Oftalmoferon: how to take eye drops

Diseases of the eyelids and conjunctiva have the largest share (24.2 and 68.1%, respectively) in the structure of inflammatory eye diseases, the number of cases of which is recorded up to 18 million annually [1]. Chronic year-round allergic conjunctivitis, often accompanied by involvement of the eyelids in the pathological process, deserves special attention. In recent years, the prevalence of this pathology exceeds 23% of the total number of allergic eye diseases [2, 3]. The etiological factor of this disease can be any allergen, either independently or as a polyvalent, as well as cross-allergy [2, 4, 5]. Hypersensitivity to pollen, household, epidermal, infectious (chlamydial - Chl

.
psittaci
, bacterial, fungal, etc.) and especially food allergens. It is generally accepted that the development of such processes is based on a delayed type allergic reaction (type IV - cell-mediated immune reactions) [2, 4, 6, 7]. However, polyvalent allergies and cross-allergic reactions additionally include mechanisms of rapid immune response - type I, and the reaction to food allergens, which often accompanies the pathology in question, - immune response type III (damage by immune complexes) [4, 7, 8].

In the diagnosis of chronic year-round allergic conjunctivitis, a carefully collected allergological history is important, which in 70% of cases allows one to correctly assume the etiological allergen. A clarifying diagnosis is made using skin allergy tests, laboratory allergy diagnostics (provocative tests, radioallergosorbent test, enzyme-linked immunosorbent assay, as well as tests using the CAP-system, MAST-CLA-system, etc. are carried out) and, finally, the method of detecting eosinophils in scrapings from conjunctiva (from 4.0 to 90.0%) and in the blood (10.0–12.0%) [4, 8].

The opportunistic Demodex

, which can be found on the eyelashes in 39-88% of patients with blepharoconjunctivitis under 70 years of age and in every patient over 70 years of age [6, 9]. In such cases, a delayed type allergic reaction develops (type IV - cell-mediated immune reactions), predisposing to allergic reactions to other antigens, especially bacterial ones [10]. The relevance of this problem is also associated with the fairly frequent (in relatively healthy individuals) detection of microflora in the conjunctival cavity in such patients [11, 12].

Treatment of patients with allergic blepharoconjunctivitis is based on the systemic and local use of antiallergic drugs (antihistamines, mast cell membrane stabilizers and drugs with a combined effect), many of which can also be used in the treatment of children (Table 1).

Table 1. Main directions of therapy for patients with chronic allergic blepharoconjunctivitis

Of the antihistamines, the most widely used is azelastine, which selectively blocks H1 receptors, stabilizes mast cell membranes, slows down the formation and release of biologically active substances, and also reduces the number of eosinophils and molecular adhesion cells. Cromoglycic acid is most often used as a mast cell membrane stabilizer.

At the same time, combination drugs that simultaneously have an antihistamine and mast cell stabilizing effect are increasingly used in the treatment of patients with this profile. Among them is olopatadine, approved for use in children from 3 years of age.

In addition, a number of drugs from the pharmacological group under consideration contain a combination of several active ingredients. Thus, the combination of diphenhydramine hydrochloride (a first-generation histamine H1 receptor antagonist) with the alpha-adrenergic agonist naphazoline is used in the drugs “Betadrin” and “Polinadim”. The combination of loratadine (a long-acting blocker of H1-histamine receptors that inhibits the release of histamine and leukotriene C4 from mast cells) with human recombinant interferon alpha-2b is presented in the domestic drug “Allergoferon” (gel for local and external use, manufactured by a biotechnology company FIRN M).

The original combination of human recombinant interferon alpha-2b with diphenhydramine hydrochloride (Ophthalmoferon eye drops, FIRN M) turned out to be widely in demand in pediatric ophthalmology [3, 9, 13-16]. The literature provides numerous information proving the immunomodulatory, antiviral, disinfectant, antiproliferative, and anti-inflammatory effects of this drug in both adults and children. It was also noted that the drug additionally has an antihistamine effect and partly has the properties of artificial tears [1-3, 5, 6]. At the same time, the researchers did not note any adverse events of either a local or systemic nature [1, 5, 8, 13, 14].

At the same time, there is little data indicating the possibility of using the drug in question in patients with chronic blepharoconjunctivitis, in the pathogenesis of which allergic reactions are of great importance, and dry eye syndrome is diagnosed more often than in 80.0% of cases [17]. These circumstances were the reason for carrying out this study.

The purpose of the work is to study the possibilities of using the drug “Ophthalmoferon” in the treatment of children with chronic allergic and demodectic blepharoconjunctivitis.

How to treat conjunctivitis.

August 17, 2021
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1

Content

• Symptoms of conjunctivitis
• Types of conjunctivitis
• How to treat conjunctivitis
• The most effective drops for conjunctivitis
• Ciprofloxacin-Optic
• Montevisin
• Levomycetin
• Opatanol
• Oftalmoferon
• Aktipol
• Drops for conjunctivitis for children
• Tsiprolet
• Diclofenac
• Vitabact
• Visine Classic

Conjunctivitis

is a common eye disease in which the mucous membrane of the eyeball, the inside of the eyelids and the sclera (the “white” of the eye) become inflamed.

Conjunctivitis usually does not pose a health risk and can go away on its own without treatment, but there are forms of conjunctivitis that cause complications or are contagious.

Types of conjunctivitis

There are two main forms

conjunctivitis: infectious and allergic.

1. Infectious conjunctivitis
   (viral, bacterial, fungal or chlamydial).
2. Allergic conjunctivitis
   (develops as an allergic reaction to various types of irritants).

In addition, conjunctivitis can be acute and chronic.

Causes of conjunctivitis

Photos from open sources

Cause of bacterial conjunctivitis

usually become streptococcal and staphylococcal bacteria. With this type of conjunctivitis, pus is released from the eyes.

Viral conjunctivitis

develop due to adenoviruses, herpes virus, etc. With viral conjunctivitis, the mucous membrane of the eye is irritated, there is redness, and lacrimation. Often a person has a fever, general weakness, headache, cough, runny nose.

Allergic conjunctivitis

occur due to contact with an allergen (plant, house dust, animal hair, certain products, household chemicals, cosmetics, etc.). In addition to the above symptoms, allergic conjunctivitis is accompanied by severe itching of the eyes.

Indications for use

The drops contain 2 components:

• interferon alpha-2a – has broad antiviral properties, additionally has an immunomodulatory, antimicrobial, anti-inflammatory, regenerating effect;
• diphenhydramine – has antiallergic, decongestant, local analgesic effect.

An auxiliary component is boric acid, which has an antiseptic effect and prevents the development of superinfection. Another useful additional substance is hypromellose, which is part of the drops for dry eye syndrome. In this preparation, it retains the drops on the surface of the cornea and prolongs their therapeutic effect.

The drug is not used as a means to relieve symptoms of dry eye syndrome, only as an additional measure to the main treatment.

The drug affects 3 groups of viruses: adenovirus, herpes virus, enterovirus.

Thanks to the components included in the composition, the drops are used for the following indications:

• conjunctivitis caused by enterovirus, adenovirus, herpes virus;
• keratitis provoked by adenovirus and herpes virus, accompanied by or without corneal ulcerations;
• keratoconjunctivitis caused by herpes virus and adenovirus;
• uveitis and keratouveitis of herpetic nature;
• prevention of infectious complications after surgical interventions.

How to treat conjunctivitis

Treatment of conjunctivitis should be aimed at eliminating the causes that caused it. And the causes of the disease can be determined by an ophthalmologist.

For bacterial

form, you need to wash your eyes with saline solution, plus the doctor prescribes drops for conjunctivitis.
Viral
conjunctivitis is usually not treated (like colds), since there are no special antiviral drugs for this disease - the person recovers on his own.
If necessary, treatment is reduced to symptomatic therapy to reduce negative symptoms (artificial tears, cool compresses). Allergic
conjunctivitis involves eliminating the causes of allergies.

Basic rules of hygiene when treating conjunctivitis:

• If you wear contact lenses, remove them until you recover;
• do not touch your eyes with your hands;
• wash your hands frequently and thoroughly;
• exclude close contact with others;
• during illness you should have your own soap and towel, change pillowcases and bed linen as often as possible;
• with conjunctivitis, women need to give up eye cosmetics;
• Ventilate the room you are in more often.

Treatment regimens for retinal angiopathy

Drug therapy in the case of angiopathy and its vascular complications should be comprehensive. If necessary, treatment can be continued in courses. Before prescribing it, an ophthalmologist develops a specific, most effective regimen for using drugs. As a rule, these are the following appointments:

• Drug therapy aimed at activating blood circulation in the vessels of the eyes is necessary. This is a course treatment with Emoxipin, Vazonit, Mildronate, Arbiflex, Solcoseryl, Trenatal. They help activate local microcirculation processes. Another property of these drugs is improving the plasticity of red blood cells. This allows them to move faster through the small vessels of the eyes.
• Pentoxifylline and Curantil help prevent possible thrombus formation. Xanthiol nicotinate and nicotinic acid improve blood rheology.
• To reduce vascular permeability, ginkgo biloba and calcium dobesilate are prescribed.
• Actovegin injections are designed to provide better nutrition to the eye tissues. To improve metabolic processes in eye tissues, ATP and cocarboxylase are used.
• It is mandatory to take vitamin complexes to maintain eye health - Lutein-intensive, Anthocyan Forte. It is important to take ascorbic acid, which accelerates microcirculation processes in blood vessels and maintains visual acuity.
• For diabetic retinopathy, it is necessary to adhere to a special diet that can neutralize diabetes mellitus and improve blood flow in the retinal vessels. It is worth remembering that prohibited foods include any food rich in fast carbohydrates (baked sweets, sweet soda, etc.). The same applies to excessively high-calorie foods. Limiting salt is also important, because it helps normalize metabolism and improve recovery processes.
• Vigorous physical exercise, included in the daily routine to give energy to the muscular system, also improves the condition of the eye vessels.
• When treating angiopathy caused by hypertension, it is mandatory to lower blood pressure levels through medications and specially designed dietary adjustments. To do this, you should contact a cardiologist and nutritionist.
• It would not be superfluous to prescribe physiotherapeutic procedures. In the case of angiopathy, magnetic therapy courses and acupuncture can show good results.
• Another physiotherapeutic method is “Sidorenko Glasses”. This device combines the effects of pneumomassage, infrasound, phonophoresis, and color therapy. The powerful effect on the retina of such a complex makes it possible to achieve good results in a short time.
• Treatment also helps with massage courses on the cervical spine.

Ciprofloxacin-Optic

Ciprofloxacin-Optic drops are an inexpensive broad-spectrum antibiotic that copes well with purulent conjunctivitis. These eye drops are odorless and come in a glass bottle. Dosing the drug is very convenient thanks to the narrow spout-tip. Literally a day after using Ciprofloxacin, pus stops coming out of the eyes, and after three days of treatment, conjunctivitis completely disappears. Eye drops do not “harm” the eyes, and patients note a rapid recovery: swelling of the eyelids, inflammation and burning in the eyes disappear. If you want to quickly cure conjunctivitis, use Ciprofloxacin drops, strictly following the instructions.

Ciprofloxacin-Optic

OJSC Pharmstandard-Leksredstva, Russia

Treatment of corneal ulcers and infections of the anterior segment of the eyeball and its appendages caused by bacteria sensitive to ciprofloxacin in adults, newborns (from 0 to 27 days), infants and infants (from 28 to 23 months), children (from 2 to 11 years) and teenagers (from 12 to 18 years old).
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Shelf life and storage

An unopened dropper bottle can be stored for 2 years from the date of release. Opening the medicine reduces the shelf life to 30 days from the date of first use.

To ensure the safety of the properties stated in the instructions, the drops must be stored in the refrigerator - from 2 to 8 degrees. Fast transportation without cold is allowed. The bottle must also be protected from light.

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Montevisin

Eye drops for conjunctivitis "Montevisin" are excellent value for money. This is a kind of “first aid” for conjunctivitis, when you need to quickly get rid of symptoms. Drops instantly relieve eye fatigue, pain, pain, swelling and redness. A few minutes after instillation, the vascular network is no longer so visible, the view becomes clearer. But Montevisin has a number of contraindications associated with high blood pressure and heart disease, so be sure to consult your doctor. Thanks to the convenient pipette, it is very convenient to use Montevisin eye drops.

Montevisin

Swelling of the conjunctiva, secondary hyperemia in allergic eye diseases, irritation of the conjunctiva;
- hyperemia and/or swelling of the conjunctiva caused by various nonspecific causes (condition after tonometry, dust, cigarette smoke, smog, swimming, reading, driving). from 132

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Levomycetin

Drops for conjunctivitis "Levomycetin" are prescribed to both adults and children. This drug treats bacterial conjunctivitis, blepharitis and blepharoconjunctivitis, keratitis and keratoconjunctivitis, and secondary bacterial infections. Once on the eyeball, these drops destroy pathogenic microflora and unpleasant symptoms; eye inflammation goes away within a few days. Ophthalmologists recommend dripping Levomycetin into your eyes every 2-3 hours for a week or more (it all depends on the specific case). The active ingredient of Levomycetin is chloramphenicol, which destroys bacteria on the mucous membrane of the eye. Levomycetin drops effectively fight staphylococci, salmonella, gonococci, spirochetes and other harmful microorganisms. Conjunctivitis can be treated with Levomycetin drops for children over 3 years old. Please note the short shelf life of the drops after opening the bottle, as well as the list of side effects.

Levomycetin

Slavyanskaya Pharmacy, Russia; Lecco FF ZAO, Russia; PJSC "Biopharma", Ukraine

A drug for the prevention and treatment of infectious eye diseases: conjunctivitis, blepharitis, keratitis.
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Opatanol

Drops for conjunctivitis "Opatanol" produced in Belgium are used for the allergic nature of the disease. "Opatanol" is intended for adults and children over 3 years old. These drops are also suitable for pregnant women. To treat allergic conjunctivitis, you need to use these eye drops 2 times a day, but do not forget to shake the bottle before each drop. Opatanol is well tolerated and has almost no side effects. The active substance of the drug is olopatadine hydrochloride, which triggers anti-allergenic mechanisms.

Opatanol

Alkon, Switzerland

Opatanol - decongestant and antiallergic eye drops for use in ophthalmology.
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Oftalmoferon

“Ophthalmoferon” for conjunctivitis is a drug that not all doctors have a positive attitude towards, indicating that it does not have a sufficient evidence base. The manufacturer positions these antiviral eye drops as the most powerful in the fight against conjunctivitis. "Ophthalmoferon" is suitable for adults and children, and is indicated during pregnancy. Eye drops destroy bacteria in the conjunctiva, on the membrane of the eye, and on the mucous membrane of the eyelids. Some ophthalmologists prescribe these drops to prevent viral eye diseases. The active substance of the product - interferon - relieves inflammation, stimulates the immune system, and kills viruses. "Ophthalmoferon" also contains acid with diphenhydramine, which works as an antiseptic. All components of these drops for conjunctivitis are safe for the body and are not absorbed into the blood. Remember that after opening the bottle, Oftalmoferon drops must be stored in the refrigerator.

Oftalmoferon

Firn M, Russia

adenoviral, hemorrhagic (enteroviral), herpetic conjunctivitis;
adenoviral, herpetic (vesicular, punctate, tree-like, map-shaped) keratitis; herpetic stromal keratitis with and without corneal ulceration; adenoviral and herpetic keratoconjunctivitis; herpetic uveitis and herpetic keratouveitis (with and without ulceration); dry eye syndrome; prevention of graft disease and prevention of relapse of herpetic keratitis after keratoplasty; prevention and treatment of complications after excimer laser refractive surgery of the cornea. from 232

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Release form

Oftalmoferon is an antiviral drug in the form of eye drops, produced by the Russian pharmaceutical plant FIRN M. The bottle capacity is 10 ml. Ease of use is ensured by the existing pipette.

When stored correctly and within the expiration dates, the drug has no color or a slightly yellowish tint without sediment or foreign impurities. If there is a change in color, precipitation, or the appearance of suspensions and impurities, the medicine cannot be used.

Aktipol

Actipol drops for conjunctivitis are suitable for advanced stages of the disease. "Aktipol" not only treats conjunctivitis, but also strengthens local immunity. Often these eye drops are prescribed for ARVI and herpes. "Aktipol" also helps relieve inflammation in case of minor eye bruises and damage to the mucous membrane in those who wear lenses. You need to drip Actipol into your eyes 3 to 8 times a day. The drug helps to completely cure conjunctivitis in a week or two. The main active ingredient of these eye drops is para-aminobenzoic acid, which strengthens local immunity, thanks to which the body independently resists viruses. "Aktipol" can be used by pregnant women in the second and third trimester.

Aktipol

Diapharm, Russia

Actipol is an ophthalmic antiviral agent that is an inducer of endogenous interferon.
In addition to the antiviral effect, it has antioxidant and regenerative properties. from 232

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Instructions for use for children

The maximum time for using the drug in pediatric practice is determined by the complete cure and disappearance of the symptoms of the disease.

The average course of treatment for the prevention of infectious complications is 10-14 days. For the treatment of conjunctivitis and keratitis of various natures, the duration of therapy is up to a month. In the acute stage, the medicine is used up to 6-8 times a day, 1-2 drops in each eye.

As you recover, the number of installations is reduced to 2-3 times a day.

When instilling, it is important not to touch the eye mucosa with the tip of the pipette, so as not to transfer the pathogen and cause a superinfection. Residues of the drug should be wiped off the dropper bottle with a clean, sterile swab.

For better distribution of the drops after installation, you need to lightly press the inner corner of the eye with your finger and massage.

Tsiprolet

Tsiprolet eye drops are inexpensive (compared to analogues), but are very effective for childhood conjunctivitis. One bottle of this Indian drug is enough to completely get rid of conjunctivitis in a child. If you follow the instructions and apply drops to your child’s eyes every 5 hours for three days, the symptoms of conjunctivitis will completely go away. "Tsiprolet" can be used in children from 1 year of age. The duration of treatment for conjunctivitis is no more than 1 week. “Tsiprolet” perfectly relieves inflammation of the eyes, it is sold in a convenient package, but it stings a little, so take this point into account.

Tsiprolet

Dr. Reddy's Laboratories, India

Tsiprolet eye drops are an aqueous solution of ciprofloxacin for topical use in ophthalmology.
The drug belongs to antimicrobial drugs from the fluoroquinolone group, exhibits a bactericidal effect against most gram-negative and gram-positive bacteria, and is used to treat bacterial eye diseases (conjunctivitis, keratitis), including those caused by microorganisms resistant to other groups of antibiotics. from 45

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Research results

In children with allergic blepharoconjunctivitis (group 1), in both compared subgroups, after 1 week of therapy, stable positive dynamics were noted in relation to most objective clinical signs of blepharoconjunctivitis (Table 2). Thus, the indicators of hyperemia of the edges of the eyelids and conjunctiva were 1.2±0.2 compared to the initial 2.5±0.2 in the first subgroup and 1.7±0.1 compared to 2.4±0.2 in the second (control) subgroup ( p

<0.01).
Similar dynamics can be observed in relation to the pastiness of the eyelids (1.0±0.2 and 2.1±0.2; 1.6±0.2 and 2.3±0.2, respectively, p
<0.01).

Table 2. Dynamics of the severity of objective clinical signs of blepharoconjunctivitis (M ± m) in children receiving various therapies (n=34, 68 eyes) Note.
Here and in Table 3: * - determined on a 4-point scale: 0 - absence of a characteristic, 1 - subtle manifestations of a characteristic, 2 - distinct manifestations of a characteristic, 3 - pronounced manifestations of a characteristic; ♦ — differences compared to the original data are statistically significant (p<0.05—0.001); ♥ — differences compared to the values ​​in the corresponding comparison subgroup are statistically significant (p<0.05—0.001). Moreover, already from the 1st week of treatment, the dynamics of the severity of hyperemia of the edges of the eyelids and conjunctiva, as well as the pastiness of the eyelids in subgroup A (patients of which, in addition to basic therapy, received Oftalmoferon) turned out to be significantly more positive in comparison with the corresponding indicators of subgroup B ( control) (1.2±0.2 and 1.7±0.1; 1.0±0.2 and 1.6±0.2 points, respectively, p

<0.01). It is noteworthy that the differences between the controlled indicators of both subgroups remained statistically significant for 2 weeks.

The exception was the dynamics of the thickness of the eyelid margins, for which reliable results were obtained only after 2 weeks of therapy. However, they did not differ significantly in the compared subgroups.

As can be seen from table. 3, a similar trend can be seen in relation to the dynamics of subjective symptoms of allergic blepharoconjunctivitis. Thus, already from the 1st week of treatment in both subgroups there was a statistically significant decrease in the severity of eyelid severity, discomfort and itching ( p

<0.01).
At the same time, patients who received additional instillations of Oftalmoferon, in contrast to patients in the control subgroup, significantly less often complained of itching of the eyelids for 2 weeks ( p
<0.01) and sensations of heaviness of the eyelids for 4 weeks (
p
<0.01), respectively .

Table 3. Dynamics of the severity of subjective symptoms of blepharoconjunctivitis (M±m) in children receiving various therapies (n=34, 68 eyes)
With demodectic blepharoconjunctivitis (group 2) as well as with a chronic allergic process (group 1 ), regardless of the treatment regimen used, significant ( p

<0.01) a decrease in the severity of hyperemia of the edges of the eyelids and conjunctiva, as well as the pastiness of the eyelids, was noted already in the 1st week of therapy (see Table 2).
Moreover, in subgroup A, against the background of additional instillations of Oftalmoferon, the dynamics of these indicators in the 1st week of treatment turned out to be significantly more pronounced than in subgroup B (control) ( p
<0.01).
Thus, indicators of pasty eyelids, as well as hyperemia of the edges of the eyelids and conjunctiva in children receiving instillations of Oftalmoferon were 0.9±0.1 and 0.8±0.1, respectively, compared to 1.3±0.1 and 1. 6±0.2 in the control subgroup ( p
<0.01). At the same time, a significant difference in the indicators of both subgroups also persisted during the first 2 weeks of therapy.

The dynamics of subjective symptoms of chronic demodectic blepharitis (see Table 3) obeys the patterns noted above. Thus, in both subgroups, already from the 1st week of treatment, there was a significant decrease in the severity of sensations of heaviness of the eyelids, discomfort and itching ( p

<0.01).
At the same time, children from subgroup A, in comparison with patients in subgroup B, significantly less often ( p
<0.01) complained of itching of the eyelids and a feeling of heaviness of the eyelids within 2 weeks, and of discomfort during the 1st week of therapy .

In addition, it was found that in patients with demodectic blepharoconjunctivitis, 4-week instillations of Oftalmoferon into the conjunctival cavity affected the acarogram indicators (8.6 ± 0.1 before treatment compared with 2.9 ± 0.3 at the 6th week of therapy , p

<0.005) in contrast to the data of the control subgroup (8.3±0.3 compared with 4.6±0.3,
p
<0.01).
This may be due to the stimulation of the patient's local immunity by recombinant interferon alpha-2b, which appears to be reflected in the life cycle of the Demodex
.

As can be seen from table. 4, in patients with allergic and demodectic blepharoconjunctivitis who received Ophthalmoferon instillations, a slightly more pronounced decrease in cellular infiltration of the conjunctiva by eosinophils was noted, which, however, did not manifest statistically significant differences ( p

>0,01).

Table 4. Frequency of detection of eosinophils in cytograms of scraping material from the conjunctiva in patients with chronic blepharoconjunctivitis (n = 10, 20 eyes)
And, finally, against the background of the therapy, a significant decrease in the patients’ need for tear replacement therapy was noted. Thus, the frequency of instillations of tear substitutes for children of the 1st and 2nd groups, who additionally received Oftalmoferon, decreased (or their need was completely absent) on average from 2.2±0.3 to 1.0±0.3 and from 2 .4±0.2 to 1.1±0.2, respectively ( p

<0.01).
In subgroups B - only from 2.4±0.3 to 2.0±0.3 and from 2.2±0.3 to 1.9±0.2, respectively ( p
>0.05).

The full therapeutic effect (registered when the severity of the analyzed symptoms of blepharoconjunctivitis was from 0 to 1) in all children with chronic allergic blepharoconjunctivitis was achieved by the 4th week of therapy, without a significant difference between the indicators of the compared subgroups. In children with demodectic blepharoconjunctivitis, regardless of the type of therapy used, a similar result was obtained only by the 6th week of treatment.

Throughout the study, we did not identify any undesirable side effects from the use of these treatment regimens for chronic blepharoconjunctivitis in all compared subgroups of patients.

Diclofenac

Diclofenac eye drops relieve inflammation in conjunctivitis and are prescribed after injuries and eye surgeries to reduce pain. The active ingredient of the drug is diclofenac sodium, which, due to its rapid absorption into the blood, instantly relieves unpleasant symptoms. Use Diclofenac drops strictly according to the instructions, since the drug has contraindications and side effects (allergies, itching, swelling, nausea and vomiting). An opened bottle of Diclofenac can be stored for a month.

Diclofenac drops

Sintez OJSC, Russia

Has anti-inflammatory and analgesic effects.
In inflammatory processes that occur after operations, it relieves pain and reduces inflammatory swelling at the wound site. from 20

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Interaction with other drugs

Drops do not have a negative effect on other drugs. They can be prescribed together with antibacterial drugs (Tsipromed, Tobrex, etc.), glucocorticoids (Dexamethasone), and combination drugs (Dexa-Gentamicin).

Oftalmoferon is also compatible with local anesthetics and anti-inflammatory drugs (Nevanak, Diclofer, Diclofenac).

The medicine has a therapeutic effect for dry eye syndrome and can be used with drugs that are substitutes for natural and artificial tears. Due to the content of hypromellose, the drops retain other medications on the surface of the eye, increasing the time and effect of their action.

Vitabact

Vitabact eye drops produced in France are the safest broad-spectrum antimicrobial agent. Vitabact drops for conjunctivitis are indicated even for newborns. “Vitabakt” not only relieves eye inflammation and reduces purulent discharge, but also directly affects the causative agents of the disease. Judging by the reviews, these eye drops moisturize the eyes well, relieve mucous membrane irritation and discomfort. Among the disadvantages of Vitabact are the rather high price and short shelf life after opening the bottle (1 month). Parents say that these drops for conjunctivitis are well tolerated even by the youngest children because they do not cause a burning sensation.

Vitabact

Novartis Pharma Services AG (Novartis Pharma), Switzerland

Adults and children from 0 years: - bacterial infections of the anterior part of the eye;
- dacryocystitis; — prevention of infectious complications in the postoperative period after surgical interventions in the anterior eye area. from 156

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How to take it correctly

Oftalmoferon can be used until the symptoms completely disappear, as well as for preventive purposes.

Dry eye syndrome

You should use the product twice a day, 2 drops. Duration of use – 3-4 weeks.

Viral lesions

Children and adults with acute illness need to drip 2 drops 6-7 times a day. If there is an improvement in the condition, then the number of instillations per day can be reduced to 3 times.

For prevention purposes

Eye drops are used for prophylactic purposes after surgery on the cornea of ​​the eye. The product must be used every day. Instill 2 drops twice a day per day. Duration of treatment – ​​10 days.

In case of graft disease, as well as in order to prevent the recurrence of herpetic keratitis, drops should be used every day. Apply 3-4 drops 3-4 times a day. Duration of treatment is 2-3 weeks.

Important! If you have contact lenses, you need to remove them and only then apply eye drops. They can be put on no earlier than 20 minutes after completion of the procedure.

Visine Classic

These American-made eye drops are great for patients with allergic conjunctivitis. Literally 5-7 minutes after instillation, the condition of the eyes noticeably improves. The positive effect after Visin Classic lasts 4-8 hours. Visin Classic drops for conjunctivitis relieve inflammation, dry mucous membranes, swelling and redness if they are caused by wearing lenses, a reaction to dust and cosmetics, or chemical irritants. Visin Classic can be used in children from 2 years of age, but only if there are indications for this (inflammation and swelling). Allergic conjunctivitis with proper use of the drug goes away in 3-4 days.

Visine Classic