taking it, you must tell your doctor that you are taking or have recently taken any medications. Concomitant use of drugs for the treatment of depression (monoamine oxidase inhibitors of the tranylcypromine type or tricyclic antidepressants), as well as drugs that increase blood pressure, may lead to an increase in blood pressure. When used simultaneously with medications for the treatment of influenza, as well as sympathomimetics contained in cold and cough medications (for example, pseudoephedrine, ephedrine, phenylephrine, oxymetazoline, xylometazoline, tramazoline, naphazoline, tuaminoheptane), the risk of cardiovascular side effects increases. vascular and central nervous systems.

Storage conditions

Store at a temperature not exceeding 25 °C. Keep out of the reach of children.

Best before date

2 years After opening the bottle, the drug should be used within 3 months. Do not use after the expiration date stated on the package. The expiration date refers to the last day of the month.

Vacation conditions

Without a doctor's prescription.

Package

White plastic bottle (HDPE) with white pump and translucent plastic cap: 10 ml nasal spray in a box with package insert. 10 ml nasal spray corresponds to 100 sprays.

Buy Septanazal spray for adults, dosage. 1mg/50mg/1ml per bottle. 10ml in pack No. 1 in the pharmacy

Price for Septanazal spray for adults, dosage no. 1mg/50mg/1ml per bottle. 10ml in pack No. 1

Instructions for use for Septanazal for adults, spray, dosage. 1mg/50mg/1ml per bottle. 10ml in pack No. 1

Overdose

Symptoms: mydriasis, nausea, vomiting, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmias, vascular insufficiency, cardiac arrest, increased blood pressure, pulmonary edema, respiratory dysfunction, hallucinations. Patients may also experience symptoms of central nervous system depression, including drowsiness, decreased body temperature, bradycardia, shock, respiratory arrest, and coma.

Treatment: gastric lavage, intake of enterosorbents (activated carbon), oxygen ventilation of the lungs. To reduce blood pressure, use 5 mg of phentolamine in 0.9% sodium chloride solution by slow intravenous administration or prescribe 100 mg of phentolamine orally. Vasoconstrictor drugs are contraindicated. If necessary, antipyretic and anticonvulsant drugs are used.

special instructions

Before use, it is necessary to clean the nasal passages. Does not contain preservatives. After opening the bottle, the drug should be used within 12 weeks.

Dosed dose nasal spray - should not be used for more than 5 days.

Nasal spray dosed for children - should not be used for more than 7 days. The duration of use of the drug in children is determined after consultation with a doctor.

Impact on the ability to perform potentially hazardous activities that require special attention and quick reactions (for example, driving, working with moving mechanisms). During the period of use of the drug, you should take precautions or avoid driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.