Pharmacodynamics
Nazivin® Sensitive (oxymetazoline) has a vasoconstrictor effect. When applied topically to the inflamed mucous membrane of the nasal cavity, it reduces swelling and nasal discharge. Restores nasal breathing.
Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which reduces the likelihood of bacterial complications of respiratory diseases (sinusitis, sinusitis, otitis media).
When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa. Oxymetazoline begins to act quickly, within a few minutes. The duration of action of Nazivin® Sensitive is up to 12 hours.
Nazivin (sensitive 22.5 µg/dose 10 ml-220 doses spray dosage)
A country
Austria, Spain
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Active substance
Oxymetazoline
Compound
Active ingredient: oxymetazoline hydrochloride
pharmachologic effect
Nazivin Sensitive (oxymetazoline) has a vasoconstrictor effect. When applied topically to the inflamed mucous membrane of the nasal cavity, it reduces swelling and nasal discharge. Restores nasal breathing. Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which reduces the likelihood of bacterial complications (sinusitis, sinusitis, otitis media). When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa. Oxymetazoline begins to act quickly, within a few minutes. The duration of action of Nazivin Sensitive is up to 12 hours. When administered locally intranasally, oxymetazoline does not have a systemic effect. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces.
Indications for use
Colds or viral infections of the upper respiratory tract, accompanied by a runny nose, sinusitis, eustachitis, otitis media, rhinitis of any etiology; to eliminate swelling before diagnostic manipulations in the nasal passages.
Mode of application
Nazivin Sensitive nasal spray dosed 22.5 mcg/dose is intended for intranasal administration. Adults and children over 6 years old: 1 injection of Nazivin Sensitive into each nasal cavity 2-3 times a day. If symptoms worsen or improvement does not occur within 3 days, you should consult your doctor. Use the recommended dose for no more than 7 days without consulting a doctor. Doses higher than recommended can only be used under medical supervision. One injection of 45 μl contains: 22.5 μg of oxymetazoline hydrochloride - for Nakhivin Sensitive nasal spray dosed 22.5 μg/dose.
Interaction
Slows down the absorption of local anesthetic drugs and prolongs their effect. In patients taking monoamine oxidase inhibitors (MAOIs) during the previous 2 weeks and within 2 weeks after their discontinuation, tricyclic antidepressants or other drugs that increase blood pressure - increased blood pressure. Co-administration of other vasoconstrictor drugs increases the risk of side effects.
Side effect
Sometimes: burning or dryness of the nasal mucosa, sneezing. In rare cases: after that. how will the effect of using Nazivin Sensitive go away, a strong feeling of “stuffiness” in the nose (reactive hyperemia). Rarely: increased blood pressure, headache, dizziness, palpitations, tachycardia, anxiety, irritability, sleep disturbances (in children), nausea, insomnia, exanthema, blurred vision (if it gets in the eyes). Long-term continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (rhinitis medicamentosa).
Contraindications
Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug. Children's age up to 6 years. With caution: with increased intraocular pressure, chronic heart failure, arterial hypertension, angina pectoris; arrhythmias, chronic renal failure, in patients with prostatic hyperplasia with clinical symptoms (urinary retention), severe atherosclerosis, hyperthyroidism, diabetes mellitus, pheochromocytoma. Use during pregnancy and lactation: when used during pregnancy or breastfeeding, do not exceed the recommended dose. The drug can only be used in cases where the potential benefit to the mother outweighs the potential risk to the fetus and child.
Overdose
Symptoms: nausea, increased blood pressure, tachycardia, depression of the central nervous system. Treatment: symptomatic.
special instructions
Avoid getting the drug into your eyes. To avoid the spread of infection, it is necessary to use the drug individually.
Side effects
Sometimes - burning or dryness of the nasal mucosa, sneezing.
In rare cases, after the effect of using Nazivin® Sensitive wears off, a strong feeling of nasal congestion (reactive hyperemia) occurs.
Rarely - increased blood pressure, headache, dizziness, palpitations, tachycardia, anxiety, irritability, sleep disturbance (in children), nausea, insomnia, exanthema, blurred vision (if it gets in the eyes).
Long-term continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy of the nasal mucosa and recurrent swelling of the nasal mucosa (rhinitis medicamentosa).
Forms and composition
Nazivin Sensitive is available in the form of intranasal drops and spray:
- transparent light yellow solution, packaged in plastic bottles of 5 and 10 ml with special dispensing nozzles;
- concentration of the active substance in the drop preparation: 0.01%, and 1 ml of spray contains 250 mcg of oxymetazoline;
- auxiliary components of the medicinal solution: distilled water, glycerin, stabilizers.
Drops are allowed to be used in the treatment of children in the first days of life. The spray is indicated for runny noses in children 1–6 years old. Unlike drugs intended for adolescents and adults, Nazivin Sensitive contains a lower dosage of oxymetazoline, which is safe for infants.
Manufacturer
1. Ursafarm Arzneimittel GmbH, Germany
2. Farmmaster, France.
Release quality control: Merck Selbstmedication GmbH, Germany. Rösslerstrasse 96 D-64293 Darmstadt, Germany.
Tel.: +49 (0) 61 51/856-0; fax: +49 (0)61 51/8 56-203.
www.merckselbstmedikation.de
Consumer complaints should be sent to Takeda Pharmaceuticals LLC: 119048, Moscow, st. Usacheva, 2, building 1.
Tel.; Fax.
www.takeda.com.ru
How to use children's Nazivin drops: instructions
Newborns and infants up to 4 weeks are allowed to instill 1 dose of the drug into each nostril three times a day:
- shake the bottle;
- Carefully turn the child's head up and insert the dispenser into the nasal sinus, drip the solution.
Starting from the fifth week of life, you can increase the dosage by instilling 2 doses of the drug once. You can repeat the procedure up to 4 times a day. If there is a fear of overdose, it is allowed to use the solution as follows:
- moisten a cotton swab with liquid and gently wipe the child’s nasal passages from the inside;
- Repeat the application of drops as many times as necessary.
The maximum duration of treatment without pediatrician supervision is no more than 1 week.
Note!
Description of the drug Nazivin Sensitive nasal spray. 0.025% fl. 10ml on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
How to use Nazivin spray
The Nazivin form is indicated for the treatment of runny nose in children 1–6 years old. The bottle with the drug must first be shaken and a test spray into the air.
- Before use, the nasal passages are cleared of mucus clots with a cotton swab, the child is allowed to blow his nose, and if possible, the sinuses are washed with a special saline solution or water.
- Throwing your head up, carefully bring the dispenser to your nostrils and inject the drug once.
- The procedure is repeated up to three times a day.
The general course of treatment is up to 7 days.
special instructions
Long-term use and overdose of the drug should be avoided. Long-term use of nasal decongestants may lead to a decrease in the severity of the drug's effect. abuse of this drug can cause mucosal atrophy and reactive hyperemia with rhinitis medicamentosa, as well as damage to the mucosal epithelium and inhibition of epithelial activity.
After using the drug, special monitoring is necessary for patients with chronic rhinitis and in case of elimination of edema before diagnostic procedures. Doses higher than recommended should only be used under medical supervision.
Use during pregnancy or breastfeeding. The drug should be used during pregnancy and breastfeeding only after a careful assessment of the risk to the fetus versus the benefit to the mother. Do not exceed the recommended dosage.
Children. The drug is used in children (see APPLICATION).
The ability to influence reaction speed when driving vehicles or working with other mechanisms. After long-term use of the drug in doses exceeding the recommended ones, a general effect on the cardiovascular and nervous systems cannot be excluded. In such cases, the ability to control the vehicle may be reduced.
Overdose
After a significant overdose or accidental ingestion, the following symptoms may occur: mydriasis, nausea, vomiting, cyanosis, increased body temperature, spasms, tachycardia, arrhythmia, cardiovascular failure, cardiac arrest, hypertension, pulmonary edema, respiratory disorders, mental disorders.
In addition, depression of functions of the central nervous system may occur, accompanied by drowsiness, decreased body temperature, bradycardia, arterial hypotension, apnea and the possible development of coma.
Therapeutic measures in case of overdose: gastric lavage, taking activated carbon, ventilation. When blood pressure decreases, phentolamine is used. Vasopressors should not be taken. If necessary, anticonvulsant therapy is indicated.
Contraindications
Hypersensitivity to the components of the drug, atrophic rhinitis.
The use of the drug is possible only after a thorough benefit/risk assessment for:
- the use of MAO inhibitors and other drugs that increase blood pressure;
- increased intraocular pressure, especially with angle-closure glaucoma;
- severe forms of cardiovascular diseases (for example, ischemic heart disease, hypertension);
- pheochromocytoma;
- metabolic disorders (hyperthyroidism, diabetes mellitus).
It is contraindicated to use Nazivin Sensitive nasal spray 0.025% in children under 1 year of age, Nazivin Sensitive nasal spray 0.05% in children under 6 years of age.
