Rinicold HotCap, powder for oral solution, orange flavor, 5 g, 10 pcs.

Release form and composition

The drug is produced in the form of a powder for preparing a solution for oral administration (pineapple, orange, lemon): pineapple - free-flowing, pale yellow with white inclusions, the prepared solution is green-yellow with the smell of pineapple; orange - free-flowing, almost white with a pink tint, with white inclusions, the prepared solution is orange in color with the smell of orange; lemon - free-flowing, almost white with a yellow tint, with white inclusions, the prepared solution is yellow with a slight green tint and opalescence, with the smell of lemon [5 g in a bag (sachet) made of three-layer material, in a cardboard pack of 1, 5, 10 or 50 sachets (sachets) and instructions for use of Rinicold HotMix].

5 g of powder (1 sachet/sachet) contains:

• active ingredients: phenylephrine hydrochloride – 10 mg, pheniramine maleate – 20 mg, caffeine – 30 mg, paracetamol – 750 mg;
• additional components: anhydrous citric acid, sodium chloride, anhydrous lactose, anhydrous sodium citrate, mannitol, aspartame, disodium edetate, quinoline yellow dye (pineapple and lemon), sunset yellow dye (orange), pineapple/orange/lime flavoring.

Compound

Name

Most anti-cold combinations contain three components: paracetamol, phenylephrine hydrochloride and ascorbic acid, less often they contain antihistamines pheniramine or chlorphenamine maleate, which stop the allergic component of colds, reducing a runny nose, discomfort in the throat, itching in the nose and eyes, as well as lacrimation . The stimulant caffeine is sometimes used as an additional component, which reduces fatigue and drowsiness, and increases the mental and physical performance of the person with a cold. The secretolytic guaifenesin contained in the drug makes it possible to recommend the complex for ARVI and influenza, which are accompanied by a wet cough.

The most “complex” combination of six ingredients, including the antiviral rimantadine, the 2nd generation antihistamine loratadine, as well as the angioprotector rutoside and calcium gluconate, is contained in the drug “Anvimax”.

Minimum concentrations of paracetamol contain drugs intended for use in pediatrics. Its average content in anti-cold combinations for adults is 500–650 mg. Paracetamol in a maximum single dose of 1000 mg is included in three drugs. Let us remind you that the maximum daily dose of paracetamol is 4 g, and therefore the buyer should be warned that anti-cold combinations with a dosage of 1000 mg of paracetamol are extremely dangerous to take more than four times a day.

Pharmacological properties

Pharmacodynamics

The therapeutic effect of Rinicold HotMix is ​​due to the action of its active substances:

• pheniramine: exhibits an antiallergic effect - relieves itching of the eyes, throat and nose, hyperemia and swelling of the mucous membranes of the nasal cavity, paranasal sinuses and nasopharynx, weakens exudative manifestations;
• paracetamol: has an antipyretic and analgesic effect - it reduces headaches, muscle and joint pain, sore throat that occur against the background of colds, and also lowers high body temperature;
• phenylephrine: exhibits a vasoconstrictor effect - reduces swelling and hyperemia of the paranasal sinuses and mucous membranes of the upper respiratory tract;
• caffeine: has a stimulating effect on the central nervous system (CNS), which reduces drowsiness and fatigue, and increases physical and mental performance.

Contraindications

Absolute:

• age up to 15 years;
• pregnancy and lactation;
• combination therapy with other drugs containing active substances included in the drug;
• combined use with tricyclic antidepressants, β-blockers, monoamine oxidase inhibitors (MAOIs), as well as a period of 2 weeks after their discontinuation;
• hypersensitivity to any of the components of Rinicold HotMix powder.

Relative (treatment with the drug should be carried out with caution):

• arterial hypertension;
• severe atherosclerosis of the coronary arteries;
• pheochromocytoma;
• thyrotoxicosis;
• liver and/or kidney failure;
• hereditary disorders of sugar absorption and diabetes mellitus;
• prostatic hyperplasia;
• chronic obstructive pulmonary disease;
• bronchial asthma;
• congenital hyperbilirubinemia (Gilbert, Rotor and Dubin-Johnson syndromes);
• deficiency of glucose-6-phosphate dehydrogenase;
• angle-closure glaucoma.

Presence of sugar

Most drugs contain sugar, but there are still drugs in which it is replaced with sweeteners aspartame and saccharin, which are approved for diabetes.

Both aspartame and saccharin have a zero glycemic index. That is, they do not affect blood sugar levels in any way, which is very convenient for patients with diabetes. The difference between aspartame and saccharin is in caloric content: for the first sweetener it is 4 kcal/g, and the second contains no calories at all, since it is not metabolized in the human body.

Rinicold HotMix, instructions for use: method and dosage

The drug is taken orally.

Rinicold HotMix powder from 1 sachet should be poured into a glass, pour hot water and stir until completely dissolved. You can optionally add honey or sugar to the resulting solution. The product should be taken 1-2 hours after meals with plenty of liquid.

For adolescents over 15 years of age and adults, it is recommended to use 1 sachet 3-4 times a day, with breaks between doses of 4-6 hours. The maximum daily dose is no more than 4 sachets.

It is not recommended to use Rinicold HotMix as an analgesic for more than 5 days, and as an antipyretic for more than 3 days without a doctor’s prescription and supervision.

Increasing the daily dose of the drug or the duration of treatment is allowed only under the supervision of a specialist. Do not exceed the recommended dose. If you suspect an overdose, you should immediately visit a doctor, even if you feel well.

Rinicold hotmix

Rinicold HotMix is ​​a combined four-component drug for symptomatic (affecting the symptoms, not the cause of the disease) treatment of the common cold. Paracetamol has an antipyretic and analgesic effect: it eliminates pain characteristic of a cold (sore throat, cephalgia, arthralgia and myalgia), reduces febrile and subfebrile temperature. Phenylephrine reduces the lumen of blood vessels, thereby eliminating swelling and reducing the intensity of blood flow to the mucous membranes of the upper respiratory tract and sinuses. Pheniramine exhibits an antiallergic effect: eliminates itching in the eyes, throat and nasal passages, promotes the resorption of edema, and eliminates increased blood flow to the mucous membranes. Caffeine is a psychostimulant that eliminates fatigue, drowsiness, and increases physical and mental endurance. Single dose – 1 sachet. Method of preparation: dissolving in hot water. You can add sugar or honey to add flavor. The peculiarity of the application is the need to drink a large volume of liquid. The optimal time to take is 1-2 hours after eating. Frequency of application – 3-4 times a day at regular intervals. Maximum duration of the drug course: 5 days as an analgesic and 3 days as an antipyretic. Increasing the prescribed duration of use or dose is allowed only in consultation with the doctor. Possible undesirable side reactions associated with taking Rinicold HotMix: skin rashes, a feeling of painful tickling irritation of the skin, causing the need to scratch the irritated area, urticaria, Quincke's edema, vertigo, somnological disorders, increased excitability, transient arterial hypertension, rapid heartbeat, painful sensation in epigastric region, chest, oral cavity and pharynx, preceding vomiting (as well as vomiting itself), epigastric pain, hyposalivation, toxic liver damage, dilated pupils, accommodation paresis, increased pressure inside the eye, bronchospasm, difficulty urinating.

Rinicold HotMix is ​​not prescribed simultaneously with amitriptyline and other tricyclic antidepressants, beta-adrenergic blockers, monoamine oxidase inhibitors, in case of individual intolerance to any active or auxiliary component, as well as during pregnancy and breastfeeding. In pediatric practice, the drug is used after the patient reaches 15 years of age. The drug is used with extreme caution in persons with severe atherosclerotic changes in the arteries of the heart, hypertension, hyperfunction of the thyroid gland, diabetes mellitus, bronchial asthma, COPD, insufficiency of liver and/or kidney function, prostate adenoma. If the patient is taking the antiemetic drug metoclopramide, the prokinetic drug domperidone, the hypocholesterolemic drug cholestyramine, warfarin and other anticoagulants, then if it is necessary to take Rinicold HotMix, a doctor's consultation is necessary. While taking the drug, you must avoid drinking alcohol, using sleeping pills and anxiolytics. To avoid an overdose of paracetamol, it is not recommended to take Rinicold HotMix together with other drugs containing this component as an active ingredient. If there is no improvement in the clinical situation within 3-5 days, a medical consultation is necessary to clarify the diagnosis and/or adjust the treatment. The drug potentiates the effects of monoamine oxidase inhibitors, sedatives, and ethyl alcohol. Taking the drug together with antidepressants, neuroleptics, and antiparkinsonian drugs increases the likelihood of developing side effects such as delayed urination, hyposalivation, slow, difficult, or systematically insufficient bowel movements.

Side effects

• digestive system: dry mouth, nausea, epigastric pain, vomiting, hepatotoxic effect;
• cardiovascular system: increased blood pressure (BP), tachycardia;
• nervous system: increased excitability, difficulty falling asleep, dizziness;
• hematopoietic organs: thrombocytopenia, agranulocytosis;
• sensory organs: mydriasis, increased intraocular pressure (IOP), accommodation paresis;
• allergic reactions: itching, skin rash, urticaria, angioedema;
• others: urinary retention, bronchospasm.

Overdose

An overdose of Rinicold HotMix is ​​caused primarily by paracetamol and is detected after taking this substance in a dose exceeding 10–15 g.

Symptoms of overdose include pale skin, nausea, anorexia, vomiting, increased prothrombin time, increased activity of liver transaminases. If such effects occur, you should immediately consult a doctor. In this case, gastric lavage with further intake of activated charcoal is indicated, as well as the prescription of symptomatic therapy. Methionine is administered 8–9 hours after the overdose, and N-acetylcysteine ​​is administered 12 hours later.

RiniCold Hotmix powder lemon 5 g 10 pcs ➤ instructions for use

In case of overdose of RiniCold HotCap®, you should immediately consult a doctor. Prompt medical attention is critical, even if you do not experience any signs or symptoms.

Symptoms (due to the presence of paracetamol)

Symptoms appear after taking paracetamol over 7.5-10 g.

The threshold for overdose may be lowered in elderly patients and children, as well as in patients taking certain drugs (eg, liver microsomal enzyme inducers), alcohol, or who are malnourished.

During the first 24 hours after administration - pale skin, nausea, vomiting; anorexia, abdominal pain; increased prothrombin time, impaired glucose metabolism, hypokalemia and metabolic acidosis (including lactic acidosis). Symptoms of liver dysfunction may appear 12-48 hours after an overdose: increased activity of “liver” transaminases, hepatonecrosis. In severe cases - liver failure with progressive encephalopathy, coma. Rarely, liver failure develops rapidly and can be complicated by renal failure (tubular necrosis).

Treatment

If you suspect an overdose of RiniCold HotCap®, you must stop using the drug and immediately seek medical help.

Symptomatic treatment: in the first 6 hours after an overdose, gastric lavage and the use of enterosorbents (activated carbon, etc.) are recommended. Administration of SH-group donors and precursors for the synthesis of glutathione - methionine is most effective in the first 8-9 hours after an overdose, acetylcysteine ​​- after 12 hours. The need for additional therapeutic measures (further administration of methionine and acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as time , passed after its reception.

Symptoms (due to caffeine)

Symptoms of acute overdose: abdominal pain; vomit; feeling of heat; facial redness; fever; chills; excitation; insomnia; irritability; loss of appetite; weakness; tremor; increased muscle tone; state of altered consciousness; rave; hallucinations; increased blood pressure followed by arterial hypotension; tachycardia; tachypnea; increased diuresis; hypokalemia; hyponatremia; hyperglycemia; metabolic acidosis; convulsions; myoclonus and rhabdomyolysis; supraventricular and ventricular arrhythmias.

Symptoms of chronic caffeine intoxication “caffeineism”: irritability; insomnia; anxiety; emotional lability; chronic abdominal pain.

Symptoms (due to the presence of chlorphenamine)

Central nervous system depression, hyperthermia, anticholinergic syndrome (mydriasis, flushing, fever, dry mouth, urinary retention, intestinal paresis), tachycardia, arterial hypotension, arterial hypertension, nausea, vomiting, agitation, disorientation, hallucinations, psychosis, convulsions, arrhythmias . Rarely, patients with agitation, seizures, or comatose patients develop rhabdomyolysis and renal failure.

Symptoms (due to the presence of phenylephrine)

Nausea; vomit; irritability; excitation; insomnia; psychosis; convulsions; feeling of heartbeat; tachycardia; increased blood pressure; reflex bradycardia.

special instructions

If the patient is being treated with drugs such as domperidone, cholestyramine, metoclopramide, anticoagulants (warfarin), you should consult a doctor before taking Rinicold HotMix.

During the period of therapy, it is necessary to refrain from drinking alcohol, taking anxiolytic (tranquilizers) and sleeping pills, as well as drugs containing paracetamol.

If the symptoms of the disease cannot be eliminated within 3-5 days, you should consult a specialist.

Patients with a tendency to chronic alcohol consumption should not take paracetamol due to the risk of toxic liver damage.

Impact on the ability to drive vehicles and complex mechanisms

During treatment, caution should be exercised when driving vehicles and operating other complex equipment.

Drug interactions

• antipsychotics, antidepressants, phenothiazine derivatives, antiparkinsonian drugs: the risk of dry mouth, urinary retention, and constipation increases;
• sedatives, MAO inhibitors, ethanol: the effects of these drugs are enhanced;
• uricosuric drugs: the effectiveness of these drugs is reduced under the influence of paracetamol;
• chlorpheniramine: the risk of developing agitation, hypertensive crisis, hyperpyrexia increases when taken in combination with furazolidone, MAO inhibitors;
• guanethidine: the hypotensive effect of this substance is reduced when combined with phenylephrine, and the alpha-adrenergic stimulating effect of the latter is enhanced;
• halothane: increases the likelihood of ventricular arrhythmia;
• tricyclic antidepressants: the sympathomimetic effect of phenylephrine increases;
• glucocorticosteroids: increases the risk of developing glaucoma;
• barbiturates, diphenin, rifampicin, carbamazepine and other inducers of microsomal liver enzymes: the risk of hepatotoxicity of paracetamol increases.

Rinicold HotCap®

In case of overdose of RiniCold HotCap®, you should immediately consult a doctor. Prompt medical attention is critical, even if you do not experience any signs or symptoms.

Symptoms (due to the presence of paracetamol)

Symptoms appear after taking paracetamol over 7.5-10 g.

The threshold for overdose may be lowered in elderly patients and children, as well as in patients taking certain drugs (eg, liver microsomal enzyme inducers), alcohol, or who are malnourished.

During the first 24 hours after administration - pallor of the skin, nausea, vomiting; anorexia, abdominal pain; increased prothrombin time, impaired glucose metabolism, hypokalemia and metabolic acidosis (including lactic acidosis).

Symptoms of liver dysfunction may appear 12-48 hours after an overdose: increased activity of “liver” transaminases, hepatonecrosis. In severe cases - liver failure with progressive encephalopathy, coma. Rarely, liver failure develops rapidly and can be complicated by renal failure (tubular necrosis).

Treatment

If you suspect an overdose of RiniCold HotCap®, you must stop using the drug and immediately seek medical help.

Symptomatic treatment

: in the first 6 hours after an overdose, gastric lavage and the use of enterosorbents (activated carbon, etc.) are recommended. Administration of SH-group donors and precursors for the synthesis of glutathione - methionine is most effective in the first 8-9 hours after an overdose, acetylcysteine ​​- after 12 hours. The need for additional therapeutic measures (further administration of methionine and acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as time , passed after its reception.

Symptoms (due to caffeine)

Symptoms of acute overdose:

abdominal pain; vomit; feeling of heat; facial redness; fever; chills; excitation; insomnia; irritability; loss of appetite; weakness; tremor; increased muscle tone; state of altered consciousness; rave; hallucinations; increased blood pressure followed by arterial hypotension; tachycardia; tachypnea; increased diuresis; hypokalemia; hyponatremia; hyperglycemia; metabolic acidosis; convulsions; myoclonus and rhabdomyolysis; supraventricular and ventricular arrhythmias.

Symptoms of chronic caffeine intoxication “caffeinism”:

irritability; insomnia; anxiety; emotional lability; chronic abdominal pain.

Symptoms (due to the presence of chlorphenamine)

Central nervous system depression, hyperthermia, anticholinergic syndrome (mydriasis, flushing, fever, dry mouth, urinary retention, intestinal paresis), tachycardia, arterial hypotension, arterial hypertension, nausea, vomiting, agitation, disorientation, hallucinations, psychosis, convulsions, arrhythmias . Rarely, patients with agitation, seizures, or comatose patients develop rhabdomyolysis and renal failure.

Symptoms (due to the presence of phenylephrine)

Nausea; vomit; irritability; excitation; insomnia; psychosis; convulsions; feeling of heartbeat; tachycardia; increased blood pressure; reflex bradycardia.

Reviews of Rinikold HotMix

According to reviews about Rinicold HotMix found on medical websites, the drug quickly and effectively relieves the symptoms of colds and acute respiratory viral infections, not being inferior in effectiveness to its more expensive analogues. Many patients note that after several doses of the drug per day, nasal breathing is significantly easier, body temperature decreases, a sore throat is eliminated, pain in muscles and joints, and headaches are alleviated. Some patients, however, believe that Rinicold HotMix helps only when it is started to be used immediately after the first signs of acute respiratory infections appear, and for advanced diseases, taking the drug is not advisable.

The disadvantages of Rinicold HotMix include its unpleasant medicinal taste, the presence of contraindications and side effects. Sometimes there are complaints about the lack of improvement in the condition after a full course of drug therapy.