Colds por d/prig solution with black currant flavor 5g N10

Composition and release form

in disposable bags made of combined material, 5 g each; There are 5 or 10 sachets in a cardboard pack.

Pharmacodynamics

Combined drug for symptomatic treatment of acute respiratory infections. Provides effective relief of cold and flu symptoms.

The effect of the drug is due to the components included in its composition.

Paracetamol - has an antipyretic and analgesic effect, reduces elevated body temperature and reduces pain (sore throat, headache).

Phenylephrine is a sympathomimetic, constricts the vessels of the nose, eliminates swelling of the mucous membrane of the nasal cavity and nasopharynx, resulting in a decrease in runny nose and easier nasal breathing.

Ascorbic acid (vitamin C) - replenishes the increased need for vitamin C during colds and flu, especially in the initial stage of the disease.

The onset of action is 20–30 minutes after administration, duration is 4–4.5 hours.

Side effects

Allergic reactions: sometimes - skin rash, itching, urticaria, angioedema.

From the hematopoietic system: rarely - thrombocytopenia, leukopenia, agranulocytosis.

From the digestive system: rarely - nausea, vomiting, epigastric pain.

Other: rarely - increased intraocular pressure, urinary retention.

With long-term use in excess of the recommended dose, hepatotoxic and nephrotoxic effects may occur.

Phenylephrine hydrochloride may cause nausea, headache, and increased blood pressure; rarely - palpitations. These symptoms disappear after discontinuation of the drug.

Storage conditions

In a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies

over the counter

Colds are a good choice. The quality of goods, including Colds, undergo quality control by our suppliers. You can buy Prostudox on our website by clicking on the “Add to cart” button. We will be happy to deliver Prostudox to you at any address within our delivery zone indicated in the “Delivery” section, or you can order Prostudox for pickup.

Interaction

Stimulators of microsomal oxidation in the liver (including phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxications with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity of the drug.

Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol.

With the simultaneous use of Prostudox® with ethanol, the development of acute pancreatitis is possible.

With the simultaneous use of Prostudox® with antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives, the risk of urinary retention, dry mouth, and constipation increases.

With the simultaneous use of Prostudox® with GCS, the risk of developing glaucoma increases.

When used simultaneously with Prostudox®, the hypotensive effect of guanethidine is reduced.

With simultaneous use of Prostudox® with guanethidine, the α-adrenergic stimulating effect is enhanced, and with tricyclic antidepressants, the sympathomimetic effect of phenylephrine is enhanced.

Concomitant use with Prostudox® reduces the effectiveness of uricosuric drugs.

When gastric emptying slows down (under the influence of propantheline), a delayed onset of the drug's effect may occur. By accelerating gastric emptying (after taking metoclopramide), the drug begins to act faster.

Prostudox® may enhance the effect of indirect anticoagulants.

Overdose

An overdose of paracetamol appears after taking 10–15 g (15–20 packs of Prostudox®).

Symptoms: discomfort in the epigastric region, nausea, vomiting, pallor of the skin, loss of appetite, hepatonecrosis (the severity of necrosis directly depends on the degree of overdose), increased activity of liver transaminases, increased prothrombin time (12–48 hours after administration). The full clinical picture of liver damage appears after 1–6 days. Rarely, liver dysfunction develops suddenly and can be complicated by renal failure (renal tubular necrosis).

Treatment: symptomatic, gastric lavage, administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N- acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Colds por d/prig solution with black currant flavor 5g N10

Registration Certificate Holder

SYNTHESIS (Russia)

Dosage form

Medicine - Prostudox®

Description

Powder for solution for oral administration

White to almost white in color with a blackcurrant scent.

1 pack

paracetamol 750 mg phenylephrine hydrochloride 10 mg ascorbic acid 60 mg

Excipients

: sodium citrate pentahemihydrate, citric acid, sodium saccharinate, currant flavoring (food powder “blackcurrant” flavoring), sugar.

5 g - disposable bags (5) - cardboard packs. 5 g - disposable bags (10) - cardboard packs.

Indications

• cold and flu symptoms (fever, headache, chills, nasal congestion, sore throat when swallowing).

Contraindications for use

• diseases of the cardiovascular system (severe aortic stenosis, acute myocardial infarction, tachyarrhythmia);
• arterial hypertension;
• diabetes;
• prostatic hyperplasia;
• angle-closure glaucoma;
• thyrotoxicosis;
• pheochromocytoma;
• pregnancy;
• lactation period;
• children's age (up to 14 years);
• simultaneous use of tricyclic antidepressants, beta-blockers, MAO inhibitors (including within 14 days after their discontinuation);
• simultaneous use with other paracetamol-containing drugs;
• hypersensitivity to the components of the drug.

Should be done with caution

use the drug for renal/liver failure, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), COPD, glucose-6-phosphate dehydrogenase deficiency, blood diseases, and in elderly patients.

pharmachologic effect

A combined drug, the effect of which is determined by its constituent components (NSAID paracetamol, alpha-adrenergic agonist phenylephrine and vitamin C). It has an antipyretic, analgesic (pain reliever), vasoconstrictor effect, and eliminates cold symptoms. Constricts nasal vessels, eliminates swelling of the mucous membrane of the nasal cavity and nasopharynx, and replenishes vitamin C deficiency during colds.

The onset of action is 20-30 minutes after administration, duration is 4-4.5 hours.

Drug interactions

Stimulators of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxications with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity of the drug.

Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol.

Ethanol contributes to the development of acute pancreatitis.

Antidepressants, antiparkinsonian, antipsychotic drugs, phenothiazine derivatives increase the risk of urinary retention, dry mouth, and constipation.

GCS increase the risk of developing glaucoma.

Phenylephrine reduces the hypotensive effect of guanethidine.

Guanethidine enhances the alpha-adrenergic stimulating effect, and tricyclic antidepressants enhance the sympathomimetic effects of phenylephrine.

The drug reduces the effectiveness of uricosuric drugs.

If gastric emptying is delayed (propantheline), the onset of the drug's effect may be delayed.

By accelerating gastric emptying (metoclopramide), the drug begins to work faster.

The drug may enhance the effect of indirect anticoagulants.

Dosage regimen

For adults

and
children over 14 years of age
should take 1 sachet every 4-6 hours, but no more than 4 sachets within 24 hours.
The drug is not recommended to be taken for more than 5 days without consulting a doctor.
If symptoms persist, you should consult a doctor. Pour the contents of 1 sachet into a glass and fill it with hot water, stir until completely dissolved and add sugar or honey to taste.

Overdose

An overdose of paracetamol appears after taking 10-15 g (15-20 sachets of Prostudox).
Symptoms:
discomfort in the epigastric region, nausea, vomiting, pallor of the skin, loss of appetite, nausea, vomiting, hepatonecrosis (the severity of necrosis directly depends on the degree of overdose), increased activity of liver transaminases, increased prothrombin time (12-48 hours after administration) , a detailed clinical picture of liver damage appears after 1-6 days. Rarely, liver dysfunction develops suddenly and can be complicated by renal failure (renal tubular necrosis).

Treatment:

symptomatic, gastric lavage, administration of SH-group donors and precursors for the synthesis of glutathione - methionine 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Side effect

Allergic reactions:

sometimes - skin rash, itching, urticaria, angioedema.

From the hematopoietic system:

rarely - thrombocytopenia, leukopenia, agranulocytosis.

From the digestive system:

rarely - nausea, vomiting, epigastric pain.

Other:

rarely - increased intraocular pressure, urinary retention.
With long-term use in excess of the recommended dose, hepatotoxic and nephrotoxic effects may occur.
Phenylephrine hydrochloride may cause nausea, headache, and increased blood pressure; rarely - palpitations. These symptoms disappear after discontinuation of the drug.

special instructions

You should not simultaneously use other drugs containing paracetamol, as well as other non-opioid analgesics, NSAIDs (including metamizole, acetylsalicylic acid, ibuprofen), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.

The simultaneous use of other drugs should be agreed with a doctor.

The drug may interfere with the results of laboratory tests assessing the concentration of glucose and uric acid in plasma.

Storage conditions

The drug should be stored out of the reach of children, in a dry place, protected from light, at a temperature not exceeding 25°C.

Best before date

Shelf life: 3 years.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.

The use of the drug Prostudox® is contraindicated during pregnancy and breastfeeding.

Use for renal impairment

Restrictions for impaired renal function - With caution.

Should be done with caution

use the drug for renal failure.

Use for liver dysfunction

Restrictions for liver dysfunction - With caution.

Should be done with caution

use the drug for liver failure, congenital hyperbilirubinemia (including Gilbert, Dubin-Johnson and Rotor syndrome).

Use in children

Restrictions for children - Contraindicated. Contraindicated in children under 14 years of age.

Terms of sale

The drug is approved for use as a means of OTC.

Contacts for inquiries

SYNTHEZ OJSC Kurgan Joint-Stock Company of Medical Preparations and Products (Russia)

SYNTHEZ JSC

640008 Kurgan, Constitution Ave. 7 Tel.; Fax

special instructions

You should not simultaneously use other drugs containing paracetamol, as well as other non-narcotic analgesics, NSAIDs (including metamizole, acetylsalicylic acid, ibuprofen), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.

The simultaneous use of other drugs should be agreed with a doctor.

The drug may interfere with the results of laboratory tests assessing the concentration of glucose and uric acid in plasma.

Impact on the ability to drive vehicles and operate machinery

When using Prostudox®, the active components of the drug do not cause drowsiness and do not impair concentration.

Contraindications

The drug should not be taken simultaneously with other paracetamol-containing drugs, in case of hypersensitivity to the ingredients included in the drug. Hypersensitivity, hyperthyroidism, diseases of the cardiovascular system (severe aortic stenosis, acute myocardial infarction, tachyarrhythmia), arterial hypertension, diabetes mellitus, pheochromocytoma, prostatic hyperplasia, angle-closure glaucoma, concomitant use of tricyclic antidepressants, beta-blockers, monoamine oxidase inhibitors (including .h. within 14 days after their cancellation), children's age (up to 14 years), pregnancy, lactation period.