Xefocam Rapid, 12 pcs., 8 mg, film-coated tablets


Xefocam Rapid, 12 pcs., 8 mg, film-coated tablets

The risk of the ulcerogenic effect of the drug can be reduced by the simultaneous administration of proton pump inhibitors and synthetic analogues of PG. If bleeding occurs in the gastrointestinal tract, the drug should be stopped immediately and appropriate emergency measures taken. It is especially necessary to carefully monitor the condition of those patients with gastrointestinal pathology who are receiving a course of treatment with Xefocam® for the first time.

Like other oxicams, it inhibits platelet aggregation and may therefore increase bleeding time. When using this drug, it is necessary to carefully monitor the condition of patients who require absolutely normal functioning of the blood coagulation system (for example, patients who are undergoing surgery), who have disorders of the blood coagulation system, or who are receiving drugs that inhibit coagulation (including low-dose heparin), for in order to promptly detect signs of bleeding.

If signs of liver damage appear (itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased levels of liver transaminases), you should stop taking the drug and consult your doctor.

The drug should not be used simultaneously with other NSAIDs.

The drug can change the properties of platelets, but does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.

For patients with impaired renal function caused by large blood loss or severe dehydration, the drug Xefocam®, as an inhibitor of PG synthesis, can be prescribed only after hypovolemia and the associated risk of reducing renal perfusion have been eliminated. Like other NSAIDs, it can cause an increase in blood urea and creatinine concentrations, as well as water and sodium retention, peripheral edema, hypertension and other early signs of nephropathy. Long-term treatment of such patients with Xefocam® can lead to the following consequences: glomerulonephritis, papillary necrosis and nephrotic syndrome with transition to acute renal failure. The drug should not be prescribed to patients with a pronounced decrease in renal function (see “Contraindications”). In elderly patients, as well as in patients suffering from arterial hypertension and/or obesity, it is necessary to control blood pressure levels.

It is especially important to monitor renal function in elderly patients, as well as in patients simultaneously receiving diuretics and drugs that can cause kidney damage.

With long-term use of the drug Xefocam®, it is necessary to periodically monitor hematological parameters, as well as renal and liver function. The use of the drug may adversely affect female fertility and is not recommended for women planning pregnancy.

Patients using the drug must refrain from activities that require increased attention, rapid mental and motor reactions, and alcohol consumption.

Instructions for use of XEFOCAM RAPID

For the following disorders, the drug should be prescribed with caution

and only after a thorough assessment of the expected benefits of therapy and the possible risks.

History of gastrointestinal ulcers and bleeding.

Clinical follow-up at regular intervals is recommended. If a patient develops a peptic ulcer and/or gastrointestinal bleeding while taking the drug, then it is necessary to discontinue the drug and carry out appropriate treatment.

Kidney failure.

Patients with mild renal failure (serum creatinine 150-300 µmol/l) require quarterly examination; in case of moderate renal failure (serum creatinine 300-700 µmol/l), examinations should be carried out at intervals of 1-2 months. If renal function deteriorates, the drug should be discontinued.

Patients with bleeding disorders.

Careful clinical observation and assessment of laboratory parameters (for example, prothrombin index) are recommended.

Liver diseases (for example, cirrhosis of the liver).

Clinical observation and evaluation of laboratory parameters at regular intervals (eg, liver enzyme activity) are recommended.

Long-term treatment (more than a month).

Regular blood tests (hemoglobin), kidney function (serum creatinine) and liver function (liver enzyme activity) are recommended.

Elderly patients (65 years and older),

because
a decrease in the clearance of lornoxicam is possible ,
as well as
in patients weighing less than 50 kg and after surgery.
Monitoring of renal and liver functions is recommended.

Monitoring of renal function is necessary in the following
patients:

Xefocam

The non-steroidal anti-inflammatory drug xefocam may not be as well known among a wide range of drug consumers as its more “promoted” “brothers” in the pharmacological group, but the strength of its analgesic effect, coupled with the reputation of the manufacturer - known in Europe and outside the pharmaceutical industry - makes this drug very competitive, especially when it is necessary to quickly suppress severe pain. The active ingredient of Xefocam is lornoxicam, which has, first of all, an analgesic and anti-inflammatory effect.

The mechanism of action of Xefocam for a person ignorant of the nuances of biochemistry and pharmacology will seem too complex. Meanwhile, everything can be explained in fairly accessible language. The drug inhibits the activity of the enzyme cyclooxygenase, which takes part in the synthesis of prostaglandins. For all their considerable benefits in the body, prostaglandins also bring a certain amount of costs, being the initiators of pain and inflammatory processes. By excluding cyclooxygenase from the biochemical chain, xefocam thereby suppresses the formation of these generators of pain and inflammation. Lack of cyclooxygenase makes peripheral pain receptors less sensitive, which in turn inhibits inflammation. It should be noted that the analgesic effect of Xefocam is in no way associated with an opiate-like effect on the central nervous system and, unlike narcotic analgesics, the drug does not depress breathing and is not addictive.

Another positive property of Xefocam is its “non-interference policy”: it does not affect body temperature, heart rate and respiration, blood pressure and ECG readings.

Xefocam is available in two dosage forms: tablets and lyophilized powder for the preparation of a solution for intravenous and intramuscular injections. The tablets should be taken before meals. For severe pain, it is recommended to take 8-16 mg of the drug per day, dividing this dose into 2-3 doses. The duration of treatment depends on the specific disease and the severity of its course. Considering the presence of a number of undesirable side effects of non-steroidal anti-inflammatory drugs, especially from the digestive tract, it is recommended not to exceed the minimum effective dosage of the drug and not to abuse the duration of therapy. The injection form of Xefocam is used, as a rule, in a hospital setting to relieve postoperative pain. Due to the need to prepare the solution yourself, this dosage form is not particularly popular for treatment at home, although in an acute attack of radiculitis it can be very effective.

Dosage forms and composition

Xefocam contains one active component - lornoxicam, which affects the production of prostaglandins. The drug is produced:

  • In tablet form: with a dosage of 4–8 mg. Formative components: silicon dioxide, starch, lactose, magnesium stearate. White oblong pills are packaged in paper cellular blisters of 10 pieces. On the surface they have an engraving Lo and a dose designation - the number 4 or 8. The cardboard packaging of the medicine contains from 10 to 50 tablets.
  • In the form of a lyophilisate for the preparation of solutions. Yellow dense mass placed in glass bottles - 5 pieces per package. One container contains a medicine in a dose of 8 mg, auxiliary compounds: mannitol, tromethanol.

How to use Xefocam

The medication in tablets is prescribed to adults at 4–8 mg per day. The maximum dose per day is 16 mg. The pills should be swallowed without chewing, with 50–100 ml of water. It is important to follow the regimen, taking the medicine orally before meals - 30–40 minutes. Food slows down absorption and reduces the activity of the analgesic in severe pain.

Xefocam injections are given intramuscularly or intravenously. A single dose of the drug is 8 mg. Before administration, the lyophilisate from the bottle is diluted with distilled water in a volume of 2 ml. If necessary, the injection of the drug is repeated after 4–6 hours.

When is Xefocam indicated: instructions

Among the indications for taking the medication: pain of various origins, subject to the action of non-steroidal analgesics. Including those caused by:

  • rheumatoid arthritis;
  • deforming arthrosis;
  • gout;
  • ankylosing spondylitis.

The medication effectively reduces pain to moderate and moderate-to-severe intensity. Xefocam does not affect the general course of diseases; it is used only for symptomatic therapy: in short courses.

The drug is used with caution for pathologies of the gastrointestinal tract, smoking, alcoholism, heart failure, and diabetes.

Rating
( 2 ratings, average 4.5 out of 5 )
Did you like the article? Share with friends:
For any suggestions regarding the site: [email protected]
Для любых предложений по сайту: [email protected]