Acyclovir Sandoz cream for external use 5% 5g

Acyclovir Sandoz, 200 mg, tablets, 25 pcs.

The drug can be taken with food, since food intake does not significantly impair the absorption of acyclovir.

Adults

Treatment of infections caused by Herpes simplex virus types 1 and 2

The recommended dose is 200 mg 5 times a day (every 4 hours, except during night sleep). As a rule, the course of treatment is 5 days, but can be extended for severe primary infections.

In case of severe immunodeficiency (for example, after bone marrow transplantation) or in case of impaired absorption from the intestine, the dose of acyclovir can be increased to 400 mg. As an alternative, the use of acyclovir by IV infusion may be considered.

Treatment should begin as soon as possible after infection occurs; in case of relapses, it is recommended to prescribe acyclovir already in the prodromal period or when the first elements of the rash appear.

Prevention of relapse of infections caused by Herpes simplex virus types 1 and 2 in patients with normal immune status

The recommended dose is 200 mg 4 times a day (every 6 hours); a regimen of 400 mg 2 times a day (every 12 hours) can be used.

In some cases, lower doses of acyclovir are effective - 200 mg 3 times / day (every 8 hours) or 200 mg 2 times / day (every 12 hours).

Some patients may experience exacerbation of infection when taking a total daily dose of 800 mg.

Treatment with acyclovir should be periodically interrupted for 6-12 months to identify possible changes in the course of the disease.

Prevention of infections caused by Herpes simplex virus types 1 and 2 in immunocompromised patients

The recommended dose of acyclovir is 200 mg 4 times a day (every 6 hours).

In case of severe immunodeficiency (for example, after bone marrow transplantation) or in case of impaired absorption from the intestine, the dose of acyclovir can be increased to 400 mg 4 times a day. As an alternative, the use of acyclovir by IV infusion may be considered.

The duration of the preventive course of therapy is determined by the length of the period when there is

risk of infection.

Treatment of primary and recurrent infections caused by the Varicella zosler virus - chickenpox and herpes zoster

The recommended dose of acyclovir is 800 mg 5 times a day (every 4 hours, except during night sleep). The course of treatment is 7 days.

In cases of severe immunodeficiency (for example, after bone marrow transplantation) or in cases of impaired absorption from the intestine, the use of acyclovir in the form of intravenous infusion should be considered.

The drug should be prescribed as soon as possible after the onset of infection, because in this case, treatment is more effective.

Children aged 3 years and older

Treatment of infections caused by Herpes simplex virus types 1 and 2; prevention of infections caused by Herpes simplex virus types 1 and 2 in patients with immunodeficiency

Acyclovir is used in the same doses as for adults.

Treatment of chickenpox

Children aged 6 years and older - 800 mg 4 times a day; at the age of 3 to 6 years - 400 mg 4 times a day per day. More precisely, the dose can be determined at the rate of 20 mg/kg body weight (but not more than 800 mg) 4 times/day. The course of treatment is 5 days.

Prevention of recurrence of infections caused by Herpes simplex virus types 1 and 2; treatment of herpes zoster

There are no data on dosage regimen.

Elderly patients

The dose of the drug should be adjusted depending on the degree of renal failure.

It is necessary to ensure that adequate water balance is maintained.

Patients with impaired renal function

Acyclovir should be prescribed with caution. It is necessary to ensure that adequate water balance is maintained.

In patients with renal failure, oral administration of acyclovir in recommended doses for the treatment and prevention of infections caused by Herpes simplex virus types 1 and 2 does not lead to the accumulation of the active substance to concentrations exceeding the established safe level. However, in patients with CC <10 ml/min, it is recommended to reduce the dose of acyclovir to 200 mg 2 times a day (every 12 hours).

When treating chickenpox and herpes zoster, the recommended doses of acyclovir are:

CC < 10 ml/min - 800 mg 2 times/day (every 12 hours);

CC 10-25 ml/min - 800 mg 3 times/day (every 8 hours).

Acyclovir Sandoz tablets 200 mg 25 pcs.

The drug can be taken with food, since food intake does not significantly impair the absorption of acyclovir. Adults. Treatment of infections caused by the Herpes simplex virus types 1 and 2. The recommended dose is 200 mg 5 times a day (every 4 hours, except during night sleep). As a rule, the course of treatment is 5 days, but can be extended for severe primary infections. In case of severe immunodeficiency (for example, after bone marrow transplantation) or in case of impaired absorption from the intestine, the dose of acyclovir can be increased to 400 mg. As an alternative, the use of acyclovir by IV infusion may be considered. Treatment should begin as soon as possible after infection occurs; in case of relapses, it is recommended to prescribe acyclovir already in the prodromal period or when the first elements of the rash appear. Prevention of relapse of infections caused by Herpes simplex virus types 1 and 2 in patients with normal immune status. The recommended dose is 200 mg 4 times a day (every 6 hours); a regimen of 400 mg 2 times a day (every 12 hours) can be used. In some cases, lower doses of acyclovir are effective - 200 mg 3 times / day (every 8 hours) or 200 mg 2 times / day (every 12 hours). Some patients may experience exacerbation of infection when taking a total daily dose of 800 mg. Treatment with acyclovir should be periodically interrupted for 6-12 months to identify possible changes in the course of the disease. Prevention of infections caused by Herpes simplex virus types 1 and 2 in patients with immunodeficiency. The recommended dose of acyclovir is 200 mg 4 times a day (every 6 hours). In case of severe immunodeficiency (for example, after bone marrow transplantation) or in case of impaired absorption from the intestine, the dose of acyclovir can be increased to 400 mg 4 times a day. As an alternative, the use of acyclovir by IV infusion may be considered. The duration of the preventive course of therapy is determined by the length of the period when there is a risk of infection. Treatment of primary and recurrent infections caused by the Varicella zosler virus - chickenpox and herpes zoster. The recommended dose of acyclovir is 800 mg 5 times a day (every 4 hours, except during night sleep). The course of treatment is 7 days. In cases of severe immunodeficiency (for example, after bone marrow transplantation) or in cases of impaired absorption from the intestine, the use of acyclovir in the form of intravenous infusion should be considered. The drug should be prescribed as soon as possible after the onset of infection, because in this case, treatment is more effective. Children aged 3 years and older. Treatment of infections caused by Herpes simplex virus types 1 and 2; prevention of infections caused by Herpes simplex virus types 1 and 2 in patients with immunodeficiency. Acyclovir is used in the same doses as for adults. Treatment of chicken pox. Children aged 6 years and older - 800 mg 4 times a day; at the age of 3 to 6 years - 400 mg 4 times a day per day. More precisely, the dose can be determined at the rate of 20 mg/kg body weight (but not more than 800 mg) 4 times/day. The course of treatment is 5 days. Prevention of recurrence of infections caused by Herpes simplex virus types 1 and 2; treatment of herpes zoster. There are no data on dosage regimen. Elderly patients. The dose of the drug should be adjusted depending on the degree of renal failure. It is necessary to ensure that adequate water balance is maintained. Patients with impaired renal function. Acyclovir should be prescribed with caution. It is necessary to ensure that adequate water balance is maintained. In patients with renal failure, oral administration of acyclovir in recommended doses for the treatment and prevention of infections caused by Herpes simplex virus types 1 and 2 does not lead to the accumulation of the active substance to concentrations exceeding the established safe level. However, in patients with CC <10 ml/min, it is recommended to reduce the dose of acyclovir to 200 mg 2 times a day (every 12 hours). In the treatment of chickenpox and herpes zoster, the recommended doses of acyclovir are: -Cr < 10 ml/min - 800 mg 2 times/day (every 12 hours); -CC 10-25 ml/min - 800 mg 3 times/day (every 8 hours).

Acyclovir Sandoz

Use during pregnancy and breastfeeding

The use of acyclovir during pregnancy is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
IV use of acyclovir during lactation is contraindicated (excreted in breast milk).

Experimental studies on animals have shown that acyclovir penetrates the placental barrier.

Use for renal impairment

Use is not recommended for severe renal impairment.

In case of renal failure, adjustment of the dosage regimen is necessary.

It should be taken into account that when using acyclovir, acute renal failure may develop due to the formation of sediment from acyclovir crystals, which is especially likely with rapid intravenous administration, simultaneous use of nephrotoxic drugs, in patients with impaired renal function and with insufficient water load.

When using acyclovir, it is necessary to monitor renal function (determining the level of urea nitrogen in the blood and creatinine in the blood plasma).

Use in children

Orally for children over 2 years old - 200-400 mg 3-5 times a day, if necessary - 20 mg/kg (up to 800 mg per dose) 4 times a day. In children under 2 years of age, use a dose equal to half the dose for adults. The duration of treatment is 5-10 days.

Use in elderly patients

Treatment of elderly patients should be carried out with a sufficient increase in water load and under the supervision of a physician, because in this category of patients, the half-life of acyclovir increases.

special instructions

Use is not recommended for severe renal impairment.

It should be taken into account that when using acyclovir, acute renal failure may develop due to the formation of sediment from acyclovir crystals, which is especially likely with rapid intravenous administration, simultaneous use of nephrotoxic drugs, in patients with impaired renal function and with insufficient water load.

When using acyclovir, it is necessary to monitor renal function (determining the level of urea nitrogen in the blood and creatinine in the blood plasma).

Treatment of elderly patients should be carried out with a sufficient increase in water load and under the supervision of a physician, because in this category of patients, T1/2 of acyclovir increases.

When treating genital herpes, you should avoid sexual intercourse or use condoms, because the use of acyclovir does not prevent transmission of the virus to partners.

Acyclovir in the form of dosage forms for external use should not be applied to the mucous membranes of the mouth, eyes, or vagina.

Acyclovir Sandoz cream for external use 5% 5g

Description:

Active substance:

Acyclovir.

Clinical and pharmacological group

Antiviral drug for external use

Release form, composition and packaging

Cream for external use 5% white or almost white, homogeneous.

Excipients: macrogol and fatty acid ester (arlaton 983S) - 5 g, dimethicone 350 - 0.3 g, cetyl alcohol - 1.5 g, white - 9 g, liquid paraffin - 5 g, propylene glycol - 15 g, purified water - 59.2 g.

2 g - aluminum tubes (1) - cardboard packs. 5 g - aluminum tubes (1) - cardboard packs. 5 g - aluminum tubes (4) - cardboard packs.

pharmachologic effect

Antiviral drug for external use. Acyclovir is active against Herpes simplex types 1 and 2, Varicella zoster virus, Epstein-Barr virus and cytomegaloviruses. Thymidine kinase of virus-infected cells, through a series of sequential reactions, actively converts acyclovir into mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is integrated into the DNA that is synthesized for new viruses. Thus, “defective” viral DNA is formed, which leads to the suppression of the replication of new generations of viruses.

Pharmacokinetics

Suction . When used topically, it is practically not absorbed through intact skin and is not detected in the blood or urine. When applied to affected skin, absorption is moderate.

Excretion. Excreted by the kidneys (up to 9.4% of the daily dose). In patients with normal renal function, the concentration of acyclovir in the blood serum is up to 0.28 mcg/ml.

Pharmacokinetics in special clinical situations

In patients with chronic renal failure, the concentration of acyclovir in the blood serum is up to 0.78 mcg/ml.

Indications

- skin infections caused by the Herpes simplex virus types 1 and 2, including genital herpes and herpes labialis;

- herpes zoster;

- chicken pox.

Contraindications

- hypersensitivity to acyclovir and other components of the drug;

The drug should be prescribed with caution during pregnancy, lactation, dehydration, and renal failure.

Dosage

Externally. The drug is applied 5 times a day (every 4 hours) in a thin layer to the affected and adjacent areas of the skin. The cream is applied either with a cotton swab or with clean hands to avoid additional infection of the affected areas. Therapy should be continued until a crust forms on the blisters or until they are completely healed. The duration of therapy is on average 5 days and should not exceed 10 days.

Side effects

Local reactions: hyperemia, dryness, peeling of the skin; burning, inflammation upon contact with mucous membranes.

Allergic dermatitis may develop.

Drug interactions

When used externally, no interactions with other drugs were detected.

An enhanced effect is observed with the simultaneous administration of immunostimulants.

special instructions

To achieve the maximum therapeutic effect, it is necessary to start using the drug as early as possible after the onset of infection (at the first signs of the disease - burning, itching, tingling, a feeling of tension and redness).

The cream is not recommended to be applied to the mucous membranes of the mouth and eyes, because the development of severe local inflammation is possible.

When treating genital herpes, you should avoid sexual intercourse or use condoms, because the use of acyclovir does not prevent transmission of the virus to partners.

Pregnancy and lactation

The drug should be prescribed with caution during pregnancy and lactation (breastfeeding).

Adequate and controlled clinical studies of the safety of the drug during pregnancy have not been conducted. Use is indicated only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

During the treatment period, it is necessary to decide whether to stop breastfeeding.

For impaired renal function

The drug should be prescribed with caution in case of renal failure.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 4 years.

ACICLOVIR SANDOZ (tablets)

e terms, both with antiviral drugs and without them.
Maybe I'm wrong when I don't give children antiviral drugs, maybe it's some kind of immune support or something like that. But I consider them unnecessary, because doctors always prescribe such a list of medications for treatment, which I consider unnecessary.

But for some reason I trust Acyclovir, even though it is an antiviral drug. When half of my husband’s face was covered in herpes, I bought both ointment and tablets, because I thought that the ointment would not be enough, but his herpes began to pop up often. Well, this is where the work takes its toll: in the summer it’s hot at the plant, in the winter it’s cold, in the spring and autumn you know it’s either cold or warm. So the body reacts, and just like herpes is already on the face.

Okay, when one blister still pops up, it can be cured with ointment, and even if the disease does not occur often. But I just noticed that it became more frequent for him, only after the New Year holidays there was a small blister on his lip, and then in the spring there were definitely about four blisters on both his lips and his nose. Therefore, I decided that I couldn’t do without pills.

But, of course, as always, we self-medicate, because at the clinic we had to wait in line with our therapist first, we didn’t want to spend the weekend on this, and the cure for this nasty thing has been known to everyone for a long time anyway - ointment and pills.

If I took the antiviral ointment from “it cost me thirty-five rubles,” then I bought the tablets from another “. Of course, there are also tablets from Akrikhin, but their dosage is larger than necessary, and the price is twice as high. You won’t split the pill, it’s better to take the dosage for your age.

And for an adult with herpes simplex, a dosage of two hundred milligrams is usually recommended - this is one tablet. And a higher dosage, for example, Akrikhin’s “Acyclovir” tablets have a dosage of four hundred milligrams, probably their effect is aimed at more complex diseases - genital herpes, chickenpox, shingles, which are also caused, in theory, by the same virus.

But for an ordinary person, an adult who has a normal immune status (without HIV or AIDS), a dosage of two hundred milligrams is the most optimal.

There are twenty of them in a pack of Sandoz Acyclovir tablets. My husband took one tablet four times a day, there was some time interval between doses. And you definitely need it after a meal, or after some kind of snack; you don’t have to eat your fill every time in order to take a pill later.

The tablets are ordinary in appearance - white, round. To be honest, I didn’t even ask my husband what they taste like, well, probably nothing, if they were bitter or unpleasant, I would have told him.

Such a package of “Acyclovir”, which contains twenty tablets, is quite enough for a course of treatment, usually with this type of herpes it is recommended to take them only for five days, I don’t know how things are with genital herpes or with chickenpox and shingles, with I had to deal with chickenpox, but I didn’t treat it with anything like that, and probably in vain. Fortunately, I didn’t have to deal with the rest of the diseases on the list.

But, as for me, with herpes simplex it takes more than five days and there is no need to be treated, since literally from the first day there is very intensive healing, especially if you also use ointment. Not only did the blisters begin to crust over and dry out, but the rash also visually began to decrease; before this, my husband had already suffered for several days. And after the start of treatment, things became more fun.

These tablets can also be used for prevention if you have such problems, especially if you know approximately when this nasty thing can pop up, then it would be a good idea to take a course. Moreover, these tablets are not very expensive; I bought them for only one hundred and sixty rubles. Because, in general, I paid about two hundred rubles for the ointment and the pills.