General information
Trade name Galavit®
Registration number P N000088/03
INN or group name Aminodihydrophthalazindione sodium
Chemical name 5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt
Dosage form Rectal suppositories
Compound
Active substance - sodium aminodihydrophthalazindione (Galavita) 100 mg; excipients - vitepsol W-35 (fatty acid glycerides) - 575 mg, vitepsol H-15 (fatty acid glycerides) - 575 mg.
Pharmacotherapeutic group
Immunomodulatory and anti-inflammatory agent.
ATX code L03, G02
Pharmacological properties
Pharmacodynamics
The mechanism of action of the drug is associated with the ability to influence the functional and metabolic activity of macrophages.
In inflammatory diseases, the drug reversibly inhibits for 6-8 hours the excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, reactive oxygen species by hyperactivated macrophages, which determine the degree of inflammatory reactions, their cyclicity, as well as the severity of intoxication. Normalization of the functional state of macrophages leads to the restoration of the antigen-presenting and regulatory functions of macrophages and a decrease in the level of autoaggression. Stimulates the bactericidal activity of neutrophil granulocytes, enhancing phagocytosis and increasing the body's nonspecific resistance to infectious diseases.
Pharmacokinetics
It is excreted from the body mainly through the kidneys. After rectal administration, the half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours.
Russia, 123290, Moscow, dead end Magistralny 1st, 5A, room. 91 Tel/fax 8-800-707-71-81 E-mail: [email protected] ; https://www.galavit.ru Address of production site 308013, Belgorod, st. Rabochaya, 14 Send claims to the address 123290, Moscow, dead end Magistralny 1st, 5A, room. 91. Tel. 8-800-707-71-81
Indications for use
In adults and adolescents over 12 years of age (including those with secondary immune deficiency) as an immunomodulatory and anti-inflammatory agent in complex therapy:
- infectious intestinal diseases accompanied by intoxication and/or diarrhea
- peptic ulcer of the stomach and duodenum
- viral hepatitis
- chronic recurrent diseases caused by the herpes virus
- diseases caused by human papillomavirus
- infectious and inflammatory urogenital diseases (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingoophoritis, endometritis)
- purulent-inflammatory diseases of the pelvic organs
- postoperative rehabilitation of patients with uterine fibroids
- complications of the postoperative period in women of reproductive age
- purulent surgical diseases (burn lesions, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy)
- postoperative purulent-septic complications and their prevention (including in cancer patients)
- chronic recurrent furunculosis, erysipelas
- asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including in athletes); mental, behavioral and post-withdrawal disorders in alcohol and drug addiction
- inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases
- frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent ARVI, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis) and their prevention
Directions for use and doses
Rectally. The suppository is released from the contour packaging and then inserted into the rectum. It is recommended to empty the intestines first. The dose and duration of use of the drug depends on the nature, severity and duration of the disease.
- For acute infectious intestinal diseases accompanied by diarrhea syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until the symptoms of intoxication are relieved. It is possible to subsequently continue the course of 1 suppository with an interval of 72 hours. A course of 20-25 suppositories.
- For gastric and duodenal ulcers in the acute period: 2 days, 2 suppositories once a day, then 1 suppository at intervals of 72 hours. A course of 15-25 suppositories. In the chronic period: 5 days, 1 suppository once a day, then one suppository every 72 hours. Course of 20 suppositories.
- For viral hepatitis: the initial dose is 2 suppositories once, then one suppository 2 times a day until the symptoms of intoxication and inflammation subside. Subsequent continuation of the course of 1 suppository with an interval of 72 hours. Course 20 -25 suppositories.
- For chronic recurrent diseases caused by the herpes virus: 1 tablet 4 times a day for 10 days. Then 1 tablet 4 times a day every other day for 10 days.
- For diseases caused by the papilloma virus: 5 days, 1 suppository once a day, then one suppository every other day. Course – 20 suppositories.
- For urogenital diseases - urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis: 1 day, 1 suppository twice, then one suppository every other day. A course of 10-15 suppositories (depending on the severity of the pathological process).
- For salpingoophoritis, endometritis in the acute period: 2 days, 2 suppositories once a day, then one at an interval of 72 hours. In the chronic period: 5 days, 1 suppository once a day, then one every 72 hours. Course - 20 suppositories.
- For acute and chronic purulent diseases of the pelvic organs - in the acute period: 1 day, 2 suppositories once, 3 days, one suppository daily, then one every other day for 5 days. Course - 10 suppositories. In the chronic period: 5 days, 1 suppository once a day, then one every 72 hours. Course - 20 suppositories.
- For postoperative rehabilitation of patients with uterine fibroids and complications of the postoperative period in women of reproductive age: 5 days, 1 suppository once a day, then one suppository every other day. Course - 15 suppositories.
- For the prevention and treatment of surgical complications in the pre- and postoperative period (including in cancer patients): 1 suppository is prescribed once a day - 5 suppositories before surgery, 5 after surgery, one every other day and 5 suppositories at intervals 72 hours. In severe cases of the disease, the initial dose is 2 suppositories once or 2 times a day, one at a time. Course - 20 suppositories.
- For chronic recurrent furunculosis, erysipelas: 5 days, one suppository once a day, then one suppository every other day. Course - 20 suppositories.
- For asthenic conditions, neurotic and somatoform disorders, for mental, behavioral and post-abstinence disorders, in patients with alcohol and drug addiction: 5 days, one suppository daily, then one suppository every 72 hours. A course of 15-20 suppositories. To increase physical performance: 1 suppository every other day – 5 suppositories, then one suppository after 72 hours, course – up to 20 suppositories.
- For inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases: initial dose of 1 suppository daily - 5 suppositories, then one at an interval of 72 hours. Course 15 suppositories.
- For nonspecific prevention and treatment of influenza and acute respiratory infections, one suppository 1 time per day. Course 5 days.
Precautionary measures
Contraindications
Individual intolerance; pregnancy and lactation.
Side effects
In rare cases, allergic reactions are possible.
Interaction with other drugs
With simultaneous use, it is possible to reduce the course doses of antibiotics. There are no cases of incompatibility with other drugs.
Shelf life, storage conditions
Storage conditions: Store at a temperature not exceeding 25 ° C, in a place protected from light. Keep out of the reach of children.
Shelf life: 3 years. Do not use after the expiration date indicated on the carton.
Conditions for dispensing from pharmacies Dispensed without a prescription.
What else is prescribed with this study?
Immune status (screening) (Phagocytic activity of leukocytes, cellular immunity, total immunoglobulin IgE, immunoglobulins IgA, IgM, IgG)
27.960. Ven. blood 3 days
7,640 ₽ Add to cart
Immune status expanded
17.61. Ven. blood 14 days
22 310 ₽ Add to cart
Cellular immunity (T-lymphocytes, T-helpers, T-cytotoxic cells, Immunoregulatory index, B-lymphocytes, NK-T cells, NK cells, Leukocyte formula)
17.50. Ven. blood 3 days
5 200 ₽ Add to cart
Release form and composition
Available in several dosage forms: powder for injection, tablets and rectal suppositories. The active ingredient is a synthetic low molecular weight drug aminodihydrophthalazindione sodium.
Storage conditions are common for all types of medicine: the drug should be left in a dry place, without direct sunlight, at a temperature not exceeding 25 °C. Shelf life 3 years.
Candles
Cylindrical in shape with a cut off tip, white in color, perhaps a slight yellow tint.
Galavit suppositories for prostatitis are available in two dosages: 50 and 100 mg of active ingredient.
Witepsol W35 and H15 (fatty acid glycerides) are used as a base.
Each candle is packed in a separate cell, in a blister of 5 pieces. The drug with a dosage of 50 mg contains 5 suppositories per package, with 100 mg – 10 pieces.
Pills
Intended for sublingual use (absorption under the tongue). Round, white with menthol aroma.
Tablets are available in a dosage of 25 mg of aminodihydrophthalazinedione sodium.
Excipients: talc, calcium stearate, lactose, sorbitol, starch, menthol.
They come in blister packs of 10 pieces, in a box there are 1 or 2 blisters.
Powder for injection
White crystalline powder, yellow tint is acceptable. The powder is intended for preparing a solution for intramuscular injections. Available in two dosages - 50 and 100 mg. Sold in boxes of 5 bottles.
References
- Sologub T.V., Osinovets O.Yu. Use of the immunomodulatory drug Galavit in the complex therapy of influenza // Clinician. 2012. No. 2.
- Ermishina V.I., Kazeko N.I., Oskolkov S.A. Results of using the immunomodulatory drug “Galavit” for complicated chronic pyelonephritis and urolithiasis // Tyumen Medical Journal. 2015. No. 3.
- Silin DS, Lyubomska OV, Ershov FI, Frolov VM, Kutsyna GA. Synthetic and natural immunomodulators acting as interferon inducers. Curr Pharm Des. 2009;15(11):1238-47. doi: 10.2174/138161209787846847. PMID: 19355963.
- da Silva EG, Gionfriddo JR, Hudachek SF, Gustafson DL, Olea-Popelka FJ, Scofield VL, Powell CC, Hill AE. Evaluation of the ocular penetration of topical alpha-luminol (Galavit®/GVT®). Vet Ophthalmol. 2011 May;14(3):180-5. doi: 10.1111/j.1463-5224.2010.00862.x. PMID: 21521442.
pharmachologic effect
The medicine produces a complex effect on the body:
- immunomodulatory;
- anti-inflammatory;
- antioxidant;
- regenerative properties.
The active substance quickly penetrates the source of inflammation and eliminates its causes. Activates the production of antibodies that help fight certain infectious agents. Strengthens the body's resistance to infections. Stimulates the body's production of interferon, which prevents the virus from reproducing.
As a result of taking the medicine, it is possible to cope with prostatitis in a short time and prevent inflammation from spreading to neighboring organs.
The drug enhances the effect of other medications used in the treatment of prostatitis, in particular antibacterial agents.
