Mikardis Plus tablets: reviews, instructions for use, price, analogues

Micardin is a drug for hypertension that appeared on the market not so long ago, but has already managed to make a lot of noise. In any case, the advertisement is trying to convince us that with a single course this drug can relieve hypertension or, at a minimum, bring blood pressure back to normal and eliminate the accompanying symptoms of the disease - weakness, dizziness, headaches.

Before you decide to buy a drug, you should figure out whether it is good in practice. After all, too often advertised miracle pills turned out to be the simplest dummies. Let's find out what deceptive maneuvers advertisers use and why negative reviews about this product began to appear almost immediately.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Micardis Plus is a combination of telmisartan angiotensin type II receptor blocker hydrochlorothiazide ( diuretic ). The combined use of these components causes a stronger antihypertensive effect than using them separately. Taking the drug once a day leads to a pronounced gradual decrease in blood pressure.

Telmisartan is a selective angiotensin type 2 receptor blocker. Has high affinity for angiotensin II receptors of the AT1 subtype . It displaces angiotensin II from the receptor. The binding is long-term. Telmisartan does not block other receptors (including AT2 type receptors) of angiotensin . Telmisartan also reduces aldosterone .

In persons with arterial hypertension 80 mg of telmisartan per day completely suppresses the effects of angiotensin II . The onset of action occurs three hours after ingestion of the drug. The effect lasts for 24 hours. A permanent antihypertensive effect is observed a month after regular use of telmisartan .

Hydrochlorothiazide is diuretic . Affects the reabsorption of electrolytes in the renal tubules, directly increasing the excretion of sodium and chlorides. This causes a decrease in circulating blood volume, an increase in renin aldosterone synthesis .

After administration of hydrochlorothiazide, diuresis increases after two hours, and the maximum effect is achieved after four hours and persists for 6-12 hours.

Pharmacokinetics

Telmisartan. Quickly absorbed from the digestive tract. The maximum concentration of telmisartan occurs within an hour. Bioavailability is 50%.

Reaction with blood proteins is more than 99.5%. Metabolized by interaction with glucuronic acid . Telmisartan derivatives are pharmacologically inactive.

The half-life is approximately 20 hours. Excreted with feces in its original form and with the kidneys - up to 2%.

The pharmacokinetics of telmisartan in elderly patients does not differ from those in younger patients. No dose selection is required.

Hydrochlorothiazide. After oral administration of hydrochlorothiazide, maximum concentrations are achieved within 1-2 hours. Bioavailability reaches 60%.

Reaction with plasma proteins – 64%. It is not metabolized and is excreted unchanged through the kidneys.

How Micardin sellers deceive

The main buyers of hypertension medications are older people. And, unfortunately, they are the easiest to deceive. Just look at the seller's most dubious claims.

Lie #1. “Micardin saved tens of thousands of people from hypertension”

Take the capsules for just a month, and hypertension will never bother you. If you don’t believe me, look at the statistics: more than 30 thousand people forgot about hypertension after drinking Micardin.

Is it true. The very first and most terrible misconception is that hypertension is a disease that you can get rid of forever. Moreover, taking only one drug. Moreover, it is too arrogant to say about some tens of thousands of patients who are now definitely not afraid of hypertension. To draw such conclusions, many years of observation are needed. But advertisers do not skimp on statements.

Lie #2. “The reason for the increase in cases of hypertension was the collapse of the USSR”

In the Soviet Union, the grass was greener, and Soviet citizens never suffered from hypertension. But after the collapse of the state, the incidence rate increased tenfold. Nobody knows what to do about it, and only our drug is 100% effective.

Is it true. It’s understandable why advertisers are trying to connect the collapse of the USSR and the rise in cases of hypertension: to play on the nostalgic feelings of pensioners and seem more convincing. Yes, the prevalence of hypertension has increased over the past 30 years. But this is most likely due to the deterioration of the environment, the emergence of new stress factors, greater workload of people at work and the deterioration of the level of medicine. But this does not mean that Micardin will certainly compensate for such an unfavorable situation.

Lie #3. “Only today you can order Micardin for free”

You are truly lucky, because you managed to place an order right now. There are only a few packs of the drug left, which we are ready to give away just like that, you just need to place a request.

Is it true. Here we see several clever tricks at once. The first deception is “this opportunity only exists today.” Believe me, if you want to place an order tomorrow, this exclusive offer will be hanging in its place. The second trick is “limited number of packages.” Moreover, under the ad there is also a counter indicating in real time how many specific packs are available. But, if the page is refreshed, the counter will return to its original value. Finally, the biggest impudence is the statement that the drug is provided free of charge. In fact, according to the terms of the promotion, you can get one additional pack for free when you pay for the full course.

Lie No. 4: “All clients are happy, and you won’t find negative reviews”

We have such a magical drug that it helps absolutely everyone. And the proof of this is exclusively positive reviews.

Is it true. Indeed, there are no negative reviews on the manufacturer’s website. But this does not mean that they do not exist at all. If you visit independent resources, you will find plenty of complaints. We decided to publish reviews, from which it becomes clear why customers are dissatisfied. You can see these reviews along with our comments below.

Contraindications

The drug has the following contraindications:

obstruction of the biliary tract;
severe liver or kidney dysfunction;
refractory hypercalcemia, hypokalemia ;
fructose intolerance ;
lactase deficiency galactose or lactose intolerance ;
age less than 18 years;
lactation;
pregnancy;
allergy to the components of the drug.

Carefully:

stenosis of both renal arteries, severe kidney damage;
liver dysfunction or progressive liver damage;
hyperkalemia;
hypovolemia after treatment with diuretics , as well as after limiting salt intake, vomiting or diarrhea ;
chronic heart failure , functional class III-IV;
mitral and aortic valve ;
condition after kidney transplant;
obstructive cardiomyopathy;
primary aldosteronism ;
diabetes;
gout.

Documents and confirmations

If there is so little truth in advertising, and there are scammers everywhere, does the manufacturer at least have real documents? After all, looking at the reviews, you might think that the seller does not even have supporting documentation and is not registered anywhere.

A real manufacturer does not hide anything and freely posts all evidence and certificates confirming the legality of its activities and the quality of the product. You can familiarize yourself with them.

Attention! The long-awaited drug update!

Attention! The manufacturer of Micardin is constantly improving the formula of the drug. The other day we learned that the company has finally launched Cardisen syrup, which, according to research, is almost 30% more effective than Micardin capsules. This is a breakthrough in the field of cardiology! And the best part is that the new product is currently on sale, and you can get one package of the product for free!

Please note that the official manufacturer no longer produces or sells Micardin capsules. All information on the manufacturer's website is now dedicated to the new version of the drug. If you are offered to purchase Micardin on third-party sites, then this is most likely a counterfeit or expired product.

GO TO THE MANUFACTURER'S SITE

Side effects

From the respiratory system: shortness of breath, respiratory distress syndrome .
From the circulatory system: tachycardia , arrhythmias , bradycardia , severe decrease in blood pressure.
From the nervous system: fainting, paresthesia , dizziness, insomnia , anxiety, depression , excitability, headache.
From the digestive system: flatulence, diarrhea, dry mouth, abdominal pain, constipation, gastritis, hypercholesterolemia, hyperglycemia, pancreatitis, jaundice, dyspepsia.
Skin: sweating.
From the musculoskeletal system: muscle spasms, arthralgia , myalgia , arthrosis , chest pain.
From the hematopoietic system: leukopenia, eosinophilia, anemia, neutropenia, thrombocytopenia, thrombocytopenia.
From the genitourinary system: renal failure, nephritis, glucosuria.
From the eyes: visual impairment, glaucoma, xanthopsia, acute myopia .
Infections: sepsis , respiratory tract infections ( pharyngitis, bronchitis, sinusitis ), inflammation of the salivary glands.
Metabolic disorders: increased creatinine, liver enzymes, creatine phosphokinase, uric acid in the blood, hypertriglyceridemia, hyperkalemia, hypokalemia, hypoglycemia, hyponatremia, decreased hemoglobin .
Allergic reactions : skin itching, angioedema , rash, erythema , anaphylactic reactions , eczema, systemic vasculitis, necrotizing vasculitis .

Interaction

When using telmisartan with:

other antihypertensive drugs – it is possible to increase the strength of the antihypertensive effect ;
lithium preparations – a temporary increase in lithium in the blood is possible;
non-steroidal anti-inflammatory drugs acute renal failure may occur in patients with a reduced volume of circulating blood;
digoxin – it is possible to increase the concentration of digoxin in the blood by 20%.

When using hydrochlorothiazide with:

barbiturates, ethanol or opioid orthostatic hypotension may develop ;
Metformin – possible development of lactic acidosis ;
hypoglycemic agents and insulin - dose adjustment of hypoglycemic drugs ;
cholestyramine and colestipol - possible inhibition of hydrochlorothiazide ;
non-depolarizing muscle relaxants – their effect may be enhanced;
cardiac glycosides – possible development of hypokalemia or hypomagnesemia ;
anti-gout medications – it is possible to increase the level of uric acid in the blood.
calcium preparations – it is possible to increase the concentration of calcium in the blood due to inhibition of its excretion by the kidneys.
amantadine – there may be an increased risk of developing undesirable effects of amantadine ;
m-anticholinergic blockers ( atropine , biperiden ) – possible weakening of intestinal motility, increasing the bioavailability of thiazide diuretics ;
non-steroidal anti-inflammatory drugs - may weaken the diuretic and antihypertensive effects .

Negative reviews

Tatyana Skoptsova: “I wanted to order from the manufacturer, but the price there seemed too high. Therefore, I looked for where else I could buy this Micardin. It turned out that it is sold in many online stores. I chose the one that offered the drug the cheapest. I ordered it and didn’t have to wait long – the parcel arrived in about a week. I paid for it at the post office, and because of this I didn’t suspect anything. I opened it at home, and there were just some white pills in blisters. Like glucose or aspirin... I didn’t take it. At first I wanted to return the money, but then I gave up - I couldn’t get through by phone, and the return address in the package was completely fictitious.”

Marina Korneeva: “These scammers were going to swindle money out of me - I leave a request, they call me back and say that I need to make an advance payment. I might agree. But I couldn’t even find any details on the website. I decided not to risk it.”

Editor's comment. Online product fraud is indeed widespread. This is exactly how scammers act – they send dummies or ask for an advance payment, after which they disappear. In order not to be left without medicine and without money, you need to order directly from the manufacturer , avoiding third-party resources.

Alexandra, 53 years old: “I started taking Micardin because I couldn’t lower my blood pressure. But this remedy did not give any effect - after two capsules, the results were zero. I will look for some other drug."

Daria Zavyalova: “The pressure stabilized after a couple of weeks of use. I was delighted and decided not to take it for a while, otherwise what was the point of wasting the medicine? But it turned out that literally after 5 days of the break the condition worsened again, and I had to return to treatment again. Now, after the full course, the condition has completely stabilized.”

Editor's comment. The instructions for the drug indicate that the best effect can be achieved only with course use. The course, in turn, must last at least four weeks. The action of Micardin is explained by the accumulation of useful substances and a general improvement in the condition of the cardiovascular system.

Ksenia, Vyazma: “I’m not that old, but my blood pressure is already rising. Either there is weakness in the whole body, or the head begins to spin at the wrong moment. It’s too early to take heavy drugs, and I decided to stop at Micardin, which, due to its natural composition, is much safer than pharmaceutical products. You have to order online, but that's not a problem for me. But at the same time I think, what about the elderly, for whom hypertension is usually one of the most serious problems? How are they? Who orders for them if they are unfamiliar with online shopping? But the product works, and it should be made more accessible. Ideally supply to pharmacies.”

Vladimir Ivanovich: “I don’t trust these online purchases. My opinion is this: if they don’t deliver it to pharmacies, then you shouldn’t take it.”

Editor's comment. Selling a product through the official website causes inconvenience for someone. But in this way, the manufacturer can insure against cheating by pharmacies, and also avoid the appearance of outright fakes in the pharmacy chain.

Lyudmila Kulikova: “At least they wrote somewhere how to correctly calculate the full course of treatment. The operator assured me that I should take 8 or even 10 packs. That supposedly, if you buy less, it won’t be enough for complete treatment. Well, in the end, I actually ordered 8 pieces. This amount, when taken 2 capsules per day, should be enough for almost 40 days, respectively. But I didn’t have to take it for so long. After four weeks of taking it, there is still one and a half packs left. I don’t know what to do with them. Still, it’s not such a cheap product to throw away.”

Ekaterina, 58 years old: “The ordered packages were not enough. I took 4 packs, they ran out after two weeks of treatment. I still had to prove it in order to be treated completely, as the recommendations say.”

Editor's comment. Indeed, in order to calculate a sufficient, but not excessive number of packages of the drug, you need to know in advance the required duration of the course, which ranges from 4 to 6 weeks, depending on the severity of the disease. This is why it is so important to provide as much detail as possible about your own situation when talking with a consultant.

Yulia Gulina: “It seems to me that the biggest problem here is the manufacturer’s unrealistic promises. I don’t understand how you can get rid of hypertension in severe stages? It is clear that after just one month-long course, the disease did not disappear anywhere. And it’s even difficult to imagine whether a lasting effect will appear after the second or third course.”

Editor's comment. And such a problem also exists. Advertising, as we have already found out, does not reflect the real situation. Indeed, to completely eliminate the symptoms of hypertension, complex and long-term treatment is necessary. And normalization of the condition to an ideal one is only possible in cases where the disease is in its initial stage. For this reason, it is advisable to start therapy as early as possible.

Nadezhda Yu.: “I have tried to deal with pressure before by taking natural folk remedies. And I can’t say that the effect was any outstanding. But Micardin, oddly enough, turned out to be very effective. But, if the drug really consists of natural ingredients, why does it work, but folk remedies don’t? In my opinion, the manufacturer is hiding real additives from us.”

Marina, Orel: “I have never had an allergic reaction or any other inconvenience to natural medicines before. And then I drank and my stomach began to churn. It looks like there is still some chemical in the capsules.”

Editor's comment. Although the product is natural, its effectiveness is not explained by any one component, but by their combination and the correct selection of dosage. As for side effects, they are possible due to individual intolerance or, which also occurs, due to administration on an empty stomach. Therefore, the reception should be as responsible as possible.

special instructions

In patients with coronary heart disease, the use of any blood pressure-lowering drug, in case of a strong decrease in pressure, can lead to the development of myocardial or cerebral infarction.

Micardis Plus has a weaker therapeutic effect in people of the Negroid race.

When driving vehicles, you should be aware of the possibility of dizziness and drowsiness after taking the drug.

Attention! Fraudsters do not sleep!

Every now and then in the news and information programs on TV there are stories about fraud on the Internet. The most common situation is the falsification of websites related to the processing of payments, passport and bank data. For example, only a couple of weeks ago they talked about the forgery of the State Services website. Using its fake copy, scammers lured out numbers and registration information about passports, after which they criminally issued loans to unsuspecting people.

The situation with Micardin is not much different. You need to purchase it directly from the manufacturer . But there are an incredible variety of other resources that allegedly offer this drug. What are the attackers doing?

They create a website whose design matches the original one.
Through it, applications are received from those who would like to purchase the product.
They call the numbers left by people and ask to transfer money for medicine as an advance payment.
For those potential buyers who avoid such a scam, a package is issued with payment by mail.
When the customer receives the package and pays for it, he discovers not the real product, but a cheap counterfeit.

Unfortunately, it is almost impossible to return the money after this, since the scammers use “fake” details. The number from which the operator calls his future victim turns out to be unreachable. The fake site will also be blocked soon.

Analogues of Mikardis Plus

Level 4 ATX code matches:
Diokor

Gizaar

Teveten Plus

Atacand Plus

Co Diovan

Vazar N

Valz N

The following analogues of the drug are known: Atakand Plus , Valzap Plus , Valsacor , Gizaar Forte , Co-Diovan , Teveten Plus and others.

Price Mikardis Plus

In Ukraine, the price of the drug in a dosage of 80 mg/12.5 mg No. 28 averages 450 hryvnia; in Russia, such a package will cost 855-1000 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

ZdravCity

Mikardis Plus tablets 80 mg + 12.5 mg 28 pcs. Boehringer Ingelheim
RUB 1,142 order

Pharmacy Dialogue

Mikardis plus tablets 80mg/12.5mg No. 28Boehringer Ingelheim
1102 rub. order
Mikardis plus (tab. 80 mg/12.5 mg No. 28)Boehringer Ingelheim
RUB 1,119 order