Buy Tizin Classic nasal spray 0.1% 10ml in pharmacies


Pharmacological properties of the drug Tizin xylo

Pharmacodynamics. An imidazole derivative, xylometazoline, is a sympathomimetic drug with an α-adrenergic type of action. It has a vasoconstrictor effect, which reduces swelling of the mucous membranes. Improvement in nasal breathing due to a decrease in swelling and discharge of the nasal mucosa occurs 5–10 minutes after taking the drug. Pharmacokinetics. When administered intranasally, the adsorbed amount of the drug may be sufficient to cause systemic side effects, for example from the central nervous system and the cardiovascular system. There are no data from pharmacokinetic studies for use in humans.

Use of the drug Tizin xylo

Tizin Xylo 0.05% is intended for the treatment of children aged 2 to 6 years. Tizin Xylo 0.1% is intended for the treatment of adults and children aged 6 years and older. Children aged 2 to 6 years are prescribed 1 injection of Tizin Xylo (0.05% dosed spray) into each nasal passage up to 3 times a day. Children over 6 years of age and adults are prescribed 1 injection of Tizin Xylo (0.1% spray dosage) into each nasal passage up to 3 times a day. The dose depends on the individual sensitivity of the patient and the clinical effect of the drug. Xylometazoline metered-dose spray should not be used for more than 3–5 days. Treatment can be repeated only after a break in its use for several days. In the case of chronic rhinitis, due to the risk of atrophy of the nasal mucosa, prolonged use of the drug Tizin Xylo 0.05% and 0.1% dosed spray is possible only under the supervision of a physician.

Tizin Classic nasal spray 0.1% 10ml

Tizin Classic nasal spray 0.1% 10ml

Tizin® preparations are modern sprays for the treatment of runny nose(1). Thanks to the xylometazoline contained in the composition, the use of Tizin® sprays helps reduce swelling and clear the nasal sinuses. The drug can be used for complications of rhinitis such as sinusitis and otitis. The drug is approved for use in children over 6 years of age and adults.

Spray Tizin® Classic is an affordable(2) and effective remedy against nasal congestion and runny nose. Tizin® Classic dosed nasal spray has a high safety profile and allows you to accurately control the dose of the drug, which reduces the risk of overdose.

Main advantages

Helps restore nasal breathing: Tizin® Classic reduces swelling of the nasal mucosa and helps clear the sinuses.

It acts on the problem in a complex way: Tizin® Classic treats a runny nose(1) and fights the feeling of heaviness in the head!(3)

Ease of use:

The spray format is convenient to use for children over 6 years old and adults.

Wide spray area:

spray for runny nose Tizin® evenly delivers the product to the mucous membrane, and the active substance does not flow down the throat.

High safety profile:

Tizin® has a gentle effect on the nasal mucosa.

Remedy for runny nose at an affordable price(2) – a budget option for nasal congestion spray in the Tizin® line.

TIZIN® lines against runny nose:

Tizin® Expert and Tizin® Classic are used to treat colds (1). For the treatment of adults, a 0.1% solution is used, for children from 2 to 6 years old - 0.05%.

Tizin® Alergy is suitable for the treatment of allergic rhinitis in adults and children from 6 years of age.

1. Symptomatic treatment for rhinitis. 2. Among the line of drugs TIZIN®. 3. A feeling of heaviness caused by swelling of the nasal mucosa.

Composition per 1 ml of solution contains:

Active ingredient: xylometazoline hydrochloride 1.0 mg (0.1%); the amount of active ingredient in one dose for 0.1% is 0.14 mg of xylometazoline hydrochloride;

Excipients: benzalkonium chloride – 0.2 mg, sorbitol 70% – 20.0 mg, sodium chloride – 4.16 mg, sodium dihydrogen phosphate dihydrate – 3.38 mg, disodium hydrogen phosphate dihydrate – 2.08 mg, disodium edetate – 1 .0 mg, purified water – sufficient amount.

Indications for use: to reduce swelling of the mucous membrane of the nasopharynx and discharge in acute allergic rhinitis, acute respiratory infections with symptoms of rhinitis, sinusitis, hay fever, otitis media.

Preparing the patient for diagnostic manipulations in the nasal passages.

Directions for use and doses

Adults and school-age children (over 6 years old)

— 3 times a day, one dose of Tizin® Classic is administered in the form of a 0.1% nasal spray dosed into each nostril. The dose depends on the individual sensitivity of the patient and the clinical effect.

Xylometazoline nasal metered spray should not be used for more than 5–7 days, unless your doctor recommends a different duration of treatment.

After completion of therapy, the drug can be re-administered only after a few days.

Always consult your doctor regarding the duration of use in children.

General recommendations for administration

Remove the protective cap. Before first use, press the spray nozzle several times (Fig. 1) until a uniform cloud of “fog” appears. The bottle is ready for further use. When using, press once (Fig. 2). Inhale the drug through the nose. If possible, keep the spray bottle vertical. Do not spray horizontally or downward. After use, close the bottle with a cap.

Contraindications

Hypersensitivity to any of the components of the drug, concomitant use of monoamine oxidase inhibitors (MAO) or other drugs that can cause an increase in blood pressure; arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions on the meninges (history), childhood (up to 6 years - for a dosage of 0.1%, up to 2 years - for a dosage of 0.05%).

Side effect

Tizin® Classic may cause transient mild nasal irritation (burning), paresthesia, sneezing and hypersecretion in susceptible individuals.

In some cases, after using the drug, increased swelling of the nasal mucosa (reactive hyperemia) may be observed.

Long-term or frequent use of xylometazoline or its use in high doses can lead to a burning sensation in the nose or dry mucous membrane, as well as reactive congestion with the development of drug-induced rhinitis. This effect can be observed even 5-7 days after completion of treatment, and with prolonged use it can cause irreversible damage to the mucous membrane with the formation of crusts (rhinitis sicca).

In very rare cases, headache, insomnia or fatigue, and depression may occur (with long-term use in high doses).

In isolated cases, local intranasal use of sympathomimetics may be accompanied by systemic effects, such as palpitations, tachycardia, arrhythmias, increased blood pressure, and blurred vision.

Overdose

Symptoms of intoxication

Overdose or accidental ingestion of the drug can lead to the following symptoms: dilated pupils, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmias, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders.

In addition, the following symptoms may be observed: suppression of central nervous system function, accompanied by drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and coma.

Treatment of intoxication

The use of activated carbon, gastric lavage, artificial respiration with the introduction of oxygen. To lower blood pressure, use phentolamine 5 mg in saline solution intravenously slowly or 100 mg orally.

Vasopressor drugs are contraindicated. If necessary, antipyretic and anticonvulsant drugs are used.

Interaction with other drugs

Concomitant use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants may lead to an increase in blood pressure due to the cardiovascular effects of these substances.

special instructions

Long-term use and overdose of sympathomimetics that have a decongestant effect can lead to reactive hyperemia of the nasal mucosa.

The rebound phenomenon can cause airway obstruction, which leads to the patient using the drug repeatedly or even continuously. This can lead to chronic swelling (rhinitis medicamentosa), and eventually even to atrophy of the nasal mucosa (ozena).

In case of chronic rhinitis, Tizin® Classic 0.05% and 0.1% can only be used under the supervision of a physician, taking into account the risk of atrophy of the nasal mucosa.

Tizin® Classic should not be used if you are hypersensitive to benzalkonium chloride, which is included in the drug as a preservative.

Do not exceed recommended doses, especially in children and the elderly.

Vacation:

over the counter

Expiration date, days:

1080

Age:

from 6 years old

Precautionary measures

Keep out of the reach of children.

Storage conditions

Store at a temperature not exceeding 25°C. Keep out of the reach of children.

Side effects of the drug Tizin xylo

Respiratory system. Tizin Xylo may cause transient, mild signs of irritation (burning sensation) in the nasal cavity. In some cases, when the effect of the drug decreases, an increase in swelling of the nasal mucosa (reactive hyperemia) may be observed. Long-term and frequent intranasal administration of xylometazoline, as well as its use in high doses, can lead to reactive hyperemia or dryness of the nasal mucosa, as well as reactive congestion (hyperemia, congestion) with signs of drug-induced rhinitis. This effect can be observed even after 5–7 days of treatment and after long-term use and lead to permanent damage to the mucous membrane of the nasal cavity with the formation of a scab ( rhinitis sicca ). Nervous system. In rare cases, headache, insomnia or fatigue may occur. The cardiovascular system. With local intranasal use, systemic sympathomimetic effects may be observed: increased heart rate and pulse, as well as increased blood pressure.

Special instructions for the use of the drug Tizin xylo

Long-term use and overdose of sympathomimetic decongestants (decongestants) can lead to reactive hyperemia of the nasal mucosa. This side effect can lead to airway obstruction, which in turn forces the patient to use the drug repeatedly or even continuously. This can lead to chronic edema (rhinitis medicamentosa), as well as atrophy of the nasal mucosa and osena. In some cases, it is possible to stop administering the sympathomimetic drug into the 1st nasal passage, and when the complication subsides, continue treatment with administration into the 2nd nasal passage in order to maintain at least partial nasal breathing. Tizin Xylo should only be used after a careful assessment of the benefit/risk ratio in patients:

  • who have taken MAO inhibitor drugs or other drugs with potential hypertensive activity;
  • with severe cardiovascular diseases (coronary artery disease, hypertension (arterial hypertension));
  • with pheochromocytoma;
  • with endocrine diseases (hyperthyroidism, diabetes).

During pregnancy and breastfeeding . Due to the lack of research data on the effect of the drug on the fetus, xylometazoline should not be used during pregnancy. Due to the lack of data on the excretion of the active substance into breast milk, the drug cannot be used during breastfeeding. Impact on the ability to drive vehicles and operate machinery . In the case of prolonged use of Tizin Xylo in high doses, an undesirable effect of the drug on the cardiovascular system may occur, which may adversely affect the ability to drive vehicles and operate machinery.

Special Warnings

Tizin spray is not prescribed, the instructions for use warn about this, along with drugs that increase blood pressure. The medicine should be used with caution when diagnosing diabetes mellitus, pheochromocytoma, hyperthyroidism, ischemic heart disease, prostatic hyperplasia, and thyrotoxicosis.

It should be remembered that with prolonged use of Tizin spray, which has vasoconstrictor properties, paradoxical reactions may occur. They are manifested by severe nasal congestion and the development of drug-induced rhinitis.

You can buy Tizin spray in pharmacies without a prescription. However, it is strictly forbidden to use the medicine for self-medication. It should be prescribed by a doctor, taking into account existing contraindications. The shelf life of the medicine is 1 year at a temperature not exceeding 25°C. It is important to store the spray in a place where children do not have access.

Overdose of the drug Tizin xylo, symptoms and treatment

Symptoms of intoxication Overdose of the drug or accidental oral administration can lead to mydriasis, nausea, vomiting, cyanosis, fever, cramps, tachycardia, cardiac arrhythmia, circulatory collapse (vascular insufficiency), cardiac arrest, hypertension, pulmonary edema, respiratory dysfunction, mental impairment . In addition, the following symptoms may also be observed: depression of central nervous system functions, accompanied by drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and coma. Treatment of intoxication: Taking activated carbon, gastric lavage, oxygen therapy, mechanical ventilation. To reduce blood pressure in adults, it is necessary to slowly administer 5 mg of phentolamine in physiological solution intravenously or take 100 mg orally. Taking vasoconstrictors is contraindicated. If necessary, treatment with antipyretics or anticonvulsants should be prescribed.

Indications

The main indication for the use of Tizin spray is the symptomatic treatment of nasal congestion. It is prescribed for a runny nose, which often accompanies seasonal ARVI. It can also be used in cases of allergic rhinitis, including hay fever, which occurs due to an allergy to pollen.

Doctors recommend buying a spray for the treatment of sinusitis, which is characterized by inflammation of the nasal sinuses. During an exacerbation, the disease is characterized by copious discharge from the nose of a yellowish-green hue. In addition, symptoms of intoxication of the body are observed.

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