Release form: Vaginal tablets, 10 pieces per package.
Meratin Combi (ornidazole, neomycin, nystatin, prednisolone).
A convenient combination for the sanitization of vaginal microcenosis. Hygienic administration, controlled release.
Advantages of Meratin Combi:
• Vaginal tablets for initial treatment of vaginal infections with triple action - antiprotozoal, antifungal, antibacterial - and a powerful anti-inflammatory and anti-adhesive effect;
• Lack of systemic action;
• Can be used during pregnancy (2-3 trimester) and breastfeeding;
• No need to interrupt treatment during menstruation;
• Convenient applicator;
• Controlled release - use 1 time per day;
• One package is enough for a course of treatment;
• A combination of local and systemic drugs is possible - Meratin + Meratin Combi;
Indications for use:
In gynecology, urology, dermatovenerology: for the treatment of gynecological diseases such as bacterial vaginosis and vaginitis, trichomonas vaginitis, fungal vaginitis caused by Candida albicans; vaginitis caused by mixed infections (Trichomonas, anaerobic flora, including gardnerella and yeast-like fungi);
For prophylactic purposes before surgical treatment of gynecological diseases, for sanitation of the vagina before childbirth or abortion, before and after the introduction of intrauterine contraceptives, before and after diathermocoagulation of cervical erosions, before intrauterine examination.
Manufacturer: Mepro Pharmaceuticals Pvt. Ltd., India/Mepro Pharmaceuticals Pvt., Ltd, India.
Registration Certificate: No.UA/8691/01/01 Order of the Ministry of Health of Ukraine No. 916 dated October 28, 2013
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Compound:
1 tablet contains ornidazole 500 mg, neomycin sulfate BP 100 mg, nystatin BP 100,000 units, prednisolone BP 3 mg.
Excipients: starch, microcrystalline cellulose, propyl galate, sodium methylparaben, sodium propyl paraben, colloidal anhydrous silicon dioxide, purified talc, magnesium stearate, sodium starch glycolate, carmellose (carboxymethyl cellulose), starch for gluing, dry starch.
Release form. Vaginal tablets.
Pharmacotherapeutic group. Antimicrobial/antiseptic drugs in combination with corticosteroids, which are used in gynecology. ATC code G01BF.
Pharmacological properties.
Pharmacodynamics.
Ornidazole: the mechanism of action of ornidazole is associated with disruption of the DNA structure in microorganisms sensitive to it. The drug easily penetrates the microbial cell and, by binding to DNA, disrupts the replication process. Ornidazole is active against Trichomonas vaginalis, Entamoebahistolytica, Giardia lamblia (Giardia intestinalis), as well as some anaerobic bacteria such as Bacteroides and Clostridium spp., Fusobacterium spp. and anaerobic cocci;
neomycin is an antibiotic that belongs to the group of aminoglycosides. Aminoglycosides are highly active against Gram-negative bacteria and are also effective against Gram-positive bacteria. Neomycin penetrates the bacterial cell structure through the production of abnormal proteins. These proteins block the production of proteins necessary for the survival of bacteria. Nystatin is an antifungal drug that belongs to the polyene group. Nystatin acts on the fungal membrane by binding to one of the components - ergosterol. As a result, the structure of the fungal cell is disrupted and it dies. This component of the drug has selective toxicity to fungi, since human cells or bacterial cells contain cholesterol instead of ergosterol;
Prednisolone is a synthetic corticosteroid drug that is used to reduce the symptoms of inflammation. Prednisolone inhibits the secretion and release of inflammatory mediators. Prednisolone inhibits proliferative processes in inflammatory diseases and reduces the likelihood of scar formation.
Pharmacokinetics.
Ornidazole: When applied topically, the concentration of this component of the drug in the vaginal tissues significantly exceeds the concentration achieved with oral and intravenous use; no systemic effect is observed;
neomycin penetrates the bacterial cell structure through the production of abnormal proteins. These proteins block the production of proteins necessary for the bacteria to survive. There is a high activity of the drug when applied topically;
Nystatin, when applied topically, has selective toxicity to yeast-like fungi of the genus Candida; Prednisolone for local use reduces the symptoms of inflammation, including hyperemia; no systemic effect is observed.
Meratin Combi - instructions, composition, dosage, side effects of use
Meratin Combi
Meratin Combi
General characteristics:
international and chemical name: ornidazole, α-(chloromethyl)-2methyl-5-nitroimidazole-1-ethanol;
neomycin sulfate, 4-O-(2.6-diamino-2.6-dideoxy-a-glycopyranosyl)-5-O-(3-O-(2.6-diamino-2.6-dideoxy-b- idopyranosyl)-b-ribofuranosyl-2-deoxy-streptamine (neomycin B);
nystatin, (19-mycosaminyl nystatinolide) is produced due to the growth of the corresponding strains of Streptomyces noursel;
prednisolone, 11b, 17, 21-trihydroxypregna-1, 4-den-3, 20-dione;
Main physical and chemical characteristics : cream-colored, wallpaper-convex tablets, embossed “MERATIN COMBI” on one side;
Compound. 1 tablet contains ornidazole 500 mg, neomycin sulfate B. P 100 mg, nystatin B. P 100,000 IU, prednisolone B. P 3 mg;
other ingredients: starch, microcrystalline cellulose, propyl galate, sodium methylparaben, sodium propylparaben, colloidal anhydrous silicon dioxide, purified talc, magnesium stearate, sodium starch glycolate, carmellose (carboxymethyl cellulose), starch for gluing, dry starch.
Release form of the medicine.
Vaginal tablets.
Pharmacotherapeutic group. Antimicrobial/antiseptic drugs in combination with corticosteroids, which are used in gynecology. ATC code G01BF.
Action of the medicine.
Pharmacodynamics. Ornidazole : the mechanism of action of ornidazole is associated with disruption of the DNA structure in microorganisms sensitive to it. The drug easily penetrates the microbial cell and, by binding to DNA, disrupts the replication process. Ornidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia (Giardia intestinalis), as well as some anaerobic bacteria such as Bacteroides and Clostridium spp. , Fusobacterium spp. and anaerobic cocci;
VOLTAREN® suppositories, Novartis Pharma description and instructions for use of the drug.
neomycin is an antibiotic that belongs to the group of aminoglycosides. Aminoglycosides have high activity against gram-negative bacteria and are also effective against gram-positive bacteria. Neomycin penetrates the bacterial cell structure through the production of abnormal proteins. These proteins block the production of proteins essential for bacterial survival; Nystatin is an antifungal drug that belongs to the polyene group. Nystatin affects the fungal membrane by binding to one of the components - ergosterol. As a result, the structure of the fungal cell is disrupted and it dies. This component of the drug has selective toxicity to fungi because human cells or bacterial cells put cholesterol in place of ergosterol;
Prednisolone is a synthetic corticosteroid drug that is used to reduce symptoms of inflammation. Prednisolone inhibits the secretion and release of inflammatory mediators. Prednisolone inhibits proliferative processes in inflammatory diseases and reduces the likelihood of scar formation.
Pharmacokinetics. Ornidazole : When applied topically, the concentration of this component of the drug in the vaginal tissues significantly exceeds the concentration achieved with oral and intravenous use; no systemic effect is observed;
neomycin penetrates the structure of the bacterial cell, due to the production of abnormal proteins. These proteins block the production of proteins necessary for the bacteria to survive. There is a high activity of the drug when applied topically;
Fenazide - instructions, composition, dosage, side effects of use
Nystatin, when applied topically, has selective toxicity to yeast-like fungi of the genus Candida; Prednisolone for topical use reduces the symptoms of inflammation, including hyperemia; no systemic effect is observed.
Indications for use.
Meratin Combi is used to treat patients with gynecological diseases, such as bacterial vaginosis and vaginitis, trichomonas vaginitis, fungal vaginitis caused by Candida albicans; vaginitis caused by mixed infections (Trichomonas, anaerobic infection, including Gardnerli and yeast-like fungi);
for prophylactic purposes before surgical treatment of gynecological diseases, vaginal sanitation before childbirth or abortion, before and after the introduction of intrauterine contraceptives, before and after diathermocoagulation of cervical erosions, before intrauterine examinations.
Application and dosage of the drug . Inject deep into the vagina, 1 tablet of Meratin Combi at night, after administration you should lie down for at least 15 minutes. The average duration of treatment is 10 days. Treatment should not be interrupted during menstruation.
Procedure of introduction
1. Place the vaginal tablet in the applicator.
2. Immerse the applicator with the tablet in warm (30 - 40 ° C) boiled water for 15 - 30 seconds.
3. Insert the applicator with the tablet carefully, as deep as possible into the vagina (preferably in a supine position).
UNAZIN®, Pfizer Inc. description and instructions for use of the drug.
4. Leave the tablet in the vagina, removing it from the applicator.
Side effect.
Meratin Combi is a non-toxic drug that does not cause sensitization. The drug is well tolerated by all patients. Irritation or hypersensitivity to the drug rarely occurs.
Treatment: Discontinue treatment if increased sensitivity or irritation occurs upon use.
Contraindications . Hypersensitivity to any of the components of the drug.
Exceeding the permissible dose of the drug (overdose).
Due to the local effect of the drug, no overdose was observed.
Features of use.
Due to the low absorption of the drug, the concentration of its components in the systemic circulation is minimal, which allows its use during pregnancy and lactation.
Interaction with other drugs . No clinically significant interactions with drugs have been identified so far.
Intravaginal drugs, such as Meratin Combi, can cause harm to latex contraceptives and other contraceptives, so you should abstain from sexual intercourse or use other means of contraception while using the drug.
Features of conditions, shelf life and sales..
Keep at room temperature (15-25 °C), in a dry place, protected from light and out of reach of children.
Shelf life: 2 years.
The drug should not be used after the expiration date.
Indications for use.
Meratin Combi is used to treat patients with gynecological diseases, such as bacterial vaginosis and vaginitis, trichomonas vaginitis, fungal vaginitis caused by Candida albicans; vaginitis caused by mixed infections (Trichomonas, anaerobic infection, including gardnerellosis, yeast-like fungi);
for prophylactic purposes before surgical treatment of gynecological diseases, vaginal sanitation before childbirth or abortion, before and after ingestion of uterine contraceptives, before and after diathermocoagulation of cervical erosions, before intrauterine examinations.
Method of administration and dose.
Inject 1 tablet deep into the vagina at night; after administration, lie down for at least 15 minutes. The average duration of treatment is 10 days. Treatment is not interrupted during menstruation.
Procedure of introduction
1. Place the vaginal tablet in the applicator.
2. Immerse the applicator with the tablet in warm (30 - 40 ° C) boiled water for 15-30 seconds.
3. Insert the applicator with the tablet carefully, as deep as possible into the vagina (preferably in a supine position).
4. Leave the tablet in the vagina, removing it from the applicator.
Features of application.
Due to the low absorption of the drug, the concentration of its components in the systemic circulation is minimal, which allows its use during pregnancy and lactation.
Interaction with other drugs. No clinically significant interactions with drugs have been detected so far.
Intravaginal drugs such as Meratin Combi may harm latex contraceptives and other contraceptives, so you should avoid sexual intercourse or use other forms of contraception while using the drug.
Note!
Description of the drug Meratin Combi table. vagina. No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
